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GSE80451: E.coli grown aerobically and anaerobically

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Results for FadR

Z-value: 1.20

Transcription factors associated with FadR

Gene Symbol Gene ID Gene Info
fadR
fadR FadR DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
fadR0.875.8e-02Click!

Activity profile of FadR motif

Sorted Z-values of FadR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
fadD-sroD 3.31
sroD
fadD
SroD
fatty acyl-CoA synthetase
fadE 2.74
fadE
acyl-CoA dehydrogenase/acyl-CoA dehydrogenase/acyl-CoA dehydrogenase/acyl-CoA dehydrogenase/acyl-CoA dehydrogenase/acyl-CoA dehydrogenase/acyl-CoA dehydrogenase/acyl-CoA dehydrogenase
fadBA 2.16
fadB
fadA
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase
3-ketoacyl-CoA thiolase
fadIJ 1.89
fadJ
fadI
FadJ component of anaerobic fatty acid oxidation complex
FadI component of anaerobic fatty acid oxidation complex
accA 1.63
accA
acetyl-CoA carboxyltransferase, α subunit
fadL 1.47
fadL
long-chain fatty acid outer membrane porin; bacteriophage T2 receptor
fadR 1.31
fadR
FadR DNA-binding transcriptional dual regulator
fabHDG 1.19
fabD
fabG
fabH
malonyl-CoA-ACP transacylase
3-oxoacyl-[acyl-carrier-protein] reductase subunit
β-ketoacyl-ACP synthase III
fadM 1.13
fadM
thioesterase III
fadH 0.79
fadH
2,4-dienoyl-CoA reductase
fabI 0.26
fabI
enoyl-[acyl-carrier-protein] reductase subunit
fabA 0.22
fabA
β-hydroxyacyl-ACP dehydratase/isomerase
uspA 0.07
uspA
universal stress global stress response regulator

Network of associatons between targets according to the STRING database.

First level regulatory network of FadR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 13.3 GO:0019395 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.5 1.4 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.5 GO:0006869 lipid transport(GO:0006869)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 GO:0098562 cytoplasmic side of plasma membrane(GO:0009898) cytoplasmic side of membrane(GO:0098562)
0.0 1.5 GO:0009279 cell outer membrane(GO:0009279)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.6 1.1 GO:0016289 CoA hydrolase activity(GO:0016289) thiolester hydrolase activity(GO:0016790)
0.5 1.5 GO:0022836 gated channel activity(GO:0022836) transmembrane receptor activity(GO:0099600)
0.5 3.3 GO:0016877 ligase activity, forming carbon-sulfur bonds(GO:0016877)
0.2 1.2 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 3.8 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 0.2 GO:0019171 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways