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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Gli2

Z-value: 0.39

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Transcription factors associated with Gli2

Gene Symbol Gene ID Gene Info
Gli2
ENSRNOG00000007261 GLI family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gli2rn6_v1_chr13_-_35048444_350484440.602.9e-01Click!

Activity profile of Gli2 motif

Sorted Z-values of Gli2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_12658065 0.25 ENSRNOT00000072951
ENSRNOT00000001679
Col6a1
collagen type VI alpha 1 chain
chr7_-_70552897 0.18 ENSRNOT00000080594
Kif5a
kinesin family member 5A
chr1_+_141767940 0.14 ENSRNOT00000064034
Zfp710
zinc finger protein 710
chr3_+_56125924 0.14 ENSRNOT00000011380
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr8_+_116332796 0.13 ENSRNOT00000021408
Hyal1
hyaluronoglucosaminidase 1
chr10_-_27179254 0.12 ENSRNOT00000004619
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr8_-_116531784 0.12 ENSRNOT00000024529
Rbm5
RNA binding motif protein 5
chrX_-_20070537 0.12 ENSRNOT00000093602
ENSRNOT00000003397
Gnl3l
G protein nucleolar 3 like
chr6_+_58468155 0.12 ENSRNOT00000091263
Etv1
ets variant 1
chr6_+_132702448 0.11 ENSRNOT00000005743
Yy1
YY1 transcription factor
chr1_+_215214853 0.11 ENSRNOT00000071235
ENSRNOT00000080442
LOC103690160
SH3 and multiple ankyrin repeat domains protein 2-like
chr2_-_196526886 0.10 ENSRNOT00000077325
Setdb1
SET domain, bifurcated 1
chr8_+_32530806 0.10 ENSRNOT00000083659
Nfrkb
nuclear factor related to kappa B binding protein
chr10_+_58860940 0.10 ENSRNOT00000056551
ENSRNOT00000074523
XAF1
XIAP associated factor-1
chr10_+_104582955 0.09 ENSRNOT00000009733
Unk
unkempt family zinc finger
chr12_+_41385241 0.09 ENSRNOT00000074974
Dtx1
deltex E3 ubiquitin ligase 1
chr9_-_15700235 0.09 ENSRNOT00000088713
ENSRNOT00000035907
Trerf1
transcriptional regulating factor 1
chr17_-_90756048 0.09 ENSRNOT00000085669
Ero1b
endoplasmic reticulum oxidoreductase 1 beta
chr8_-_116532169 0.09 ENSRNOT00000085364
Rbm5
RNA binding motif protein 5
chr14_-_114649173 0.09 ENSRNOT00000083528
Sptbn1
spectrin, beta, non-erythrocytic 1
chr9_+_54558202 0.08 ENSRNOT00000068433
Myo1b
myosin Ib
chr13_-_83202864 0.08 ENSRNOT00000003976
Xcl1
X-C motif chemokine ligand 1
chr10_-_56530842 0.08 ENSRNOT00000077451
AABR07029863.3

chrX_+_53360839 0.07 ENSRNOT00000091467
ENSRNOT00000034372
ENSRNOT00000081061
Dmd
dystrophin
chr5_-_77031120 0.07 ENSRNOT00000022987
Inip
INTS3 and NABP interacting protein
chr7_-_2353875 0.07 ENSRNOT00000074873
LOC100911319
zinc finger protein 36, C3H1 type-like 2-like
chr4_+_122282279 0.07 ENSRNOT00000038244
Zxdc
ZXD family zinc finger C
chr14_-_80169431 0.07 ENSRNOT00000079769
ENSRNOT00000058315
Ablim2
actin binding LIM protein family, member 2
chr17_-_90755852 0.07 ENSRNOT00000003526
Ero1b
endoplasmic reticulum oxidoreductase 1 beta
chr18_+_56887354 0.07 ENSRNOT00000044346
ENSRNOT00000066133
Csnk1a1
casein kinase 1, alpha 1
chr15_-_86105273 0.07 ENSRNOT00000012600
ENSRNOT00000064942
Tbc1d4
TBC1 domain family, member 4
chr16_+_23668595 0.07 ENSRNOT00000067886
Psd3
pleckstrin and Sec7 domain containing 3
chr18_+_56887722 0.06 ENSRNOT00000078783
Csnk1a1
casein kinase 1, alpha 1
chr5_+_135962911 0.06 ENSRNOT00000087353
Ptch2
patched 2
chrX_+_29157470 0.06 ENSRNOT00000081986
LOC100910245
ribose-phosphate pyrophosphokinase 2-like
chr12_-_44999074 0.06 ENSRNOT00000079177
ENSRNOT00000038293
Vsig10
V-set and immunoglobulin domain containing 10
chr9_-_111220651 0.06 ENSRNOT00000016028
Gin1
gypsy retrotransposon integrase 1
chr7_+_2718700 0.06 ENSRNOT00000050792
Pan2
PAN2 poly(A) specific ribonuclease subunit
chr12_+_21721837 0.05 ENSRNOT00000073353
Mepce
methylphosphate capping enzyme
chr9_-_43022998 0.05 ENSRNOT00000063781
ENSRNOT00000089843
Lman2l
lectin, mannose-binding 2-like
chr8_-_22821397 0.05 ENSRNOT00000045488
Kank2
KN motif and ankyrin repeat domains 2
chr14_+_39661968 0.05 ENSRNOT00000064779
Gabra2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr1_-_281756159 0.05 ENSRNOT00000013170
Prlhr
prolactin releasing hormone receptor
chr3_-_11410732 0.05 ENSRNOT00000034930
RGD1561113
similar to Hypothetical UPF0184 protein C9orf16 homolog
chr8_+_22050222 0.05 ENSRNOT00000028096
Icam5
intercellular adhesion molecule 5
chr9_+_111220858 0.04 ENSRNOT00000076669
Ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr10_-_13580821 0.04 ENSRNOT00000009735
Ntn3
netrin 3
chr5_-_165442048 0.04 ENSRNOT00000049822
Tardbp
TAR DNA binding protein
chr7_-_11257977 0.04 ENSRNOT00000027932
Tbxa2r
thromboxane A2 receptor
chrX_+_73390903 0.04 ENSRNOT00000077002
Zfp449
zinc finger protein 449
chr2_+_125752130 0.04 ENSRNOT00000038703
Fat4
FAT atypical cadherin 4
chr1_+_60106034 0.04 ENSRNOT00000014930
AC091336.1

chr6_+_79254339 0.04 ENSRNOT00000073970
Sstr1
somatostatin receptor 1
chr14_+_60123169 0.04 ENSRNOT00000006610
Sel1l3
SEL1L family member 3
chr19_-_25288335 0.04 ENSRNOT00000050214
Nanos3
nanos C2HC-type zinc finger 3
chr2_-_196527127 0.04 ENSRNOT00000028709
Setdb1
SET domain, bifurcated 1
chr8_-_22821223 0.04 ENSRNOT00000014135
Kank2
KN motif and ankyrin repeat domains 2
chr3_+_61658245 0.04 ENSRNOT00000033511
Hoxd3
homeo box D3
chr10_+_89089646 0.04 ENSRNOT00000027505
Cntnap1
contactin associated protein 1
chr3_-_112371664 0.04 ENSRNOT00000079606
ENSRNOT00000012636
LOC100910478
leucine-rich repeat-containing protein 57-like
chr5_-_144341586 0.03 ENSRNOT00000014586
Adprhl2
ADP-ribosylhydrolase like 2
chr7_+_66595742 0.03 ENSRNOT00000031191
Usp15
ubiquitin specific peptidase 15
chr14_-_16452890 0.03 ENSRNOT00000067222
ENSRNOT00000091577
Sept11
septin 11
chr8_-_103554399 0.03 ENSRNOT00000079965
ENSRNOT00000089833
LOC100909709
short transient receptor potential channel 1-like
chr10_+_103934797 0.03 ENSRNOT00000035865
Cdr2l
cerebellar degeneration-related protein 2-like
chr20_+_3555135 0.03 ENSRNOT00000085380
Ddr1
discoidin domain receptor tyrosine kinase 1
chr19_-_11263980 0.03 ENSRNOT00000025086
Nup93
nucleoporin 93
chr17_+_16333415 0.03 ENSRNOT00000060550
Ptpdc1
protein tyrosine phosphatase domain containing 1
chr5_-_144996431 0.03 ENSRNOT00000016992
Zmym4
zinc finger MYM-type containing 4
chr8_+_49354115 0.02 ENSRNOT00000032837
Mpzl3
myelin protein zero-like 3
chr3_-_165741967 0.02 ENSRNOT00000017063
Zfp64
zinc finger protein 64
chr7_+_120125633 0.02 ENSRNOT00000012480
Sh3bp1
SH3-domain binding protein 1
chr1_+_85112834 0.02 ENSRNOT00000026107
Dyrk1b
dual specificity tyrosine phosphorylation regulated kinase 1B
chr1_+_221099998 0.02 ENSRNOT00000028262
Ltbp3
latent transforming growth factor beta binding protein 3
chr4_+_168689163 0.02 ENSRNOT00000049848
Cdkn1b
cyclin-dependent kinase inhibitor 1B
chr18_-_28017925 0.02 ENSRNOT00000075420
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr10_-_90265017 0.02 ENSRNOT00000064283
ENSRNOT00000048418
Ubtf
upstream binding transcription factor, RNA polymerase I
chr3_-_95418679 0.02 ENSRNOT00000018074
Rcn1
reticulocalbin 1
chr10_-_88533829 0.02 ENSRNOT00000080521
Dnajc7
DnaJ heat shock protein family (Hsp40) member C7
chr5_+_171441560 0.02 ENSRNOT00000019873
Wrap73
WD repeat containing, antisense to TP73
chr20_+_12773427 0.02 ENSRNOT00000001695
Col6a2
collagen type VI alpha 2 chain
chr19_+_10519493 0.02 ENSRNOT00000030229
Ccdc102a
coiled-coil domain containing 102A
chr9_+_47386626 0.01 ENSRNOT00000021270
Slc9a2
solute carrier family 9 member A2
chr9_-_11108741 0.01 ENSRNOT00000072357
Ccdc94
coiled-coil domain containing 94
chr3_+_170354141 0.01 ENSRNOT00000005901
Fam210b
family with sequence similarity 210, member B
chr20_-_2652952 0.01 ENSRNOT00000078871
C4a
complement component 4A (Rodgers blood group)
chr6_+_12253788 0.01 ENSRNOT00000061675
Ppp1r21
protein phosphatase 1, regulatory subunit 21
chr2_+_18937458 0.01 ENSRNOT00000022377
Tmem167a
transmembrane protein 167A
chr14_-_43072843 0.01 ENSRNOT00000064263
Limch1
LIM and calponin homology domains 1
chr7_-_11443357 0.01 ENSRNOT00000082126
Zbtb7a
zinc finger and BTB domain containing 7a
chr3_+_172719432 0.01 ENSRNOT00000033863
Zfp831
zinc finger protein 831
chrX_+_20216587 0.01 ENSRNOT00000073114
AABR07037412.2
FYVE, RhoGEF and PH domain-containing protein 1
chrX_-_14642424 0.01 ENSRNOT00000004808
Dynlt3
dynein light chain Tctex-type 3
chr5_-_144274981 0.01 ENSRNOT00000065871
Map7d1
MAP7 domain containing 1
chr1_-_59347472 0.01 ENSRNOT00000017718
Lnpep
leucyl and cystinyl aminopeptidase
chr17_-_27452314 0.01 ENSRNOT00000018936
Riok1
RIO kinase 1
chr4_+_168976859 0.01 ENSRNOT00000068663
Fam234b
family with sequence similarity 234, member B
chr20_+_5933303 0.01 ENSRNOT00000000617
Mapk14
mitogen activated protein kinase 14
chr3_-_112385528 0.01 ENSRNOT00000049756
Lrrc57
leucine rich repeat containing 57
chr18_+_83471342 0.01 ENSRNOT00000019384
Neto1
neuropilin and tolloid like 1
chr5_+_67708676 0.01 ENSRNOT00000075061
AABR07048211.1

chr4_+_6559545 0.01 ENSRNOT00000067183
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
chr3_+_112371677 0.01 ENSRNOT00000013316
LOC100912076
HAUS augmin-like complex subunit 2-like
chr6_+_7900972 0.01 ENSRNOT00000006953
ENSRNOT00000068030
Dync2li1
dynein cytoplasmic 2 light intermediate chain 1
chr8_-_107380933 0.01 ENSRNOT00000022179
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr20_-_4401610 0.01 ENSRNOT00000091468
Ppt2
palmitoyl-protein thioesterase 2
chr1_+_68436917 0.00 ENSRNOT00000088586
LOC108348118
leucyl-cystinyl aminopeptidase
chr10_+_57462447 0.00 ENSRNOT00000041443
Rabep1
rabaptin, RAB GTPase binding effector protein 1
chr12_-_17972737 0.00 ENSRNOT00000001783
Fam20c
FAM20C, golgi associated secretory pathway kinase
chr5_-_72000318 0.00 ENSRNOT00000029187
AABR07048308.1

chr9_-_100624638 0.00 ENSRNOT00000051155
Hdlbp
high density lipoprotein binding protein
chr10_+_107502695 0.00 ENSRNOT00000038088
Engase
endo-beta-N-acetylglucosaminidase
chr1_+_221043119 0.00 ENSRNOT00000028185
Map3k11
mitogen-activated protein kinase kinase kinase 11
chr9_-_84101172 0.00 ENSRNOT00000018652
Pax3
paired box 3
chr14_+_89253373 0.00 ENSRNOT00000035922
LOC688553
hypothetical protein LOC688553
chr7_+_80351774 0.00 ENSRNOT00000081948
Oxr1
oxidation resistance 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Gli2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.2 GO:0030070 insulin processing(GO:0030070)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0034696 response to prostaglandin F(GO:0034696)
0.0 0.1 GO:2000537 immunoglobulin production in mucosal tissue(GO:0002426) T-helper 1 cell activation(GO:0035711) granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) regulation of thymocyte migration(GO:2000410) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0021627 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
0.0 0.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.1 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.1 GO:0090073 negative regulation of protein sumoylation(GO:0033234) positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0042048 olfactory behavior(GO:0042048)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0036117 hyaluranon cable(GO:0036117)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.0 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829)
0.0 0.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation