ISMARA results: LexA

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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for LexA

Z-value: 3.26

Transcription factors associated with LexA

Gene Symbol	Gene ID	Gene Info
lexA RegulonDB EcoCyc	lexA	LexA DNA-binding transcriptional repressor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
lexA		0.96	1.7e-04	Click!

Activity profile of LexA motif

Sorted Z-values of LexA motif

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Promoter	Log-likelihood	Gene	Gene Info
sulA Show fit	20.69	sulA RegulonDB EcoCyc Show fit	SOS cell division inhibitor
recA Show fit	20.03	recA RegulonDB EcoCyc Show fit	DNA strand exchange and recombination protein with protease and nuclease activity
recN Show fit	14.21	recN RegulonDB EcoCyc Show fit	protein used in recombination and DNA repair
sbmC Show fit	12.95	sbmC RegulonDB EcoCyc Show fit	DNA gyrase inhibitor
dinI Show fit	12.01	dinI RegulonDB EcoCyc Show fit	DNA damage-inducible protein I
ruvAB Show fit	11.32	ruvA RegulonDB EcoCyc Show fit ruvB RegulonDB EcoCyc Show fit	branch migration of Holliday structures; repair branch migration of Holliday structures; repair helicase
dinQ Show fit	10.12	dinQ RegulonDB EcoCyc Show fit	toxic inner membrane peptide DinQ
yebG Show fit	10.05	yebG RegulonDB EcoCyc Show fit	conserved protein regulated by LexA
uvrB Show fit	9.24	uvrB RegulonDB EcoCyc Show fit	DNA repair; excision nuclease subunit B
recAX Show fit	8.09	recX RegulonDB EcoCyc Show fit recA RegulonDB EcoCyc Show fit	regulatory protein RecX; inhibitor of RecA DNA strand exchange and recombination protein with protease and nuclease activity

Showing 1 to 10 of 23 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of LexA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.8	91.2	GO:0009432	SOS response(GO:0009432)
6.9	20.7	GO:0051726	regulation of cell cycle process(GO:0010564) regulation of cytokinesis(GO:0032465) regulation of GTPase activity(GO:0043087) regulation of cell cycle(GO:0051726)
4.3	12.9	GO:2000104	regulation of ATPase activity(GO:0043462) negative regulation of DNA-dependent DNA replication(GO:2000104)
2.6	7.8	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.1	7.2	GO:0009314	response to radiation(GO:0009314)
0.2	2.6	GO:0006261	DNA-dependent DNA replication(GO:0006261)
0.3	2.5	GO:0090305	nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.3	1.0	GO:0015835	peptidoglycan transport(GO:0015835)

Showing 1 to 8 of 8 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	50.7	GO:0005829	cytosol(GO:0005829)
4.0	19.9	GO:0009380	excinuclease repair complex(GO:0009380)
1.6	11.3	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.0	8.7	GO:0016020	membrane(GO:0016020)
1.6	4.9	GO:0042575	DNA polymerase complex(GO:0042575)
0.2	2.6	GO:0015935	small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)

Showing 1 to 6 of 6 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	34.7	GO:0003697	single-stranded DNA binding(GO:0003697)
0.1	34.2	GO:0005515	protein binding(GO:0005515)
4.3	12.9	GO:0060590	ATPase regulator activity(GO:0060590)
4.2	12.5	GO:0015616	DNA translocase activity(GO:0015616)
1.5	12.0	GO:0019899	enzyme binding(GO:0019899)
1.1	7.4	GO:0003678	DNA helicase activity(GO:0003678) ATP-dependent DNA helicase activity(GO:0004003)
0.1	6.3	GO:0016887	ATPase activity(GO:0016887)
2.0	6.0	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1	5.1	GO:0003677	DNA binding(GO:0003677)
0.9	2.6	GO:0000990	transcription factor activity, core RNA polymerase binding(GO:0000990) core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) sigma factor activity(GO:0016987)

Showing 1 to 10 of 13 entries

Results for LexA

Z-value: 3.26

Transcription factors associated with LexA

Activity-expression correlation:

Activity profile of LexA motif

Sorted Z-values of LexA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of LexA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category: