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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for EvgA

Z-value: 2.82

Transcription factors associated with EvgA

Gene Symbol Gene ID Gene Info
evgA
evgA EvgA transcriptional activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
evgA0.811.4e-02Click!

Activity profile of EvgA motif

Sorted Z-values of EvgA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
safA-ydeO 18.49
ydeO
safA
YdeO DNA-binding transcriptional dual regulator
two-component system connector protein
yegRZ 18.31
yegR
yegZ
predicted protein
predicted protein fragment
emrKY 16.42
emrY
emrK
EmrKY multidrug efflux pump - membrane subunit
EmrKY-TolC multidrug efflux pump - membrane fusion protein
yfdX-frc-oxc-yfdVE 12.31
frc
yfdE
yfdV
yfdX
oxc
formyl-CoA transferase
acetyl-CoA:oxalate CoA-transferase
putative transport protein, auxin efflux carrier family
predicted protein
oxalyl-CoA decarboxylase
frc 11.67
frc
formyl-CoA transferase
acrD 8.99
acrD
AcrAD-TolC multidrug efflux pump - permease subunit
ydeP 8.90
ydeP
acid resistance protein
evgAS 1.35
evgA
evgS
EvgA transcriptional activator
EvgS sensory histidine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of EvgA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 24.0 GO:0071468 cellular response to acidic pH(GO:0071468)
2.2 9.0 GO:0006855 drug transmembrane transport(GO:0006855)
2.0 10.2 GO:0010447 response to acidic pH(GO:0010447)
0.3 8.8 GO:0046677 response to antibiotic(GO:0046677)
0.3 18.5 GO:1902680 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 48.6 GO:0005886 plasma membrane(GO:0005886)
0.1 1.3 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 24.0 GO:0008410 CoA-transferase activity(GO:0008410)
3.0 9.0 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.4 1.3 GO:0009927 histidine phosphotransfer kinase activity(GO:0009927)
0.2 18.5 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 8.8 GO:0005215 transporter activity(GO:0005215)