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GSE67402: E.coli regulatory changes under long-term starvation

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Results for LexA

Z-value: 2.06

Transcription factors associated with LexA

Gene Symbol Gene ID Gene Info
lexA
lexA LexA DNA-binding transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lexA-0.481.1e-02Click!

Activity profile of LexA motif

Sorted Z-values of LexA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
insK 17.32
insK
IS150 conserved protein InsB
ydjM 14.89
ydjM
predicted inner membrane protein regulated by LexA
recN 14.04
recN
protein used in recombination and DNA repair
umuDC 13.90
umuD
umuC
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC
SOS mutagenesis and repair
dinJ-yafQ 13.16
dinJ
yafQ
DinJ antitoxin of YafQ-DinJ toxin-antitoxin system and DNA-binding transcriptional repressor
toxin of the YafQ-DinJ toxin-antitoxin system
hokE 12.79
hokE
HokE
yebG 10.88
yebG
conserved protein regulated by LexA
cho 10.18
cho
endonuclease of nucleotide excision repair
molR_1 9.20
molR_1
molybdate metabolism regulator (interrupted)
sbmC 8.96
sbmC
DNA gyrase inhibitor
symE 6.86
symE
toxin-like protein of the SOS response
polB 6.82
polB
DNA polymerase II
yafNOP 6.33
yafN
yafO
yafP
antitoxin of the YafO-YafN toxin-antitoxin system
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system
predicted acyltransferase with acyl-CoA N-acyltransferase domain
phr 6.31
phr
deoxyribodipyrimidine photolyase (photoreactivation)
dinQ 5.22
dinQ
toxic inner membrane peptide DinQ
dinB-yafNOP 5.13
yafN
yafO
yafP
dinB
antitoxin of the YafO-YafN toxin-antitoxin system
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system
predicted acyltransferase with acyl-CoA N-acyltransferase domain
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis)
uvrYC 4.62
uvrC
uvrY
excinuclease ABC, subunit C; repair of UV damage to DNA
UvrY transcriptional regulator
uvrC 4.44
uvrC
excinuclease ABC, subunit C; repair of UV damage to DNA
sulA 4.36
sulA
SOS cell division inhibitor
tisB 4.34
tisB
toxic peptide TisB
uvrB 4.24
uvrB
DNA repair; excision nuclease subunit B
dinD 4.22
dinD
DNA-damage-inducible protein
ssb 3.36
ssb
ssDNA-binding protein
ptrA 0.43
ptrA
protease III

Network of associatons between targets according to the STRING database.

First level regulatory network of LexA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 19.0 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731) DNA biosynthetic process(GO:0071897)
3.3 13.2 GO:0043624 translational termination(GO:0006415) cellular protein complex disassembly(GO:0043624) negative regulation of DNA-templated transcription, initiation(GO:2000143)
3.0 9.0 GO:0043462 regulation of ATPase activity(GO:0043462) negative regulation of DNA-dependent DNA replication(GO:2000104)
2.7 19.2 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
2.3 42.0 GO:0009432 SOS response(GO:0009432)
0.3 6.3 GO:0044092 negative regulation of molecular function(GO:0044092)
0.1 4.2 GO:0009314 response to radiation(GO:0009314)
0.1 6.3 GO:0036211 cellular protein modification process(GO:0006464) protein modification process(GO:0036211)
0.0 5.6 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0042575 DNA polymerase complex(GO:0042575)
3.1 15.6 GO:0009380 excinuclease repair complex(GO:0009380)
0.0 20.7 GO:0016020 membrane(GO:0016020)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 25.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
3.0 9.0 GO:0060590 ATPase regulator activity(GO:0060590)
2.2 13.2 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters(GO:0016894)
2.0 10.2 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
1.1 4.3 GO:0005216 ion channel activity(GO:0005216)
0.8 4.6 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.6 6.3 GO:0004521 endoribonuclease activity(GO:0004521)
0.6 3.4 GO:0008047 enzyme activator activity(GO:0008047)
0.1 6.3 GO:0016830 carbon-carbon lyase activity(GO:0016830)