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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for CRP

Z-value: 0.92

Transcription factors associated with CRP

Gene Symbol Gene ID Gene Info
crp
crp CRP transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
crp0.196.5e-01Click!

Activity profile of CRP motif

Sorted Z-values of CRP motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
fur 4.30
fur
Fur transcriptional dual regulator
sodB 1.50
sodB
superoxide dismutase (Fe)
preTA 1.41
preT
preA
NADH-dependent dihydropyrimidine dehydrogenase subunit
NADH-dependent dihydropyrimidine dehydrogenase subunit
ompF 1.17
ompF
outer membrane porin F
pck 1.01
pck
phosphoenolpyruvate carboxykinase (ATP)
raiA 0.95
raiA
stationary phase translation inhibitor and ribosome stability factor
mdh 0.82
mdh
malate dehydrogenase
glgS 0.82
glgS
surface composition regulator
ompW 0.81
ompW
outer membrane protein W
ompA 0.79
ompA
outer membrane porin A
aspA 0.74
aspA
aspartate ammonia-lyase
manXYZ 0.72
manX
manY
manZ
mannose PTS permease - ManX subunit
mannose PTS permease - ManY subunit
mannose PTS permease - ManZ subunit
gatYZABCD 0.71
gatY
gatZ
gatD
gatA
gatB
gatC
tagatose-1,6-bisphosphate aldolase 2 subunit GatY
tagatose-1,6-bisphosphate aldolase 2 subunit GatZ
L-galactitol-1-phosphate 5-dehydrogenase
galactitol PTS permease - GatA subunit
galactitol PTS permease - GatB subunit
galactitol PTS permease - GatC subunit
dcuB-fumB 0.68
fumB
dcuB
fumarase B
dicarboxylate transporter DcuB
tnaCAB 0.68
tnaA
tnaC
tnaB
tryptophanase
tryptophanase operon leader peptide
tryptophan:H+ symporter TnaB
ansB 0.68
ansB
asparaginase II
ychH 0.61
ychH
stress-induced protein
ptsHI-crr 0.61
ptsI
ptsH
crr
PTS enzyme I
HPr
Enzyme IIAGlc; Crr
tdcABCDEFG 0.61
tdcE
tdcD
tdcG
tdcF
tdcA
tdcC
tdcB
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4, inactive
propionate kinase
L-serine deaminase III
predicted enamine/imine deaminase
TdcA DNA-binding transcriptional activator
serine / threonine:H+ symporter TdcC
catabolic threonine dehydratase
treBC 0.60
treC
treB
trehalose-6-phosphate hydrolase
trehalose PTS permease - TreB subunit
nupG 0.59
nupG
nucleoside:H+ symporter NupG
cyaR 0.57
cyaR
CyaR
aspA-dcuA 0.54
aspA
dcuA
aspartate ammonia-lyase
dicarboxylate transporter DcuA
lpd 0.51
lpd
lipoamide dehydrogenase
nmpC 0.51
nmpC
outer membrane porin protein; locus of qsr prophage
hupA 0.48
hupA
transcriptional dual regulator HU-α (HU-2)
nagE 0.42
nagE
N-acetylglucosamine PTS permease
gapA 0.42
gapA
glyceraldehyde 3-phosphate dehydrogenase
cspE 0.41
cspE
transcription antiterminator and regulator of RNA stability
cspD 0.40
cspD
DNA replication inhibitor
rhaSR 0.40
rhaS
rhaR
RhaS transcriptional activator
RhaR transcriptional activator
grcA 0.39
grcA
stress-induced alternate pyruvate formate-lyase subunit
glgCAP 0.36
glgP
glgA
glgC
glycogen phosphorylase
glycogen synthase
glucose-1-phosphate adenylyltransferase
sdhCDAB-sucABCD 0.35
sucA
sucC
sucB
sucD
sdhA
sdhC
sdhB
sdhD
subunit of E1(0) component of 2-oxoglutarate dehydrogenase
succinyl-CoA synthetase, β subunit
dihydrolipoyltranssuccinylase
succinyl-CoA synthetase, α subunit
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, membrane protein SdhC
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
srlAEBD-gutM-srlR-gutQ 0.33
srlB
srlA
srlE
srlD
gutQ
srlR
gutM
sorbitol PTS permease - SrlB subunit
sorbitol PTS permease - SrlA subunit
sorbitol PTS permease - SrlE subunit
sorbitol-6-phosphate dehydrogenase
D-arabinose 5-phosphate isomerase
GutR DNA-binding transcriptional repressor
GutM DNA-binding transcriptional activator
gntP 0.33
gntP
gluconate / fructuronate transporter GntP
hupB 0.31
hupB
transcriptional dual regulator HU-β, NS1 (HU-1)
rpoS 0.31
rpoS
RNA polymerase, sigma S (sigma 38) factor
udp 0.30
udp
uridine phosphorylase
nanA 0.29
nanA
N-acetylneuraminate lyase
secB-gpsA 0.29
gpsA
secB
glycerol-3-phosphate dehydrogenase
SecB chaperone
ivbL 0.29
ivbL
ilvB operon leader peptide
flhDC 0.29
flhC
flhD
FlhC transcriptional dual regulator
FlhD transcriptional dual regulator
oxyR 0.27
oxyR
OxyR DNA-binding transcriptional dual regulator
metK 0.27
metK
methionine adenosyltransferase
gntX-nfuA 0.27
gntX
nfuA
protein involved in utilization of DNA as a carbon source
iron-sulfur cluster scaffold protein
gltBDF 0.27
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
nupC 0.26
nupC
nucleoside:H+ symporter NupC
fumA 0.25
fumA
fumarase A
gntT 0.24
gntT
gluconate transporter GntT
glpFKX 0.24
glpF
glpX
glpK
glycerol channel GlpF
fructose 1,6-bisphosphatase II
glycerol kinase
fucPIKUR 0.24
fucU
fucR
fucK
fucP
fucI
L-fucose mutarotase
FucR transcriptional activator
L-fuculokinase
fucose:H+ symporter
L-fucose isomerase
rbsDACBKR 0.23
rbsK
rbsA
rbsC
rbsB
rbsD
rbsR
ribokinase
ribose ABC transporter - putative ATP binding subunit
ribose ABC transporter - membrane subunit
ribose ABC transporter - putative periplasmic binding protein
ribose pyranase
RbsR DNA-binding transcriptional dual regulator
sdhDAB 0.23
sdhA
sdhB
sdhD
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
araFGH 0.23
araF
araG
araH
arabinose ABC transporter - periplasmic binding protein
arabinose ABC transporter - ATP binding subunit
arabinose ABC transporter - membrane subunit
cytR 0.22
cytR
CytR DNA-binding transcriptional repressor
ycdZ 0.21
ycdZ
predicted inner membrane protein
tsx 0.21
tsx
nucleoside channel; receptor of phage T6 and colicin K
uxaB 0.21
uxaB
altronate oxidoreductase
rpsF-priB-rpsR-rplI 0.20
rpsF
priB
rpsR
rplI
30S ribosomal subunit protein S6
primosomal replication protein N
30S ribosomal subunit protein S18
50S ribosomal subunit protein L9
xylAB 0.19
xylA
xylB
xylose isomerase
xylulokinase
galETKM 0.19
galT
galE
galM
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactose-1-epimerase
galactokinase
melR 0.19
melR
MelR DNA-binding transcriptional dual regulator
agp 0.18
agp
glucose-1-phosphatase
yhfA 0.18
yhfA
conserved protein
tnaC 0.18
tnaC
tryptophanase operon leader peptide
epd-pgk-fbaA 0.18
epd
pgk
fbaA
erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
fructose bisphosphate aldolase class II
sfsA-dksA 0.17
dksA
sfsA
RNA polymerase-binding transcription factor DksA
predicted DNA-binding transcriptional regulator of maltose metabolism
spf 0.17
spf
Spot42
ppiA 0.16
ppiA
peptidyl-prolyl cis-trans isomerase A (rotamase A)
relA-mazEF 0.16
mazE
relA
mazF
MazE antitoxin of the MazF-MazE toxin-antitoxin system
GDP pyrophosphokinase/GTP pyrophosphokinase
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity
cstA 0.16
cstA
peptide transporter induced by carbon starvation
glpEGR 0.15
glpE
glpG
glpR
thiosulfate sulfurtransferase
intramembrane serine protease GlpG
GlpR DNA-binding transcriptional repressor
sxy 0.15
sxy
transcriptional coactivator for CRP
galE 0.14
galE
UDP-glucose 4-epimerase
fumC 0.14
fumC
fumarase C
idnDOTR 0.13
idnD
idnO
idnR
idnT
L-idonate 5-dehydrogenase
5-keto-D-gluconate 5-reductase
IdnR transcriptional regulator
L-idonate / 5-ketogluconate / gluconate transporter IdnT
murQP 0.13
murP
murQ
N-acetylmuramic acid PTS permease / anhydro-N-acetylmuramic acid permease
N-acetylmuramic acid 6-phosphate etherase
aaeR 0.12
aaeR
quorum sensing transcriptional regulator of LYSR-type
zraSR 0.12
zraS
zraR
ZraS sensory histidine kinase
ZraR transcriptional activator
acnB 0.12
acnB
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase
yiaJ 0.12
yiaJ
YiaJ DNA-binding transcriptional repressor
fucAO 0.11
fucO
fucA
L-1,2-propanediol oxidoreductase
L-fuculose-phosphate aldolase
malT 0.11
malT
MalT transcriptional activator
mlc 0.10
mlc
Mlc DNA-binding transcriptional repressor
rplM-rpsI 0.10
rplM
rpsI
50S ribosomal subunit protein L13
30S ribosomal subunit protein S9
gcvTHP 0.10
gcvH
gcvP
gcvT
glycine cleavage system H protein
glycine decarboxylase
aminomethyltransferase
dsdA 0.10
dsdA
D-serine ammonia-lyase
galETK 0.10
galT
galE
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactokinase
exuT 0.09
exuT
hexuronate transporter
malXY 0.08
malX
malY
MalX PTS permease
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon
pncB 0.08
pncB
nicotinate phosphoribosyltransferase
prpR 0.08
prpR
PrpR DNA-binding transcriptional dual regulator
aldB 0.08
aldB
acetaldehyde dehydrogenase
putP 0.07
putP
proline:Na+ symporter
nagBAC-umpH 0.07
nagB
nagC
umpH
nagA
glucosamine-6-phosphate deaminase
NagC DNA-binding transcriptional dual regulator
UMP phosphatase
N-acetylglucosamine-6-phosphate deacetylase
epd-pgk 0.07
epd
pgk
erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
malK-lamB-malM 0.06
lamB
malM
malK
maltose outer membrane porin / phage lambda receptor protein
maltose regulon periplasmic protein
maltose ABC transporter - ATP binding subunit
ivbL-ilvBN 0.06
ilvB
ilvN
ivbL
acetohydroxy acid synthase I, large subunit
acetohydroxy acid synthase I, small subunit
ilvB operon leader peptide
mtlADR 0.06
mtlR
mtlA
mtlD
MtlR DNA-binding transcriptional repressor
mannitol PTS permease
mannitol-1-phosphate 5-dehydrogenase
grpE 0.05
grpE
nucleotide exchange factor
araE 0.05
araE
arabinose:H+ symporter
pdhR-aceEF-lpd 0.05
pdhR
lpd
aceF
aceE
PdhR DNA-binding transcriptional dual regulator
lipoamide dehydrogenase
pyruvate dehydrogenase, E2 subunit
subunit of E1p component of pyruvate dehydrogenase complex
malI 0.04
malI
MalI DNA-binding transcriptional repressor
yaeQ-arfB-nlpE 0.04
arfB
yaeQ
nlpE
peptidyl-tRNA hydrolase, ribosome rescue factor
conserved protein
outer membrane lipoprotein NlpE, involved in surface sensing
focA-pflB 0.04
focA
pflB
formate channel FocA
pyruvate formate-lyase (inactive)
araC 0.04
araC
AraC DNA-binding transcriptional dual regulator
ampDE 0.04
ampD
ampE
N-acetyl-anhydromuramyl-L-alanine amidase
inner membrane protein
comR 0.03
comR
ComR DNA-binding transcriptional repressor
aaeXAB 0.03
aaeA
aaeX
aaeB
hydroxylated, aromatic carboxylic acid exporter - putative membrane fusion protein
hypothetical protein
hydroxylated, aromatic carboxylic acid exporter - putative membrane subunit
hfq-hflXKC 0.03
hflC
hfq
hflK
hflX
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
ribosome-dissociating factor, GTPase
patZ 0.03
patZ
peptidyl-lysine acetyltransferase
malEFG 0.03
malF
malG
malE
maltose ABC transporter - membrane subunit
maltose ABC transporter - membrane subunit
maltose ABC transporter - periplasmic binding protein
gadE-mdtEF 0.03
mdtF
mdtE
gadE
MdtEF-TolC multidrug efflux pump - permease subunit
MdtEF-TolC multidrug efflux pump - membrane fusion protein
GadE DNA-binding transcriptional activator
galET 0.02
galT
galE
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
dcuR 0.02
dcuR
DcuR transcriptional activator
fumAC 0.02
fumA
fumC
fumarase A
fumarase C
bglGFB 0.01
bglB
bglG
bglF
6-phospho-β-glucosidase B; cryptic
BglG transcriptional antiterminator
BglF
cpdB 0.01
cpdB
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase
galS 0.01
galS
GalS DNA-binding transcriptional dual regulator
kbaZ-agaVWA 0.01
agaA
agaW
agaV
kbaZ
predicted truncated N-acetylgalactosamine-6-phosphate deacetylase
N-acetyl-D-galactosamine PTS permease (cryptic) - AgaW subunit (pseudogene)
N-acetyl-D-galactosamine PTS permease (cryptic) - AgaV subunit
tagatose-1,6-bisphosphate aldolase 1 subunit KbaZ
xylFGHR 0.01
xylH
xylR
xylG
xylF
xylose ABC transporter - membrane subunit
XylR transcriptional dual regulator
xylose ABC transporter - ATP binding subunit
xylose ABC transporter - periplasmic binding protein
araE-ygeA 0.00
ygeA
araE
predicted racemase
arabinose:H+ symporter

Network of associatons between targets according to the STRING database.

First level regulatory network of CRP

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.5 1.4 GO:0000303 response to superoxide(GO:0000303) superoxide metabolic process(GO:0006801)
0.4 1.1 GO:0006059 hexitol metabolic process(GO:0006059) hexitol catabolic process(GO:0019407)
0.3 1.0 GO:0051828 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.3 1.0 GO:0006108 malate metabolic process(GO:0006108)
0.3 1.0 GO:0015755 fructose transport(GO:0015755)
0.3 1.4 GO:0010675 regulation of cellular carbohydrate metabolic process(GO:0010675)
0.2 1.4 GO:0006094 gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319)
0.2 0.9 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.2 0.7 GO:0006528 asparagine metabolic process(GO:0006528)
0.2 0.7 GO:0019464 glycine decarboxylation via glycine cleavage system(GO:0019464)
0.2 0.9 GO:0090357 regulation of cellular amino acid metabolic process(GO:0006521) regulation of cellular amine metabolic process(GO:0033238) regulation of tryptophan metabolic process(GO:0090357)
0.2 0.8 GO:0015858 nucleoside transport(GO:0015858)
0.2 1.0 GO:0006567 threonine catabolic process(GO:0006567)
0.2 0.6 GO:0046686 response to cadmium ion(GO:0046686)
0.2 0.6 GO:0005993 trehalose catabolic process(GO:0005993)
0.2 2.4 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.2 0.3 GO:0034214 protein hexamerization(GO:0034214)
0.1 0.4 GO:0042873 aldonate transport(GO:0042873)
0.1 0.6 GO:0009254 peptidoglycan turnover(GO:0009254)
0.1 1.2 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.4 GO:0043242 negative regulation of protein complex disassembly(GO:0043242) negative regulation of DNA-templated transcription, termination(GO:0060567)
0.1 0.4 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.5 GO:0015750 pentose transport(GO:0015750)
0.1 0.3 GO:0043952 protein transport by the Sec complex(GO:0043952) chaperone-mediated protein transport(GO:0072321)
0.1 0.3 GO:0046498 S-adenosylmethionine cycle(GO:0033353) S-adenosylhomocysteine metabolic process(GO:0046498) S-adenosylmethionine metabolic process(GO:0046500)
0.1 0.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.1 GO:0015931 nucleobase-containing compound transport(GO:0015931)
0.1 0.2 GO:0046348 N-acetylneuraminate metabolic process(GO:0006054) N-acetylneuraminate catabolic process(GO:0019262) amino sugar catabolic process(GO:0046348)
0.1 0.2 GO:0015768 maltose transport(GO:0015768)
0.1 0.2 GO:0015969 guanosine tetraphosphate metabolic process(GO:0015969) purine ribonucleoside bisphosphate metabolic process(GO:0034035) ncRNA catabolic process(GO:0034661)
0.1 0.4 GO:0009099 valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0015976 carbon utilization(GO:0015976)
0.0 0.1 GO:0008156 negative regulation of DNA replication(GO:0008156) negative regulation of DNA metabolic process(GO:0051053)
0.0 0.5 GO:0006096 glycolytic process(GO:0006096)
0.0 0.2 GO:0006276 plasmid maintenance(GO:0006276)
0.0 0.1 GO:0046174 polyol catabolic process(GO:0046174)
0.0 0.1 GO:0006063 uronic acid metabolic process(GO:0006063)
0.0 0.1 GO:0097305 response to alcohol(GO:0097305)
0.0 0.1 GO:0010043 response to zinc ion(GO:0010043)
0.0 0.1 GO:0009071 serine family amino acid catabolic process(GO:0009071)
0.0 0.2 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0046930 pore complex(GO:0046930)
0.2 0.6 GO:0045273 respiratory chain complex II(GO:0045273) plasma membrane respiratory chain complex II(GO:0045274)
0.2 0.5 GO:0009295 nucleoid(GO:0009295)
0.1 1.2 GO:0015935 small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)
0.1 1.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.3 GO:0005618 cell wall(GO:0005618)
0.0 9.3 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 0.3 GO:0019146 arabinose-5-phosphate isomerase activity(GO:0019146)
0.3 1.2 GO:0005469 succinate:fumarate antiporter activity(GO:0005469)
0.3 1.1 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.3 1.0 GO:0008861 formate C-acetyltransferase activity(GO:0008861)
0.2 1.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337) nucleobase-containing compound transmembrane transporter activity(GO:0015932)
0.2 2.4 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.2 0.6 GO:0015927 trehalase activity(GO:0015927)
0.2 0.6 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.2 0.7 GO:0015128 gluconate transmembrane transporter activity(GO:0015128) aldonate transmembrane transporter activity(GO:0042879)
0.2 0.7 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.8 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 0.5 GO:0043211 carbohydrate-transporting ATPase activity(GO:0043211)
0.2 1.3 GO:0030955 potassium ion binding(GO:0030955)
0.1 0.4 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.4 GO:0019534 toxin transporter activity(GO:0019534)
0.1 0.4 GO:0009011 starch synthase activity(GO:0009011)
0.1 0.4 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
0.1 0.4 GO:0004333 fumarate hydratase activity(GO:0004333)
0.1 0.4 GO:0001070 RNA binding transcription factor activity(GO:0001070) transcription antitermination factor activity, RNA binding(GO:0001072)
0.1 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.3 GO:0042900 fucose transmembrane transporter activity(GO:0015150) arabinose transmembrane transporter activity(GO:0042900)
0.1 0.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.6 GO:0008047 enzyme activator activity(GO:0008047)
0.1 0.6 GO:0015149 hexose transmembrane transporter activity(GO:0015149)
0.1 0.2 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.1 0.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.3 GO:0001000 bacterial-type RNA polymerase core enzyme binding(GO:0001000)
0.1 5.0 GO:0008270 zinc ion binding(GO:0008270)
0.1 0.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.2 GO:0008893 GTP diphosphokinase activity(GO:0008728) guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
0.0 0.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0003984 acetolactate synthase activity(GO:0003984)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0031405 lipoic acid binding(GO:0031405)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.1 0.2 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
0.0 0.4 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation