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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hsf1

Z-value: 0.65

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Transcription factors associated with Hsf1

Gene Symbol Gene ID Gene Info
Hsf1
ENSRNOG00000021732 heat shock transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hsf1rn6_v1_chr7_+_117538523_1175385230.158.1e-01Click!

Activity profile of Hsf1 motif

Sorted Z-values of Hsf1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_23841049 0.28 ENSRNOT00000031555
Hspb1
heat shock protein family B (small) member 1
chr1_+_80135391 0.22 ENSRNOT00000021893
Gpr4
G protein-coupled receptor 4
chr7_+_11737293 0.18 ENSRNOT00000046059
Lingo3
leucine rich repeat and Ig domain containing 3
chr3_+_154043873 0.15 ENSRNOT00000072502
ENSRNOT00000034166
Nnat
neuronatin
chr7_-_59763219 0.15 ENSRNOT00000041210
RGD1564883
similar to 60S ribosomal protein L12
chr1_-_164308317 0.15 ENSRNOT00000022983
Serpinh1
serpin family H member 1
chr20_+_295250 0.15 ENSRNOT00000000955
Clic2
chloride intracellular channel 2
chr7_-_125497691 0.15 ENSRNOT00000049445
AABR07058578.1

chr20_+_3149114 0.14 ENSRNOT00000084770
RT1-N2
RT1 class Ib, locus N2
chr1_-_154170409 0.13 ENSRNOT00000089014
Hikeshi
Hikeshi, heat shock protein nuclear import factor
chr4_-_161757447 0.13 ENSRNOT00000008737
Fkbp4
FK506 binding protein 4
chr12_-_6341902 0.13 ENSRNOT00000001201
Hsph1
heat shock protein family H (Hsp110) member 1
chr10_-_105787803 0.13 ENSRNOT00000064671
Jmjd6
jumonji domain containing 6
chr5_-_139864393 0.13 ENSRNOT00000030016
Zfp69
zinc finger protein 69
chr5_+_57028467 0.13 ENSRNOT00000010061
Dnaja1
DnaJ heat shock protein family (Hsp40) member A1
chr2_-_187668677 0.12 ENSRNOT00000056898
ENSRNOT00000092563
Tsacc
TSSK6 activating co-chaperone
chr1_-_222293148 0.11 ENSRNOT00000028743
Stip1
stress-induced phosphoprotein 1
chr20_+_28920616 0.11 ENSRNOT00000070897
P4ha1
prolyl 4-hydroxylase subunit alpha 1
chr11_+_37798370 0.11 ENSRNOT00000002679
Bace2
beta-site APP-cleaving enzyme 2
chr20_-_12938891 0.11 ENSRNOT00000017141
RGD1564149
similar to Protein C21orf58
chr5_-_151768123 0.10 ENSRNOT00000079380
Nudc
nuclear distribution C, dynein complex regulator
chr5_+_58393233 0.09 ENSRNOT00000000142
Dnajb5
DnaJ heat shock protein family (Hsp40) member B5
chr5_+_169357517 0.09 ENSRNOT00000000079
Acot7
acyl-CoA thioesterase 7
chr2_-_251532312 0.09 ENSRNOT00000019501
Cyr61
cysteine-rich, angiogenic inducer, 61
chr1_-_12952906 0.08 ENSRNOT00000078193
LOC100360362
hypothetical protein LOC100360362
chr11_+_64472072 0.08 ENSRNOT00000042756
RGD1563835
similar to ribosomal protein L27
chrX_-_112328642 0.08 ENSRNOT00000083150
Psmd10
proteasome 26S subunit, non-ATPase 10
chr20_-_32133431 0.08 ENSRNOT00000000443
Srgn
serglycin
chr14_-_17225389 0.07 ENSRNOT00000052035
Art3
ADP-ribosyltransferase 3
chr8_-_111965889 0.07 ENSRNOT00000032376
Bfsp2
beaded filament structural protein 2
chr1_+_105094411 0.07 ENSRNOT00000036258
Htatip2
HIV-1 Tat interactive protein 2
chr2_-_84678790 0.07 ENSRNOT00000015886
Cct5
chaperonin containing TCP1 subunit 5
chr10_+_31324512 0.06 ENSRNOT00000008559
Fndc9
fibronectin type III domain containing 9
chr6_-_127248372 0.06 ENSRNOT00000085517
Asb2
ankyrin repeat and SOCS box-containing 2
chr14_+_107767392 0.06 ENSRNOT00000012847
Cct4
chaperonin containing TCP1 subunit 4
chr7_-_122635731 0.06 ENSRNOT00000025925
St13
suppression of tumorigenicity 13
chr14_-_43143973 0.05 ENSRNOT00000003248
Uchl1
ubiquitin C-terminal hydrolase L1
chr8_+_17421557 0.05 ENSRNOT00000030569
Chordc1
cysteine and histidine rich domain containing 1
chr11_-_61530567 0.05 ENSRNOT00000076277
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_-_252461461 0.05 ENSRNOT00000026093
Ankrd22
ankyrin repeat domain 22
chr14_-_85350948 0.05 ENSRNOT00000083464
LOC100912481
RNA-binding protein EWS-like
chr9_-_61690956 0.04 ENSRNOT00000066589
Hspd1
heat shock protein family D member 1
chr4_+_24612205 0.04 ENSRNOT00000057382
Ewsr1
EWS RNA-binding protein 1
chr11_-_81379640 0.04 ENSRNOT00000002484
Eif4a2
eukaryotic translation initiation factor 4A2
chrX_+_157095937 0.04 ENSRNOT00000091792
Bcap31
B-cell receptor-associated protein 31
chr6_-_94980004 0.04 ENSRNOT00000006373
Rtn1
reticulon 1
chr12_-_31323810 0.04 ENSRNOT00000001247
Ran
RAN, member RAS oncogene family
chr14_+_88543630 0.04 ENSRNOT00000060515
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
chr19_+_24747178 0.04 ENSRNOT00000038879
ENSRNOT00000079106
Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
chrX_+_45213228 0.04 ENSRNOT00000088538
LOC103690319
odorant-binding protein
chr18_-_77579969 0.04 ENSRNOT00000034896
Sall3
spalt-like transcription factor 3
chr17_+_36771639 0.04 ENSRNOT00000015147
Gpr50
G protein-coupled receptor 50
chr14_-_85350786 0.03 ENSRNOT00000012634
LOC100912481
RNA-binding protein EWS-like
chr3_+_122928964 0.03 ENSRNOT00000074724
LOC100365450
rCG26795-like
chrX_+_15321713 0.03 ENSRNOT00000071835
LOC108348138
GTPase ERas
chr16_+_20336638 0.03 ENSRNOT00000080467
Kcnn1
potassium calcium-activated channel subfamily N member 1
chr10_-_56008885 0.03 ENSRNOT00000067677
Kdm6b
lysine demethylase 6B
chr16_+_50049828 0.03 ENSRNOT00000034448
Fam149a
family with sequence similarity 149, member A
chr1_-_89045586 0.03 ENSRNOT00000063808
Zbtb32
zinc finger and BTB domain containing 32
chr2_+_187668796 0.03 ENSRNOT00000025824
Cct3
chaperonin containing TCP1 subunit 3
chr12_-_6956914 0.03 ENSRNOT00000072129
ENSRNOT00000001210
Uspl1
ubiquitin specific peptidase like 1
chr7_+_40318490 0.03 ENSRNOT00000081374
LOC500827
similar to hypothetical protein FLJ35821
chr10_+_105787935 0.03 ENSRNOT00000000266
Mettl23
methyltransferase like 23
chr8_+_55178289 0.03 ENSRNOT00000059127
Cryab
crystallin, alpha B
chr1_+_192025357 0.03 ENSRNOT00000025072
Ubfd1
ubiquitin family domain containing 1
chr12_-_30501860 0.02 ENSRNOT00000001227
Cct6a
chaperonin containing TCP1 subunit 6A
chrX_-_112159458 0.02 ENSRNOT00000087403
Tex13b
testis expressed 13B
chr2_+_178354890 0.02 ENSRNOT00000037890
Ppid
peptidylprolyl isomerase D
chr8_-_49301125 0.02 ENSRNOT00000091190
Cd3e
CD3e molecule
chrX_-_1346181 0.02 ENSRNOT00000042736
LOC102555453
60S ribosomal protein L12-like
chr8_-_58293102 0.02 ENSRNOT00000011913
Rab39a
RAB39A, member RAS oncogene family
chr1_-_48033343 0.02 ENSRNOT00000019531
ENSRNOT00000076422
Tcp1
t-complex 1
chr1_+_221443896 0.02 ENSRNOT00000073942
Tmem262
transmembrane protein 262
chr20_+_3148665 0.02 ENSRNOT00000086026
RT1-N2
RT1 class Ib, locus N2
chr20_+_4118461 0.02 ENSRNOT00000083085
RT1-Db2
RT1 class II, locus Db2
chr15_+_87886783 0.02 ENSRNOT00000065710
Slain1
SLAIN motif family, member 1
chr19_-_41161765 0.01 ENSRNOT00000023117
Hydin
Hydin, axonemal central pair apparatus protein
chr14_-_64535170 0.01 ENSRNOT00000082338
Gba3
glucosidase, beta, acid 3
chr11_+_83855753 0.01 ENSRNOT00000030686
RGD1563956
similar to 60S ribosomal protein L12
chr9_+_64643281 0.01 ENSRNOT00000081497
Spats2l
spermatogenesis associated, serine-rich 2-like
chr3_+_94035905 0.01 ENSRNOT00000014767
RGD1563222
similar to RIKEN cDNA A930018P22
chr11_-_27141881 0.01 ENSRNOT00000002169
Cct8
chaperonin containing TCP1 subunit 8
chrX_-_83864150 0.01 ENSRNOT00000073734
Obp1f
odorant binding protein I f
chr6_+_93539271 0.01 ENSRNOT00000078791
Tomm20l
translocase of outer mitochondrial membrane 20 homolog (yeast)-like
chr9_+_10172832 0.01 ENSRNOT00000074555
Acsbg2
acyl-CoA synthetase bubblegum family member 2
chr8_+_128790348 0.00 ENSRNOT00000025142
Slc25a38
solute carrier family 25, member 38
chr16_-_930527 0.00 ENSRNOT00000014787
Spin1
spindlin 1
chr14_+_7169519 0.00 ENSRNOT00000003026
Klhl8
kelch-like family member 8
chr2_-_173087648 0.00 ENSRNOT00000091079
Iqcj
IQ motif containing J
chr8_-_76239995 0.00 ENSRNOT00000071321
LOC100912027
60S ribosomal protein L27-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071348 cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544)
0.0 0.2 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.0 0.1 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.1 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112) fatty-acyl-CoA catabolic process(GO:0036115)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.2 GO:1904871 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0 0.1 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.0 0.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0 0.0 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.1 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.0 GO:0045041 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 0.0 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.0 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0032564 dATP binding(GO:0032564)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC