ISMARA results: zic3

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Results for zic3

Z-value: 0.43

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Transcription factors associated with zic3

Gene Symbol	Gene ID	Gene Info
zic3 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000071497	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
zic3	dr10_dc_chr14_-_31676235_31676332	-0.88	5.6e-06	Click!

Activity profile of zic3 motif

Sorted Z-values of zic3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of zic3

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr22_-_20236308 Show fit	0.96
chr22_+_37688839 Show fit	0.91	ENSDART00000174664 ENSDART00000178200	FO704589.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	ENSDARG00000108910
chr19_+_24398149 Show fit	0.79	ENSDART00000080673	syt11a NCBI UniProt ZFIN ENSEMBL Google Show fit	synaptotagmin XIa
chr9_-_3548211 Show fit	0.74	ENSDART00000145043 ENSDART00000169586	dcaf17 NCBI UniProt ZFIN ENSEMBL Google Show fit	ddb1 and cul4 associated factor 17
chr6_+_27100350 Show fit	0.69	ENSDART00000121558	atg4b NCBI UniProt ZFIN ENSEMBL Google Show fit	autophagy related 4B, cysteine peptidase
chr22_+_37689055 Show fit	0.60
chr6_+_27100249 Show fit	0.51	ENSDART00000121558	atg4b NCBI UniProt ZFIN ENSEMBL Google Show fit	autophagy related 4B, cysteine peptidase
chr9_-_9729041 Show fit	0.51	ENSDART00000175212	gpr156 NCBI UniProt ZFIN ENSEMBL Google Show fit	G protein-coupled receptor 156
chr2_-_30800968 Show fit	0.45	ENSDART00000056735	rgs20 NCBI UniProt ZFIN ENSEMBL Google Show fit	regulator of G protein signaling 20
chr25_-_34235582 Show fit	0.39	ENSDART00000137665	frs2b NCBI UniProt ZFIN ENSEMBL Google Show fit	fibroblast growth factor receptor substrate 2b
chr22_+_37688988 Show fit	0.37
chr25_-_34235633 Show fit	0.37	ENSDART00000137665	frs2b NCBI UniProt ZFIN ENSEMBL Google Show fit	fibroblast growth factor receptor substrate 2b
chr2_-_7772932 Show fit	0.37	ENSDART00000160053	ripk2 NCBI UniProt ZFIN ENSEMBL Google Show fit	receptor-interacting serine-threonine kinase 2
chr1_-_39141284 Show fit	0.36	ENSDART00000053763	dctd NCBI UniProt ZFIN ENSEMBL Google Show fit	dCMP deaminase
chr22_-_37630428 Show fit	0.21	ENSDART00000149482	fxr1 NCBI UniProt ZFIN ENSEMBL Google Show fit	fragile X mental retardation, autosomal homolog 1
chr7_-_44455032 Show fit	0.15	ENSDART00000019270	nae1 NCBI UniProt ZFIN ENSEMBL Google Show fit	nedd8 activating enzyme E1 subunit 1
chr16_-_20044830 Show fit	0.05
chr11_+_34659252 Show fit	0.05	ENSDART00000128070	gnai2a NCBI UniProt ZFIN ENSEMBL Google Show fit	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0046078	dUMP biosynthetic process(GO:0006226) dUMP metabolic process(GO:0046078)
0.0	0.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.5	GO:0014046	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0	0.4	GO:0007257	activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0	0.2	GO:0051489	regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0038039	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1	0.2	GO:0044326	dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.0	0.7	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.1	0.5	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.5	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.4	GO:0019239	deaminase activity(GO:0019239)
0.0	1.2	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.4	ST G ALPHA I PATHWAY	G alpha i Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.4	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.4	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events