Project

GSE49485: Hypoxia transcriptome sequencing of rat brain.

Navigation
Downloads

Results for Hif1a

Z-value: 0.83

Motif logo

logo of

Transcription factors associated with Hif1a

Gene Symbol Gene ID Gene Info
Hif1a
ENSRNOG00000008292 hypoxia inducible factor 1 alpha subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hif1arn6_v1_chr6_+_96810907_968109070.741.5e-01Click!

Activity profile of Hif1a motif

Sorted Z-values of Hif1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_4362717 0.92 ENSRNOT00000002887
Barhl2
BarH-like homeobox 2
chr7_-_13751271 0.91 ENSRNOT00000009931
Slc1a6
solute carrier family 1 member 6
chr17_-_9695292 0.61 ENSRNOT00000036162
Prr7
proline rich 7 (synaptic)
chr3_+_147585947 0.56 ENSRNOT00000006833
Scrt2
scratch family transcriptional repressor 2
chr10_+_59529785 0.56 ENSRNOT00000064840
ENSRNOT00000065181
Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr16_+_49462889 0.38 ENSRNOT00000039909
Ankrd37
ankyrin repeat domain 37
chr1_+_33910912 0.36 ENSRNOT00000044690
Irx1
iroquois homeobox 1
chr20_-_29511382 0.35 ENSRNOT00000085026
Ddit4
DNA-damage-inducible transcript 4
chr7_-_119441487 0.33 ENSRNOT00000067635
Pvalb
parvalbumin
chr2_-_197991198 0.32 ENSRNOT00000056322
Ciart
circadian associated repressor of transcription
chr2_-_197991574 0.31 ENSRNOT00000085632
Ciart
circadian associated repressor of transcription
chr1_+_163445527 0.31 ENSRNOT00000020520
Lrrc32
leucine rich repeat containing 32
chr15_-_28406046 0.22 ENSRNOT00000015418
Zfp219
zinc finger protein 219
chr20_-_13706205 0.21 ENSRNOT00000038623
Derl3
derlin 3
chr10_-_104054805 0.20 ENSRNOT00000004853
Nt5c
5', 3'-nucleotidase, cytosolic
chr8_-_104221342 0.19 ENSRNOT00000015476
Atp1b3
ATPase Na+/K+ transporting subunit beta 3
chr20_+_46429222 0.18 ENSRNOT00000076818
Foxo3
forkhead box O3
chr12_+_52359310 0.17 ENSRNOT00000071857
ENSRNOT00000065893
Fbrsl1
fibrosin-like 1
chr1_+_12823363 0.17 ENSRNOT00000086790
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr6_+_137997335 0.15 ENSRNOT00000006872
Tmem121
transmembrane protein 121
chr3_+_151032952 0.15 ENSRNOT00000064013
Acss2
acyl-CoA synthetase short-chain family member 2
chr1_-_174378926 0.15 ENSRNOT00000018309
Tmem9b
TMEM9 domain family, member B
chr1_+_86873253 0.14 ENSRNOT00000071239
Fbxo27
F-box protein 27
chr12_-_31323810 0.14 ENSRNOT00000001247
Ran
RAN, member RAS oncogene family
chr14_-_37770059 0.14 ENSRNOT00000029721
Slc10a4
solute carrier family 10, member 4
chr11_+_84321078 0.14 ENSRNOT00000058043
Map6d1
MAP6 domain containing 1
chr16_-_75855745 0.14 ENSRNOT00000031291
Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr1_-_211265161 0.13 ENSRNOT00000080041
ENSRNOT00000023477
Bnip3
BCL2 interacting protein 3
chr20_+_11393877 0.13 ENSRNOT00000001625
Pfkl
phosphofructokinase, liver type
chr17_-_27112820 0.12 ENSRNOT00000018359
Bmp6
bone morphogenetic protein 6
chr2_-_23097610 0.11 ENSRNOT00000075286
Jmy
junction-mediating and regulatory protein
chr8_-_36314811 0.11 ENSRNOT00000013243
St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr3_-_5976244 0.11 ENSRNOT00000009893
Vav2
vav guanine nucleotide exchange factor 2
chr3_+_147643250 0.10 ENSRNOT00000000013
Tcf15
transcription factor 15
chr11_+_80255790 0.10 ENSRNOT00000002522
Bcl6
B-cell CLL/lymphoma 6
chr2_-_84531192 0.10 ENSRNOT00000065312
ENSRNOT00000090540
Ropn1l
rhophilin associated tail protein 1-like
chr20_+_11972381 0.09 ENSRNOT00000001642
Adarb1
adenosine deaminase, RNA-specific, B1
chrX_+_106523278 0.08 ENSRNOT00000070802
MGC109340
similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23)
chr10_-_29450644 0.08 ENSRNOT00000087937
Adra1b
adrenoceptor alpha 1B
chr5_+_147069616 0.08 ENSRNOT00000072908
Trim62
tripartite motif-containing 62
chr4_-_157679962 0.07 ENSRNOT00000050443
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr7_-_97759852 0.07 ENSRNOT00000007484
Derl1
derlin 1
chr3_-_5975734 0.07 ENSRNOT00000081376
Vav2
vav guanine nucleotide exchange factor 2
chr3_-_176958880 0.07 ENSRNOT00000078661
Zbtb46
zinc finger and BTB domain containing 46
chr16_+_9563218 0.07 ENSRNOT00000035915
Arhgap22
Rho GTPase activating protein 22
chr1_-_146029840 0.07 ENSRNOT00000016455
Mesdc1
mesoderm development candidate 1
chr16_+_19896986 0.07 ENSRNOT00000060355
Gtpbp3
GTP binding protein 3
chr20_+_6018374 0.07 ENSRNOT00000000621
Mapk13
mitogen activated protein kinase 13
chr14_+_61136746 0.07 ENSRNOT00000005126
Dhx15
DEAH-box helicase 15
chr1_-_85220237 0.06 ENSRNOT00000026907
Sycn
syncollin
chr13_-_109629482 0.06 ENSRNOT00000072452
Flvcr1
feline leukemia virus subgroup C cellular receptor 1
chr14_-_11198194 0.06 ENSRNOT00000003083
Enoph1
enolase-phosphatase 1
chr4_+_117235023 0.06 ENSRNOT00000021030
Cct7
chaperonin containing TCP1 subunit 7
chr15_-_19655381 0.06 ENSRNOT00000009404
Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
chr1_+_127802978 0.06 ENSRNOT00000055877
Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr7_+_143810892 0.06 ENSRNOT00000016240
Znf740
zinc finger protein 740
chr3_+_93495106 0.06 ENSRNOT00000029922
ENSRNOT00000085760
Abtb2
ankyrin repeat and BTB domain containing 2
chr5_+_169506138 0.06 ENSRNOT00000014904
Rpl22
ribosomal protein L22
chr2_+_9526209 0.06 ENSRNOT00000021818
Lysmd3
LysM domain containing 3
chr8_+_116325286 0.05 ENSRNOT00000017461
Hyal2
hyaluronoglucosaminidase 2
chr14_+_77322012 0.05 ENSRNOT00000088600
ENSRNOT00000041639
Zbtb49
zinc finger and BTB domain containing 49
chr14_-_86333424 0.05 ENSRNOT00000083191
Nudcd3
NudC domain containing 3
chr10_+_55687050 0.05 ENSRNOT00000057136
Per1
period circadian clock 1
chr7_+_116943057 0.05 ENSRNOT00000056527
Tigd5
tigger transposable element derived 5
chr4_-_117234928 0.05 ENSRNOT00000073135
Pradc1
protease-associated domain containing 1
chr3_+_164822111 0.05 ENSRNOT00000014568
Pard6b
par-6 family cell polarity regulator beta
chr9_+_82033543 0.04 ENSRNOT00000023439
Wnt6
wingless-type MMTV integration site family, member 6
chr7_+_130431213 0.04 ENSRNOT00000055792
Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr9_-_16612136 0.04 ENSRNOT00000023495
Mea1
male-enhanced antigen 1
chr7_-_11824742 0.04 ENSRNOT00000051467
Dot1l
DOT1 like histone lysine methyltransferase
chr11_+_7210209 0.04 ENSRNOT00000076695
Gbe1
1,4-alpha-glucan branching enzyme 1
chr1_-_222178725 0.04 ENSRNOT00000028697
Esrra
estrogen related receptor, alpha
chr20_-_19825150 0.04 ENSRNOT00000032159
Ccdc6
coiled-coil domain containing 6
chr5_-_78379346 0.04 ENSRNOT00000020625
Alad
aminolevulinate dehydratase
chr3_+_9643047 0.04 ENSRNOT00000035805
Ntmt1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chr2_-_43393207 0.04 ENSRNOT00000017968
LOC100912399
mitogen-activated protein kinase kinase kinase 1-like
chr9_+_16612433 0.04 ENSRNOT00000023979
Klhdc3
kelch domain containing 3
chr10_-_58973020 0.03 ENSRNOT00000020379
Smtnl2
smoothelin-like 2
chr7_-_75422268 0.03 ENSRNOT00000080218
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr17_-_75886523 0.03 ENSRNOT00000046266
Usp6nl
USP6 N-terminal like
chr4_-_17594598 0.03 ENSRNOT00000008936
Sema3e
semaphorin 3E
chr10_-_59049482 0.03 ENSRNOT00000078272
Spns2
spinster homolog 2
chr1_+_219759183 0.03 ENSRNOT00000026316
Pc
pyruvate carboxylase
chr12_+_25093149 0.03 ENSRNOT00000050059
Eif4h
eukaryotic translation initiation factor 4H
chr12_+_39253409 0.03 ENSRNOT00000001774
Camkk2
calcium/calmodulin-dependent protein kinase kinase 2
chr1_+_165170645 0.03 ENSRNOT00000022879
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr4_+_29639154 0.03 ENSRNOT00000073687
Casd1
CAS1 domain containing 1
chr1_+_102900286 0.03 ENSRNOT00000017468
Ldha
lactate dehydrogenase A
chr7_-_134560713 0.02 ENSRNOT00000006621
Yaf2
YY1 associated factor 2
chr8_-_6203515 0.02 ENSRNOT00000087278
ENSRNOT00000031189
ENSRNOT00000008074
ENSRNOT00000085285
ENSRNOT00000007866
Yap1
yes-associated protein 1
chr6_+_128750795 0.02 ENSRNOT00000005781
Glrx5
glutaredoxin 5
chr9_+_15068399 0.02 ENSRNOT00000064229
ENSRNOT00000087107
Foxp4
forkhead box P4
chr19_-_55367353 0.02 ENSRNOT00000091139
Piezo1
piezo-type mechanosensitive ion channel component 1
chr4_+_140886545 0.02 ENSRNOT00000088273
Edem1
ER degradation enhancing alpha-mannosidase like protein 1
chr9_-_61690956 0.02 ENSRNOT00000066589
Hspd1
heat shock protein family D member 1
chr9_-_16611899 0.02 ENSRNOT00000089168
Mea1
male-enhanced antigen 1
chr14_+_60657686 0.01 ENSRNOT00000070892
Sepsecs
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr2_-_148891900 0.01 ENSRNOT00000018488
Siah2
siah E3 ubiquitin protein ligase 2
chr8_+_114897011 0.01 ENSRNOT00000074683
Twf2
twinfilin actin-binding protein 2
chr10_+_4411766 0.01 ENSRNOT00000003213
LOC100911685
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr5_-_136748980 0.01 ENSRNOT00000026844
Ipo13
importin 13
chr1_-_101457126 0.01 ENSRNOT00000087061
ENSRNOT00000028328
Bax
BCL2 associated X, apoptosis regulator
chr10_+_39435227 0.01 ENSRNOT00000042144
ENSRNOT00000077185
P4ha2
prolyl 4-hydroxylase subunit alpha 2
chr1_-_91832058 0.01 ENSRNOT00000079088
Nudt19
nudix hydrolase 19
chr14_+_83510278 0.00 ENSRNOT00000081161
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr3_+_103726238 0.00 ENSRNOT00000006776
Lpcat4
lysophosphatidylcholine acyltransferase 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 0.9 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.2 GO:0006083 acetate metabolic process(GO:0006083) propionate metabolic process(GO:0019541)
0.0 0.2 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.2 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.0 0.2 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.0 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.0 0.1 GO:0061744 motor behavior(GO:0061744)
0.0 0.1 GO:2000860 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.4 GO:0045820 negative regulation of glycolytic process(GO:0045820)
0.0 0.1 GO:0001982 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) positive regulation of glycogen catabolic process(GO:0045819)
0.0 0.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 0.6 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0032763 regulation of mast cell cytokine production(GO:0032763) regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.9 GO:0001709 cell fate determination(GO:0001709)
0.0 0.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.0 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.0 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.2 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.1 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.0 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.0 GO:0004655 porphobilinogen synthase activity(GO:0004655)
0.0 0.0 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.0 GO:0004736 pyruvate carboxylase activity(GO:0004736)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation