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Results for zic2a+zic2b

Z-value: 1.33

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Transcription factors associated with zic2a+zic2b

Gene Symbol Gene ID Gene Info
zic2a
ENSDARG00000015554 zic family member 2 (odd-paired homolog, Drosophila), a
zic2b
ENSDARG00000037178 zic family member 2 (odd-paired homolog, Drosophila) b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic2adr10_dc_chr9_+_31471391_314714610.811.3e-04Click!
zic2bdr10_dc_chr1_+_29054033_290541180.674.1e-03Click!

Activity profile of zic2a+zic2b motif

Sorted Z-values of zic2a+zic2b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of zic2a+zic2b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_10919978 5.68 ENSDART00000005944
rpl5a
ribosomal protein L5a
chr15_+_29153215 5.48 ENSDART00000156799
si:ch211-137a8.4
si:ch211-137a8.4
chr23_+_20496283 5.29 ENSDART00000144047
ENSDART00000104336
tnnc2
troponin C type 2 (fast)
chr8_+_29953399 3.85 ENSDART00000149372
ENSDART00000007640
ptch1
ptch1
patched 1
patched 1
chr12_+_42281025 3.81 ENSDART00000167324
ebf3a
early B-cell factor 3a
chr16_-_14506846 3.80 ENSDART00000170957
crabp2a
cellular retinoic acid binding protein 2, a
chr9_-_8752098 3.77

chr2_-_34010299 3.60 ENSDART00000140910
ptch2
patched 2
chr18_+_23004984 3.57 ENSDART00000171871
cbfb
core-binding factor, beta subunit
chr23_-_27226280 3.42 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr17_+_45931793 3.38 ENSDART00000155372
kif26ab
kinesin family member 26Ab
chr1_-_19152361 3.11 ENSDART00000132958
grhprb
glyoxylate reductase/hydroxypyruvate reductase b
chr6_-_39661423 3.08 ENSDART00000110380
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr7_-_69639922 3.07

chr17_-_45383925 3.05

chr3_-_55956030 2.78 ENSDART00000158163
srl
sarcalumenin
chr11_-_4216204 2.73 ENSDART00000121716
ENSDARG00000086300
ENSDARG00000086300
chr16_-_46605991 2.67 ENSDART00000115248
zgc:174938
zgc:174938
chr24_-_2278409 2.64

chr3_+_56008829 2.61

chr10_+_32160464 2.60 ENSDART00000099880
wnt11r
wingless-type MMTV integration site family, member 11, related
chr14_+_25168063 2.60 ENSDART00000173436
si:dkey-280e21.3
si:dkey-280e21.3
chr5_+_26840147 2.59 ENSDART00000064701
loxl2b
lysyl oxidase-like 2b
chr23_-_27226387 2.44 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr9_+_8752130 2.41 ENSDART00000137813
FP103004.1
ENSDARG00000092413
chr19_-_18316262 2.41 ENSDART00000151133
top2b
topoisomerase (DNA) II beta
chr8_-_47811709 2.36 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr6_-_59510397 2.31 ENSDART00000170685
gli1
GLI family zinc finger 1
chr17_+_27417635 2.30 ENSDART00000052446
vgll2b
vestigial-like family member 2b
chr9_-_46272322 2.27 ENSDART00000169682
hdac4
histone deacetylase 4
chr13_-_39821399 2.24 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr20_+_15653121 2.21 ENSDART00000152702
jun
jun proto-oncogene
chr18_+_23891068 2.20 ENSDART00000146490
BX569787.1
ENSDARG00000092402
chr12_-_17357133 2.18 ENSDART00000079115
papss2b
3'-phosphoadenosine 5'-phosphosulfate synthase 2b
chr21_-_30378764 2.15 ENSDART00000136247
grpel2
GrpE-like 2, mitochondrial
chr21_-_38534139 2.14 ENSDART00000148939
pof1b
premature ovarian failure, 1B
chr11_-_18542803 2.14 ENSDART00000059732
id1
inhibitor of DNA binding 1
chr9_-_23081250 2.14

chr17_-_6191539 2.10 ENSDART00000081707
ENSDARG00000058775
ENSDARG00000058775
chr12_+_27026112 1.99 ENSDART00000076154
hoxb8b
homeobox B8b
chr14_-_30363703 1.98 ENSDART00000134098
efemp2a
EGF containing fibulin-like extracellular matrix protein 2a
chr23_-_9556986 1.96 ENSDART00000139688
soga1
suppressor of glucose, autophagy associated 1
chr17_-_35004687 1.93

chr16_+_1338291 1.88 ENSDART00000149299
cers2b
ceramide synthase 2b
chr10_-_15090647 1.88 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr23_+_34079219 1.87 ENSDART00000132668
si:ch211-207e14.4
si:ch211-207e14.4
chr5_+_44316830 1.85

chr16_+_32605735 1.82 ENSDART00000093250
pou3f2b
POU class 3 homeobox 2b
chr10_+_43360137 1.79 ENSDART00000012522
vcanb
versican b
chr3_+_17210396 1.79 ENSDART00000090676
si:ch211-210g13.5
si:ch211-210g13.5
chr3_+_13114740 1.73 ENSDART00000162724
ENSDARG00000074231
ENSDARG00000074231
chr4_+_22020246 1.73 ENSDART00000112035
ENSDART00000127664
myf5
myogenic factor 5
chr5_+_32732535 1.71 ENSDART00000156913
BX927184.1
ENSDARG00000097904
chr20_-_28739099 1.69 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr18_+_23891152 1.69 ENSDART00000146490
BX569787.1
ENSDARG00000092402
chr21_-_22914947 1.65 ENSDART00000083449
dub
duboraya
chr13_+_41998500 1.61 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr6_+_9192009 1.58 ENSDART00000022620
kalrnb
kalirin RhoGEF kinase b
chr25_+_1773157 1.58

chr6_+_36965023 1.56 ENSDART00000028895
negr1
neuronal growth regulator 1
chr9_-_20562293 1.55 ENSDART00000113418
igsf3
immunoglobulin superfamily, member 3
chr5_+_37363015 1.55 ENSDART00000051224
pafah1b2
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
chr19_+_15538967 1.52 ENSDART00000171403
lin28a
lin-28 homolog A (C. elegans)
chr3_-_19942214 1.49 ENSDART00000029386
slc4a1a
solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
chr17_+_45931756 1.46 ENSDART00000155372
kif26ab
kinesin family member 26Ab
chr18_+_20504980 1.41 ENSDART00000060295
rapsn
receptor-associated protein of the synapse, 43kD
KN150339v1_-_34304 1.39

chr14_+_34174018 1.34 ENSDART00000024440
foxi3b
forkhead box I3b
chr5_+_40724281 1.31 ENSDART00000134112
arid3c
AT rich interactive domain 3C (BRIGHT-like)
chr24_-_6048914 1.30 ENSDART00000146830
ENSDART00000021981
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr19_-_18316039 1.29 ENSDART00000151133
top2b
topoisomerase (DNA) II beta
chr24_-_16995194 1.29 ENSDART00000111079
CR376737.1
ENSDARG00000077318
chr17_+_45932080 1.26 ENSDART00000157326
kif26ab
kinesin family member 26Ab
chr14_+_31564252 1.26

chr4_+_5124186 1.25 ENSDART00000127874
ccnd2b
cyclin D2, b
chr8_+_48488009 1.25

chr6_+_7395817 1.24 ENSDART00000150939
ENSDART00000151114
myh10
myosin, heavy chain 10, non-muscle
chr23_+_22051774 1.24 ENSDART00000145172
eif4g3b
eukaryotic translation initiation factor 4 gamma, 3b
chr18_+_23890892 1.23 ENSDART00000146490
BX569787.1
ENSDARG00000092402
chr22_+_38220826 1.23 ENSDART00000010537
cp
ceruloplasmin
chr19_+_43908885 1.22 ENSDART00000159421
BX649384.3
ENSDARG00000100839
chr14_+_24637864 1.21 ENSDART00000170871
ppargc1b
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr24_-_16994956 1.19 ENSDART00000111079
CR376737.1
ENSDARG00000077318
chr19_-_22983970 1.17 ENSDART00000160153
pleca
plectin a
chr24_+_252774 1.16 ENSDART00000178656
ENSDART00000175867
CABZ01080224.1
ENSDARG00000107432
chr14_-_10065562 1.15 ENSDART00000003879
fam199x
family with sequence similarity 199, X-linked
chr13_+_24148474 1.11 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle
chr23_-_31585883 1.06 ENSDART00000157511
eya4
EYA transcriptional coactivator and phosphatase 4
chr21_-_44707326 1.05 ENSDART00000013814
ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr20_+_22780756 1.00

chr3_-_62143464 0.98 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr3_+_23538277 0.98 ENSDART00000111227
hoxb10a
homeo box B10a
chr9_-_8752195 0.95

chr8_+_29733109 0.94 ENSDART00000020621
mapk4
mitogen-activated protein kinase 4
chr16_-_7963894 0.94 ENSDART00000172836
CABZ01061349.1
ENSDARG00000105487
chr7_-_34854886 0.91 ENSDART00000141211
hsd11b2
hydroxysteroid (11-beta) dehydrogenase 2
chr19_+_24398194 0.89 ENSDART00000080673
syt11a
synaptotagmin XIa
chr23_-_7283514 0.88 ENSDART00000156369
CR589876.1
ENSDARG00000096997
chr11_+_25248195 0.88 ENSDART00000026249
gnl3l
guanine nucleotide binding protein-like 3 (nucleolar)-like
chr22_-_14103803 0.87 ENSDART00000062902
ENSDARG00000042857
ENSDARG00000042857
chr6_+_4000287 0.87 ENSDART00000111817
trim25l
tripartite motif containing 25, like
chr15_-_26911132 0.86 ENSDART00000077582
pitpnm3
PITPNM family member 3
chr8_+_7297981 0.86 ENSDART00000170975
BX469901.2
ENSDARG00000103232
chr18_+_6418004 0.86 ENSDART00000169401
b4galnt3b
beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr11_-_36088889 0.84 ENSDART00000146495
psma5
proteasome subunit alpha 5
chr11_-_25222937 0.83

chr5_+_45823481 0.82

chr3_+_24007046 0.79

chr21_-_44707514 0.79 ENSDART00000013814
ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr19_-_22984081 0.79 ENSDART00000160153
pleca
plectin a
chr2_+_27000558 0.78 ENSDART00000099208
asph
aspartate beta-hydroxylase
chr9_+_14180954 0.78 ENSDART00000148055
si:ch211-67e16.11
si:ch211-67e16.11
chr6_-_6816548 0.77

chr1_-_21241192 0.75

chr7_+_25735562 0.73 ENSDART00000112908
pelp1
proline, glutamate and leucine rich protein 1
chr17_-_120568 0.73

chr6_+_10491884 0.71 ENSDART00000151017
BX936397.2
ENSDARG00000096373
chr13_-_37320497 0.70

chr2_-_844040 0.69 ENSDART00000028159
foxf2a
forkhead box F2a
chr3_-_55278137 0.66 ENSDART00000123544
tex2
testis expressed 2
chr5_-_52197945 0.66

chr20_+_26196386 0.65 ENSDART00000139350
syne1a
spectrin repeat containing, nuclear envelope 1a
chr18_+_20504641 0.64

chr16_-_22260272 0.63 ENSDART00000138419
CR855277.1
ENSDARG00000092020
chr20_+_25727285 0.62 ENSDART00000143883
ppat
phosphoribosyl pyrophosphate amidotransferase
chr1_-_18880244 0.61 ENSDART00000131614
si:dkey-245p14.7
si:dkey-245p14.7
chr3_+_56507117 0.61 ENSDART00000154405
rac1b
ras-related C3 botulinum toxin substrate 1b (rho family, small GTP binding protein Rac1)
chr19_-_20148533 0.59 ENSDART00000163790
evx1
even-skipped homeobox 1
chr3_-_19942332 0.59 ENSDART00000124326
slc4a1a
solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
chr18_+_49230636 0.58 ENSDART00000167609
ENSDART00000135026
ENSDART00000171618
si:ch211-136a13.1
si:ch211-136a13.1
chr20_-_25727347 0.58 ENSDART00000136475
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr22_-_14103942 0.58 ENSDART00000140323
ENSDARG00000042857
ENSDARG00000042857
chr21_+_11686197 0.55 ENSDART00000031786
glrx
glutaredoxin (thioltransferase)
chr10_-_13158018 0.55 ENSDART00000164568
musk
muscle, skeletal, receptor tyrosine kinase
chr19_+_15538619 0.53 ENSDART00000151732
lin28a
lin-28 homolog A (C. elegans)
chr3_+_43125015 0.53 ENSDART00000165145
litaf
lipopolysaccharide-induced TNF factor
chr10_+_39325810 0.52 ENSDART00000170079
foxred1
FAD-dependent oxidoreductase domain containing 1
chr16_-_8606700 0.51 ENSDART00000137365
grb10b
growth factor receptor-bound protein 10b
chr20_+_32646617 0.51

chr14_+_31564287 0.50

chr2_-_59006559 0.50

chr16_-_14506818 0.50 ENSDART00000170957
crabp2a
cellular retinoic acid binding protein 2, a
chr17_-_120755 0.49

chr13_-_4238224 0.48 ENSDART00000124716
si:dkeyp-121d4.3
si:dkeyp-121d4.3
chr10_-_13438574 0.48 ENSDART00000030976
il11ra
interleukin 11 receptor, alpha
chr4_+_10367008 0.47 ENSDART00000138890
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr22_+_22694622 0.46

chr13_+_41998172 0.45 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr10_+_17490443 0.45

chr13_+_41998364 0.44 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr5_+_32732654 0.43 ENSDART00000156913
BX927184.1
ENSDARG00000097904
chr14_-_50657786 0.43 ENSDART00000169456
nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr15_+_509915 0.43

chr6_+_40924749 0.41 ENSDART00000133599
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr7_+_37105966 0.40 ENSDART00000111842
sall1a
spalt-like transcription factor 1a
chr5_+_35839198 0.40 ENSDART00000102973
ENSDART00000103020
eda
ectodysplasin A
chr5_-_29935062 0.38 ENSDART00000040328
h2afx
H2A histone family, member X
chr19_-_35688014 0.38

chr13_-_4238408 0.37 ENSDART00000124716
si:dkeyp-121d4.3
si:dkeyp-121d4.3
chr16_-_42235969 0.36 ENSDART00000076030
fbl
fibrillarin
chr8_+_31110356 0.36 ENSDART00000136578
syn1
synapsin I
chr3_-_55278055 0.36 ENSDART00000123544
tex2
testis expressed 2
chr10_+_36096599 0.36

chr4_+_43151489 0.35 ENSDART00000166967
si:ch211-226o13.2
si:ch211-226o13.2
chr21_-_37914590 0.35

chr11_+_2936759 0.31 ENSDART00000126071
cpne5b
copine Vb
chr5_-_14990023 0.28

chr9_+_24344001 0.26

chr5_-_56874791 0.26

chr13_-_36785295 0.24 ENSDART00000167154
trim9
tripartite motif containing 9
chr15_+_855739 0.22 ENSDART00000046783
zgc:113294
zgc:113294
chr24_+_39405332 0.22

chr7_+_20008453 0.22 ENSDART00000012450
dvl2
dishevelled segment polarity protein 2
chr20_-_51373292 0.21 ENSDART00000027836
ENSDART00000114407
rbm25b
RNA binding motif protein 25b
chr5_-_13335073 0.21 ENSDART00000114841
add2
adducin 2 (beta)
chr5_-_12789388 0.16

chr7_+_25735735 0.14 ENSDART00000112908
pelp1
proline, glutamate and leucine rich protein 1
chr3_-_40385511 0.13

chr24_+_9371496 0.13

chr19_-_10277398 0.13 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr11_+_34659252 0.13 ENSDART00000128070
gnai2a
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr3_+_32499605 0.13 ENSDART00000129339
srrm2
serine/arginine repetitive matrix 2
chr8_-_49315811 0.11 ENSDART00000147020
prickle3
prickle homolog 3
chr3_-_19942415 0.10 ENSDART00000124326
slc4a1a
solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
chr1_-_686007 0.10 ENSDART00000165894
adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_-_747292 0.09 ENSDART00000159458
zbtb42
zinc finger and BTB domain containing 42
chr15_-_24243608 0.07 ENSDART00000077980
pipox
pipecolic acid oxidase
chr11_+_18862603 0.04

chr19_-_22984023 0.04 ENSDART00000160153
pleca
plectin a
chr5_-_23296575 0.03 ENSDART00000134184
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr25_+_29631947 0.03 ENSDART00000154849
ENSDARG00000029431
ENSDARG00000029431
chr1_-_58183299 0.01 ENSDART00000166615
dnm2b
dynamin 2b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.5 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.9 3.6 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.9 2.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.8 2.3 GO:0021742 glossopharyngeal nerve development(GO:0021563) abducens nucleus development(GO:0021742)
0.8 2.3 GO:0036073 perichondral ossification(GO:0036073)
0.7 2.2 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.4 1.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 1.3 GO:0009957 epidermal cell fate specification(GO:0009957)
0.4 1.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.4 3.6 GO:0007412 axon target recognition(GO:0007412)
0.4 2.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.4 2.2 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.3 5.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 5.3 GO:0014823 response to activity(GO:0014823)
0.3 0.8 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 0.9 GO:0034650 cortisol metabolic process(GO:0034650)
0.2 4.3 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.2 1.1 GO:2001240 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2 2.2 GO:0015701 bicarbonate transport(GO:0015701)
0.2 1.2 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 1.6 GO:0046686 response to cadmium ion(GO:0046686)
0.1 2.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.6 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.5 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.1 1.3 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 1.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 2.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.0 GO:0031272 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.2 GO:0006825 copper ion transport(GO:0006825)
0.1 2.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 1.8 GO:0001885 endothelial cell development(GO:0001885)
0.0 2.6 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 1.4 GO:0007416 synapse assembly(GO:0007416)
0.0 0.6 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.5 GO:1900077 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 1.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 6.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 1.6 GO:0003146 heart jogging(GO:0003146)
0.0 0.4 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.4 GO:0042476 odontogenesis(GO:0042476)
0.0 1.8 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 1.2 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 2.0 GO:0010506 regulation of autophagy(GO:0010506)
0.0 1.1 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.1 GO:0019477 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.1 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 1.5 GO:0016042 lipid catabolic process(GO:0016042)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.6 2.3 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.5 2.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 1.0 GO:0070062 extracellular exosome(GO:0070062)
0.2 5.3 GO:0005861 troponin complex(GO:0005861)
0.2 2.0 GO:0030056 hemidesmosome(GO:0030056)
0.2 0.5 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 5.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 6.1 GO:0005871 kinesin complex(GO:0005871)
0.1 1.1 GO:0005869 dynactin complex(GO:0005869)
0.1 0.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)
0.0 3.6 GO:0030018 Z disc(GO:0030018)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.0 0.6 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.9 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.6 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.5 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
1.1 5.7 GO:0008097 5S rRNA binding(GO:0008097)
1.0 3.1 GO:0008465 glycerate dehydrogenase activity(GO:0008465)
0.7 3.6 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.5 1.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 2.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.4 1.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.4 4.3 GO:0001972 retinoic acid binding(GO:0001972)
0.4 2.2 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.4 5.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 0.6 GO:0004044 amidophosphoribosyltransferase activity(GO:0004044)
0.2 1.4 GO:0043495 protein anchor(GO:0043495)
0.2 2.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 2.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 2.0 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 2.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.1 6.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.5 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 1.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 0.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.4 GO:0005123 death receptor binding(GO:0005123)
0.0 0.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.9 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.9 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 1.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.0 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.6 GO:0004620 phospholipase activity(GO:0004620)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.2 GO:0003774 motor activity(GO:0003774)
0.0 2.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.5 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 2.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 1.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.1 PID IL3 PATHWAY IL3-mediated signaling events
0.1 3.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 1.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 7.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 1.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.2 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 1.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo