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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Epas1_Bcl3

Z-value: 1.54

Motif logo

Transcription factors associated with Epas1_Bcl3

Gene Symbol Gene ID Gene Info
ENSRNOG00000021318 endothelial PAS domain protein 1
ENSRNOG00000043416 B-cell CLL/lymphoma 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Epas1rn6_v1_chr6_+_10348308_103483080.847.8e-02Click!
Bcl3rn6_v1_chr1_-_80744831_80744831-0.355.6e-01Click!

Activity profile of Epas1_Bcl3 motif

Sorted Z-values of Epas1_Bcl3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_245817809 2.56 ENSRNOT00000080607

chr12_-_45801842 1.75 ENSRNOT00000078837

chr17_+_20619324 1.74 ENSRNOT00000079788

chr3_+_71210301 1.50 ENSRNOT00000006504
family with sequence similarity 171, member B
chr2_+_30094421 1.30 ENSRNOT00000082226

chr1_+_226435979 1.29 ENSRNOT00000048704
ENSRNOT00000036232
ENSRNOT00000035576
ENSRNOT00000036180
ENSRNOT00000036168
ENSRNOT00000047964
ENSRNOT00000036283
ENSRNOT00000007429
synaptotagmin 7
chr18_-_18079560 1.13 ENSRNOT00000072093

chr4_-_123713319 1.04 ENSRNOT00000012875
ENSRNOT00000086982
solute carrier family 6 member 6
chr10_+_14136883 1.01 ENSRNOT00000082295

chr1_+_100577056 0.94 ENSRNOT00000026992
napsin A aspartic peptidase
chr1_+_104635989 0.85 ENSRNOT00000078477
neuron navigator 2
chr20_+_47779056 0.79 ENSRNOT00000090015

chr20_+_3558827 0.76 ENSRNOT00000088130
discoidin domain receptor tyrosine kinase 1
chr6_-_122572925 0.76 ENSRNOT00000090869

chr7_-_76035096 0.75 ENSRNOT00000072255

chr12_+_31934343 0.68 ENSRNOT00000011181
transmembrane protein 132D
chr1_+_277459200 0.66 ENSRNOT00000086008

chr1_-_260992291 0.63 ENSRNOT00000035415
ENSRNOT00000034758
slit guidance ligand 1
chr18_+_56193978 0.62 ENSRNOT00000041533
ENSRNOT00000080177
calcium/calmodulin-dependent protein kinase II alpha
chr8_-_123829749 0.59 ENSRNOT00000090467

chr5_+_63781801 0.58 ENSRNOT00000008302
nuclear receptor subfamily 4, group A, member 3
chr3_+_161413298 0.55 ENSRNOT00000023965
ENSRNOT00000088776
matrix metallopeptidase 9
chrX_+_151103576 0.54 ENSRNOT00000015401
SLIT and NTRK-like family, member 2
chrX_-_124464963 0.53 ENSRNOT00000036472
ENSRNOT00000077697
transmembrane protein 255A
chr14_+_17064353 0.50 ENSRNOT00000003052
scavenger receptor class B, member 2
chr5_+_16463597 0.49 ENSRNOT00000091550

chr4_-_144869919 0.49 ENSRNOT00000009066
SLIT-ROBO Rho GTPase activating protein 3
chr8_-_94563760 0.47 ENSRNOT00000032792
synaptosomal-associated protein 91
chr7_+_45328105 0.45 ENSRNOT00000029208
ENSRNOT00000090641
solute carrier family 6 member 15
chr3_+_110442637 0.45 ENSRNOT00000010471
p21 (RAC1) activated kinase 6
chr9_-_20528879 0.45 ENSRNOT00000085293

chr7_+_70946228 0.45 ENSRNOT00000039306
signal transducer and activator of transcription 6
chr2_+_2694480 0.43 ENSRNOT00000083565

chr20_+_46428124 0.43 ENSRNOT00000000327
forkhead box O3
chr1_-_255171691 0.43 ENSRNOT00000090224

chr7_-_3074359 0.41 ENSRNOT00000019738
IKAROS family zinc finger 4
chr5_-_113939127 0.40 ENSRNOT00000039554
myb-like, SWIRM and MPN domains 1
chr6_+_135610743 0.39 ENSRNOT00000010906
Tnf receptor-associated factor 3
chr8_+_48805684 0.38 ENSRNOT00000064041
B-cell CLL/lymphoma 9-like
chr14_-_12387102 0.38 ENSRNOT00000038872
bone morphogenetic protein 3
chr8_-_48597867 0.37 ENSRNOT00000077958
NLR family member X1
chr1_-_163554839 0.36 ENSRNOT00000081509
EMSY BRCA2-interacting transcriptional repressor
chr17_-_1085885 0.36 ENSRNOT00000026287
patched 1
chr4_+_100209951 0.36 ENSRNOT00000015807
hypothetical protein LOC691113
chr4_+_161720501 0.35 ENSRNOT00000008196
ENSRNOT00000055886
nuclear receptor interacting protein 2
chr11_-_84008946 0.35 ENSRNOT00000037612
von Willebrand factor A domain containing 5B2
chr2_-_179704629 0.34 ENSRNOT00000083361
ENSRNOT00000077941
glutamate ionotropic receptor AMPA type subunit 2
chr3_-_94419048 0.34 ENSRNOT00000015775
homeodomain interacting protein kinase 3
chr15_-_100348760 0.34 ENSRNOT00000085607

chr7_-_118396728 0.33 ENSRNOT00000066431
RNA binding protein, fox-1 homolog 2
chr1_+_165625350 0.33 ENSRNOT00000087534
RAB6A, member RAS oncogene family
chr4_-_125958112 0.33 ENSRNOT00000071315
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_-_85517683 0.32 ENSRNOT00000016070
SRC kinase signaling inhibitor 1
chr3_+_97723901 0.31 ENSRNOT00000080416
metallophosphoesterase domain containing 2
chr16_+_65256751 0.31 ENSRNOT00000092012

chr13_-_35668968 0.31 ENSRNOT00000042862
ENSRNOT00000003428
erythrocyte membrane protein band 4.1 like 5
chr10_+_27973681 0.30 ENSRNOT00000004970
gamma-aminobutyric acid type A receptor beta 2 subunit
chr9_+_73529612 0.30 ENSRNOT00000032430
unc-80 homolog, NALCN activator
chr17_-_77687456 0.29 ENSRNOT00000045765
ENSRNOT00000081645
FERM domain containing 4A
chr4_-_117153907 0.29 ENSRNOT00000091374
RAB11 family interacting protein 5
chr18_+_60392376 0.29 ENSRNOT00000023890
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr6_+_146784915 0.28 ENSRNOT00000008362
Sp8 transcription factor
chr3_+_171832500 0.28 ENSRNOT00000007554
VAMP associated protein B and C
chrX_-_142131545 0.27 ENSRNOT00000077402
fibroblast growth factor 13
chr10_+_83231238 0.26 ENSRNOT00000077625
speckle type BTB/POZ protein
chr10_-_90994437 0.26 ENSRNOT00000093167
glial fibrillary acidic protein
chr5_-_7941822 0.26 ENSRNOT00000079917
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr14_+_104250617 0.26 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr8_-_48582353 0.25 ENSRNOT00000011582
PDZ domain containing 3
chr11_+_57430166 0.25 ENSRNOT00000093201
pleckstrin homology-like domain, family B, member 2
chr12_-_11808977 0.24 ENSRNOT00000071795

chr20_-_31956649 0.24 ENSRNOT00000072429
hexokinase 1
chr16_+_23668595 0.24 ENSRNOT00000067886
pleckstrin and Sec7 domain containing 3
chr8_-_21492801 0.24 ENSRNOT00000077465
zinc finger protein 426
chr10_+_86157608 0.24 ENSRNOT00000082668
ENSRNOT00000008256
cyclin-dependent kinase 12
chr13_-_67206688 0.24 ENSRNOT00000003630
ENSRNOT00000090693
phospholipase A2 group IVA
chr10_-_85084850 0.24 ENSRNOT00000012462
TBK1 binding protein 1
chr7_+_97559841 0.24 ENSRNOT00000007326
zinc fingers and homeoboxes 2
chr4_+_133286114 0.22 ENSRNOT00000084158
protein phosphatase 4, regulatory subunit 2
chr15_-_42898150 0.22 ENSRNOT00000030036
protein tyrosine kinase 2 beta
chr2_+_205783252 0.21 ENSRNOT00000025633
ENSRNOT00000025600
tripartite motif-containing 33
chr16_+_4469468 0.21 ENSRNOT00000021164
wingless-type MMTV integration site family, member 5A
chr6_+_21708487 0.21 ENSRNOT00000087358

chr1_+_219250265 0.21 ENSRNOT00000024353
double C2-like domains, gamma
chr3_-_94418711 0.20 ENSRNOT00000089554
homeodomain interacting protein kinase 3
chr13_+_90260783 0.20 ENSRNOT00000050547
CD84 molecule
chr16_-_930527 0.20 ENSRNOT00000014787
spindlin 1
chr6_-_100011226 0.20 ENSRNOT00000083286
ENSRNOT00000041442
MYC associated factor X
chr5_-_147412705 0.20 ENSRNOT00000010688
similar to mKIAA1522 protein
chr2_-_96668222 0.20 ENSRNOT00000016567
cAMP-dependent protein kinase inhibitor alpha
chr10_-_40296470 0.20 ENSRNOT00000086456
TNFAIP3 interacting protein 1
chr10_-_88389347 0.19 ENSRNOT00000022695
kelch-like family member 11
chr18_-_37819097 0.19 ENSRNOT00000025880
dihydropyrimidinase-like 3
chr15_-_13228607 0.19 ENSRNOT00000042010
ENSRNOT00000088214
protein tyrosine phosphatase, receptor type, G
chr10_+_84979717 0.18 ENSRNOT00000065555
mitochondrial ribosomal protein L10
chr8_-_84522588 0.17 ENSRNOT00000076213
muscular LMNA-interacting protein
chr1_+_192379543 0.17 ENSRNOT00000078705
protein kinase C, beta
chr12_+_24978483 0.17 ENSRNOT00000040069
elastin
chr18_+_56364620 0.17 ENSRNOT00000068535
ENSRNOT00000086033
platelet derived growth factor receptor beta
chr15_+_102164751 0.16 ENSRNOT00000076400
glypican 6
chr13_-_89242443 0.16 ENSRNOT00000029202
activating transcription factor 6
chr15_-_52317219 0.16 ENSRNOT00000016555
dematin actin binding protein
chr4_+_22445414 0.16 ENSRNOT00000087657
ENSRNOT00000030224
RUN domain containing 3B
chr9_+_50892605 0.16 ENSRNOT00000033133
basic, immunoglobulin-like variable motif containing
chr8_+_27777179 0.15 ENSRNOT00000009825
beta-1,3-glucuronyltransferase 1
chr9_-_81864202 0.15 ENSRNOT00000084964
zinc finger protein 142
chr17_-_51912496 0.15 ENSRNOT00000019272
inhibin beta A subunit
chr15_-_14737704 0.14 ENSRNOT00000011307
synaptoporin
chr6_-_111015598 0.14 ENSRNOT00000015046
zinc finger, DHHC-type containing 22
chr2_-_210550490 0.14 ENSRNOT00000081835
ENSRNOT00000025222
ENSRNOT00000086403
colony stimulating factor 1
chr2_-_188718704 0.14 ENSRNOT00000028010
zinc finger and BTB domain containing 7B
chr2_+_58448917 0.14 ENSRNOT00000082562
RAN binding protein 3-like
chr18_+_59748444 0.14 ENSRNOT00000024752
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr1_-_188895223 0.14 ENSRNOT00000032796
G protein-coupled receptor 139
chr16_-_85306366 0.14 ENSRNOT00000089650
tumor necrosis factor superfamily member 13b
chr8_+_62482140 0.13 ENSRNOT00000026492
enhancer of mRNA decapping 3
chr3_+_55094637 0.13 ENSRNOT00000058763
ceramide synthase 6
chr1_-_129776276 0.13 ENSRNOT00000051402
arrestin domain containing 4
chr7_-_140454268 0.13 ENSRNOT00000081468
wingless-type MMTV integration site family, member 10B
chr4_-_129846642 0.13 ENSRNOT00000010717
FERM domain containing 4B
chr16_-_73670482 0.13 ENSRNOT00000024532
NK6 homeobox 3
chr2_+_238257031 0.13 ENSRNOT00000016066
integrator complex subunit 12
chr13_-_49313940 0.13 ENSRNOT00000012190
contactin 2
chr14_-_5033941 0.13 ENSRNOT00000072818
ENSRNOT00000082331
zinc finger protein 326
chr3_+_4106477 0.13 ENSRNOT00000078985

chr14_+_15059387 0.12 ENSRNOT00000002843
CCR4-NOT transcription complex, subunit 6-like
chr10_-_89700283 0.12 ENSRNOT00000028213
ets variant 4
chr9_+_73334618 0.12 ENSRNOT00000092717
microtubule-associated protein 2
chr2_+_198721724 0.12 ENSRNOT00000043535
ankyrin repeat domain 34A
chr5_+_135735825 0.12 ENSRNOT00000068267
zinc finger, SWIM-type containing 5
chr15_-_33333417 0.12 ENSRNOT00000018982
apoptotic chromatin condensation inducer 1
chr1_-_7064870 0.11 ENSRNOT00000019983
syntaxin 11
chr1_-_59732409 0.11 ENSRNOT00000014824
hyaluronan synthase 1
chr8_-_45137893 0.11 ENSRNOT00000010743
similar to hypothetical protein FLJ23554
chr1_+_78767911 0.11 ENSRNOT00000022360
protein kinase D2
chr11_+_73936750 0.11 ENSRNOT00000002350
ATPase 13A3
chr5_-_137125737 0.11 ENSRNOT00000088532

chr8_+_117068582 0.11 ENSRNOT00000073559
aminomethyltransferase
chr14_-_21127868 0.11 ENSRNOT00000020608
ENSRNOT00000092172
RUN and FYVE domain containing 3
chr8_-_7426611 0.11 ENSRNOT00000031492
Rho GTPase activating protein 42
chr1_+_192613372 0.11 ENSRNOT00000016632
calcium voltage-gated channel auxiliary subunit gamma 3
chr1_+_170262156 0.11 ENSRNOT00000024077
ENSRNOT00000085395
cholecystokinin B receptor
chr7_-_62972084 0.11 ENSRNOT00000064251
methionine sulfoxide reductase B3
chr1_+_190671696 0.11 ENSRNOT00000084934

chr17_-_29895386 0.10 ENSRNOT00000048757
chromodomain Y-like
chr1_+_164502389 0.10 ENSRNOT00000043554
arrestin, beta 1
chr9_+_15309127 0.10 ENSRNOT00000019177
prickle planar cell polarity protein 4
chr12_+_21721837 0.10 ENSRNOT00000073353
methylphosphate capping enzyme
chr2_+_18354542 0.10 ENSRNOT00000042958
hyaluronan and proteoglycan link protein 1
chr11_-_87628502 0.10 ENSRNOT00000002568
mediator complex subunit 15
chr17_+_36690249 0.10 ENSRNOT00000089476
ENSRNOT00000082140
similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a)
chr7_+_25808419 0.10 ENSRNOT00000091571
regulatory factor X4
chr18_+_64008048 0.10 ENSRNOT00000083414
low density lipoprotein receptor class A domain containing 4
chr1_+_266333440 0.10 ENSRNOT00000071243
sideroflexin 2
chr1_+_80920747 0.10 ENSRNOT00000026077
zinc finger protein 180
chr13_+_60619309 0.09 ENSRNOT00000082129

chr12_+_25093524 0.09 ENSRNOT00000081084
eukaryotic translation initiation factor 4H
chr18_+_17043903 0.09 ENSRNOT00000068139
formin homology 2 domain containing 3
chr4_-_180234804 0.09 ENSRNOT00000070957
basic helix-loop-helix family, member e41
chr4_-_157372861 0.09 ENSRNOT00000021578
prolyl 3-hydroxylase 3
chr6_-_39363367 0.09 ENSRNOT00000088687
ENSRNOT00000065531
family with sequence similarity 84, member A
chr9_-_44419998 0.09 ENSRNOT00000091397
ENSRNOT00000083747
testis specific 10
chr5_-_7874909 0.08 ENSRNOT00000064774
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_84328114 0.08 ENSRNOT00000028266
homeodomain interacting protein kinase 4
chr1_+_176854816 0.07 ENSRNOT00000087461
ubiquitin specific peptidase 47
chr10_+_17261541 0.07 ENSRNOT00000005478
SH3 and PX domains 2B
chr5_+_31568419 0.07 ENSRNOT00000050137
matrix metallopeptidase 16
chr1_+_82174451 0.07 ENSRNOT00000027783
transmembrane protein 145
chr2_+_178679395 0.07 ENSRNOT00000088686
family with sequence similarity 198, member B
chr12_-_38691075 0.07 ENSRNOT00000084192
BCL tumor suppressor 7A
chr1_+_177183209 0.07 ENSRNOT00000085326
MICAL C-terminal like
chr8_+_408001 0.07 ENSRNOT00000046058
guanylate cyclase 1 soluble subunit alpha 2
chr14_-_20920286 0.06 ENSRNOT00000004391
solute carrier family 4 member 4
chr3_-_52510507 0.06 ENSRNOT00000091259
sodium voltage-gated channel alpha subunit 1
chr1_-_265798167 0.06 ENSRNOT00000079483
LIM domain binding 1
chr9_+_81783349 0.06 ENSRNOT00000021548
CCR4-NOT transcription complex subunit 9
chr10_-_63491713 0.06 ENSRNOT00000063941
tumor suppressor candidate 5
chr8_+_111495331 0.06 ENSRNOT00000091275
ENSRNOT00000012162
solute carrier organic anion transporter family, member 2a1
chr1_+_89491654 0.06 ENSRNOT00000028632
leucine-rich repeat LGI family, member 4
chr12_+_48598647 0.06 ENSRNOT00000000889
transmembrane protein 119
chr20_+_44803666 0.06 ENSRNOT00000057227
REV3 like, DNA directed polymerase zeta catalytic subunit
chr6_-_107678156 0.06 ENSRNOT00000014158
ELM2 and Myb/SANT domain containing 1
chr1_+_80953275 0.06 ENSRNOT00000087253
zinc finger protein 112
chr15_-_84748525 0.06 ENSRNOT00000090009
Kruppel-like factor 12
chr5_+_137356801 0.06 ENSRNOT00000027432
similar to RIKEN cDNA 2610528J11
chr1_+_140792049 0.05 ENSRNOT00000049681
aggrecan
chr17_-_9792007 0.05 ENSRNOT00000021596
regulator of G-protein signaling 14
chr12_+_25498198 0.05 ENSRNOT00000076916
neutrophil cytosolic factor 1
chr11_-_27094364 0.05 ENSRNOT00000050902
RWD domain containing 2B
chr2_+_62150493 0.05 ENSRNOT00000080241
zinc finger RNA binding protein
chr20_+_44803885 0.05 ENSRNOT00000077936
REV3 like, DNA directed polymerase zeta catalytic subunit
chr5_-_62186372 0.05 ENSRNOT00000089789
coronin 2A
chr17_-_6244612 0.05 ENSRNOT00000042145
ENSRNOT00000090914
ENSRNOT00000082611
neurotrophic receptor tyrosine kinase 2
chr2_+_211546560 0.04 ENSRNOT00000033443
AKNA domain containing 1
chr16_-_755990 0.04 ENSRNOT00000013501
RNA polymerase III subunit A
chr9_-_60923706 0.04 ENSRNOT00000047517

