ISMARA results: EvgA

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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for EvgA

Z-value: 2.82

Transcription factors associated with EvgA

Gene Symbol	Gene ID	Gene Info
evgA RegulonDB EcoCyc	evgA	EvgA transcriptional activator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
evgA		0.81	1.4e-02	Click!

Activity profile of EvgA motif

Sorted Z-values of EvgA motif

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Promoter	Log-likelihood	Gene	Gene Info
safA-ydeO Show fit	18.49	ydeO RegulonDB EcoCyc Show fit safA RegulonDB EcoCyc Show fit	YdeO DNA-binding transcriptional dual regulator two-component system connector protein
yegRZ Show fit	18.31	yegR RegulonDB EcoCyc Show fit yegZ RegulonDB EcoCyc Show fit	predicted protein predicted protein fragment
emrKY Show fit	16.42	emrY RegulonDB EcoCyc Show fit emrK RegulonDB EcoCyc Show fit	EmrKY multidrug efflux pump - membrane subunit EmrKY-TolC multidrug efflux pump - membrane fusion protein
yfdX-frc-oxc-yfdVE Show fit	12.31	frc RegulonDB EcoCyc Show fit yfdE RegulonDB EcoCyc Show fit yfdV RegulonDB EcoCyc Show fit yfdX RegulonDB EcoCyc Show fit oxc RegulonDB EcoCyc Show fit	formyl-CoA transferase acetyl-CoA:oxalate CoA-transferase putative transport protein, auxin efflux carrier family predicted protein oxalyl-CoA decarboxylase
frc Show fit	11.67	frc RegulonDB EcoCyc Show fit	formyl-CoA transferase
acrD Show fit	8.99	acrD RegulonDB EcoCyc Show fit	AcrAD-TolC multidrug efflux pump - permease subunit
ydeP Show fit	8.90	ydeP RegulonDB EcoCyc Show fit	acid resistance protein
evgAS Show fit	1.35	evgA RegulonDB EcoCyc Show fit evgS RegulonDB EcoCyc Show fit	EvgA transcriptional activator EvgS sensory histidine kinase

Showing 1 to 8 of 8 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EvgA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.8	24.0	GO:0071468	cellular response to acidic pH(GO:0071468)
0.3	18.5	GO:1902680	positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)
2.0	10.2	GO:0010447	response to acidic pH(GO:0010447)
2.2	9.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.3	8.8	GO:0046677	response to antibiotic(GO:0046677)

Showing 1 to 5 of 5 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	48.6	GO:0005886	plasma membrane(GO:0005886)
0.1	1.3	GO:0016021	integral component of membrane(GO:0016021)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.0	24.0	GO:0008410	CoA-transferase activity(GO:0008410)
0.2	18.5	GO:0003700	transcription factor activity, sequence-specific DNA binding(GO:0003700)
3.0	9.0	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	8.8	GO:0005215	transporter activity(GO:0005215)
0.4	1.3	GO:0009927	histidine phosphotransfer kinase activity(GO:0009927)

Showing 1 to 5 of 5 entries

Results for EvgA

Z-value: 2.82

Transcription factors associated with EvgA

Activity-expression correlation:

Activity profile of EvgA motif

Sorted Z-values of EvgA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EvgA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category: