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GSE67402: E.coli regulatory changes under long-term starvation

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Results for HU

Z-value: 0.48

Transcription factors associated with HU

Gene Symbol Gene ID Gene Info
hupA
hupA DNA-binding protein HU-alpha
hupB
hupB DNA-binding protein HU-beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hupB0.442.3e-02Click!
hupA0.348.2e-02Click!

Activity profile of HU motif

Sorted Z-values of HU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
galETKM 8.05
galT
galE
galM
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactose-1-epimerase
galactokinase
seqA-pgm 5.61
seqA
pgm
SeqA, negative modulator of initiation of replication
phosphoglucomutase
galETK 3.36
galT
galE
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactokinase
galET 2.27
galT
galE
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galE 1.58
galE
UDP-glucose 4-epimerase

Network of associatons between targets according to the STRING database.

First level regulatory network of HU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 20.9 GO:0019388 galactose metabolic process(GO:0006012) galactose catabolic process(GO:0019388)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 15.3 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0004335 galactokinase activity(GO:0004335) UDP-glucose:hexose-1-phosphate uridylyltransferase activity(GO:0008108)
1.6 1.6 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
1.1 5.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 15.3 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates