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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Foxd1

Z-value: 0.37

Motif logo

Transcription factors associated with Foxd1

Gene Symbol Gene ID Gene Info
ENSRNOG00000043332 forkhead box D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxd1rn6_v1_chr2_+_28460068_284600680.819.9e-02Click!

Activity profile of Foxd1 motif

Sorted Z-values of Foxd1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_27558089 0.23 ENSRNOT00000027499
family with sequence similarity 53, member C
chr10_-_74298599 0.21 ENSRNOT00000007379
yippee-like 2
chr1_+_261337594 0.17 ENSRNOT00000019874
phosphatidylinositol 4-kinase type 2 alpha
chr13_+_90533365 0.17 ENSRNOT00000082469
DDB1 and CUL4 associated factor 8
chr13_+_97838361 0.16 ENSRNOT00000003641
consortin, connexin sorting protein
chr8_-_104593625 0.15 ENSRNOT00000016625
zinc finger and BTB domain containing 38
chr3_-_148932878 0.15 ENSRNOT00000013881
nucleolar protein 4-like
chr2_-_208225888 0.15 ENSRNOT00000054860

chr4_-_115516296 0.14 ENSRNOT00000019399
poly(A) binding protein interacting protein 2B
chr20_+_5262946 0.14 ENSRNOT00000082900
bromodomain containing 2
chr8_-_80631873 0.13 ENSRNOT00000091661
ENSRNOT00000080662
unc-13 homolog C
chr3_-_60795951 0.12 ENSRNOT00000002174
activating transcription factor 2
chr5_-_60559533 0.11 ENSRNOT00000092899
zinc finger and BTB domain containing 5
chr6_+_73553210 0.11 ENSRNOT00000006562
A-kinase anchoring protein 6
chr10_+_89646195 0.11 ENSRNOT00000048140
DEAH-box helicase 8
chr17_+_81922329 0.11 ENSRNOT00000031542
calcium voltage-gated channel auxiliary subunit beta 2
chr4_+_157438605 0.10 ENSRNOT00000079988

chr8_-_118696187 0.10 ENSRNOT00000056141
kelch-like family member 18
chr10_-_109267500 0.09 ENSRNOT00000005977
centrosomal protein 131
chr4_-_30556814 0.09 ENSRNOT00000012760
pyruvate dehydrogenase kinase 4
chrX_+_71155601 0.09 ENSRNOT00000076453
ENSRNOT00000048521
forkhead box O4
chr7_-_120780108 0.09 ENSRNOT00000018185
DEAD-box helicase 17
chr4_+_168599331 0.09 ENSRNOT00000086719
cAMP responsive element binding protein-like 2
chr15_+_34552410 0.09 ENSRNOT00000027802
KH and NYN domain containing
chr14_-_3351553 0.09 ENSRNOT00000061556
BTB (POZ) domain containing 8
chr10_+_103395511 0.09 ENSRNOT00000004256
G protein-coupled receptor, class C, group 5, member C
chr12_+_21767606 0.09 ENSRNOT00000059602
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like
chr2_+_205553163 0.08 ENSRNOT00000039572
neuroblastoma RAS viral oncogene homolog
chr7_-_120780641 0.08 ENSRNOT00000076164
DEAD-box helicase 17
chr9_+_119542328 0.08 ENSRNOT00000082005
lipin 2
chr9_-_38196273 0.08 ENSRNOT00000044452
dystonin
chr8_+_77107536 0.08 ENSRNOT00000083255
ADAM metallopeptidase domain 10
chr7_-_114590119 0.08 ENSRNOT00000079599
protein tyrosine kinase 2
chr10_+_94988362 0.08 ENSRNOT00000066525
centrosomal protein 95
chr15_-_37983882 0.08 ENSRNOT00000087978
large tumor suppressor kinase 2
chrX_+_115563038 0.08 ENSRNOT00000087859
ALG13, UDP-N-acetylglucosaminyltransferase subunit
chr15_-_77736892 0.07 ENSRNOT00000057924
protocadherin 9
chr16_-_19583386 0.07 ENSRNOT00000090131
zinc finger protein 617
chr5_-_60559329 0.07 ENSRNOT00000017046
zinc finger and BTB domain containing 5
chr10_-_90501819 0.07 ENSRNOT00000050474
G patch domain containing 8
chr4_-_67520356 0.07 ENSRNOT00000014604
B-Raf proto-oncogene, serine/threonine kinase
chr17_-_9721542 0.07 ENSRNOT00000047958
ENSRNOT00000079063
G protein-coupled receptor kinase 6
chr4_+_157594436 0.07 ENSRNOT00000029053
lysophosphatidic acid receptor 5
chr13_-_98480419 0.07 ENSRNOT00000086306
coenzyme Q8A
chr15_+_24942218 0.07 ENSRNOT00000016629
pellino E3 ubiquitin protein ligase family member 2
chr7_+_99954492 0.07 ENSRNOT00000005885
tribbles pseudokinase 1
chr6_+_54488038 0.07 ENSRNOT00000084661
ENSRNOT00000005637
sorting nexin 13
chr7_+_70753101 0.07 ENSRNOT00000090001
R3H domain containing 2
chr2_+_185590986 0.06 ENSRNOT00000088807
ENSRNOT00000088188
LPS responsive beige-like anchor protein
chr1_+_190671696 0.06 ENSRNOT00000084934

chr17_+_86408151 0.06 ENSRNOT00000022734
OTU deubiquitinase 1
chr4_-_40136061 0.06 ENSRNOT00000009752
base methyltransferase of 25S rRNA 2 homolog
chr20_+_29655226 0.06 ENSRNOT00000089059
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
chr7_-_139318455 0.06 ENSRNOT00000092029
histone deacetylase 7
chr12_-_1816414 0.06 ENSRNOT00000041155
ENSRNOT00000067448
insulin receptor
chr1_+_15642153 0.06 ENSRNOT00000079845
microtubule-associated protein 7
chr1_+_221236773 0.06 ENSRNOT00000051979
solute carrier family 25, member 45
chr10_+_89645973 0.06 ENSRNOT00000086892
DEAH-box helicase 8
chr19_-_52206310 0.06 ENSRNOT00000087886
membrane-bound transcription factor peptidase, site 1
chr16_-_20807070 0.06 ENSRNOT00000072536
cartilage oligomeric matrix protein
chr5_+_48290061 0.06 ENSRNOT00000076508
ubiquitin-conjugating enzyme E2, J1
chr20_+_3823596 0.06 ENSRNOT00000087670
retinoid X receptor beta
chr8_+_11931767 0.06 ENSRNOT00000087963
mastermind-like transcriptional coactivator 2
chr2_+_257633425 0.05 ENSRNOT00000071770
zinc finger, ZZ-type containing 3
chr6_+_108167716 0.05 ENSRNOT00000064426
lin-52 DREAM MuvB core complex component
chr3_+_177351518 0.05 ENSRNOT00000023989
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr1_-_90520344 0.05 ENSRNOT00000078598
potassium channel tetramerization domain containing 15
chr10_-_40296470 0.05 ENSRNOT00000086456
TNFAIP3 interacting protein 1
chr17_-_1093873 0.05 ENSRNOT00000086130
patched 1
chr6_-_50786967 0.05 ENSRNOT00000009566
Cbl proto-oncogene like 1
chr15_+_34216833 0.05 ENSRNOT00000025260
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr10_+_56824505 0.05 ENSRNOT00000067128
solute carrier family 16, member 11
chr2_+_31378743 0.05 ENSRNOT00000050384

chr10_-_94988461 0.05 ENSRNOT00000048490
DEAD-box helicase 5
chr18_-_69671199 0.04 ENSRNOT00000082484
SMAD family member 4
chr6_+_27768943 0.04 ENSRNOT00000015820
kinesin family member 3C
chr5_+_113725717 0.04 ENSRNOT00000032248
TEK receptor tyrosine kinase
chr11_-_11585078 0.04 ENSRNOT00000088878
roundabout guidance receptor 2
chr5_-_157165767 0.04 ENSRNOT00000000167
UBX domain protein 10
chr1_+_178039063 0.04 ENSRNOT00000046313
aryl hydrocarbon receptor nuclear translocator-like
chr4_+_169161585 0.04 ENSRNOT00000079785
epithelial membrane protein 1
chr7_-_91538673 0.04 ENSRNOT00000006209
RAD21 cohesin complex component
chr3_-_46051096 0.04 ENSRNOT00000081302
bromodomain adjacent to zinc finger domain, 2B
chr4_+_153921115 0.04 ENSRNOT00000018821
solute carrier family 6 member 12
chr4_-_138885556 0.04 ENSRNOT00000008873
cereblon
chr3_+_156886454 0.04 ENSRNOT00000022403
lipin 3
chr5_-_50075454 0.04 ENSRNOT00000011085
origin recognition complex, subunit 3
chr3_+_120726906 0.04 ENSRNOT00000051069
BCL2 like 11
chr4_-_17594598 0.04 ENSRNOT00000008936
semaphorin 3E
chr15_+_34234755 0.04 ENSRNOT00000059987
DDB1 and CUL4 associated factor 11
chr1_-_59347472 0.03 ENSRNOT00000017718
leucyl and cystinyl aminopeptidase
chr18_+_29972808 0.03 ENSRNOT00000074051
protocadherin alpha 4
chr6_-_109095557 0.03 ENSRNOT00000033493
mutL homolog 3
chr2_+_189615948 0.03 ENSRNOT00000092144
CREB regulated transcription coactivator 2
chr9_-_32019205 0.03 ENSRNOT00000016194
adhesion G protein-coupled receptor B3
chr15_+_34234193 0.03 ENSRNOT00000077584
DDB1 and CUL4 associated factor 11
chr2_+_198683159 0.03 ENSRNOT00000028793
thioredoxin interacting protein
chr7_-_137856485 0.03 ENSRNOT00000007003
similar to splicing factor, arginine/serine-rich 2, interacting protein
chr4_-_157433467 0.03 ENSRNOT00000028965
lymphocyte activating 3
chr15_+_8730871 0.03 ENSRNOT00000081845
nuclear receptor subfamily 1, group D, member 2
chr6_-_51257625 0.03 ENSRNOT00000012004
HMG-box transcription factor 1
chr1_-_264706476 0.03 ENSRNOT00000045446

chr9_+_43093138 0.03 ENSRNOT00000021592
cyclin and CBS domain divalent metal cation transport mediator 3
chr6_-_107080524 0.03 ENSRNOT00000011662
zinc finger FYVE-type containing 1
chr7_+_141053876 0.03 ENSRNOT00000084674
transmembrane BAX inhibitor motif containing 6
chr1_-_246110218 0.03 ENSRNOT00000077544
regulatory factor X3
chr5_+_152533349 0.02 ENSRNOT00000067524
tripartite motif containing 63
chr1_+_68436917 0.02 ENSRNOT00000088586
leucyl-cystinyl aminopeptidase
chr2_-_3124543 0.02 ENSRNOT00000036547
family with sequence similarity 81, member B
chr6_-_108167185 0.02 ENSRNOT00000015545
aldehyde dehydrogenase 6 family, member A1
chr1_+_154606490 0.02 ENSRNOT00000024095
coiled-coil domain containing 89
chr4_+_145195070 0.02 ENSRNOT00000010723
myotubularin related protein 14
chr7_-_98197087 0.02 ENSRNOT00000010484
ENSRNOT00000079961
kelch-like family member 38
chr9_-_37144015 0.02 ENSRNOT00000015638
PHD finger protein 3
chr9_-_71651512 0.02 ENSRNOT00000032782
pleckstrin homology domain containing M3
chr1_-_13395370 0.02 ENSRNOT00000085519
coiled-coil domain containing 28A
chr1_+_68436593 0.02 ENSRNOT00000080325
leucyl-cystinyl aminopeptidase
chr18_+_65155685 0.02 ENSRNOT00000081797
transcription factor 4
chr1_+_220114228 0.02 ENSRNOT00000026718
cathepsin F
chr13_-_101697684 0.02 ENSRNOT00000078834
BRO1 domain and CAAX motif containing
chr4_-_27331508 0.02 ENSRNOT00000090751
ENSRNOT00000010118
A-kinase anchoring protein 9
chr2_-_234296145 0.02 ENSRNOT00000014155
ELOVL fatty acid elongase 6
chr8_+_111209908 0.02 ENSRNOT00000090221
angiomotin like 2
chr1_-_100845392 0.02 ENSRNOT00000027436
TBC1 domain family, member 17
chr14_+_34455934 0.01 ENSRNOT00000085991
ENSRNOT00000002981
clock circadian regulator
chrX_+_159513800 0.01 ENSRNOT00000065636
HIV-1 Tat specific factor 1
chr1_+_107262659 0.01 ENSRNOT00000022499
growth arrest-specific 2
chr6_+_93462852 0.01 ENSRNOT00000089473
AT-rich interaction domain 4A
chr6_-_124735741 0.01 ENSRNOT00000064716
ENSRNOT00000091693
ribosomal protein S6 kinase A5
chr13_-_113871842 0.01 ENSRNOT00000079549
complement C3b/C4b receptor 1 like
chr14_+_83560541 0.01 ENSRNOT00000057738
ENSRNOT00000085228
phosphoinositide-3-kinase interacting protein 1
chr20_-_4390436 0.01 ENSRNOT00000000497
ENSRNOT00000077655
palmitoyl-protein thioesterase 2
chr4_+_62380914 0.01 ENSRNOT00000029845
transmembrane protein 140
chr8_-_117446019 0.01 ENSRNOT00000042577
ariadne RBR E3 ubiquitin protein ligase 2
chr19_-_25345790 0.01 ENSRNOT00000010050
zinc finger, SWIM-type containing 4
chr1_+_260798239 0.01 ENSRNOT00000036791
ligand dependent nuclear receptor corepressor
chr2_+_34255305 0.01 ENSRNOT00000016649
ENSRNOT00000016596
tripartite motif-containing 23
chr13_+_89597138 0.01 ENSRNOT00000004662
apolipoprotein A2
chr3_-_147865393 0.01 ENSRNOT00000009852
SRY box 12
chrX_-_154722220 0.01 ENSRNOT00000089743
ENSRNOT00000087893
fragile X mental retardation 1
chr18_-_5314511 0.01 ENSRNOT00000022637
ENSRNOT00000079682
zinc finger protein 521
chr6_+_8220228 0.01 ENSRNOT00000079279
ENSRNOT00000048656
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr10_+_11206226 0.01 ENSRNOT00000006979
transcription factor AP-4
chr8_+_104040934 0.01 ENSRNOT00000081204
transcription factor Dp-2
chr15_-_28314459 0.00 ENSRNOT00000042055
ENSRNOT00000040540
NDRG family member 2
chr1_-_134870255 0.00 ENSRNOT00000055829
chromodomain helicase DNA binding protein 2
chr4_+_139670092 0.00 ENSRNOT00000008879
leucine rich repeat neuronal 1
chr3_-_94657377 0.00 ENSRNOT00000077484
t-complex 11 like 1
chr8_-_116469915 0.00 ENSRNOT00000024193
semaphorin 3F
chr16_+_53957858 0.00 ENSRNOT00000013078
FSHD region gene 1
chr10_-_87136026 0.00 ENSRNOT00000014230
ENSRNOT00000083233
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr18_+_3887419 0.00 ENSRNOT00000093089
laminin subunit alpha 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045575 basophil activation(GO:0045575)
0.0 0.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.2 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
0.0 0.0 GO:0009957 epidermal cell fate specification(GO:0009957) neural plate axis specification(GO:0021997)
0.0 0.0 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.0 GO:0035262 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) gonad morphogenesis(GO:0035262) nephrogenic mesenchyme morphogenesis(GO:0072134)
0.0 0.0 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:1990785 response to water-immersion restraint stress(GO:1990785)
0.0 0.2 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.0 GO:0009992 cellular water homeostasis(GO:0009992)
0.0 0.0 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.0 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0 0.1 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0010813 neuropeptide catabolic process(GO:0010813)
0.0 0.1 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035838 growing cell tip(GO:0035838)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.0 GO:0005712 chiasma(GO:0005712)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.0 GO:0005119 smoothened binding(GO:0005119)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway