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GSE67402: E.coli regulatory changes under long-term starvation

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Results for NtrC

Z-value: 3.21

Transcription factors associated with NtrC

Gene Symbol Gene ID Gene Info
glnG
glnG NtrC transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glnG0.963.0e-15Click!

Activity profile of NtrC motif

Sorted Z-values of NtrC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
glnA 128.00
glnA
glutamine synthetase
glnALG 116.07
glnL
glnA
glnG
NtrB
glutamine synthetase
NtrC transcriptional dual regulator
glnHPQ 57.06
glnH
glnQ
glnP
L-glutamine ABC transporter - periplasmic binding protein
L-glutamine ABC transporter - ATP binding subunit
L-glutamine ABC transporter - membrane subunit
argT-hisJQMP 42.33
hisM
hisP
argT
hisQ
hisJ
lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit
lysine / arginine / ornithine ABC transporter - periplasmic binding protein
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit
histidine ABC transporter - periplasmic binding protein
glnK-amtB 35.45
glnK
amtB
nitrogen regulatory protein GlnK
ammonia / ammonium transporter
relA 22.17
relA
GDP pyrophosphokinase/GTP pyrophosphokinase
potFGHI 22.12
potI
potH
potG
potF
putrescine ABC transporter - membrane subunit
putrescine ABC transporter - membrane subunit
putrescine ABC transporter - ATP binding subunit
putrescine ABC transporter - periplasmic binding protein
ddpXABCDF 17.78
ddpX
ddpD
ddpF
ddpA
ddpB
ddpC
D-Ala-D-Ala dipeptidase
YddP
YddO
YddS
YddR
YddQ
yhdWXYZ 15.31
yhdZ
yhdY
yhdX
yhdW
putative transport protein, ABC superfamily - periplasmic binding protein
putative transport protein, ABC superfamily - membrane component
putative transport protein, ABC superfamily - ATP-binding component
putative transport protein, ABC superfamily - membrane component
glnLG 11.21
glnG
glnL
NtrC transcriptional dual regulator
NtrB
rutABCDEFG 9.43
rutC
rutB
rutA
rutG
rutF
rutE
rutD
predicted aminoacrylate peracid reductase
peroxyureidoacrylate / ureidoacrylate amido hydrolase
pyrimidine oxygenase
uracil:H+ symporter RutG
flavin reductase
predicted malonic semialdehyde reductase
predicted aminoacrylate hydrolase

Network of associatons between targets according to the STRING database.

First level regulatory network of NtrC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
81.4 244.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
11.8 35.5 GO:0006808 regulation of nitrogen utilization(GO:0006808)
10.6 42.3 GO:0097638 L-arginine import(GO:0043091) L-amino acid import(GO:0043092) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine import into cell(GO:1902765) L-arginine transmembrane transport(GO:1903400) L-lysine transmembrane transport(GO:1903401) arginine transmembrane transport(GO:1903826)
9.4 9.4 GO:0019740 nitrogen utilization(GO:0019740)
7.4 22.2 GO:0034035 guanosine tetraphosphate metabolic process(GO:0015969) purine ribonucleoside bisphosphate metabolic process(GO:0034035)
7.4 22.1 GO:0015846 organic cation transport(GO:0015695) polyamine transport(GO:0015846) putrescine transport(GO:0015847)
5.2 57.1 GO:0015804 neutral amino acid transport(GO:0015804)
1.8 17.8 GO:0006024 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024) peptidoglycan biosynthetic process(GO:0009252)
0.4 11.2 GO:0000160 phosphorelay signal transduction system(GO:0000160) protein autophosphorylation(GO:0046777)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 22.2 GO:0005618 cell wall(GO:0005618)
2.8 121.5 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.7 322.0 GO:0016020 membrane(GO:0016020)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
61.0 244.1 GO:0016211 ammonia ligase activity(GO:0016211)
10.6 42.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
7.4 22.2 GO:0008728 GTP diphosphokinase activity(GO:0008728) guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
6.3 57.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
5.9 35.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
4.4 17.8 GO:0008235 metalloexopeptidase activity(GO:0008235)
3.1 9.4 GO:0004497 monooxygenase activity(GO:0004497) pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.9 11.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.3 22.1 GO:0005524 ATP binding(GO:0005524)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.2 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology