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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for FliZ

Z-value: 1.16

Transcription factors associated with FliZ

Gene Symbol Gene ID Gene Info
fliZ
fliZ FliZ DNA-binding transcriptional regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
fliZ0.695.7e-02Click!
fliA0.695.7e-02Click!

Activity profile of FliZ motif

Sorted Z-values of FliZ motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
csgDEFG 10.46
csgG
csgF
csgE
csgD
curli secretion channel
curli assembly component
curli transport specificity factor
CsgD DNA-binding transcriptional dual regulator
mlrA 6.51
mlrA
MlrA DNA binding transcriptional activator
gadBC 3.96
gadB
gadC
glutamate decarboxylase B subunit
glutamic acid:4-aminobutyrate antiporter
csgBAC 3.89
csgC
csgB
csgA
inhibitor of CsgA amyloid formation
curlin, minor subunit
curlin, major subunit
osmY 3.20
osmY
periplasmic chaperone, osmotically induced
pdeR 0.68
pdeR
cyclic di-GMP phosphodiesterase

Network of associatons between targets according to the STRING database.

First level regulatory network of FliZ

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.4 GO:0022610 biological adhesion(GO:0022610)
1.0 4.0 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.4 3.2 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.7 GO:0043086 negative regulation of catalytic activity(GO:0043086)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 10.5 GO:0031246 intrinsic component of periplasmic side of cell outer membrane(GO:0031246)
0.6 3.9 GO:0042995 cell projection(GO:0042995)
0.0 4.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.7 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.5 GO:0001159 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding(GO:0000986) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.3 4.0 GO:0015297 antiporter activity(GO:0015297)
0.1 0.7 GO:0071111 cyclic-guanylate-specific phosphodiesterase activity(GO:0071111)
0.1 6.5 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)