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GSE80451: E.coli grown aerobically and anaerobically

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Results for CpxR

Z-value: 1.09

Transcription factors associated with CpxR

Gene Symbol Gene ID Gene Info
cpxR
cpxR CpxR transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cpxR0.922.6e-02Click!

Activity profile of CpxR motif

Sorted Z-values of CpxR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
yqaE 4.69
yqaE
predicted membrane protein
yqaE-kbp 3.63
kbp
yqaE
K+ binding protein
predicted membrane protein
cpxPQ 2.79
cpxQ
cpxP
CpxQ small regulatory RNA
CpxP
ldtD 2.75
ldtD
L,D-transpeptidase LdtD
tomB-hha 1.98
tomB
hha
protein that modulates Hha toxicity
haemolysin expression modulating protein
spy 1.87
spy
ATP-independent periplasmic chaperone
ompC 1.70
ompC
outer membrane protein C
rpoE-rseABC 1.49
rpoE
rseB
rseC
rseA
RNA polymerase, sigma 24 (sigma E) factor
rseB
protein RseC
anti-sigma factor
yebE 1.37
yebE
conserved inner membrane protein
dgcZ 1.22
dgcZ
diguanylate cyclase
degP 0.90
degP
serine protease Do
bamE 0.64
bamE
Outer Membrane Protein Assembly Complex - BamE subunit
sbmA-yaiW 0.47
sbmA
yaiW
peptide antibiotic / peptide nucleic acid transporter
surface exposed outer membrane lipoprotein
yccA 0.46
yccA
putative carrier/transport protein; substrate or modulator of FtsH-mediated proteolysis
skp-lpxD-fabZ-lpxA 0.41
lpxA
lpxD
skp
fabZ
UDP-N-acetylglucosamine acyltransferase
UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase
periplasmic chaperone
3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
bacA 0.25
bacA
undecaprenyl pyrophosphate phosphatase
dsbC 0.11
dsbC
protein disulfide isomerase/protein disulfide oxidoreductase - DsbCreduced
motAB-cheAW 0.05
motA
motB
cheW
cheA
MotA protein, proton conductor component of motor; no effect on switching
MotB protein, enables flagellar motor rotation, linking torque machinery to cell wall
CheW
CheA(S)
yqjA-mzrA 0.04
yqjA
mzrA
membrane transport protein; required for proton-motive force (PMF) dependent drug efflux
MzrA

Network of associatons between targets according to the STRING database.

First level regulatory network of CpxR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0043164 Gram-negative-bacterium-type cell wall biogenesis(GO:0043164)
0.5 3.3 GO:0030162 regulation of proteolysis(GO:0030162)
0.4 1.7 GO:0015748 organophosphate ester transport(GO:0015748)
0.4 1.2 GO:0010639 negative regulation of organelle organization(GO:0010639) negative regulation of cell projection organization(GO:0031345) negative regulation of organelle assembly(GO:1902116) negative regulation of bacterial-type flagellum assembly(GO:1902209)
0.3 8.2 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.9 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.4 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
0.1 1.9 GO:0010033 response to organic substance(GO:0010033)
0.0 1.4 GO:0009266 response to temperature stimulus(GO:0009266)
0.0 0.1 GO:0031399 regulation of protein modification process(GO:0031399)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0045203 integral component of cell outer membrane(GO:0045203)
0.0 3.9 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)
0.0 1.8 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0070004 cysteine-type peptidase activity(GO:0008234) cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) peptidoglycan L,D-transpeptidase activity(GO:0071972)
0.5 1.5 GO:0045152 antisigma factor binding(GO:0045152)
0.5 3.6 GO:0030955 potassium ion binding(GO:0030955)
0.4 5.1 GO:0051082 unfolded protein binding(GO:0051082)
0.3 1.2 GO:0052621 diguanylate cyclase activity(GO:0052621)
0.2 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.1 0.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.2 GO:0050380 undecaprenyl-diphosphatase activity(GO:0050380)