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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for NsrR

Z-value: 0.49

Transcription factors associated with NsrR

Gene Symbol Gene ID Gene Info
nsrR
nsrR NsrR DNA-binding transcriptional repressor

Activity profile of NsrR motif

Sorted Z-values of NsrR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
sodB 1.00
sodB
superoxide dismutase (Fe)
hmp 0.87
hmp
nitric oxide dioxygenase
hcp-hcr 0.85
hcr
hcp
NADH oxidoreductase
hybrid-cluster protein
ndh 0.59
ndh
NADH:quinone oxidoreductase II
grxD 0.53
grxD
glutaredoxin 4
tehAB 0.37
tehA
tehB
tellurite resistance protein / ethidium exporter
tellurite methyltransferase
lrp 0.33
lrp
Lrp transcriptional dual regulator
cdd 0.32
cdd
cytidine deaminase
hypABCDE-fhlA 0.30
fhlA
hypE
hypD
hypA
hypC
hypB
FhlA transcriptional activator
hydrogenase maturation protein, carbamoyl dehydratase
HypD, scaffold protein for assembly of the Fe-(CN)2CO cofactor
accessory protein for nickel incorporation into hydrogenase 3
HypC, protein involved in hydrogenase 3 maturation
accessory protein for nickel incorporation into hydrogenase isoenzymes
ygbA 0.30
ygbA
predicted protein
ytfE 0.27
ytfE
iron-sulfur cluster repair protein YtfE
hypABCDE 0.26
hypE
hypD
hypA
hypC
hypB
hydrogenase maturation protein, carbamoyl dehydratase
HypD, scaffold protein for assembly of the Fe-(CN)2CO cofactor
accessory protein for nickel incorporation into hydrogenase 3
HypC, protein involved in hydrogenase 3 maturation
accessory protein for nickel incorporation into hydrogenase isoenzymes
aceEF 0.24
aceF
aceE
pyruvate dehydrogenase, E2 subunit
subunit of E1p component of pyruvate dehydrogenase complex
fliAZ-tcyJ 0.18
tcyJ
fliZ
fliA
cystine/cysteine ABC transporter - periplasmic binding protein
FliZ DNA-binding transcriptional regulator
RNA polymerase, sigma 28 (sigma F) factor
thrS-infC-rpmI-rplT-pheMST-ihfA 0.16
pheS
rplT
infC
pheM
rpmI
pheT
ihfA
thrS
phenylalanine-tRNA ligase α-chain
50S ribosomal subunit protein L20
protein chain initiation factor IF-3
phenylalanyl-tRNA synthetase (pheST) operon leader peptide
50S ribosomal subunit protein L35
phenylalanine-tRNA ligase β-chain
integration host factor (IHF), α subunit
threonine-tRNA ligase
nrfABCDEFG 0.13
nrfF
nrfG
nrfD
nrfE
nrfB
nrfC
nrfA
activator of formate-dependent nitrite reductase complex
NrfG
formate dependent nitrite reductase - NrfD subunit
formate-dependent nitrite reductase; possible assembly function
formate-dependent nitrite reductase - penta-heme cytochrome c
formate-dependent nitrite reductase, 4Fe-4S subunit
formate dependent nitrite reductase - NrfA subunit
yeaE 0.07
yeaE
methylglyoxal reductase
bamE 0.02
bamE
Outer Membrane Protein Assembly Complex - BamE subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of NsrR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0046209 nitric oxide metabolic process(GO:0046209) nitric oxide catabolic process(GO:0046210)
0.3 1.0 GO:0000303 response to superoxide(GO:0000303) superoxide metabolic process(GO:0006801)
0.1 0.6 GO:0019646 aerobic electron transport chain(GO:0019646)
0.1 0.6 GO:0046892 protein dehydration(GO:0018249) peptidyl-S-carbamoyl-L-cysteine dehydration(GO:0046892)
0.1 0.2 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.3 GO:0030091 protein repair(GO:0030091)
0.1 0.3 GO:0009078 alanine metabolic process(GO:0006522) leucine metabolic process(GO:0006551) pyruvate family amino acid metabolic process(GO:0009078) leucine biosynthetic process(GO:0009098) response to amino acid(GO:0043200)
0.1 0.1 GO:0018198 peptidyl-cysteine modification(GO:0018198)
0.1 0.2 GO:1903712 L-cystine transport(GO:0015811) cysteine transmembrane transport(GO:1903712)
0.1 0.3 GO:0046133 pyrimidine ribonucleoside metabolic process(GO:0046131) pyrimidine ribonucleoside catabolic process(GO:0046133) pyrimidine nucleoside catabolic process(GO:0046135)
0.0 0.2 GO:0000027 ribosomal large subunit assembly(GO:0000027) ribosomal large subunit biogenesis(GO:0042273)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.6 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 0.2 GO:0022625 large ribosomal subunit(GO:0015934) cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 0.9 GO:0032843 hydroperoxide reductase activity(GO:0032843)
0.2 0.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.6 GO:0070025 carbon monoxide binding(GO:0070025)
0.1 0.9 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.2 GO:0033229 core promoter binding(GO:0001047) L-cystine transmembrane transporter activity(GO:0015184) cysteine transmembrane transporter activity(GO:0033229)
0.1 0.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0031405 lipoic acid binding(GO:0031405)
0.0 0.1 GO:0016662 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.0 0.2 GO:0000049 tRNA binding(GO:0000049)