ISMARA results: NtrC

Project

GSE80451: E.coli grown aerobically and anaerobically

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Results for NtrC

Z-value: 0.54

Transcription factors associated with NtrC

Gene Symbol	Gene ID	Gene Info
glnG RegulonDB EcoCyc	glnG	NtrC transcriptional dual regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
glnG		0.74	1.5e-01	Click!

Activity profile of NtrC motif

Sorted Z-values of NtrC motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
astCADBE Show fit	2.59		astA RegulonDB EcoCyc Show fit astB RegulonDB EcoCyc Show fit astC RegulonDB EcoCyc Show fit astD RegulonDB EcoCyc Show fit astE RegulonDB EcoCyc Show fit	arginine succinyltransferase succinylarginine dihydrolase succinylornithine transaminase aldehyde dehydrogenase succinylglutamate desuccinylase
patA Show fit	0.88		patA RegulonDB EcoCyc Show fit	putrescine aminotransferase
yeaGH Show fit	0.82		yeaG RegulonDB EcoCyc Show fit yeaH RegulonDB EcoCyc Show fit	protein kinase conserved protein
cbl Show fit	0.62		cbl RegulonDB EcoCyc Show fit	Cbl DNA-binding transcriptional activator
glnLG Show fit	0.43		glnG RegulonDB EcoCyc Show fit glnL RegulonDB EcoCyc Show fit	NtrC transcriptional dual regulator NtrB
glnHPQ Show fit	0.28		glnH RegulonDB EcoCyc Show fit glnQ RegulonDB EcoCyc Show fit glnP RegulonDB EcoCyc Show fit	L-glutamine ABC transporter - periplasmic binding protein L-glutamine ABC transporter - ATP binding subunit L-glutamine ABC transporter - membrane subunit
argT-hisJQMP Show fit	0.26		hisM RegulonDB EcoCyc Show fit hisP RegulonDB EcoCyc Show fit argT RegulonDB EcoCyc Show fit hisQ RegulonDB EcoCyc Show fit hisJ RegulonDB EcoCyc Show fit	lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit lysine / arginine / ornithine ABC transporter - periplasmic binding protein lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit histidine ABC transporter - periplasmic binding protein
rutABCDEFG Show fit	0.23		rutC RegulonDB EcoCyc Show fit rutB RegulonDB EcoCyc Show fit rutA RegulonDB EcoCyc Show fit rutG RegulonDB EcoCyc Show fit rutF RegulonDB EcoCyc Show fit rutE RegulonDB EcoCyc Show fit rutD RegulonDB EcoCyc Show fit	predicted aminoacrylate peracid reductase peroxyureidoacrylate / ureidoacrylate amido hydrolase pyrimidine oxygenase uracil:H⁺ symporter RutG flavin reductase predicted malonic semialdehyde reductase predicted aminoacrylate hydrolase
glnK-amtB Show fit	0.17		glnK RegulonDB EcoCyc Show fit amtB RegulonDB EcoCyc Show fit	nitrogen regulatory protein GlnK ammonia / ammonium transporter
nac Show fit	0.06		nac RegulonDB EcoCyc Show fit	Nac DNA-binding transcriptional dual regulator
yhdWXYZ Show fit	0.03		yhdZ RegulonDB EcoCyc Show fit yhdY RegulonDB EcoCyc Show fit yhdX RegulonDB EcoCyc Show fit yhdW RegulonDB EcoCyc Show fit	putative transport protein, ABC superfamily - periplasmic binding protein putative transport protein, ABC superfamily - membrane component putative transport protein, ABC superfamily - ATP-binding component putative transport protein, ABC superfamily - membrane component

Network of associatons between targets according to the STRING database.

First level regulatory network of NtrC

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.6	GO:0006105	succinate metabolic process(GO:0006105) arginine catabolic process(GO:0006527)
0.1	0.9	GO:0009447	polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.1	0.2	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) pyrimidine nucleobase transport(GO:0015855)
0.1	0.3	GO:1903400	L-arginine import(GO:0043091) L-amino acid import(GO:0043092) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine import into cell(GO:1902765) L-arginine transmembrane transport(GO:1903400) L-lysine transmembrane transport(GO:1903401) arginine transmembrane transport(GO:1903826)
0.1	0.2	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.0	0.8	GO:0009267	cellular response to starvation(GO:0009267)
0.0	0.3	GO:0015804	neutral amino acid transport(GO:0015804)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0098533	ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.6	GO:0016813	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity(GO:0003992) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1	0.2	GO:0005350	monooxygenase activity(GO:0004497) pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.1	0.3	GO:0015181	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1	0.9	GO:0008483	transaminase activity(GO:0008483)
0.0	0.9	GO:0004672	protein kinase activity(GO:0004672)
0.0	0.3	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.0	0.2	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	Genes involved in Signaling by the B Cell Receptor (BCR)