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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for Fur
Z-value: 3.17
Transcription factors associated with Fur
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fur | -0.99 | 1.8e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| cirA Show fit | 15.09 |
outer membrane receptor involved in uptake of ferric dihyroxybenzoylserine |
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| yjjZ Show fit | 12.58 |
predicted protein |
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| entCEBAH Show fit | 10.82 |
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase proofreading thioesterase in enterobactin biosynthesis isochorismate synthase 1 EntB 2,3-dihydroxybenzoate-AMP ligase |
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| fhuF Show fit | 10.46 |
hydroxamate siderophore iron reductase |
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| feoABC Show fit | 10.24 |
Fe2+ transporter FeoB predicted DNA-binding transcriptional regulator ferrous iron transport protein A |
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| fecIR Show fit | 10.23 |
regulator for fec operon, periplasmic RNA polymerase, sigma 19 factor |
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| fes-ybdZ-entF-fepE Show fit | 9.32 |
MbtH-like protein that enhances the catalytic function of EntF enterochelin esterase ferric enterobactin (enterochelin) transport apo-serine activating enzyme |
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| exbBD Show fit | 9.27 |
TonB energy transducing system - ExbB subunit tonB energy transducing system - ExbD subunit |
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| sufABCDSE Show fit | 9.05 |
SufB component of SufBCD Fe-S cluster scaffold complex SufC component of SufBCD Fe-S cluster scaffold complex Fe-S transport protein in Fe-S cluster assembly SufD component of SufBCD Fe-S cluster scaffold complex sulfur acceptor for SufS cysteine desulfurase L-cysteine desulfurase |
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| tonB Show fit | 8.96 |
TonB energy transducing system - TonB subunit |
Network of associatons between targets according to the STRING database.
First level regulatory network of Fur
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 47.8 | GO:0006826 | iron ion transport(GO:0006826) |
| 8.0 | 32.2 | GO:0033212 | iron assimilation(GO:0033212) |
| 9.6 | 28.7 | GO:0019290 | siderophore metabolic process(GO:0009237) enterobactin metabolic process(GO:0009238) enterobactin biosynthetic process(GO:0009239) catechol-containing compound metabolic process(GO:0009712) catechol-containing compound biosynthetic process(GO:0009713) nonribosomal peptide biosynthetic process(GO:0019184) siderophore biosynthetic process(GO:0019290) siderophore biosynthetic process from catechol(GO:0019540) phenol-containing compound biosynthetic process(GO:0046189) |
| 3.9 | 15.5 | GO:0015891 | siderophore transport(GO:0015891) |
| 1.7 | 15.2 | GO:0043085 | positive regulation of catalytic activity(GO:0043085) |
| 1.6 | 8.0 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.3 | 2.6 | GO:0015696 | ammonium transport(GO:0015696) |
| 0.3 | 2.0 | GO:0006972 | hyperosmotic response(GO:0006972) |
| 0.6 | 1.8 | GO:0031329 | regulation of glucose metabolic process(GO:0010906) regulation of cellular catabolic process(GO:0031329) regulation of cellular carbohydrate catabolic process(GO:0043471) |
| 0.3 | 1.0 | GO:0046686 | response to cadmium ion(GO:0046686) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.1 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.6 | 27.3 | GO:0009279 | cell outer membrane(GO:0009279) |
| 0.9 | 10.7 | GO:0055052 | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing(GO:0055052) |
| 0.3 | 10.3 | GO:0098797 | plasma membrane protein complex(GO:0098797) |
| 0.9 | 9.8 | GO:0071575 | integral component of external side of plasma membrane(GO:0071575) |
| 0.2 | 9.3 | GO:0043234 | protein complex(GO:0043234) |
| 1.1 | 8.6 | GO:0045203 | integral component of cell outer membrane(GO:0045203) |
| 0.1 | 7.1 | GO:0030288 | outer membrane-bounded periplasmic space(GO:0030288) |
| 0.3 | 4.1 | GO:1990204 | oxidoreductase complex(GO:1990204) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 53.0 | GO:0042927 | siderophore transmembrane transporter activity(GO:0015343) siderophore transporter activity(GO:0042927) |
| 8.7 | 17.3 | GO:0031992 | energy transducer activity(GO:0031992) |
| 8.1 | 16.2 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 3.6 | 10.8 | GO:0016803 | hydrolase activity, acting on ether bonds(GO:0016801) ether hydrolase activity(GO:0016803) phosphopantetheine binding(GO:0031177) |
| 1.5 | 9.0 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.6 | 7.9 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 2.1 | 6.2 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.6 | 5.4 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.3 | 3.2 | GO:0071949 | FAD binding(GO:0071949) |
| 0.3 | 2.6 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.3 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.3 | REACTOME DEVELOPMENTAL BIOLOGY | Genes involved in Developmental Biology |