nhaAR | 6.495 | 0.650 | 0.982 | nhaR (NhaR transcriptional activator), nhaA (Na+:H+ antiporter NhaA) |
yggE | 8.205 | 1.460 | 0.973 | yggE (conserved protein) |
otsA | 6.063 | 0.572 | 0.968 | otsA (trehalose-6-phosphate synthase) |
ptsHI-crr | 11.760 | 1.561 | 0.962 | crr (Enzyme IIAGlc; Crr), ptsH (HPr), ptsI (PTS enzyme I) |
ilvIH | 6.007 | 1.574 | 0.962 | ilvH (acetolactate synthase / acetohydroxybutanoate synthase, regulatory subunit), ilvI (acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit) |
purR | 3.075 | 1.100 | 0.958 | purR (PurR transcriptional repressor) |
hisJQMP | 5.873 | 1.354 | 0.943 | hisP (lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit), hisM (lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit), hisQ (lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit), hisJ (histidine ABC transporter - periplasmic binding protein) |
poxB | 7.362 | 2.084 | 0.937 | poxB (pyruvate oxidase) |
argE | 5.616 | 1.195 | 0.932 | argE (acetylornithine deacetylase) |
talA-tktB | 6.918 | 1.681 | 0.927 | tktB (transketolase II), talA (transaldolase A) |
alkA | 4.323 | 0.725 | 0.922 | alkA (3-methyl-adenine DNA glycosylase II, inducible) |
livKHMGF | 5.754 | 0.811 | 0.913 | livK (L-leucine / L-phenylalanine ABC transporter - periplasmic binding protein), livM (branched chain amino acid / phenylalanine ABC transporter - membrane subunit), livF (branched chain amino acid / phenylalanine ABC transporter - ATP binding subunit), livH (branched chain amino acid / phenylalanine ABC transporter - membrane subunit), livG (branched chain amino acid / phenylalanine ABC transporter - ATP binding subunit) |
narU | 4.218 | 0.560 | 0.904 | narU (nitrate / nitrite transporter NarU) |
gltBDF | 2.530 | 3.081 | 0.893 | gltF (periplasmic protein), gltD (glutamate synthase, small subunit), gltB (glutamate synthase, large subunit) |
nrdAB-yfaE | 4.569 | 0.743 | 0.892 | yfaE (2Fe-2S cluster-containing protein involved in diferric-tyrosyl radical cofactor maintenance), nrdB (ribonucleoside diphosphate reductase 1, β subunit, ferritin-like), nrdA (ribonucleoside diphosphate reductase 1, α subunit) |
serA | 6.431 | 2.242 | 0.886 | |
gcvTHP | 5.843 | 2.032 | 0.882 | gcvH (glycine cleavage system H protein), gcvP (glycine decarboxylase), gcvT (aminomethyltransferase) |
zwf | 5.197 | 0.782 | 0.879 | zwf (glucose-6-phosphate dehydrogenase (NADP+)) |
pqiAB | 6.320 | 1.083 | 0.865 | pqiA (paraquat-inducible protein A), pqiB (paraquat-inducible protein B) |
gadAX | 4.622 | 1.321 | 0.857 | gadX (GadX DNA-binding transcriptional dual regulator), gadA (glutamate decarboxylase A subunit) |
carAB | 2.392 | 2.705 | 0.845 | carA (carbamoyl phosphate synthetase, α chain), carB (carbamoyl phosphate synthetase, β chain) |
ydbK-ompN | 7.147 | 1.914 | 0.843 | ydbK (pyruvate:flavodoxin oxidoreductase), ompN (outer membrane pore protein N, non-specific) |
metR | 1.417 | 1.579 | 0.841 | metR (MetR DNA-binding transcriptional dual regulator) |
araFGH | 7.579 | 0.875 | 0.837 | araF (arabinose ABC transporter - periplasmic binding protein), araG (arabinose ABC transporter - ATP binding subunit), araH (arabinose ABC transporter - membrane subunit) |
fdhF | 2.694 | 0.618 | 0.829 | fdhF (formate dehydrogenase H) |
tehAB | 5.367 | 0.255 | 0.829 | tehB (tellurite methyltransferase), tehA (tellurite resistance protein / ethidium exporter) |
evgAS | 2.777 | 0.602 | 0.828 | evgS (EvgS sensory histidine kinase), evgA (EvgA transcriptional activator) |
rssAB | 7.813 | 0.986 | 0.825 | rssB (regulator of RpoS), rssA (conserved protein) |
gadE-mdtEF | 3.797 | 1.241 | 0.813 | mdtF (MdtEF-TolC multidrug efflux pump - permease subunit), gadE (GadE DNA-binding transcriptional activator), mdtE (MdtEF-TolC multidrug efflux pump - membrane fusion protein) |
dapD | 4.755 | 0.407 | 0.811 | dapD (tetrahydrodipicolinate succinylase) |
asnC-mioC | 3.921 | 0.427 | 0.811 | mioC (flavoprotein involved in biotin synthesis), asnC (AsnC DNA-binding transcriptional dual regulator) |
acnA | 7.401 | 2.614 | 0.810 | acnA (aconitate hydratase 1) |
fepA-entD | 3.271 | 0.380 | 0.809 | fepA (ferric enterobactin / colicin B / colicin D outer membrane porin FepA), entD (phosphopantetheinyl transferase/phosphopantetheinyl transferase) |
codBA | 3.576 | 1.547 | 0.806 | codA (cytosine deaminase), codB (cytosine transporter) |
mazEFG | 6.220 | 1.595 | 0.806 | mazE (MazE antitoxin of the MazF-MazE toxin-antitoxin system), mazF (MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity), mazG (nucleoside triphosphate pyrophosphohydrolase) |
glk | 5.650 | 0.376 | 0.804 | glk (glucosamine kinase/glucokinase) |
dhaKLM | 4.551 | 0.870 | 0.804 | dhaL (dihydroxyacetone kinase subunit L), dhaM (dihydroxyacetone kinase subunit M and protein-acetyllysine deacetylase), dhaK (dihydroxyacetone kinase subunit K) |
fbaB | 5.695 | 1.685 | 0.803 | fbaB (fructose bisphosphate aldolase class I) |
yahE | -0.528 | 0.318 | 0.800 | yahE (predicted protein) |
gnd | 4.197 | 0.552 | 0.800 | gnd (6-phosphogluconate dehydrogenase, decarboxylating) |
fpr | 6.359 | 1.249 | 0.799 | fpr (flavodoxin-NADP+ reductase/ferredoxin-NADP+ reductase) |
pdeR | 6.145 | 1.456 | 0.798 | pdeR (cyclic di-GMP phosphodiesterase) |
guaBA | 3.414 | 1.529 | 0.796 | guaB (IMP dehydrogenase), guaA (GMP synthetase) |
fabI | 6.472 | 0.363 | 0.794 | fabI (enoyl-[acyl-carrier-protein] reductase subunit) |
hflD-purB | 5.191 | 1.294 | 0.782 | hflD (lysogenization regulator), purB (adenylosuccinate lyase) |
pfkB | 8.375 | 2.303 | 0.780 | pfkB (6-phosphofructokinase II) |
speB | 4.066 | 1.012 | 0.776 | speB (agmatinase) |
osmF-yehYXW | 5.654 | 0.687 | 0.775 | osmF (glycine betaine ABC transporter - periplasmic binding protein), yehW (glycine betaine ABC transporter - putative membrane subunit), yehY (glycine betaine ABC transporter - putative membrane subunit), yehX (glycine betaine ABC transporter - putative ATP binding subunit) |
serC | 5.108 | 1.300 | 0.762 | |
purMN | 4.613 | 1.228 | 0.760 | purM (phosphoribosylformylglycinamide cyclo-ligase), purN (phosphoribosylglycinamide formyltransferase 1) |
glgS | 9.795 | 2.348 | 0.760 | glgS (surface composition regulator) |
gcl-hyi-glxR-ybbW-allB-ybbY-glxK | 4.957 | 0.906 | 0.757 | glxK (glycerate kinase II), ybbY (putative transport protein, nucleobase:cation symporter-2 (NCS2) family), glxR (tartronate semialdehyde reductase 2), hyi (hydroxypyruvate isomerase), gcl (glyoxylate carboligase), allB (allantoinase), ybbW (putative transporter, nucleobase:cation symporter-1 (NCS1) family) |
dhaR | 3.222 | 0.469 | 0.755 | dhaR (DhaR DNA-binding transcriptional dual regulator) |
pgi | 7.007 | 1.082 | 0.754 | pgi (phosphoglucose isomerase) |
ada-alkB | 5.831 | 1.646 | 0.751 | ada (Ada DNA-binding transcriptional dual regulator / DNA repair protein), alkB (AlkB repair system for alkylated DNA and RNA) |
nac | 3.107 | 0.649 | 0.751 | nac (Nac DNA-binding transcriptional dual regulator) |
hcaEFCBD | 3.801 | 0.189 | 0.747 | hcaC (3-phenylpropionate dioxygenase, predicted ferredoxin subunit), hcaF (3-phenylpropionate dioxygenase, β subunit), hcaE (3-phenylpropionate dioxygenase, α subunit), hcaB (2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase), hcaD (3-phenylpropionate dioxygenase, predicted ferredoxin reductase subunit) |
gadXW | 4.312 | 1.103 | 0.746 | gadX (GadX DNA-binding transcriptional dual regulator), gadW (GadW DNA-binding transcriptional dual regulator) |
malT | 5.962 | 1.105 | 0.745 | malT (MalT transcriptional activator) |
lpd | 5.627 | 1.045 | 0.742 | lpd (lipoamide dehydrogenase) |
cadBA | 1.011 | 0.329 | 0.740 | cadB (lysine:cadaverine antiporter), cadA (lysine decarboxylase 1) |
yhiM | 3.876 | 1.408 | 0.738 | yhiM (inner membrane protein with a role in acid resistance) |
gadW | 2.722 | 1.261 | 0.738 | gadW (GadW DNA-binding transcriptional dual regulator) |
gntT | 2.403 | 0.971 | 0.737 | gntT (gluconate transporter GntT) |
gapA | 8.500 | 2.103 | 0.736 | gapA (glyceraldehyde 3-phosphate dehydrogenase) |
hdeAB-yhiD | 4.486 | 0.687 | 0.734 | yhiD (inner membrane protein YhiD), hdeB (HdeB monomer), hdeA (HdeA monomer, chaperone active form) |
gadE | 3.256 | 1.699 | 0.734 | gadE (GadE DNA-binding transcriptional activator) |
yeaR-yoaG | 2.954 | 0.347 | 0.733 | yoaG (predicted protein), yeaR (conserved protein) |
purHD | 3.762 | 1.021 | 0.731 | purD (phosphoribosylamine-glycine ligase), purH (AICAR transformylase/IMP cyclohydrolase) |
yaaU | 1.261 | 0.384 | 0.731 | yaaU (putative transport protein YaaU, major facilitator superfamily (MFS)) |
zraSR | 2.271 | 1.197 | 0.730 | zraR (ZraR transcriptional activator), zraS (ZraS sensory histidine kinase) |
hycABCDEFGHI | 5.867 | 1.295 | 0.726 | hycF (formate hydrogenlyase complex iron-sulfur protein), hycB (hydrogenase 3, Fe-S subunit), hycA (regulator of the transcriptional regulator FhlA), hycH (protein required for maturation of hydrogenase 3), hycI (hydrogenase 3 maturation protease), hycG (hydrogenase 3 and formate hydrogenlyase complex, HycG subunit), hycE (hydrogenase 3, large subunit), hycD (hydrogenase 3, membrane subunit), hycC (hydrogenase 3, membrane subunit) |
cfa | 8.366 | 2.616 | 0.721 | cfa (cyclopropane fatty acyl phospholipid synthase) |
hydN-hypF | 2.216 | 0.422 | 0.718 | hydN (putative electron transport protein HydN), hypF (hydrogenase maturation protein, carbamoyltransferase) |
fumC | 6.440 | 2.461 | 0.709 | fumC (fumarase C) |
inaA | 5.159 | 0.614 | 0.709 | inaA (pH-inducible protein involved in stress response) |
metA | 3.259 | 0.606 | 0.707 | metA (homoserine O-succinyltransferase) |
pdeC | 5.129 | 1.177 | 0.702 | pdeC (predicted c-di-GMP-specific phosphodiesterase) |
holC-valS | 5.004 | 0.332 | 0.702 | holC (DNA polymerase III, χ subunit), valS (valine-tRNA ligase) |
narXL | 5.741 | 0.855 | 0.699 | narX (NarX), narL (NarL) |
sodB | 7.003 | 0.629 | 0.697 | sodB (superoxide dismutase (Fe)) |
dmsABC | 4.441 | 0.567 | 0.689 | dmsB (dimethyl sulfoxide reductase, chain B), dmsC (dimethyl sulfoxide reductase, chain C), dmsA (dimethyl sulfoxide reductase, chain A) |
adhE | 9.058 | 1.365 | 0.685 | adhE (aldehyde-alcohol dehydrogenase) |
fadL | 8.317 | 1.846 | 0.684 | fadL (long-chain fatty acid outer membrane porin; bacteriophage T2 receptor) |
yhjG | 4.829 | 1.380 | 0.681 | yhjG (predicted outer membrane biogenesis protein) |
treA | 7.006 | 1.369 | 0.673 | treA (periplasmic trehalase) |
serC-aroA | 5.734 | 1.638 | 0.672 | aroA (3-phosphoshikimate-1-carboxyvinyltransferase) |
hyaABCDEF | 6.778 | 0.911 | 0.672 | hyaE (protein involved in quality control of HyaA), hyaC (hydrogenase 1, b-type cytochrome subunit), hyaA (hydrogenase 1, small subunit), hyaB (hydrogenase 1, large subunit), hyaD (protein involved in processing of HyaA and HyaB proteins), hyaF (protein involved in nickel incorporation into hydrogenase 1 proteins) |
yjjQ-bglJ | 2.174 | 0.296 | 0.666 | bglJ (BglJ DNA-binding transcriptional regulator), yjjQ (YjjQ DNA-binding transcriptional repressor) |
fimE | 3.503 | 2.622 | 0.666 | fimE (regulator for fimA) |
gadBC | 5.472 | 3.315 | 0.663 | gadC (glutamic acid:4-aminobutyrate antiporter), gadB (glutamate decarboxylase B subunit) |
hupB | 6.714 | 0.907 | 0.659 | hupB (transcriptional dual regulator HU-β, NS1 (HU-1)) |
flhDC | 6.345 | 2.377 | 0.657 | flhD (FlhD transcriptional dual regulator), flhC (FlhC transcriptional dual regulator) |
hypABCDE | 3.386 | 0.500 | 0.655 | hypA (accessory protein for nickel incorporation into hydrogenase 3), hypD (HypD, scaffold protein for assembly of the Fe-(CN)2CO cofactor), hypE (hydrogenase maturation protein, carbamoyl dehydratase), hypC (HypC, protein involved in hydrogenase 3 maturation), hypB (accessory protein for nickel incorporation into hydrogenase isoenzymes) |
cdd | 5.248 | 0.708 | 0.654 | cdd (cytidine deaminase) |
cvpA-purF-ubiX | 4.290 | 1.750 | 0.652 | cvpA (membrane protein required for colicin V production), purF (amidophosphoribosyl transferase), ubiX (3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein) |
nrfABCDEFG | 2.965 | 0.961 | 0.650 | nrfD (formate dependent nitrite reductase - NrfD subunit), nrfF (activator of formate-dependent nitrite reductase complex), nrfE (formate-dependent nitrite reductase; possible assembly function), nrfB (formate-dependent nitrite reductase - penta-heme cytochrome c), nrfC (formate-dependent nitrite reductase, 4Fe-4S subunit), nrfA (formate dependent nitrite reductase - NrfA subunit), nrfG (NrfG) |
livJ | 6.317 | 1.485 | 0.649 | livJ (branched chain amino acid / phenylalanine ABC transporter - periplasmic binding protein) |
dcuB-fumB | 3.748 | 0.564 | 0.646 | dcuB (dicarboxylate transporter DcuB), fumB (fumarase B) |
yciGFE | 6.020 | 2.233 | 0.636 | yciE (conserved protein), yciF (conserved protein), yciG (predicted protein) |