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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hnf1a

Z-value: 0.48

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Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
Hnf1a
ENSRNOG00000001183 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1arn6_v1_chr12_+_47407811_474078110.128.5e-01Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_32153794 0.32 ENSRNOT00000005348
Tmem27
transmembrane protein 27
chr14_-_19132208 0.30 ENSRNOT00000060535
Afm
afamin
chr14_+_84231639 0.14 ENSRNOT00000066362
Gal3st1
galactose-3-O-sulfotransferase 1
chr19_-_39267928 0.14 ENSRNOT00000027686
Tmed6
transmembrane p24 trafficking protein 6
chr8_+_22856539 0.13 ENSRNOT00000015381
Angptl8
angiopoietin-like 8
chr4_+_66670618 0.11 ENSRNOT00000010796
Tbxas1
thromboxane A synthase 1
chr6_-_127534247 0.11 ENSRNOT00000012500
Serpina6
serpin family A member 6
chr5_-_68059933 0.08 ENSRNOT00000088716
Plppr1
phospholipid phosphatase related 1
chr13_-_50549981 0.08 ENSRNOT00000003918
ENSRNOT00000080486
Golt1a
golgi transport 1A
chr3_-_54625414 0.08 ENSRNOT00000037133
Stk39
serine threonine kinase 39
chr8_-_72204730 0.08 ENSRNOT00000023810
Fbxl22
F-box and leucine-rich repeat protein 22
chr14_-_80973456 0.08 ENSRNOT00000013257
Hgfac
HGF activator
chr9_+_95295701 0.07 ENSRNOT00000025045
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chr18_+_51492196 0.07 ENSRNOT00000020570
Gramd3
GRAM domain containing 3
chr15_-_61772516 0.07 ENSRNOT00000015605
ENSRNOT00000093399
Wbp4
WW domain binding protein 4
chr20_-_5123073 0.07 ENSRNOT00000001126
Apom
apolipoprotein M
chr13_-_91776397 0.07 ENSRNOT00000073147
Mptx1
mucosal pentraxin 1
chr3_+_159902441 0.07 ENSRNOT00000089893
ENSRNOT00000011978
Hnf4a
hepatocyte nuclear factor 4, alpha
chr5_-_79008363 0.07 ENSRNOT00000010040
Kif12
kinesin family member 12
chr11_-_17684903 0.07 ENSRNOT00000051213
Tmprss15
transmembrane protease, serine 15
chr1_+_277068761 0.07 ENSRNOT00000044183
ENSRNOT00000022382
Habp2
hyaluronan binding protein 2
chr14_-_19191863 0.07 ENSRNOT00000003921
Alb
albumin
chr2_-_88553086 0.06 ENSRNOT00000042494
LOC361914
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr14_+_87448692 0.06 ENSRNOT00000077177
Igfbp1
insulin-like growth factor binding protein 1
chr3_-_14229067 0.06 ENSRNOT00000025534
ENSRNOT00000092865
C5
complement C5
chr14_-_19159923 0.06 ENSRNOT00000003879
Afp
alpha-fetoprotein
chr5_+_33784715 0.06 ENSRNOT00000035685
Slc7a13
solute carrier family 7 member 13
chr2_-_88660449 0.06 ENSRNOT00000051741
Slc7a12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr1_-_48563776 0.06 ENSRNOT00000023368
Plg
plasminogen
chr2_+_56887987 0.05 ENSRNOT00000041288
Gdnf
glial cell derived neurotrophic factor
chr10_+_57125961 0.05 ENSRNOT00000029230
Gltpd2
glycolipid transfer protein domain containing 2
chr19_+_12097632 0.05 ENSRNOT00000049452
Ces5a
carboxylesterase 5A
chr20_-_5037022 0.05 ENSRNOT00000091022
ENSRNOT00000060762
Msh5
mutS homolog 5
chr3_-_127500709 0.05 ENSRNOT00000006330
Hao1
hydroxyacid oxidase 1
chr2_-_170301348 0.05 ENSRNOT00000088131
Si
sucrase-isomaltase
chr20_+_13498926 0.05 ENSRNOT00000070992
ENSRNOT00000045375
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chrX_+_119390013 0.05 ENSRNOT00000074269
Agtr2
angiotensin II receptor, type 2
chr2_-_182035032 0.05 ENSRNOT00000009813
Fgb
fibrinogen beta chain
chr12_-_39667849 0.05 ENSRNOT00000011499
Arpc3
actin related protein 2/3 complex, subunit 3
chr13_-_53870428 0.05 ENSRNOT00000000812
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr11_+_64882288 0.04 ENSRNOT00000077727
Pla1a
phospholipase A1 member A
chr13_-_47377703 0.04 ENSRNOT00000005461
C4bpa
complement component 4 binding protein, alpha
chr20_-_27117663 0.04 ENSRNOT00000000434
Pbld1
phenazine biosynthesis-like protein domain containing 1
chr2_-_158156444 0.04 ENSRNOT00000088559
Veph1
ventricular zone expressed PH domain-containing 1
chrX_+_71272042 0.04 ENSRNOT00000076034
ENSRNOT00000076816
Gjb1
gap junction protein, beta 1
chr8_-_77398156 0.04 ENSRNOT00000091858
ENSRNOT00000085349
ENSRNOT00000082763
Lipc
lipase C, hepatic type
chr6_+_101603319 0.04 ENSRNOT00000030470
Gphn
gephyrin
chr6_-_26385761 0.04 ENSRNOT00000073228
Gckr
glucokinase regulator
chr1_+_88955135 0.04 ENSRNOT00000083550
Prodh2
proline dehydrogenase 2
chr2_-_100372252 0.04 ENSRNOT00000011890
Hnf4g
hepatocyte nuclear factor 4, gamma
chr10_-_71491743 0.04 ENSRNOT00000038955
LOC102552988
uncharacterized LOC102552988
chr6_+_107603580 0.04 ENSRNOT00000036430
Dnal1
dynein, axonemal, light chain 1
chr3_+_159936856 0.04 ENSRNOT00000078703
Hnf4a
hepatocyte nuclear factor 4, alpha
chr10_+_89286047 0.04 ENSRNOT00000085831
G6pc
glucose-6-phosphatase, catalytic subunit
chr2_+_182006242 0.04 ENSRNOT00000064091
Fga
fibrinogen alpha chain
chr1_-_248898607 0.04 ENSRNOT00000074393
NEWGENE_1307313
dickkopf WNT signaling pathway inhibitor 1
chr7_+_58814805 0.03 ENSRNOT00000005909
Tspan8
tetraspanin 8
chr3_-_80543031 0.03 ENSRNOT00000022233
F2
coagulation factor II
chr1_+_221470674 0.03 ENSRNOT00000054835
Naaladl1
N-acetylated alpha-linked acidic dipeptidase-like 1
chrX_+_112270986 0.03 ENSRNOT00000091441
ENSRNOT00000082652
Vsig1
V-set and immunoglobulin domain containing 1
chr14_+_32257805 0.03 ENSRNOT00000039626
AABR07014804.1

chr4_-_51199570 0.03 ENSRNOT00000010788
Slc13a1
solute carrier family 13 member 1
chr3_+_117421604 0.03 ENSRNOT00000008860
ENSRNOT00000008857
Slc12a1
solute carrier family 12 member 1
chr1_+_250426158 0.03 ENSRNOT00000067643
A1cf
APOBEC1 complementation factor
chr6_-_127620296 0.03 ENSRNOT00000012577
Serpina1
serpin family A member 1
chr8_-_127912860 0.03 ENSRNOT00000040498
LOC685081
similar to solute carrier family 22 (organic cation transporter), member 13
chr2_-_88763733 0.03 ENSRNOT00000059424
LOC688389
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr3_-_150885475 0.03 ENSRNOT00000034708
ENSRNOT00000038809
Pigu
phosphatidylinositol glycan anchor biosynthesis, class U
chr10_-_85974644 0.03 ENSRNOT00000006098
ENSRNOT00000082974
Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
chr2_-_158156150 0.02 ENSRNOT00000016621
Veph1
ventricular zone expressed PH domain-containing 1
chr20_+_41266566 0.02 ENSRNOT00000000653
Frk
fyn-related Src family tyrosine kinase
chr14_-_82975263 0.02 ENSRNOT00000024165
Slc5a1
solute carrier family 5 member 1
chr19_+_568287 0.02 ENSRNOT00000016419
Cdh16
cadherin 16
chr2_-_166682325 0.02 ENSRNOT00000091198
ENSRNOT00000012422
Sptssb
serine palmitoyltransferase, small subunit B
chr13_+_49005405 0.02 ENSRNOT00000092560
ENSRNOT00000076457
Lemd1
LEM domain containing 1
chr14_-_86560694 0.02 ENSRNOT00000075827
Npc1l1
NPC1 like intracellular cholesterol transporter 1
chr8_+_119382011 0.02 ENSRNOT00000056060
Lrrfip2
LRR binding FLII interacting protein 2
chr7_-_68549763 0.02 ENSRNOT00000078014
Slc16a7
solute carrier family 16 member 7
chr1_+_88955440 0.02 ENSRNOT00000091101
Prodh2
proline dehydrogenase 2
chr6_-_127508452 0.01 ENSRNOT00000073709
LOC100909524
protein Z-dependent protease inhibitor-like
chr4_+_68849033 0.01 ENSRNOT00000016912
Mgam
maltase-glucoamylase
chr20_-_13458110 0.01 ENSRNOT00000072183
Slc5a4
solute carrier family 5 member 4
chr6_-_25507073 0.01 ENSRNOT00000061176
Plb1
phospholipase B1
chr1_+_214203861 0.01 ENSRNOT00000023219
Rassf7
Ras association domain family member 7
chr17_-_69711689 0.01 ENSRNOT00000041925
Akr1c12
aldo-keto reductase family 1, member C12
chr3_-_11452529 0.00 ENSRNOT00000020206
Slc25a25
solute carrier family 25 member 25
chr1_+_213511874 0.00 ENSRNOT00000078080
ENSRNOT00000016883
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr9_-_88534710 0.00 ENSRNOT00000020880
Tm4sf20
transmembrane 4 L six family member 20
chr3_+_80081647 0.00 ENSRNOT00000057161
Arfgap2
ADP-ribosylation factor GTPase activating protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.0 0.1 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.1 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441) negative regulation of lipoprotein oxidation(GO:0034443)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:1904975 response to bleomycin(GO:1904975)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.0 GO:0032304 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) negative regulation of icosanoid secretion(GO:0032304) regulation of metanephros size(GO:0035566)
0.0 0.0 GO:0045959 negative regulation of complement activation, classical pathway(GO:0045959)
0.0 0.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.1 GO:0072106 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0072108)
0.0 0.0 GO:0051594 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.1 GO:0001907 killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004) response to platinum ion(GO:0070541)
0.0 0.0 GO:1905225 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) response to thyrotropin-releasing hormone(GO:1905225)
0.0 0.0 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
0.0 0.0 GO:0033986 response to methanol(GO:0033986)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.1 GO:0031714 C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.0 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.1 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.1 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.0 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.0 0.0 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate