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GSE80451: E.coli grown aerobically and anaerobically

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Results for GadE

Z-value: 0.46

Transcription factors associated with GadE

Gene Symbol Gene ID Gene Info
gadE
gadE DNA-binding transcriptional activator GadE

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gadE-0.523.7e-01Click!

Activity profile of GadE motif

Sorted Z-values of GadE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
purA 0.98
purA
adenylosuccinate synthetase
cyoABCDE 0.94
cyoA
cyoC
cyoB
cyoE
cyoD
cytochrome bo terminal oxidase subunit II
cytochrome bo terminal oxidase subunit III
cytochrome bo terminal oxidase subunit I
heme O synthase
cytochrome bo terminal oxidase subunit IV
gltBDF 0.62
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
gadX 0.48
gadX
GadX DNA-binding transcriptional dual regulator
gadXW 0.33
gadW
gadX
GadW DNA-binding transcriptional dual regulator
GadX DNA-binding transcriptional dual regulator
gadE-mdtEF 0.33
mdtF
mdtE
gadE
MdtEF-TolC multidrug efflux pump - permease subunit
MdtEF-TolC multidrug efflux pump - membrane fusion protein
GadE DNA-binding transcriptional activator
gnd 0.18
gnd
6-phosphogluconate dehydrogenase, decarboxylating
hdeAB-yhiD 0.15
yhiD
hdeB
hdeA
inner membrane protein YhiD
HdeB monomer
HdeA monomer, chaperone active form

Network of associatons between targets according to the STRING database.

First level regulatory network of GadE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0046040 IMP metabolic process(GO:0046040)
0.2 0.9 GO:1902600 aerobic electron transport chain(GO:0019646) hydrogen ion transmembrane transport(GO:1902600)
0.2 0.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.0 0.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.2 GO:0046177 D-gluconate metabolic process(GO:0019521) D-gluconate catabolic process(GO:0046177)
0.0 0.1 GO:0071468 cellular response to acidic pH(GO:0071468)
0.0 0.8 GO:0051254 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0070069 cytochrome complex(GO:0070069)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004659 prenyltransferase activity(GO:0004659) ubiquinone binding(GO:0048039)
0.1 0.8 GO:0001140 transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001140) bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding(GO:0001216)
0.1 0.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 0.1 GO:0051087 chaperone binding(GO:0051087)
0.0 1.0 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.3 GO:0015238 drug transmembrane transporter activity(GO:0015238)