chr13_-_70321722 0.04 ENSRNOT00000092397
ENSRNOT00000092336
ENSRNOT00000092649
ENSRNOT00000092269
SMG7 nonsense mediated mRNA decay factor
chr14_+_99529284 0.04 ENSRNOT00000006897
ENSRNOT00000067134
V-set and transmembrane domain containing 2A
chr15_+_28023018 0.04 ENSRNOT00000090272
ribonuclease A family member 4
chr1_-_72727112 0.04 ENSRNOT00000031172
BR serine/threonine kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Epas1_Bcl3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.2 0.9 GO:0021564 vagus nerve development(GO:0021564)
0.2 0.5 GO:0009644 response to high light intensity(GO:0009644) cellular response to iron(III) ion(GO:0071283)
0.2 0.6 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.2 0.5 GO:0015820 leucine transport(GO:0015820)
0.1 0.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.6 GO:1900623 regulation of mast cell cytokine production(GO:0032763) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.6 GO:0098989 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) NMDA selective glutamate receptor signaling pathway(GO:0098989) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.4 GO:0009957 epidermal cell fate specification(GO:0009957) response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.1 0.3 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.1 0.4 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.3 GO:0042640 anagen(GO:0042640) regulation of anagen(GO:0051884)
0.1 1.2 GO:0043129 surfactant homeostasis(GO:0043129)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.4 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.1 0.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.3 GO:0042488 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488)
0.1 0.2 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 0.2 GO:0071298 cellular response to L-ascorbic acid(GO:0071298)
0.1 0.3 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725)
0.1 0.2 GO:0038091 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.1 0.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 0.2 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
0.0 0.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0060279 positive regulation of ovulation(GO:0060279)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.1 GO:1990743 protein sialylation(GO:1990743)
0.0 0.3 GO:0010625 positive regulation of Schwann cell proliferation(GO:0010625) regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.2 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.2 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.3 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:0043316 cytotoxic T cell degranulation(GO:0043316)
0.0 0.1 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0031296 B cell costimulation(GO:0031296)
0.0 0.1 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.1 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 1.0 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.5 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0010070 zygote asymmetric cell division(GO:0010070)
0.0 0.1 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.0 0.1 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0070946 neutrophil mediated killing of gram-positive bacterium(GO:0070946)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:1904179 positive regulation of adipose tissue development(GO:1904179)
0.0 0.1 GO:0040031 snRNA modification(GO:0040031)
0.0 0.3 GO:0060992 response to fungicide(GO:0060992)
0.0 0.3 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.0 GO:0000105 histidine biosynthetic process(GO:0000105)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.3 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.6 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.2 GO:0044068 modulation by symbiont of host cellular process(GO:0044068)
0.0 0.0 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:1990834 response to odorant(GO:1990834)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0098830 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.2 0.6 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.1 1.3 GO:0032009 early phagosome(GO:0032009)
0.1 0.2 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.1 0.9 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.3 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 0.7 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0043511 inhibin complex(GO:0043511)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.4 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0030977 taurine binding(GO:0030977)
0.1 0.4 GO:0005119 smoothened binding(GO:0005119)
0.1 0.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.2 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 1.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.9 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 0.3 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease