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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for HU

Z-value: 1.42

Transcription factors associated with HU

Gene Symbol Gene ID Gene Info
hupA
hupA DNA-binding protein HU-alpha
hupB
hupB DNA-binding protein HU-beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hupA0.911.7e-03Click!
hupB0.911.7e-03Click!

Activity profile of HU motif

Sorted Z-values of HU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
seqA-pgm 8.85
seqA
pgm
SeqA, negative modulator of initiation of replication
phosphoglucomutase
galETK 8.55
galT
galE
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactokinase
galE 7.38
galE
UDP-glucose 4-epimerase
micF 6.72
micF
MicF
galETKM 6.39
galT
galE
galM
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactose-1-epimerase
galactokinase
galET 5.46
galT
galE
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
mtr 0.26
mtr
tryptohan / indole:H+ symporter Mtr

Network of associatons between targets according to the STRING database.

First level regulatory network of HU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 36.6 GO:0006012 galactose metabolic process(GO:0006012) galactose catabolic process(GO:0019388)
0.1 0.3 GO:0015827 tryptophan transport(GO:0015827)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.8 GO:0032993 protein-DNA complex(GO:0032993)
0.1 27.8 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 27.8 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
1.8 8.8 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.3 GO:0015196 L-tryptophan transmembrane transporter activity(GO:0015196)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 27.8 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates