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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for IscR

Z-value: 0.64

Transcription factors associated with IscR

Gene Symbol Gene ID Gene Info
iscR
iscR IscR DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
iscR0.884.0e-03Click!

Activity profile of IscR motif

Sorted Z-values of IscR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
iscRSUA 2.43
iscU
iscA
iscS
iscR
scaffold protein for iron-sulfur cluster assembly
iron-sulfur cluster assembly protein
cysteine desulfurase
IscR DNA-binding transcriptional dual regulator
nfuA 2.15
nfuA
iron-sulfur cluster scaffold protein
napFDAGHBC 1.91
napG
napF
napD
napC
napB
napA
napH
ferredoxin-type protein
ferredoxin-type protein
signal peptide-binding chaperone for NapA
periplasmic nitrate reductase, cytochrome c protein
subunit of periplasmic nitrate reductase, cytochrome c550 protein
large subunit of periplasmic nitrate reductase, molybdoprotein
ferredoxin-type protein
erpA 1.84
erpA
essential respiratory protein A
ydiU 1.31
ydiU
conserved protein

Network of associatons between targets according to the STRING database.

First level regulatory network of IscR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.6 1.9 GO:0070201 regulation of protein localization(GO:0032880) regulation of protein transport(GO:0051223) regulation of establishment of protein localization(GO:0070201)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0008940 nitrate reductase activity(GO:0008940)
0.6 2.4 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)