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GSE67402: E.coli regulatory changes under long-term starvation

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Results for CytR

Z-value: 0.82

Transcription factors associated with CytR

Gene Symbol Gene ID Gene Info
cytR
cytR CytR DNA-binding transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cytR0.552.8e-03Click!

Activity profile of CytR motif

Sorted Z-values of CytR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
udp 5.81
udp
uridine phosphorylase
nupC 4.15
nupC
nucleoside:H+ symporter NupC
cdd 3.52
cdd
cytidine deaminase
rpoH 3.29
rpoH
RNA polymerase, sigma 32 (sigma H) factor
ycdZ 3.25
ycdZ
predicted inner membrane protein
tsx 2.08
tsx
nucleoside channel; receptor of phage T6 and colicin K
deoCABD 1.63
deoA
deoB
deoC
deoD
thymidine phosphorylase / uracil phosphorylase
phosphopentomutase
deoxyribose-phosphate aldolase
purine nucleoside phosphorylase
ppiA 1.40
ppiA
peptidyl-prolyl cis-trans isomerase A (rotamase A)
cytR 1.36
cytR
CytR DNA-binding transcriptional repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of CytR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0046049 nucleoside monophosphate catabolic process(GO:0009125) pyrimidine nucleoside monophosphate catabolic process(GO:0009131) ribonucleoside monophosphate catabolic process(GO:0009158) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate catabolic process(GO:0009175) protein hexamerization(GO:0034214) UMP metabolic process(GO:0046049) UMP catabolic process(GO:0046050)
1.2 3.5 GO:0046131 pyrimidine ribonucleoside metabolic process(GO:0046131) pyrimidine ribonucleoside catabolic process(GO:0046133) pyrimidine nucleoside catabolic process(GO:0046135)
1.0 4.0 GO:0015858 nucleoside transport(GO:0015858)
0.8 3.3 GO:0001121 transcription from bacterial-type RNA polymerase promoter(GO:0001121)
0.8 1.6 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264)
0.1 1.4 GO:0006457 protein folding(GO:0006457)
0.0 1.4 GO:0045892 negative regulation of transcription, DNA-templated(GO:0045892) negative regulation of RNA biosynthetic process(GO:1902679) negative regulation of nucleic acid-templated transcription(GO:1903507)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0046930 pore complex(GO:0046930)
0.0 1.4 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)
0.0 15.6 GO:0005829 cytosol(GO:0005829)
0.0 5.2 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 1.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.8 4.0 GO:0015932 nucleoside transmembrane transporter activity(GO:0005337) nucleobase-containing compound transmembrane transporter activity(GO:0015932)
0.7 5.8 GO:0030955 potassium ion binding(GO:0030955)
0.7 3.3 GO:0000996 transcription factor activity, core RNA polymerase binding(GO:0000990) core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) sigma factor activity(GO:0016987)
0.5 3.5 GO:0019239 deaminase activity(GO:0019239)
0.2 1.4 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 1.4 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation