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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for Sigma70

Z-value: 3.45

Transcription factors associated with Sigma70

Gene Symbol Gene ID Gene Info
rpoD
rpoD RNA polymerase sigma factor RpoD

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rpoD0.991.4e-06Click!

Activity profile of Sigma70 motif

Sorted Z-values of Sigma70 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
focA-pflB 10.57
focA
pflB
formate channel FocA
pyruvate formate-lyase (inactive)
tufA 9.69
tufA
elongation factor Tu
pgk 9.65
pgk
phosphoglycerate kinase
uvrB 9.58
uvrB
DNA repair; excision nuclease subunit B
mreB 8.41
mreB
dynamic cytoskeletal protein MreB
gapA 8.22
gapA
glyceraldehyde 3-phosphate dehydrogenase
csrA 8.17
csrA
carbon storage regulator; pleiotropic regulatory protein for carbon source metabolism
pgk-fbaA 8.17
pgk
fbaA
phosphoglycerate kinase
fructose bisphosphate aldolase class II
gltX 7.97
gltX
glutamate-tRNA ligase
icd 7.64
icd
isocitrate dehydrogenase
gpmA 7.50
gpmA
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
trxA 7.49
trxA
thioredoxin 1
rpsA-ihfB 7.38
ihfB
rpsA
integration host factor (IHF), β subunit
30S ribosomal subunit protein S1
cspE 7.31
cspE
transcription antiterminator and regulator of RNA stability
pykA 7.12
pykA
pyruvate kinase II
ahpCF 7.05
ahpF
ahpC
alkyl hydroperoxide reductase, AhpF component
alkyl hydroperoxide reductase, AhpC component
sulA 6.48
sulA
SOS cell division inhibitor
tsx 6.36
tsx
nucleoside channel; receptor of phage T6 and colicin K
recA 6.24
recA
DNA strand exchange and recombination protein with protease and nuclease activity
secG-leuU 6.23
leuU
secG
tRNAleuU
SecG
rne 6.13
rne
RNase E
nagC 6.11
nagC
NagC DNA-binding transcriptional dual regulator
kdsC-lptCAB 5.91
kdsC
lptA
lptB
lptC
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
LptA
LptB
LptC
nlpD-rpoS 5.88
rpoS
nlpD
RNA polymerase, sigma S (sigma 38) factor
NlpD divisome associated factor; activates peptidoglycan hydrolase
narK 5.56
narK
nitrate:nitrite antiporter NarK
dnaN-recF 5.34
recF
dnaN
ssDNA and dsDNA binding, ATP binding
DNA polymerase III, β subunit
prs 5.13
prs
ribose-phosphate diphosphokinase
lptD 5.08
lptD
outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
glmZ 5.04
glmZ
GlmZ
cysK 4.94
cysK
O-acetylserine sulfhydrylase A
rpsMKD-rpoA-rplQ 4.93
rpsD
rpsM
rpsK
rplQ
rpoA
30S ribosomal subunit protein S4
30S ribosomal subunit protein S13
30S ribosomal subunit protein S11
50S ribosomal subunit protein L17
RNA polymerase, α subunit
ftsK 4.86
ftsK
essential cell division protein FtsK
proS 4.70
proS
proline-tRNA ligase
lpxC 4.68
lpxC
UDP-3-O-acyl-N-acetylglucosamine deacetylase
metG 4.57
metG
methionine-tRNA ligase
rpsP-rimM-trmD-rplS 4.52
rplS
rimM
trmD
rpsP
50S ribosomal subunit protein L19
ribosome maturation protein
tRNA m1G37 methyltransferase
30S ribosomal subunit protein S16
fnrS 4.52
fnrS
FnrS
ssrA 4.49
ssrA
TmRNA
plsX-fabHDG 4.48
plsX
fabG
fabH
fabD
fatty acid/phospholipid synthesis protein
3-oxoacyl-[acyl-carrier-protein] reductase subunit
β-ketoacyl-ACP synthase III
malonyl-CoA-ACP transacylase
pepA 4.44
pepA
aminopeptidase A/I
rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF 4.41
rrlD
ileU
alaU
thrV
rrfF
rrsD
rrfD
rrlD 23S ribosomal RNA
tRNAileU
tRNAalaU
tRNAthrV
rrfF 5S ribosomal RNA
rrsD 16S ribosomal RNA
rrfD 5S ribosomal RNA
tff-rpsB-tsf 4.41
tsf
tff
rpsB
protein chain elongation factor EF-Ts
Tff
30S ribosomal subunit protein S2
valS 4.40
valS
valine-tRNA ligase
rpsF-priB-rpsR-rplI 4.40
rpsF
priB
rpsR
rplI
30S ribosomal subunit protein S6
primosomal replication protein N
30S ribosomal subunit protein S18
50S ribosomal subunit protein L9
infA 4.39
infA
protein chain initiation factor IF-1
cspA 4.39
cspA
CspA DNA-binding transcriptional activator
acpP-fabF 4.37
fabF
acpP
β-ketoacyl-ACP synthase II
apo-[acyl carrier protein]
ribA 4.36
ribA
GTP cyclohydrolase II
infC-rpmI-rplT 4.34
rpmI
rplT
infC
50S ribosomal subunit protein L35
50S ribosomal subunit protein L20
protein chain initiation factor IF-3
aspA 4.30
aspA
aspartate ammonia-lyase
yjeF-tsaE-amiB-mutL-miaA-hfq-hflXKC 4.28
miaA
tsaE
hfq
hflK
mutL
amiB
yjeF
hflX
hflC
tRNA(i6A37) synthase
N6-L-threonylcarbamoyladenine synthase, TsaE subunit
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
MutL
N-acetylmuramoyl-L-alanine amidase B
NAD(P)HX epimerase / NAD(P)HX dehydratase
ribosome-dissociating factor, GTPase
regulator of FtsH protease
acpP 4.26
acpP
apo-[acyl carrier protein]
rcsB 4.24
rcsB
RcsB
mdh 4.23
mdh
malate dehydrogenase
yccA 4.23
yccA
putative carrier/transport protein; substrate or modulator of FtsH-mediated proteolysis
thrU-tyrU-glyT-thrT-tufB 4.10
tufB
thrT
thrU
glyT
tyrU
elongation factor Tu
tRNAthrT
tRNAthrU
tRNAglyT
tRNAtyrU
tpx 4.05
tpx
lipid hydroperoxide peroxidase
araC 4.04
araC
AraC DNA-binding transcriptional dual regulator
yajG 3.98
yajG
predicted lipoprotein
mgrR 3.96
mgrR
MgrR
atpIBEFHAGDC 3.92
atpI
atpH
atpC
atpB
atpA
atpG
atpF
atpE
atpD
AtpI
ATP synthase F1 complex - delta subunit
ATP synthase F1 complex - epsilon subunit
ATP synthase F0 complex - a subunit
ATP synthase F1 complex - alpha subunit
ATP synthase F1 complex - gamma subunit
ATP synthase F0 complex - b subunit
ATP synthase F0 complex - subunit c
ATP synthase F1 complex - beta subunit
patZ 3.92
patZ
peptidyl-lysine acetyltransferase
rpsJ-rplCDWB-rpsS-rplV-rpsC-rplP-rpmC-rpsQ 3.92
rpsC
rplV
rplW
rpsJ
rplP
rpsS
rpsQ
rpmC
rplD
rplB
rplC
30S ribosomal subunit protein S3
50S ribosomal subunit protein L22
50S ribosomal subunit protein L23
30S ribosomal subunit protein S10
50S ribosomal subunit protein L16
30S ribosomal subunit protein S19
30S ribosomal subunit protein S17
50S ribosomal subunit protein L29
50S ribosomal subunit protein L4
50S ribosomal subunit protein L2
50S ribosomal subunit protein L3
glmY 3.91
glmY
GlmY
recN 3.91
recN
protein used in recombination and DNA repair
rpmI-rplT 3.90
rpmI
rplT
50S ribosomal subunit protein L35
50S ribosomal subunit protein L20
lysU 3.87
lysU
lysine-tRNA ligase / Ap4A synthetase / Ap3A synthetase
uspA 3.83
uspA
universal stress global stress response regulator
treBC 3.83
treC
treB
trehalose-6-phosphate hydrolase
trehalose PTS permease - TreB subunit
gcvB 3.82
gcvB
GcvB
yrbN-deaD 3.79
yrbN
deaD
small protein
DeaD, DEAD-box RNA helicase
rpsU 3.77
rpsU
30S ribosomal subunit protein S21
deoBD 3.76
deoB
deoD
phosphopentomutase
purine nucleoside phosphorylase
opgGH 3.75
opgG
opgH
periplasmic protein associated with synthesis of osmoregulated periplasmic glucans (OPGs)
membrane glycosyltransferase; synthesis of osmoregulated periplasmic glucans (OPGs)
mrp 3.71
mrp
P-loop NTPase family protein
pnp 3.70
pnp
polynucleotide phosphorylase
gntX-nfuA 3.69
gntX
nfuA
protein involved in utilization of DNA as a carbon source
iron-sulfur cluster scaffold protein
relA-mazEF 3.66
mazE
relA
mazF
MazE antitoxin of the MazF-MazE toxin-antitoxin system
GDP pyrophosphokinase/GTP pyrophosphokinase
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity
yneM 3.65
yneM
small membrane protein
ychH 3.64
ychH
stress-induced protein
clpA 3.61
clpA
ClpA
pck 3.59
pck
phosphoenolpyruvate carboxykinase (ATP)
purA 3.56
purA
adenylosuccinate synthetase
rrsB-gltT-rrlB-rrfB 3.56
rrlB
gltT
rrfB
rrsB
rrlB 23S ribosomal RNA
tRNAgltT
rrfB 5S ribosomal RNA
rrsB 16S ribosomal RNA
metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp 3.55
metY
rimP
rpsO
pnp
rbfA
infB
nusA
truB
tRNAfMet2
ribosome maturation factor RimP
30S ribosomal subunit protein S15
polynucleotide phosphorylase
30S ribosome binding factor
protein chain initiation factor IF2
transcription termination/antitermination L factor
tRNA pseudouridine 55 synthase
pykF 3.55
pykF
pyruvate kinase I
yobF-cspC 3.55
yobF
cspC
small protein involved in stress responses
stress protein, member of the CspA family
rrsH-ileV-alaV-rrlH-rrfH 3.54
rrlH
rrfH
rrsH
ileV
alaV
rrlH 23S ribosomal RNA
rrfH 5S ribosomal RNA
rrsH 16S ribosomal RNA
tRNAileV
tRNAalaV
tnaCAB 3.54
tnaA
tnaC
tnaB
tryptophanase
tryptophanase operon leader peptide
tryptophan:H+ symporter TnaB
ompA 3.53
ompA
outer membrane porin A
rplM-rpsI 3.50
rplM
rpsI
50S ribosomal subunit protein L13
30S ribosomal subunit protein S9
grxB 3.49
grxB
reduced glutaredoxin 2
glmUS 3.45
glmU
glmS
fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
L-glutamine:D-fructose-6-phosphate aminotransferase
tatABC 3.44
tatA
tatC
tatB
twin arginine protein translocation system - TatA protein
twin arginine protein translocation system - TatC protein
twin arginine protein translocation system - TatB protein
rpoD 3.43
rpoD
RNA polymerase, sigma 70 (sigma D) factor
udp 3.42
udp
uridine phosphorylase
dinI 3.41
dinI
DNA damage-inducible protein I
sohB 3.41
sohB
predicted inner membrane peptidase
efp 3.37
efp
protein chain elongation factor EF-P
dinQ 3.35
dinQ
toxic inner membrane peptide DinQ
pflA 3.34
pflA
pyruvate formate-lyase activating enzyme
napFDAGHBC-ccmABCDEFGH 3.33
napG
napF
napD
napC
ccmH
napA
ccmE
ccmD
ccmG
ccmF
ccmA
ccmC
ccmB
napH
napB
ferredoxin-type protein
ferredoxin-type protein
signal peptide-binding chaperone for NapA
periplasmic nitrate reductase, cytochrome c protein
holocytochrome c synthetase - thiol:disulfide oxidoreductase CcmH
large subunit of periplasmic nitrate reductase, molybdoprotein
membrane anchored periplasmic heme chaperone CcmE
ABC complex for formation and release of holoCcmE - membrane subunit CcmD
holocytochrome c synthetase - thiol:disulfide oxidoreductase CcmG
holocytochrome c synthetase - CcmF subunit
ABC complex for formation and release of holoCcmE - ATP binding subunit
ABC complex for formation and release of holoCcmE - membrane subunit CcmC
ABC complex for formation and release of holoCcmE - membrane subunit CcmB
ferredoxin-type protein
subunit of periplasmic nitrate reductase, cytochrome c550 protein
rrsA-ileT-alaT-rrlA-rrfA 3.32
rrlA
ileT
alaT
rrsA
rrfA
23S ribosomal RNA (rrlA)
tRNAileT
tRNAalaT
16S ribosomal RNA (rrsA)
5S ribosomal RNA (rrfA)
arcA 3.26
arcA
ArcA transcriptional dual regulator
cspD 3.26
cspD
DNA replication inhibitor
ybhL 3.26
ybhL
inner membrane protein
glyQS 3.25
glyS
glyQ
glycine-tRNA ligase, β subunit
glycine-tRNA ligase, α subunit
speAB 3.25
speB
speA
agmatinase
arginine decarboxylase, biosynthetic
aspA-dcuA 3.25
aspA
dcuA
aspartate ammonia-lyase
dicarboxylate transporter DcuA
hflD-purB 3.24
purB
hflD
adenylosuccinate lyase
lysogenization regulator
nudB-yebC-ruvC 3.21
ruvC
nudB
yebC
Holliday junction nuclease; resolution of structures; repair
dihydroneopterin triphosphate pyrophosphohydrolase
conserved protein
dapA-bamC 3.21
dapA
bamC
4-hydroxy-tetrahydrodipicolinate synthase
Outer Membrane Protein Assembly Complex - BamC subunit
fabB 3.21
fabB
β-ketoacyl-ACP synthase I
epd-pgk 3.18
epd
pgk
erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
gatYZABCD 3.18
gatY
gatZ
gatD
gatA
gatB
gatC
tagatose-1,6-bisphosphate aldolase 2 subunit GatY
tagatose-1,6-bisphosphate aldolase 2 subunit GatZ
L-galactitol-1-phosphate 5-dehydrogenase
galactitol PTS permease - GatA subunit
galactitol PTS permease - GatB subunit
galactitol PTS permease - GatC subunit
sodA 3.16
sodA
superoxide dismutase (Mn)
epd-pgk-fbaA 3.15
epd
pgk
fbaA
erythrose 4-phosphate dehydrogenase
phosphoglycerate kinase
fructose bisphosphate aldolase class II
gyrA 3.12
gyrA
DNA gyrase, subunit A
ycaR-kdsB 3.11
kdsB
ycaR
3-deoxy-D-manno-octulosonate cytidylyltransferase
conserved protein
thrW 3.10
thrW
tRNAthrW
rplU-rpmA 3.09
rpmA
rplU
50S ribosomal subunit protein L27
50S ribosomal subunit protein L21
sodB 3.09
sodB
superoxide dismutase (Fe)
ftsAZ 3.09
ftsZ
ftsA
essential cell division protein FtsZ
essential cell division protein FtsA
csrB 3.08
csrB
CsrB
ompX 3.08
ompX
outer membrane protein X
ivbL 3.08
ivbL
ilvB operon leader peptide
leuO 3.07
leuO
LeuO DNA-binding transcriptional dual regulator
rplY 3.06
rplY
50S ribosomal subunit protein L25
cmk-rpsA 3.04
cmk
rpsA
cytidylate kinase
30S ribosomal subunit protein S1
sdhCDAB-sucABCD 3.00
sucA
sucC
sucB
sucD
sdhA
sdhC
sdhB
sdhD
subunit of E1(0) component of 2-oxoglutarate dehydrogenase
succinyl-CoA synthetase, β subunit
dihydrolipoyltranssuccinylase
succinyl-CoA synthetase, α subunit
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, membrane protein SdhC
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
fur 2.99
fur
Fur transcriptional dual regulator
sdhDAB 2.98
sdhA
sdhB
sdhD
succinate:quinone oxidoreductase, FAD binding protein
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
succinate:quinone oxidoreductase, membrane protein SdhD
pepD 2.98
pepD
peptidase D
manA 2.98
manA
mannose-6-phosphate isomerase
mreBCD 2.97
mreB
mreC
mreD
dynamic cytoskeletal protein MreB
membrane protein required for maintenance of rod shape
membrane protein required for maintenance of rod shape
glyA 2.94
glyA
serine hydroxymethyltransferase
fnr 2.93
fnr
FNR DNA-binding transcriptional dual regulator
ygfB-pepP-ubiHI 2.92
ygfB
pepP
ubiH
ubiI
predicted protein
proline aminopeptidase P II
2-octaprenyl-6-methoxyphenol hydroxylase
2-octaprenylphenol hydroxylase
rraB 2.89
rraB
ribonuclease E inhibitor protein B
nrdR-ribDE-nusB-thiL-pgpA 2.89
nusB
nrdR
thiL
pgpA
ribE
ribD
transcription antitermination protein NusB
NrdR transcriptional repressor
thiamine monophosphate kinase
phosphatidylglycerophosphatase A
6,7-dimethyl-8-ribityllumazine synthase
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase
accA 2.89
accA
acetyl-CoA carboxyltransferase, α subunit
dcuA 2.89
dcuA
dicarboxylate transporter DcuA
clpPX 2.88
clpP
clpX
ClpP
ClpX
grxD 2.88
grxD
glutaredoxin 4
dps 2.87
dps
stationary phase nucleoid protein that sequesters iron and protects DNA from damage
secB-gpsA 2.85
gpsA
secB
glycerol-3-phosphate dehydrogenase
SecB chaperone
glnA 2.85
glnA
glutamine synthetase
frdABCD 2.83
frdA
frdB
frdC
frdD
fumarate reductase flavoprotein
fumarate reductase iron-sulfur protein
fumarate reductase membrane protein
fumarate reductase membrane protein
dut-slmA 2.82
slmA
dut
nucleoid occlusion factor SlmA
deoxyuridine triphosphatase
accD 2.81
accD
acetyl-CoA carboxyltransferase, β subunit
yebG 2.76
yebG
conserved protein regulated by LexA
ompR-envZ 2.73
envZ
ompR
EnvZ
OmpR transcriptional dual regulator
esrE 2.73
esrE
EsrE
hfq-hflXKC 2.73
hflC
hfq
hflK
hflX
regulator of FtsH protease
RNA-binding protein that affects many cellular processes; homolog of mammalian Sm/Sm-like proteins
regulator of FtsH protease
ribosome-dissociating factor, GTPase
gadE-mdtEF 2.73
mdtF
mdtE
gadE
MdtEF-TolC multidrug efflux pump - permease subunit
MdtEF-TolC multidrug efflux pump - membrane fusion protein
GadE DNA-binding transcriptional activator
serW 2.71
serW
tRNASer5
tpiA 2.70
tpiA
triosephosphate isomerase
gnd 2.70
gnd
6-phosphogluconate dehydrogenase, decarboxylating
frr 2.69
frr
ribosome recycling factor
glpFKX 2.66
glpF
glpX
glpK
glycerol channel GlpF
fructose 1,6-bisphosphatase II
glycerol kinase
yibN-grxC-secB-gpsA 2.66
grxC
gpsA
secB
yibN
reduced glutaredoxin 3
glycerol-3-phosphate dehydrogenase
SecB chaperone
predicted rhodanese-related sulfurtransferase
soxS 2.63
soxS
SoxS DNA-binding transcriptional dual regulator
panD 2.63
panD
PanD proenzyme, π protein
lpd 2.62
lpd
lipoamide dehydrogenase
ppsA 2.62
ppsA
phosphoenolpyruvate synthetase
yedX 2.61
yedX
hydroxyisourate hydrolase / transthyretin-related protein
xseB-ispA-dxs-yajO 2.61
xseB
dxs
ispA
yajO
exonuclease VII, small subunit
1-deoxyxylulose-5-phosphate synthase
geranyl diphosphate synthase/farnesyl diphosphate synthase
novel 1-deoxyxylulose-5-phosphate synthase
nrdDG 2.60
nrdD
nrdG
anaerobic ribonucleoside-triphosphate reductase
anaerobic ribonucleoside-triphosphate reductase-activating protein
rimP-nusA-infB 2.60
rimP
infB
nusA
ribosome maturation factor RimP
protein chain initiation factor IF2
transcription termination/antitermination L factor
ptsHI-crr 2.56
ptsI
ptsH
crr
PTS enzyme I
HPr
Enzyme IIAGlc; Crr
kbl-tdh 2.55
tdh
kbl
threonine dehydrogenase
2-amino-3-ketobutyrate CoA ligase
ssrS 2.54
ssrS
6S RNA
panBC 2.52
panC
panB
pantothenate synthetase
3-methyl-2-oxobutanoate hydroxymethyltransferase
yqhD-dkgA 2.52
yqhD
dkgA
NADPH-dependent aldehyde reductase
methylglyoxal reductase/isobutyraldehyde reductase/β-keto ester reductase/2,5-diketo-D-gluconate reductase
yebC-ruvC 2.51
ruvC
yebC
Holliday junction nuclease; resolution of structures; repair
conserved protein
gyrB 2.50
gyrB
DNA gyrase, subunit B
rpsU-dnaG-rpoD 2.49
rpsU
dnaG
rpoD
30S ribosomal subunit protein S21
DNA primase
RNA polymerase, sigma 70 (sigma D) factor
uidR 2.48
uidR
UidR DNA-binding transcriptional repressor
argS 2.47
argS
arginine-tRNA ligase
argU 2.46
argU
tRNAargU
rpoS 2.44
rpoS
RNA polymerase, sigma S (sigma 38) factor
rlmE-ftsH 2.42
rlmE
ftsH
23S rRNA 2'-O-ribose U2552 methyltransferase
ATP-dependent zinc metalloprotease FtsH
nrdAB-yfaE 2.40
nrdA
nrdB
yfaE
ribonucleoside diphosphate reductase 1, α subunit
ribonucleoside diphosphate reductase 1, β subunit, ferritin-like
2Fe-2S cluster-containing protein involved in diferric-tyrosyl radical cofactor maintenance
mglBAC 2.40
mglA
mglB
mglC
D-galactose / D-galactoside ABC transporter - ATP binding subunit
D-galactose / D-galactoside ABC transporter - periplasmic binding protein
D-galactose / D-galactoside ABC transporter - membrane subunit
aceEF 2.39
aceF
aceE
pyruvate dehydrogenase, E2 subunit
subunit of E1p component of pyruvate dehydrogenase complex
dapD 2.37
dapD
tetrahydrodipicolinate succinylase
rpiR-alsBACE 2.34
rpiR
alsE
alsB
alsC
alsA
AlsR DNA-binding transcriptional repressor
allulose-6-phosphate 3-epimerase
D-allose ABC transporter - periplasmic binding protein
D-allose ABC transporter - membrane subunit
D-allose ABC transporter - ATP binding subunit
iscRSUA 2.33
iscU
iscA
iscS
iscR
scaffold protein for iron-sulfur cluster assembly
iron-sulfur cluster assembly protein
cysteine desulfurase
IscR DNA-binding transcriptional dual regulator
sokB 2.33
sokB
SokB
msrB 2.30
msrB
methionine sulfoxide reductase B
hisS 2.29
hisS
histidine-tRNA ligase
fimB 2.29
fimB
regulator for fimA
cysB 2.28
cysB
CysB transcriptional dual regulator
recAX 2.28
recX
recA
regulatory protein RecX; inhibitor of RecA
DNA strand exchange and recombination protein with protease and nuclease activity
uxuAB 2.28
uxuA
uxuB
D-mannonate dehydratase
D-mannonate oxidoreductase
hchA 2.27
hchA
amino acid deglycase Hsp31
glgBXCAP 2.27
glgX
glgA
glgB
glgC
glgP
limit dextrin α-1,6-glucohydrolase
glycogen synthase
1,4-α-glucan branching enzyme
glucose-1-phosphate adenylyltransferase
glycogen phosphorylase
mlc-ynfK 2.26
mlc
ynfK
Mlc DNA-binding transcriptional repressor
predicted dethiobiotin synthetase
sfsA-dksA 2.25
dksA
sfsA
RNA polymerase-binding transcription factor DksA
predicted DNA-binding transcriptional regulator of maltose metabolism
glnQ 2.19
glnQ
L-glutamine ABC transporter - ATP binding subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of Sigma70

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0010906 regulation of glucose metabolic process(GO:0010906)
5.1 15.2 GO:0043242 negative regulation of protein complex disassembly(GO:0043242) negative regulation of DNA-templated transcription, termination(GO:0060567)
4.3 4.3 GO:0032790 ribosome disassembly(GO:0032790) ribonucleoprotein complex disassembly(GO:0032988) organelle disassembly(GO:1903008)
3.9 19.6 GO:0051782 negative regulation of cell division(GO:0051782)
3.9 11.7 GO:0043952 protein transport by the Sec complex(GO:0043952)
3.8 22.9 GO:0019319 gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319)
3.6 10.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
3.5 17.5 GO:2000765 regulation of cytoplasmic translation(GO:2000765)
3.3 16.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)
3.2 42.2 GO:0006096 glycolytic process(GO:0006096)
2.7 10.9 GO:0045727 positive regulation of cellular amide metabolic process(GO:0034250) positive regulation of translation(GO:0045727)
2.7 13.5 GO:0006567 threonine catabolic process(GO:0006567)
2.7 5.4 GO:0065002 intracellular protein transmembrane transport(GO:0065002)
2.6 2.6 GO:0006772 thiamine metabolic process(GO:0006772) thiamine biosynthetic process(GO:0009228) thiamine-containing compound metabolic process(GO:0042723) thiamine-containing compound biosynthetic process(GO:0042724)
2.5 5.0 GO:0009125 nucleoside monophosphate catabolic process(GO:0009125) pyrimidine nucleoside monophosphate catabolic process(GO:0009131) ribonucleoside monophosphate catabolic process(GO:0009158) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate catabolic process(GO:0009175) UMP metabolic process(GO:0046049) UMP catabolic process(GO:0046050)
2.5 7.4 GO:0009225 nucleotide-sugar metabolic process(GO:0009225) nucleotide-sugar biosynthetic process(GO:0009226)
2.4 7.3 GO:0042726 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231) flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
2.4 14.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
2.4 7.2 GO:0071932 replication fork reversal(GO:0071932)
2.4 7.1 GO:0030260 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
2.4 7.1 GO:0042150 plasmid recombination(GO:0042150)
2.2 38.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418) tRNA aminoacylation(GO:0043039)
2.2 10.9 GO:1990748 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
2.1 8.3 GO:0005980 glycogen catabolic process(GO:0005980)
2.1 8.2 GO:0001121 transcription from bacterial-type RNA polymerase promoter(GO:0001121)
2.0 8.2 GO:0031564 transcription antitermination(GO:0031564)
1.9 5.8 GO:0000725 recombinational repair(GO:0000725)
1.9 5.6 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process to lactate(GO:0061727)
1.8 1.8 GO:0015835 peptidoglycan transport(GO:0015835)
1.8 1.8 GO:0043101 purine-containing compound salvage(GO:0043101)
1.8 5.4 GO:0019877 diaminopimelate biosynthetic process(GO:0019877)
1.8 3.6 GO:0001522 pseudouridine synthesis(GO:0001522) tRNA pseudouridine synthesis(GO:0031119)
1.8 12.4 GO:0009156 purine nucleoside monophosphate biosynthetic process(GO:0009127) ribonucleoside monophosphate biosynthetic process(GO:0009156) purine ribonucleoside monophosphate biosynthetic process(GO:0009168)
1.8 8.8 GO:0017004 cytochrome complex assembly(GO:0017004)
1.6 6.5 GO:0043335 protein unfolding(GO:0043335)
1.6 4.8 GO:0009970 cellular response to sulfate starvation(GO:0009970)
1.6 6.4 GO:0006544 glycine metabolic process(GO:0006544) glycine catabolic process(GO:0006546)
1.5 1.5 GO:0045947 regulation of translational initiation(GO:0006446) negative regulation of translational initiation(GO:0045947)
1.5 4.5 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.5 4.5 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
1.5 4.5 GO:0030497 fatty acid elongation(GO:0030497)
1.5 4.5 GO:0006276 plasmid maintenance(GO:0006276)
1.5 1.5 GO:0019563 glycerol catabolic process(GO:0019563)
1.4 4.2 GO:0045900 negative regulation of translational elongation(GO:0045900)
1.4 1.4 GO:0097304 lipoprotein biosynthetic process via signal peptide cleavage(GO:0097304)
1.3 1.3 GO:0072321 chaperone-mediated protein transport(GO:0072321)
1.3 7.9 GO:0006739 NADP metabolic process(GO:0006739)
1.3 6.5 GO:0006364 rRNA processing(GO:0006364)
1.3 6.5 GO:0046364 monosaccharide biosynthetic process(GO:0046364)
1.3 18.2 GO:0006633 fatty acid biosynthetic process(GO:0006633)
1.3 3.8 GO:0005993 trehalose catabolic process(GO:0005993)
1.3 6.3 GO:0042273 ribosomal large subunit assembly(GO:0000027) ribosomal large subunit biogenesis(GO:0042273)
1.3 5.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
1.2 6.2 GO:0007059 chromosome segregation(GO:0007059)
1.2 11.1 GO:0006260 DNA replication(GO:0006260)
1.2 3.7 GO:0015976 carbon utilization(GO:0015976)
1.2 3.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.2 3.7 GO:0006528 asparagine metabolic process(GO:0006528)
1.2 2.4 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
1.2 4.9 GO:0009265 2'-deoxyribonucleotide biosynthetic process(GO:0009265) deoxyribose phosphate biosynthetic process(GO:0046385)
1.2 2.3 GO:0006108 malate metabolic process(GO:0006108)
1.2 3.5 GO:0015969 guanosine tetraphosphate metabolic process(GO:0015969) purine ribonucleoside bisphosphate metabolic process(GO:0034035)
1.2 1.2 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
1.2 4.6 GO:0015889 cobalamin transport(GO:0015889)
1.1 16.1 GO:0010212 response to ionizing radiation(GO:0010212)
1.0 4.2 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
1.0 3.1 GO:0051258 protein polymerization(GO:0051258)
1.0 3.0 GO:0043171 peptide catabolic process(GO:0043171)
0.9 1.9 GO:0043623 cellular protein complex assembly(GO:0043623)
0.9 2.8 GO:0006113 fermentation(GO:0006113)
0.9 1.9 GO:0046498 S-adenosylmethionine cycle(GO:0033353) S-adenosylhomocysteine metabolic process(GO:0046498) S-adenosylmethionine metabolic process(GO:0046500)
0.9 2.7 GO:0048583 regulation of response to stimulus(GO:0048583)
0.9 0.9 GO:0032508 DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.9 2.7 GO:0006063 uronic acid metabolic process(GO:0006063)
0.9 8.5 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.8 1.7 GO:0006289 nucleotide-excision repair(GO:0006289)
0.8 4.1 GO:0010876 lipid transport(GO:0006869) lipid localization(GO:0010876)
0.8 1.6 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.8 6.5 GO:0022900 electron transport chain(GO:0022900)
0.8 2.4 GO:0015755 fructose transport(GO:0015755)
0.8 2.3 GO:0030091 protein repair(GO:0030091)
0.8 4.5 GO:0030162 regulation of proteolysis(GO:0030162)
0.7 1.5 GO:0009250 glucan biosynthetic process(GO:0009250)
0.7 2.0 GO:0015765 methylgalactoside transport(GO:0015765)
0.6 5.6 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.6 1.8 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264)
0.5 2.2 GO:0009438 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process(GO:0051596)
0.5 1.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.5 1.5 GO:0015811 L-cystine transport(GO:0015811) cysteine transmembrane transport(GO:1903712)
0.5 1.0 GO:0015942 formate metabolic process(GO:0015942)
0.5 1.4 GO:0019577 aldaric acid metabolic process(GO:0019577) aldaric acid catabolic process(GO:0019579)
0.5 2.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.5 2.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.4 1.7 GO:1900190 regulation of multi-organism process(GO:0043900) regulation of single-species biofilm formation(GO:1900190)
0.4 1.7 GO:0006040 amino sugar metabolic process(GO:0006040) amino sugar catabolic process(GO:0046348)
0.4 0.4 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.4 0.4 GO:0008360 cell morphogenesis(GO:0000902) regulation of cell shape(GO:0008360) anatomical structure morphogenesis(GO:0009653) regulation of anatomical structure morphogenesis(GO:0022603) regulation of cell morphogenesis(GO:0022604) cellular component morphogenesis(GO:0032989) single-organism developmental process(GO:0044767) anatomical structure development(GO:0048856) cellular developmental process(GO:0048869) regulation of developmental process(GO:0050793)
0.4 1.2 GO:0016485 protein processing(GO:0016485)
0.4 1.6 GO:1903401 L-lysine transmembrane transport(GO:1903401)
0.4 2.7 GO:0072330 monocarboxylic acid biosynthetic process(GO:0072330)
0.4 1.1 GO:0050918 positive chemotaxis(GO:0050918)
0.4 1.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521) regulation of cellular amine metabolic process(GO:0033238) regulation of tryptophan metabolic process(GO:0090357)
0.3 1.0 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.3 0.6 GO:0009758 carbohydrate utilization(GO:0009758)
0.3 1.9 GO:0044272 sulfur compound biosynthetic process(GO:0044272)
0.3 8.0 GO:0009408 response to heat(GO:0009408)
0.3 1.2 GO:0060700 regulation of nuclease activity(GO:0032069) regulation of endoribonuclease activity(GO:0060699) regulation of ribonuclease activity(GO:0060700)
0.3 0.9 GO:0019568 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.3 0.3 GO:0010563 negative regulation of phosphorus metabolic process(GO:0010563) negative regulation of phosphate metabolic process(GO:0045936)
0.3 0.3 GO:0006089 lactate metabolic process(GO:0006089)
0.3 0.6 GO:0046174 polyol catabolic process(GO:0046174)
0.3 0.5 GO:0072490 trinitrotoluene metabolic process(GO:0018973) 2,4,6-trinitrotoluene metabolic process(GO:0018974) nitrotoluene metabolic process(GO:0019326) 2,4,6-trinitrotoluene catabolic process(GO:0046256) trinitrotoluene catabolic process(GO:0046260) nitrotoluene catabolic process(GO:0046263) toluene-containing compound metabolic process(GO:0072490) toluene-containing compound catabolic process(GO:0072491)
0.2 2.2 GO:0009266 response to temperature stimulus(GO:0009266)
0.2 0.7 GO:0042873 aldonate transport(GO:0042873)
0.2 0.5 GO:0006109 regulation of carbohydrate metabolic process(GO:0006109)
0.2 0.7 GO:0006571 tyrosine metabolic process(GO:0006570) tyrosine biosynthetic process(GO:0006571)
0.2 0.2 GO:0044257 cellular protein catabolic process(GO:0044257) proteolysis involved in cellular protein catabolic process(GO:0051603)
0.2 0.3 GO:0006824 cobalt ion transport(GO:0006824)
0.2 0.5 GO:0006284 base-excision repair(GO:0006284)
0.2 0.5 GO:0015707 nitrite transport(GO:0015707)
0.1 0.3 GO:0046417 chorismate metabolic process(GO:0046417)
0.1 0.6 GO:0051453 regulation of pH(GO:0006885) cellular monovalent inorganic cation homeostasis(GO:0030004) regulation of cellular pH(GO:0030641) regulation of intracellular pH(GO:0051453) monovalent inorganic cation homeostasis(GO:0055067)
0.1 0.2 GO:0006220 pyrimidine nucleotide metabolic process(GO:0006220)
0.1 0.1 GO:0015757 galactose transport(GO:0015757)
0.1 0.1 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.1 0.6 GO:1901698 response to nitrogen compound(GO:1901698)
0.1 0.4 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.1 GO:0010124 phenylacetate catabolic process(GO:0010124)
0.0 0.1 GO:0006596 polyamine biosynthetic process(GO:0006596)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.4 GO:0005856 cytoskeleton(GO:0005856)
2.9 8.8 GO:0045273 respiratory chain complex II(GO:0045273) plasma membrane respiratory chain complex II(GO:0045274)
2.9 46.7 GO:0015935 small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)
2.3 11.4 GO:0009380 excinuclease repair complex(GO:0009380)
1.8 9.0 GO:0046930 pore complex(GO:0046930)
1.8 5.4 GO:1990391 DNA repair complex(GO:1990391)
1.8 14.2 GO:0005618 cell wall(GO:0005618)
1.8 16.0 GO:0044391 ribosome(GO:0005840) cytosolic ribosome(GO:0022626) intracellular ribonucleoprotein complex(GO:0030529) ribosomal subunit(GO:0044391) ribonucleoprotein complex(GO:1990904)
1.8 5.3 GO:0009295 nucleoid(GO:0009295)
1.7 5.0 GO:0098562 cytoplasmic side of plasma membrane(GO:0009898) cytoplasmic side of membrane(GO:0098562)
1.6 3.2 GO:0098803 respiratory chain(GO:0070469) plasma membrane respiratory chain(GO:0070470) respiratory chain complex(GO:0098803)
1.5 3.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.3 8.0 GO:0048476 Holliday junction resolvase complex(GO:0048476)
1.3 3.9 GO:0031225 anchored component of membrane(GO:0031225)
1.1 1.1 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
1.0 4.1 GO:0005694 chromosome(GO:0005694) chromosomal part(GO:0044427)
1.0 10.1 GO:0032153 cell division site(GO:0032153)
0.9 8.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8 353.0 GO:0005829 cytosol(GO:0005829)
0.6 1.1 GO:0070069 cytochrome complex(GO:0070069)
0.2 1.7 GO:0071575 integral component of external side of plasma membrane(GO:0071575)
0.0 0.2 GO:0019898 extrinsic component of membrane(GO:0019898)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 24.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
4.8 19.2 GO:0001072 RNA binding transcription factor activity(GO:0001070) transcription antitermination factor activity, RNA binding(GO:0001072)
4.1 8.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
3.5 17.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
3.3 35.8 GO:0003735 structural constituent of ribosome(GO:0003735)
3.2 12.9 GO:0032843 hydroperoxide reductase activity(GO:0032843)
3.1 9.3 GO:0017089 glycolipid transporter activity(GO:0017089)
3.1 15.3 GO:0016987 transcription factor activity, core RNA polymerase binding(GO:0000990) core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) sigma factor activity(GO:0016987)
3.1 9.2 GO:0004532 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
2.9 8.8 GO:0000104 succinate dehydrogenase activity(GO:0000104)
2.9 20.2 GO:0003697 single-stranded DNA binding(GO:0003697)
2.9 8.6 GO:0051192 prosthetic group binding(GO:0051192)
2.7 11.0 GO:0008861 formate C-acetyltransferase activity(GO:0008861)
2.5 42.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
2.5 7.4 GO:0004177 aminopeptidase activity(GO:0004177)
2.4 7.3 GO:0015616 DNA translocase activity(GO:0015616)
2.3 2.3 GO:0004750 ribulose-phosphate 3-epimerase activity(GO:0004750)
2.3 2.3 GO:0005198 structural molecule activity(GO:0005198)
2.1 4.3 GO:0003743 translation initiation factor activity(GO:0003743)
2.1 6.3 GO:0009011 starch synthase activity(GO:0009011)
2.1 6.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
2.0 2.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
1.9 7.7 GO:0004312 fatty acid synthase activity(GO:0004312)
1.9 9.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
1.8 8.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
1.7 1.7 GO:0052381 tRNA dimethylallyltransferase activity(GO:0052381)
1.7 5.1 GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759)
1.7 3.4 GO:0003746 translation elongation factor activity(GO:0003746)
1.6 3.3 GO:0019201 nucleotide kinase activity(GO:0019201)
1.6 1.6 GO:0051920 peroxiredoxin activity(GO:0051920)
1.6 6.4 GO:0005469 succinate:fumarate antiporter activity(GO:0005469)
1.6 3.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
1.5 6.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
1.5 6.0 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
1.5 3.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
1.5 1.5 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
1.5 7.4 GO:0080146 L-cysteine desulfhydrase activity(GO:0080146)
1.4 10.1 GO:0051287 NAD binding(GO:0051287)
1.4 7.0 GO:0070569 uridylyltransferase activity(GO:0070569)
1.4 1.4 GO:0042380 hydroxymethylbutenyl pyrophosphate reductase activity(GO:0042380)
1.3 1.3 GO:0019146 arabinose-5-phosphate isomerase activity(GO:0019146)
1.3 5.2 GO:0008940 nitrate reductase activity(GO:0008940)
1.3 2.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
1.3 7.7 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
1.3 6.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337) nucleobase-containing compound transmembrane transporter activity(GO:0015932)
1.3 3.8 GO:0015927 trehalase activity(GO:0015927)
1.3 3.8 GO:0003727 single-stranded RNA binding(GO:0003727)
1.3 3.8 GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity(GO:0003849)
1.2 5.0 GO:0016211 ammonia ligase activity(GO:0016211)
1.2 8.7 GO:0016778 diphosphotransferase activity(GO:0016778)
1.2 4.8 GO:0004333 fumarate hydratase activity(GO:0004333)
1.1 1.1 GO:0019171 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451)
1.1 1.1 GO:0070403 NAD+ binding(GO:0070403)
1.1 6.4 GO:0000156 phosphorelay response regulator activity(GO:0000156)
1.1 2.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
1.0 3.1 GO:0016842 amidine-lyase activity(GO:0016842)
1.0 7.1 GO:0019843 rRNA binding(GO:0019843)
1.0 3.0 GO:0001108 basal transcription machinery binding(GO:0001098) bacterial-type RNA polymerase holo enzyme binding(GO:0001108)
1.0 2.0 GO:0015643 toxic substance binding(GO:0015643)
1.0 3.0 GO:0008235 metalloexopeptidase activity(GO:0008235)
1.0 2.9 GO:0009927 histidine phosphotransfer kinase activity(GO:0009927)
0.9 6.5 GO:0008565 protein transporter activity(GO:0008565)
0.9 5.6 GO:0019239 deaminase activity(GO:0019239)
0.9 3.7 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.9 6.5 GO:0019899 enzyme binding(GO:0019899)
0.9 8.8 GO:0051082 unfolded protein binding(GO:0051082)
0.9 2.6 GO:0034567 chromate reductase activity(GO:0034567)
0.9 3.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.8 2.5 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8 2.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.8 2.4 GO:0016417 S-acyltransferase activity(GO:0016417)
0.8 2.4 GO:0036361 racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.8 0.8 GO:0008477 purine nucleosidase activity(GO:0008477)
0.8 2.4 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.8 3.0 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.8 4.5 GO:0030955 potassium ion binding(GO:0030955)
0.7 1.4 GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor(GO:0016682)
0.7 1.4 GO:0016882 cyclo-ligase activity(GO:0016882)
0.7 8.3 GO:0043022 ribosome binding(GO:0043022)
0.7 1.3 GO:0016662 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.6 2.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821) endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.6 2.5 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.6 2.4 GO:0001217 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001141) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.6 1.7 GO:0031992 energy transducer activity(GO:0031992)
0.6 1.7 GO:0045152 antisigma factor binding(GO:0045152)
0.6 0.6 GO:0097216 guanosine tetraphosphate binding(GO:0097216)
0.6 2.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 1.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.6 0.6 GO:0015491 cation:cation antiporter activity(GO:0015491)
0.5 1.1 GO:0005543 phospholipid binding(GO:0005543)
0.5 1.5 GO:0008047 enzyme activator activity(GO:0008047)
0.5 2.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 1.0 GO:0016289 CoA hydrolase activity(GO:0016289) thiolester hydrolase activity(GO:0016790)
0.4 1.3 GO:0030151 molybdenum ion binding(GO:0030151)
0.4 0.4 GO:0008658 penicillin binding(GO:0008658)
0.4 0.4 GO:0016208 AMP binding(GO:0016208)
0.4 1.9 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.4 2.2 GO:0008198 ferrous iron binding(GO:0008198)
0.4 3.3 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.4 1.8 GO:0005525 GTP binding(GO:0005525)
0.3 0.7 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.3 1.7 GO:0016410 N-acyltransferase activity(GO:0016410)
0.3 0.7 GO:0050897 cobalt ion binding(GO:0050897)
0.3 1.0 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.3 0.7 GO:0004096 catalase activity(GO:0004096)
0.3 4.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 0.9 GO:0016803 hydrolase activity, acting on ether bonds(GO:0016801) ether hydrolase activity(GO:0016803)
0.3 1.5 GO:1902670 carbon dioxide binding(GO:1902670)
0.3 30.6 GO:0042802 identical protein binding(GO:0042802)
0.3 1.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 1.0 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.2 0.7 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.2 1.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.8 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.3 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.3 GO:0015099 nickel cation transmembrane transporter activity(GO:0015099)
0.1 0.4 GO:0015128 gluconate transmembrane transporter activity(GO:0015128) aldonate transmembrane transporter activity(GO:0042879)
0.1 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.1 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0048029 monosaccharide binding(GO:0048029)
0.0 0.0 GO:0005275 amine transmembrane transporter activity(GO:0005275)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.5 1.4 PID CMYB PATHWAY C-MYB transcription factor network
0.4 1.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
2.5 10.1 REACTOME METABOLISM OF NUCLEOTIDES Genes involved in Metabolism of nucleotides
2.0 6.0 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
1.1 3.3 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
0.6 5.8 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.4 0.4 REACTOME METABOLISM OF PROTEINS Genes involved in Metabolism of proteins