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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for ArgR

Z-value: 2.47

Transcription factors associated with ArgR

Gene Symbol Gene ID Gene Info
argR
argR ArgR transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
argR-0.974.8e-05Click!

Activity profile of ArgR motif

Sorted Z-values of ArgR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
artJ 13.08
artJ
L-arginine ABC transporter - periplasmic binding protein
argI 10.98
argI
ornithine carbamoyltransferase chain I
argG 10.03
argG
argininosuccinate synthase
carAB 9.18
carB
carA
carbamoyl phosphate synthetase, β chain
carbamoyl phosphate synthetase, α chain
argA 8.99
argA
N-acetylglutamate synthase
argF 4.96
argF
ornithine carbamoyltransferase chain F
argCBH 3.59
argH
argB
argC
argininosuccinate lyase
acetylglutamate kinase
N-acetylglutamylphosphate reductase
argD 3.45
argD
N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase
hisJQMP 2.83
hisM
hisP
hisQ
hisJ
lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit
histidine ABC transporter - periplasmic binding protein
astCADBE 2.21
astA
astB
astC
astD
astE
arginine succinyltransferase
succinylarginine dihydrolase
succinylornithine transaminase
aldehyde dehydrogenase
succinylglutamate desuccinylase
gltBDF 1.70
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
lysO 0.90
lysO
L-lysine exporter
argE 0.52
argE
acetylornithine deacetylase

Network of associatons between targets according to the STRING database.

First level regulatory network of ArgR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 38.0 GO:0006526 arginine biosynthetic process(GO:0006526)
3.0 12.1 GO:0090467 L-arginine import(GO:0043091) L-amino acid import(GO:0043092) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine import into cell(GO:1902765) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.8 1.7 GO:0009084 glutamine family amino acid biosynthetic process(GO:0009084)
0.4 0.9 GO:1903401 L-lysine transmembrane transport(GO:1903401)
0.0 3.1 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.2 GO:1902494 catalytic complex(GO:1902494)
0.1 13.8 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)
0.0 11.8 GO:0005737 cytoplasm(GO:0005737)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 15.9 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
2.3 9.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
1.5 9.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
1.4 5.7 GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity(GO:0003992)
1.3 19.5 GO:0016597 amino acid binding(GO:0016597)
0.4 0.9 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.4 10.0 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.3 1.7 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 0.5 GO:0050897 cobalt ion binding(GO:0050897)