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Results for zeb1a+zeb1b
Z-value: 3.11
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Transcription factors associated with zeb1a+zeb1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zeb1b | dr10_dc_chr12_-_26760324_26760394 | -0.93 | 1.7e-07 | Click! |
| zeb1a | dr10_dc_chr2_-_43997672_43997784 | -0.85 | 2.7e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of zeb1a+zeb1b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_55346967 Show fit | 14.17 |
ENSDART00000135304
|
poly(A) binding protein, nuclear 1-like (cytoplasmic) |
|
| chr21_-_30256477 Show fit | 11.62 |
ENSDART00000137193
|
stem-loop binding protein 2 |
|
| chr24_+_12689711 Show fit | 9.87 |
ENSDART00000114762
|
nanog homeobox |
|
| chr14_+_22159893 Show fit | 7.92 |
ENSDART00000019296
|
growth differentiation factor 9 |
|
| chr5_-_32636372 Show fit | 7.79 |
ENSDART00000085512
ENSDART00000144694 |
KN motif and ankyrin repeat domains 1b |
|
| chr7_-_73890499 Show fit | 7.76 |
ENSDART00000164992
|
RNA binding protein with multiple splicing |
|
| chr23_+_540624 Show fit | 7.72 |
ENSDART00000034707
|
LSM family member 14B |
|
| chr7_+_58448953 Show fit | 7.52 |
ENSDART00000024185
|
zgc:56231 |
|
| chr21_-_804453 Show fit | 7.33 |
|
|
|
| chr14_+_29945327 Show fit | 7.29 |
ENSDART00000173090
|
microtubule associated tumor suppressor 1a |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 24.5 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 1.6 | 19.4 | GO:0090308 | methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 3.1 | 18.7 | GO:0030237 | female sex determination(GO:0030237) |
| 4.2 | 16.8 | GO:0043622 | cortical microtubule organization(GO:0043622) |
| 1.8 | 12.8 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.4 | 12.5 | GO:0048599 | oocyte development(GO:0048599) |
| 0.0 | 12.1 | GO:0006886 | intracellular protein transport(GO:0006886) |
| 1.9 | 11.6 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.2 | 11.6 | GO:0035303 | regulation of dephosphorylation(GO:0035303) |
| 0.8 | 11.5 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 24.3 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.2 | 23.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.4 | 18.5 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.3 | 14.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.7 | 14.1 | GO:0043186 | P granule(GO:0043186) |
| 0.6 | 11.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 11.4 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 10.4 | GO:0048475 | membrane coat(GO:0030117) coated membrane(GO:0048475) |
| 0.2 | 9.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.9 | 24.5 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.4 | 23.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 17.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 14.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.5 | 13.1 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.2 | 12.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 12.1 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.2 | 11.3 | GO:0004527 | exonuclease activity(GO:0004527) |
| 2.2 | 10.8 | GO:0004508 | steroid 17-alpha-monooxygenase activity(GO:0004508) 17-alpha-hydroxyprogesterone aldolase activity(GO:0047442) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 12.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.4 | 9.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 8.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 6.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 6.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 5.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 3.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 3.6 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 3.1 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 10.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 10.4 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.9 | 8.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.5 | 7.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.3 | 7.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 6.6 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.4 | 6.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 6.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 5.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |