Project
GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for Fis
Z-value: 4.25
Transcription factors associated with Fis
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fis | 0.92 | 1.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| ssrS Show fit | 22.71 |
6S RNA |
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| rnpB Show fit | 19.26 |
RnpB |
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| rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF Show fit | 17.05 |
rrlD 23S ribosomal RNA tRNAileU tRNAalaU tRNAthrV rrfF 5S ribosomal RNA rrsD 16S ribosomal RNA rrfD 5S ribosomal RNA |
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| rrsC-gltU-rrlC-rrfC Show fit | 16.82 |
rrlC 23S ribosomal RNA tRNAgltU rrfC 5S ribosomal RNA rrsC 16S ribosomal RNA |
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| pflB Show fit | 16.19 |
pyruvate formate-lyase (inactive) |
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| rrsG-gltW-rrlG-rrfG Show fit | 15.94 |
rrlG 23S ribosomal RNA tRNAgltW rrfG 5S ribosomal RNA rrsG 16S ribosomal RNA |
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| rrsE-gltV-rrlE-rrfE Show fit | 15.25 |
rrlE 23S ribosomal RNA tRNAgltV rrsE 16S ribosomal RNA rrfE 5S ribosomal RNA |
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| rrsH-ileV-alaV-rrlH-rrfH Show fit | 14.47 |
rrlH 23S ribosomal RNA rrfH 5S ribosomal RNA rrsH 16S ribosomal RNA tRNAileV tRNAalaV |
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| rrsB-gltT-rrlB-rrfB Show fit | 14.43 |
rrlB 23S ribosomal RNA tRNAgltT rrfB 5S ribosomal RNA rrsB 16S ribosomal RNA |
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| rrsA-ileT-alaT-rrlA-rrfA Show fit | 14.30 |
23S ribosomal RNA (rrlA) tRNAileT tRNAalaT 16S ribosomal RNA (rrsA) 5S ribosomal RNA (rrfA) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Fis
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 19.9 | GO:0006567 | threonine catabolic process(GO:0006567) |
| 2.8 | 13.8 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 2.8 | 11.2 | GO:0007584 | response to nutrient(GO:0007584) |
| 0.3 | 10.7 | GO:0042594 | response to starvation(GO:0042594) |
| 1.6 | 9.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 3.1 | 9.4 | GO:0009068 | asparagine metabolic process(GO:0006528) aspartate family amino acid catabolic process(GO:0009068) |
| 2.9 | 8.7 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 2.8 | 8.4 | GO:0019464 | glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.3 | 7.5 | GO:0042493 | response to drug(GO:0042493) |
| 2.2 | 6.6 | GO:0019645 | anaerobic electron transport chain(GO:0019645) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.9 | GO:0005829 | cytosol(GO:0005829) |
| 1.3 | 21.4 | GO:0015935 | small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627) |
| 5.7 | 17.2 | GO:0009295 | nucleoid(GO:0009295) |
| 1.6 | 8.0 | GO:0098803 | respiratory chain(GO:0070469) plasma membrane respiratory chain(GO:0070470) respiratory chain complex(GO:0098803) |
| 0.4 | 6.1 | GO:0044445 | cytosolic part(GO:0044445) |
| 1.1 | 4.6 | GO:0044427 | chromosome(GO:0005694) chromosomal part(GO:0044427) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 19.9 | GO:0008861 | formate C-acetyltransferase activity(GO:0008861) |
| 0.1 | 16.4 | GO:0042802 | identical protein binding(GO:0042802) |
| 1.1 | 13.8 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 1.3 | 10.3 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 0.5 | 9.4 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.3 | 9.3 | GO:0005506 | iron ion binding(GO:0005506) |
| 2.2 | 8.7 | GO:0016211 | ammonia ligase activity(GO:0016211) |
| 1.2 | 8.4 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 1.6 | 7.8 | GO:0097216 | guanosine tetraphosphate binding(GO:0097216) |
| 2.0 | 6.1 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.2 | REACTOME INNATE IMMUNE SYSTEM | Genes involved in Innate Immune System |
| 1.2 | 3.5 | REACTOME PURINE METABOLISM | Genes involved in Purine metabolism |