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GSE67402: E.coli regulatory changes under long-term starvation

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Results for IscR

Z-value: 0.52

Transcription factors associated with IscR

Gene Symbol Gene ID Gene Info
iscR
iscR IscR DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
iscR0.481.0e-02Click!

Activity profile of IscR motif

Sorted Z-values of IscR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
iscRSUA 4.09
iscU
iscA
iscS
iscR
scaffold protein for iron-sulfur cluster assembly
iron-sulfur cluster assembly protein
cysteine desulfurase
IscR DNA-binding transcriptional dual regulator
erpA 3.94
erpA
essential respiratory protein A
nrdHIEF 2.43
nrdH
nrdI
nrdE
nrdF
glutaredoxin-like protein
flavodoxin involved in dimanganese-tyrosyl radical cofactor maintenance for ribonucleotide reductase
ribonucleoside-diphosphate reductase 2, α subunit
ribonucleoside-diphosphate reductase 2, β subunit
hyaABCDEF 1.90
hyaB
hyaC
hyaA
hyaF
hyaD
hyaE
hydrogenase 1, large subunit
hydrogenase 1, b-type cytochrome subunit
hydrogenase 1, small subunit
protein involved in nickel incorporation into hydrogenase 1 proteins
protein involved in processing of HyaA and HyaB proteins
protein involved in quality control of HyaA
sufABCDSE 0.78
sufB
sufC
sufA
sufD
sufE
sufS
SufB component of SufBCD Fe-S cluster scaffold complex
SufC component of SufBCD Fe-S cluster scaffold complex
Fe-S transport protein in Fe-S cluster assembly
SufD component of SufBCD Fe-S cluster scaffold complex
sulfur acceptor for SufS cysteine desulfurase
L-cysteine desulfurase
nfuA 0.40
nfuA
iron-sulfur cluster scaffold protein

Network of associatons between targets according to the STRING database.

First level regulatory network of IscR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 9.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.4 2.4 GO:0045454 deoxyribonucleotide biosynthetic process(GO:0009263) cell redox homeostasis(GO:0045454)
0.4 1.9 GO:0016485 protein processing(GO:0016485)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0031237 intrinsic component of periplasmic side of plasma membrane(GO:0031237)
0.1 2.4 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 9.2 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0016530 metallochaperone activity(GO:0016530)
0.8 2.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 1.9 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.3 4.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)