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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for PurR

Z-value: 0.81

Transcription factors associated with PurR

Gene Symbol Gene ID Gene Info
purR
purR PurR transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
purR0.521.9e-01Click!

Activity profile of PurR motif

Sorted Z-values of PurR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
pyrC 1.49
pyrC
dihydroorotase
purR 0.96
purR
PurR transcriptional repressor
hflD-purB 0.89
purB
hflD
adenylosuccinate lyase
lysogenization regulator
purEK 0.76
purK
purE
N5-carboxyaminoimidazole ribonucleotide synthetase
N5-carboxyaminoimidazole ribonucleotide mutase
purC 0.67
purC
phosphoribosylaminoimidazole-succinocarboxamide synthase
cvpA-purF-ubiX 0.54
cvpA
purF
ubiX
membrane protein required for colicin V production
amidophosphoribosyl transferase
3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein
guaBA 0.49
guaB
guaA
IMP dehydrogenase
GMP synthetase
prs 0.47
prs
ribose-phosphate diphosphokinase
speAB 0.44
speB
speA
agmatinase
arginine decarboxylase, biosynthetic
purMN 0.41
purN
purM
phosphoribosylglycinamide formyltransferase 1
phosphoribosylformylglycinamide cyclo-ligase
pyrD 0.16
pyrD
dihydroorotate dehydrogenase, type 2
gcvTHP 0.11
gcvH
gcvP
gcvT
glycine cleavage system H protein
glycine decarboxylase
aminomethyltransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of PurR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.2 1.0 GO:0045936 negative regulation of phosphorus metabolic process(GO:0010563) negative regulation of phosphate metabolic process(GO:0045936)
0.2 0.5 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037) GTP metabolic process(GO:0046039) guanosine-containing compound biosynthetic process(GO:1901070)
0.2 0.5 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.5 GO:0044550 secondary metabolite biosynthetic process(GO:0044550)
0.0 0.7 GO:0033014 tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014)
0.0 0.1 GO:0019464 glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.9 GO:0009408 response to heat(GO:0009408)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.3 0.9 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 1.0 GO:0001141 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001141) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.4 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.5 GO:0042301 phosphate ion binding(GO:0042301)
0.1 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.8 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 0.2 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.1 GO:0031405 lipoic acid binding(GO:0031405)