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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Fli1

Z-value: 0.73

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Transcription factors associated with Fli1

Gene Symbol Gene ID Gene Info
Fli1
ENSRNOG00000008904 Fli-1 proto-oncogene, ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Fli1rn6_v1_chr8_-_33661049_336610490.474.2e-01Click!

Activity profile of Fli1 motif

Sorted Z-values of Fli1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_14292698 0.91 ENSRNOT00000073672
AABR07069238.1

chr1_-_20155960 0.77 ENSRNOT00000061389
Samd3
sterile alpha motif domain containing 3
chr5_+_159534202 0.46 ENSRNOT00000010993
Mfap2
microfibrillar-associated protein 2
chr2_+_154604832 0.45 ENSRNOT00000013777
Vom2r44
vomeronasal 2 receptor 44
chrX_-_123788898 0.44 ENSRNOT00000009123
Akap14
A-kinase anchoring protein 14
chr1_+_150797084 0.41 ENSRNOT00000018990
Nox4
NADPH oxidase 4
chr12_-_23841049 0.40 ENSRNOT00000031555
Hspb1
heat shock protein family B (small) member 1
chr5_-_78393143 0.40 ENSRNOT00000043610
LOC100910017
60S ribosomal protein L31-like
chr3_+_171597241 0.39 ENSRNOT00000029558
LOC689618
similar to Protein C20orf85 homolog
chr9_-_17212628 0.38 ENSRNOT00000002656
ENSRNOT00000007876
RGD1562399
similar to 40S ribosomal protein S2
chr13_-_109997092 0.37 ENSRNOT00000005190
Nenf
neudesin neurotrophic factor
chr6_+_1657331 0.35 ENSRNOT00000049672
ENSRNOT00000079864
Qpct
glutaminyl-peptide cyclotransferase
chr3_+_140106766 0.33 ENSRNOT00000014046
Naa20
N(alpha)-acetyltransferase 20, NatB catalytic subunit
chr19_+_38619764 0.28 ENSRNOT00000027225
LOC100360573
ribosomal protein S12-like
chr4_-_153373649 0.28 ENSRNOT00000016495
Atp6v1e1
ATPase H+ transporting V1 subunit E1
chr5_+_128865389 0.26 ENSRNOT00000068697
Calr4
calreticulin 4
chr12_+_41636994 0.26 ENSRNOT00000001882
Sdsl
serine dehydratase-like
chr7_+_143754892 0.23 ENSRNOT00000085896
Soat2
sterol O-acyltransferase 2
chrX_-_154653758 0.22 ENSRNOT00000090728
LOC103690293
fragile X mental retardation 1 neighbor protein-like
chr8_+_127144903 0.21 ENSRNOT00000013530
Eomes
eomesodermin
chr18_-_59819113 0.20 ENSRNOT00000065939
RGD1562699
RGD1562699
chr1_-_64021321 0.20 ENSRNOT00000090819
Rps9
ribosomal protein S9
chr16_+_20020444 0.20 ENSRNOT00000024827
Pgls
6-phosphogluconolactonase
chr12_+_42097626 0.18 ENSRNOT00000001893
Tbx5
T-box 5
chr1_-_21854763 0.16 ENSRNOT00000089196
ENSRNOT00000020528
Ctgf
connective tissue growth factor
chr17_+_57074525 0.15 ENSRNOT00000020012
ENSRNOT00000074146
Crem
cAMP responsive element modulator
chr1_-_24302298 0.15 ENSRNOT00000083452
Sgk1
serum/glucocorticoid regulated kinase 1
chr14_-_84189266 0.14 ENSRNOT00000005934
Tcn2
transcobalamin 2
chr7_-_117587103 0.14 ENSRNOT00000035423
Scrt1
scratch family transcriptional repressor 1
chr14_-_72970329 0.14 ENSRNOT00000006325
Pp2d1
protein phosphatase 2C-like domain containing 1
chr4_+_14039977 0.14 ENSRNOT00000091249
ENSRNOT00000075878
Cd36
CD36 molecule
chr3_+_160092975 0.14 ENSRNOT00000080707
Pkig
cAMP-dependent protein kinase inhibitor gamma
chr1_+_256370850 0.14 ENSRNOT00000030962
Cyp26c1
cytochrome P450, family 26, subfamily C, polypeptide 1
chr1_-_259287684 0.14 ENSRNOT00000054724
Cyp2c22
cytochrome P450, family 2, subfamily c, polypeptide 22
chr20_+_18492169 0.13 ENSRNOT00000046536
LOC103690821
60S ribosomal protein L39
chr14_-_10694164 0.13 ENSRNOT00000080099
AC099384.2

chr1_+_72874404 0.13 ENSRNOT00000058900
Dnaaf3
dynein, axonemal, assembly factor 3
chr10_-_66873948 0.12 ENSRNOT00000039261
Evi2a
ecotropic viral integration site 2A
chr4_-_145699577 0.12 ENSRNOT00000014377
Sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr4_+_78735279 0.11 ENSRNOT00000011970
Malsu1
mitochondrial assembly of ribosomal large subunit 1
chr7_-_2623781 0.11 ENSRNOT00000004173
Spryd4
SPRY domain containing 4
chr1_-_225594958 0.11 ENSRNOT00000027492
Scgb1d2
secretoglobin, family 1D, member 2
chr11_+_58624198 0.11 ENSRNOT00000002091
Gap43
growth associated protein 43
chr1_-_85317968 0.10 ENSRNOT00000026891
Gmfg
glia maturation factor, gamma
chr2_-_116372226 0.10 ENSRNOT00000011932
Lrriq4
leucine-rich repeats and IQ motif containing 4
chr7_-_67345295 0.10 ENSRNOT00000087045
ENSRNOT00000005829
Avpr1a
arginine vasopressin receptor 1A
chr1_-_8878136 0.09 ENSRNOT00000064836
ENSRNOT00000075850
Vta1
vesicle trafficking 1
chr14_+_108826831 0.09 ENSRNOT00000083146
ENSRNOT00000009421
Bcl11a
B-cell CLL/lymphoma 11A
chr2_+_116416507 0.09 ENSRNOT00000030700
Actrt3
actin-related protein T3
chr4_+_172942020 0.09 ENSRNOT00000072450
Lmo3
LIM domain only 3
chr3_-_67668772 0.09 ENSRNOT00000010247
Frzb
frizzled-related protein
chr4_+_180291389 0.08 ENSRNOT00000002465
Sspn
sarcospan
chr16_+_7758996 0.08 ENSRNOT00000061063
Btd
biotinidase
chr7_+_23913830 0.08 ENSRNOT00000006570
Rtcb
RNA 2',3'-cyclic phosphate and 5'-OH ligase
chr6_-_127653124 0.08 ENSRNOT00000047324
Serpina11
serpin family A member 11
chr17_+_49322205 0.08 ENSRNOT00000017713
Pou6f2
POU domain, class 6, transcription factor 2
chr2_-_144323254 0.08 ENSRNOT00000018780
Sertm1
serine-rich and transmembrane domain containing 1
chr9_-_117867557 0.08 ENSRNOT00000056321
AABR07068760.1

chr7_+_13881583 0.07 ENSRNOT00000065282
Cyp4f37
cytochrome P450, family 4, subfamily f, polypeptide 37
chr4_-_170932618 0.07 ENSRNOT00000007779
Arhgdib
Rho GDP dissociation inhibitor beta
chr20_-_6556350 0.07 ENSRNOT00000035819
Lemd2
LEM domain containing 2
chr20_+_48881194 0.07 ENSRNOT00000000304
Rtn4ip1
reticulon 4 interacting protein 1
chr20_-_32353677 0.07 ENSRNOT00000035355
Stox1
storkhead box 1
chr1_+_80383050 0.07 ENSRNOT00000023451
Exoc3l2
exocyst complex component 3-like 2
chr1_-_91074294 0.07 ENSRNOT00000075236
LOC687508
similar to Cytochrome c oxidase polypeptide VIIa-heart, mitochondrial precursor (Cytochrome c oxidase subunit VIIa-H) (COX VIIa-M)
chr3_-_176816114 0.07 ENSRNOT00000079262
ENSRNOT00000018697
Stmn3
stathmin 3
chr12_+_22449985 0.07 ENSRNOT00000075951
Slc12a9
solute carrier family 12, member 9
chr16_-_39996338 0.06 ENSRNOT00000089665
Asb5
ankyrin repeat and SOCS box-containing 5
chrX_+_15378789 0.06 ENSRNOT00000029272
Gata1
GATA binding protein 1
chr7_+_107467260 0.06 ENSRNOT00000009240
ENSRNOT00000077382
Tg
thyroglobulin
chr5_-_136098013 0.06 ENSRNOT00000089166
RGD1563714
RGD1563714
chr2_-_250600517 0.06 ENSRNOT00000016872
Hs2st1
heparan sulfate 2-O-sulfotransferase 1
chr5_+_164751440 0.06 ENSRNOT00000010558
RGD1305350
similar to RIKEN cDNA 2510039O18
chr17_+_47302272 0.06 ENSRNOT00000090021
Nme8
NME/NM23 family member 8
chr3_+_123731539 0.05 ENSRNOT00000051064
Cdc25b
cell division cycle 25B
chr1_-_52495582 0.05 ENSRNOT00000067142
Pde10a
phosphodiesterase 10A
chrX_+_156355376 0.05 ENSRNOT00000078304
Lage3
L antigen family, member 3
chr6_+_93385457 0.05 ENSRNOT00000010300
Actr10
actin-related protein 10 homolog
chr1_+_88586837 0.05 ENSRNOT00000080555
Zfp382
zinc finger protein 382
chr5_+_133864798 0.05 ENSRNOT00000091977
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chr8_-_62458301 0.05 ENSRNOT00000021653
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
chr2_+_250600823 0.05 ENSRNOT00000083750
Sep15
selenoprotein 15
chr3_-_24601063 0.05 ENSRNOT00000037043
LOC100362366
40S ribosomal protein S17-like
chr20_-_11528332 0.05 ENSRNOT00000038419
Tspear
thrombospondin-type laminin G domain and EAR repeats
chr2_-_189903219 0.05 ENSRNOT00000017000
S100a1
S100 calcium binding protein A1
chr12_+_25264400 0.05 ENSRNOT00000087656
Gtf2ird1
GTF2I repeat domain containing 1
chr18_+_63098144 0.05 ENSRNOT00000024968
Cidea
cell death-inducing DFFA-like effector a
chr1_+_190200324 0.05 ENSRNOT00000001933
Abca16
ATP-binding cassette, subfamily A (ABC1), member 16
chr2_-_183250928 0.04 ENSRNOT00000081080
AABR07012039.1

chr9_+_81427730 0.04 ENSRNOT00000019109
ENSRNOT00000081711
Cxcr2
C-X-C motif chemokine receptor 2
chr10_+_106991935 0.04 ENSRNOT00000004007
Pgs1
phosphatidylglycerophosphate synthase 1
chr7_+_3133506 0.04 ENSRNOT00000049972
Pmel
premelanosome protein
chr2_+_205488182 0.04 ENSRNOT00000024270
Sike1
suppressor of IKBKE 1
chr17_-_14828329 0.04 ENSRNOT00000022830
Barx1
BARX homeobox 1
chr12_+_25264192 0.04 ENSRNOT00000079392
Gtf2ird1
GTF2I repeat domain containing 1
chrX_+_43625169 0.04 ENSRNOT00000086311
Sat1
spermidine/spermine N1-acetyl transferase 1
chr10_-_61576952 0.04 ENSRNOT00000092712
Pafah1b1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
chr18_+_52550739 0.04 ENSRNOT00000037529
Ctxn3
cortexin 3
chr8_+_25246292 0.04 ENSRNOT00000021625
Npsr1
neuropeptide S receptor 1
chr1_+_91433030 0.03 ENSRNOT00000015205
Slc7a10
solute carrier family 7 member 10
chr3_-_7203420 0.03 ENSRNOT00000015236
Gfi1b
growth factor independent 1B transcriptional repressor
chr14_+_70780623 0.03 ENSRNOT00000083871
ENSRNOT00000058803
Ldb2
LIM domain binding 2
chr15_-_45550285 0.03 ENSRNOT00000012948
Gucy1b2
guanylate cyclase 1 soluble subunit beta 2
chr4_+_156050054 0.03 ENSRNOT00000039855
Clec4a
C-type lectin domain family 4, member A
chr7_+_137680530 0.03 ENSRNOT00000006970
Arid2
AT-rich interaction domain 2
chr8_-_79862974 0.03 ENSRNOT00000091386
AC128582.1

chr5_-_135628750 0.03 ENSRNOT00000079236
AC126292.3

chr4_-_158705885 0.02 ENSRNOT00000087115
ENSRNOT00000026685
Ntf3
neurotrophin 3
chr4_-_163528220 0.02 ENSRNOT00000090813
Klri1
killer cell lectin-like receptor family I member 1
chr12_-_38805121 0.02 ENSRNOT00000057716
Psmd9
proteasome 26S subunit, non-ATPase 9
chr5_-_160179978 0.02 ENSRNOT00000022820
Slc25a34
solute carrier family 25, member 34
chr16_-_69884962 0.02 ENSRNOT00000078635
Cnga2
cyclic nucleotide gated channel alpha 2
chr3_+_11657370 0.02 ENSRNOT00000073840
Ak1
adenylate kinase 1
chr1_-_220787238 0.02 ENSRNOT00000083656
Tsga10ip
testis specific 10 interacting protein
chr17_+_6684621 0.02 ENSRNOT00000089138
RGD1311345
similar to CG9752-PA
chr19_-_39087880 0.02 ENSRNOT00000070822
Chtf8
chromosome transmission fidelity factor 8
chr18_+_55666027 0.02 ENSRNOT00000045950
RGD1305184
similar to CDNA sequence BC023105
chr1_-_80594136 0.02 ENSRNOT00000024800
Apoc2
apolipoprotein C2
chr3_+_100770975 0.02 ENSRNOT00000089233
Bdnf
brain-derived neurotrophic factor
chr10_+_46840113 0.01 ENSRNOT00000086083
ENSRNOT00000079133
Myo15a
myosin XVA
chr1_-_146029840 0.01 ENSRNOT00000016455
Mesdc1
mesoderm development candidate 1
chr4_-_51199570 0.01 ENSRNOT00000010788
Slc13a1
solute carrier family 13 member 1
chr1_+_248723397 0.01 ENSRNOT00000072188
LOC100911854
mannose-binding protein C-like
chr3_+_43255567 0.01 ENSRNOT00000044419
Gpd2
glycerol-3-phosphate dehydrogenase 2
chr10_-_82887497 0.01 ENSRNOT00000005644
Itga3
integrin subunit alpha 3
chr15_-_20783063 0.01 ENSRNOT00000083268
Bmp4
bone morphogenetic protein 4
chr11_-_71136673 0.01 ENSRNOT00000042240
Fyttd1
forty-two-three domain containing 1
chr9_-_24383679 0.01 ENSRNOT00000040542
Crisp1
cysteine-rich secretory protein 1
chr1_+_212558257 0.00 ENSRNOT00000024912
Prap1
proline-rich acidic protein 1
chr5_-_150390099 0.00 ENSRNOT00000014479
Ythdf2
YTH N(6)-methyladenosine RNA binding protein 2
chr6_-_111572949 0.00 ENSRNOT00000016884
RGD1565693
similar to GLE1-like, RNA export mediator isoform 1
chr14_+_100415668 0.00 ENSRNOT00000008057
C1d
C1D nuclear receptor co-repressor
chr5_+_173237642 0.00 ENSRNOT00000068770
Ankrd65
ankyrin repeat domain 65
chr5_+_137257637 0.00 ENSRNOT00000093001
Elovl1
ELOVL fatty acid elongase 1
chr13_-_72869396 0.00 ENSRNOT00000093563
RGD1304622
similar to 6820428L09 protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Fli1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903544 cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544)
0.1 0.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.5 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.2 GO:0003166 bundle of His development(GO:0003166)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0045819 cellular response to water deprivation(GO:0042631) positive regulation of glycogen catabolic process(GO:0045819)
0.0 0.2 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.1 GO:1903860 negative regulation of dendrite extension(GO:1903860)
0.0 0.1 GO:0030221 basophil differentiation(GO:0030221)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.4 GO:0032099 negative regulation of appetite(GO:0032099)
0.0 0.1 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.2 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.1 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.2 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.0 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0071500 cellular response to nitrosative stress(GO:0071500)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.0 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.0 0.5 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.0 GO:0019809 spermidine binding(GO:0019809)
0.0 0.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling