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Results for zic4+zic6

Z-value: 0.36

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Transcription factors associated with zic4+zic6

Gene Symbol Gene ID Gene Info
zic4
ENSDARG00000031307 zic family member 4
zic6
ENSDARG00000071496 zic family member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic6dr10_dc_chr14_+_31682159_316822180.581.9e-02Click!
zic4dr10_dc_chr24_+_4946542_49466280.533.3e-02Click!

Activity profile of zic4+zic6 motif

Sorted Z-values of zic4+zic6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of zic4+zic6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr23_+_32007035 1.05 ENSDART00000132981
si:dkey-126g1.9
si:dkey-126g1.9
chr7_-_32752138 0.92 ENSDART00000052383
cd81a
CD81 molecule a
chr13_-_39821399 0.84 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr15_+_37039861 0.80 ENSDART00000172664
kirrel3l
kin of IRRE like 3 like
chr3_-_23558171 0.77

chr23_-_5785468 0.74 ENSDART00000033093
lad1
ladinin
chr2_+_25363717 0.71 ENSDART00000142601
stag1a
stromal antigen 1a
chr22_+_17091411 0.70 ENSDART00000170076
frem1b
Fras1 related extracellular matrix 1b
chr18_-_46356213 0.63 ENSDART00000010813
foxa3
forkhead box A3
chr20_-_9992898 0.54 ENSDART00000080664
ACTC1
zgc:86709
chr3_-_39313029 0.53 ENSDART00000156123
CU464118.1
ENSDARG00000097747
chr12_-_26760324 0.51 ENSDART00000047724
zeb1b
zinc finger E-box binding homeobox 1b
chr5_+_44407763 0.49 ENSDART00000010786
dmrt2a
doublesex and mab-3 related transcription factor 2a
chr25_-_352985 0.49 ENSDART00000165705
szl
sizzled
chr25_-_13631707 0.42 ENSDART00000169865
lcat
lecithin-cholesterol acyltransferase
chr8_+_54171992 0.41 ENSDART00000122692
CABZ01112317.1
ENSDARG00000086057
chr23_-_28367816 0.41 ENSDART00000003548
znf385a
zinc finger protein 385A
chr20_-_23184142 0.40 ENSDART00000176282
CU693368.2
ENSDARG00000108718
KN149968v1_+_15749 0.39 ENSDART00000168977
ENSDARG00000102503
ENSDARG00000102503
chr2_-_53772219 0.39 ENSDART00000037557
admp
anti-dorsalizing morphogenic protein
chr1_-_8968543 0.38 ENSDART00000126877
ENSDART00000123773
ENSDART00000126996
ugt5b1
ugt5b3
UDP glucuronosyltransferase 5 family, polypeptide B1
UDP glucuronosyltransferase 5 family, polypeptide B3
chr6_-_7281412 0.38 ENSDART00000053776
fkbp11
FK506 binding protein 11
chr8_+_6989445 0.38 ENSDART00000134440
gpd1a
glycerol-3-phosphate dehydrogenase 1a
chr23_+_32007004 0.38 ENSDART00000145639
si:dkey-126g1.9
si:dkey-126g1.9
chr7_+_73548430 0.34 ENSDART00000092691
pea15
phosphoprotein enriched in astrocytes 15
chr1_-_45709828 0.33 ENSDART00000150029
atp11a
ATPase, class VI, type 11A
chr2_+_15459785 0.33 ENSDART00000016071
ENSDART00000141921
arhgap29b
Rho GTPase activating protein 29b
chr16_-_55320569 0.32 ENSDART00000156368
ENSDARG00000069583
ENSDARG00000069583
chr13_-_32517896 0.30 ENSDART00000132820
bend3
BEN domain containing 3
chr23_+_7537089 0.29 ENSDART00000135551
si:ch211-200e2.1
si:ch211-200e2.1
chr7_+_30516734 0.28 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr5_+_45823481 0.27

chr23_-_27621359 0.23 ENSDART00000144419
larp4aa
La ribonucleoprotein domain family, member 4Aa
chr18_+_20058028 0.23 ENSDART00000146957
uacaa
uveal autoantigen with coiled-coil domains and ankyrin repeats a
chr6_-_16156494 0.21

chr14_-_32163041 0.21 ENSDART00000034883
mcf2a
MCF.2 cell line derived transforming sequence a
chr2_-_58822653 0.20 ENSDART00000114286
ENSDART00000114181
sugp1
SURP and G patch domain containing 1
chr25_-_13737344 0.19

chr20_-_28739099 0.18 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr2_+_42342148 0.18 ENSDART00000144716
cavin4a
caveolae associated protein 4a
chr3_+_30962542 0.17 ENSDART00000153074
si:dkey-66i24.9
si:dkey-66i24.9
chr22_-_6287015 0.16 ENSDART00000148832
AL928685.4
ENSDARG00000095907
chr10_+_17490443 0.16

chr6_-_7281346 0.16 ENSDART00000133096
fkbp11
FK506 binding protein 11
chr22_+_29694605 0.15

chr12_-_41124276 0.15 ENSDART00000172022
ENSDART00000158605
ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr23_-_36319185 0.15 ENSDART00000139328
znf740b
zinc finger protein 740b
chr10_-_44675914 0.15

chr24_-_34794463 0.15 ENSDART00000171009
ENSDART00000170046
ctnna1
catenin (cadherin-associated protein), alpha 1
chr8_-_7812788 0.15 ENSDART00000160692
zgc:113363
zgc:113363
chr23_+_44249976 0.14 ENSDART00000158305
tec
tec protein tyrosine kinase
chr7_+_73548348 0.14 ENSDART00000092691
pea15
phosphoprotein enriched in astrocytes 15
chr8_-_17031599 0.14 ENSDART00000132687
rab3c
RAB3C, member RAS oncogene family
chr16_-_49672970 0.13 ENSDART00000127513
znf385d
zinc finger protein 385D
chr3_-_40020749 0.13 ENSDART00000129664
drg2
developmentally regulated GTP binding protein 2
chr24_-_25545773 0.12 ENSDART00000015391
chrnd
cholinergic receptor, nicotinic, delta (muscle)
chr1_+_11541423 0.11 ENSDART00000170760
tmod1
tropomodulin 1
chr6_+_17928720 0.11 ENSDART00000124948
srp68
signal recognition particle 68
chr13_+_37527958 0.11 ENSDART00000141988
phf3
PHD finger protein 3
chr16_-_25793780 0.10

chr5_+_68925227 0.09

chr15_+_37040064 0.09 ENSDART00000172664
kirrel3l
kin of IRRE like 3 like
chr6_+_6640324 0.08 ENSDART00000150967
si:ch211-85n16.3
si:ch211-85n16.3
chr6_-_16156294 0.08 ENSDART00000160809
agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr3_-_40020899 0.08 ENSDART00000025285
drg2
developmentally regulated GTP binding protein 2
chr14_+_40485238 0.06 ENSDART00000128588
taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr12_-_13611954 0.06 ENSDART00000124638
ENSDART00000124364
stat5b
signal transducer and activator of transcription 5b
chr3_+_16880842 0.05 ENSDART00000080854
stat3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr18_+_30443201 0.05 ENSDART00000140908
gse1
Gse1 coiled-coil protein
KN149739v1_+_40107 0.05

chr11_+_31295037 0.04 ENSDART00000140204
egln1b
egl-9 family hypoxia-inducible factor 1b
chr8_-_4562273 0.04 ENSDART00000025535
sept5a
septin 5a
KN150222v1_+_74557 0.03

chr25_-_5805538 0.03

chr18_+_49230636 0.02 ENSDART00000167609
ENSDART00000135026
ENSDART00000171618
si:ch211-136a13.1
si:ch211-136a13.1
chr3_+_23964015 0.01 ENSDART00000138270
copz2
coatomer protein complex, subunit zeta 2
chr18_-_46355957 0.01 ENSDART00000010813
foxa3
forkhead box A3
chr23_+_24778090 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.2 0.5 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.1 0.5 GO:0048785 hatching gland development(GO:0048785)
0.1 0.4 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.1 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 0.4 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.1 0.9 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.1 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.5 GO:0007548 sex differentiation(GO:0007548)
0.0 0.5 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.7 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.2 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.7 GO:0008278 cohesin complex(GO:0008278)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS Genes involved in Acetylcholine Binding And Downstream Events