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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Runx3

Z-value: 0.49

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Transcription factors associated with Runx3

Gene Symbol Gene ID Gene Info
Runx3
ENSRNOG00000054217 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx3rn6_v1_chr5_+_153507093_153507093-0.148.2e-01Click!

Activity profile of Runx3 motif

Sorted Z-values of Runx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_59533480 0.38 ENSRNOT00000087723
Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr1_-_72339395 0.33 ENSRNOT00000021772
Zfp580
zinc finger protein 580
chr4_-_170763916 0.19 ENSRNOT00000071512
Hist1h4m
histone cluster 1, H4m
chr1_+_197659187 0.19 ENSRNOT00000082228
LOC103690016
serine/threonine-protein kinase SBK1
chr20_+_4966817 0.16 ENSRNOT00000081527
ENSRNOT00000081265
Lsm2
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr20_+_4822935 0.14 ENSRNOT00000077200
Nfkbil1
NFKB inhibitor like 1
chr5_+_137371825 0.12 ENSRNOT00000072816
Tmem125
transmembrane protein 125
chr20_-_3386048 0.12 ENSRNOT00000089550
ENSRNOT00000065025
Dhx16
DEAH-box helicase 16
chr2_+_116372519 0.11 ENSRNOT00000031730
Lrrc34
leucine rich repeat containing 34
chr3_+_45683993 0.10 ENSRNOT00000038983
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr2_+_225827504 0.10 ENSRNOT00000018343
Gclm
glutamate cysteine ligase, modifier subunit
chr12_+_36638457 0.09 ENSRNOT00000085692
Ubc
ubiquitin C
chr4_-_170092848 0.08 ENSRNOT00000072147
Hist2h4
histone cluster 2, H4
chrX_-_32355296 0.08 ENSRNOT00000081652
ENSRNOT00000065075
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr10_-_15667955 0.08 ENSRNOT00000085746
ENSRNOT00000027940
Mpg
N-methylpurine-DNA glycosylase
chr4_-_170117325 0.07 ENSRNOT00000074198
LOC100912564
histone H4-like
chr4_-_170145262 0.07 ENSRNOT00000074526
Hist1h4b
histone cluster 1, H4b
chr1_-_255376833 0.07 ENSRNOT00000024941
Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
chr8_-_116872215 0.06 ENSRNOT00000045410
Apeh
acylaminoacyl-peptide hydrolase
chr7_-_120077612 0.06 ENSRNOT00000011750
Lgals2
galectin 2
chr9_-_43139870 0.06 ENSRNOT00000021956
Sema4c
semaphorin 4C
chr10_+_48240127 0.06 ENSRNOT00000080682
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr14_-_86117578 0.06 ENSRNOT00000019288
Pold2
DNA polymerase delta 2, accessory subunit
chr1_-_88558387 0.05 ENSRNOT00000074174
AABR07002896.1

chr2_-_210934749 0.05 ENSRNOT00000026710
Gnai3
G protein subunit alpha i3
chr10_+_48240330 0.05 ENSRNOT00000057798
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr15_+_47293699 0.05 ENSRNOT00000016503
Sox7
SRY box 7
chr1_-_142114634 0.05 ENSRNOT00000029471
Rccd1
RCC1 domain containing 1
chr13_+_110372164 0.05 ENSRNOT00000049634
RGD1560186
similar to ribosomal protein L37
chr10_-_56409017 0.05 ENSRNOT00000020152
Fgf11
fibroblast growth factor 11
chr16_-_69195097 0.05 ENSRNOT00000018973
Erlin2
ER lipid raft associated 2
chr7_+_141380322 0.04 ENSRNOT00000091207
Cox14
COX14, cytochrome c oxidase assembly factor
chr10_+_11046221 0.04 ENSRNOT00000005109
Nmral1
NmrA like redox sensor 1
chr10_+_11046024 0.04 ENSRNOT00000084850
Nmral1
NmrA like redox sensor 1
chr1_+_220416018 0.04 ENSRNOT00000027233
B4gat1
beta-1,4-glucuronyltransferase 1
chrX_+_63343724 0.04 ENSRNOT00000076530
ENSRNOT00000008558
Klhl15
kelch-like family member 15
chr8_+_76422359 0.04 ENSRNOT00000084148
Gtf2a2
general transcription factor2A subunit 2
chr2_-_181900856 0.04 ENSRNOT00000082156
Lrat
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
chr5_-_139505065 0.04 ENSRNOT00000013899
Ctps1
CTP synthase 1
chr12_+_2228670 0.04 ENSRNOT00000001327
Trappc5
trafficking protein particle complex 5
chr4_+_22898527 0.04 ENSRNOT00000072455
ENSRNOT00000076123
Dbf4
DBF4 zinc finger
chr1_+_140477868 0.04 ENSRNOT00000025008
Mrps11
mitochondrial ribosomal protein S11
chrX_+_63343546 0.04 ENSRNOT00000076315
Klhl15
kelch-like family member 15
chr10_+_63677396 0.04 ENSRNOT00000005100
Slc43a2
solute carrier family 43 member 2
chrX_+_157353577 0.04 ENSRNOT00000090596
Haus7
HAUS augmin-like complex, subunit 7
chr4_+_119680112 0.04 ENSRNOT00000013282
Gp9
glycoprotein IX (platelet)
chr3_-_10161989 0.04 ENSRNOT00000012312
Exosc2
exosome component 2
chr14_+_108412152 0.04 ENSRNOT00000083707
Pus10
pseudouridylate synthase 10
chr7_-_113937941 0.03 ENSRNOT00000012408
Kcnk9
potassium two pore domain channel subfamily K member 9
chr4_+_100209951 0.03 ENSRNOT00000015807
LOC691113
hypothetical protein LOC691113
chr9_+_10995198 0.03 ENSRNOT00000089071
Ubxn6
UBX domain protein 6
chr8_-_21915716 0.03 ENSRNOT00000027985
Eif3g
eukaryotic translation initiation factor 3, subunit G
chr8_-_7426611 0.03 ENSRNOT00000031492
Arhgap42
Rho GTPase activating protein 42
chrX_+_123912361 0.03 ENSRNOT00000092622
Rhox5
reproductive homeobox 5
chr3_+_138765027 0.03 ENSRNOT00000055588
RGD1566320
RGD1566320
chr14_-_16979760 0.03 ENSRNOT00000003020
Stbd1
starch binding domain 1
chr2_+_210034095 0.03 ENSRNOT00000024473
Lamtor5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
chr7_+_130431213 0.03 ENSRNOT00000055792
Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr6_+_107245820 0.03 ENSRNOT00000012757
Papln
papilin, proteoglycan-like sulfated glycoprotein
chr1_-_72468738 0.02 ENSRNOT00000029136
Zfp628
zinc finger protein 628
chr1_-_204855627 0.02 ENSRNOT00000023121
Mettl10
methyltransferase like 10
chr12_+_8725517 0.02 ENSRNOT00000001243
Slc46a3
solute carrier family 46, member 3
chr9_-_61418679 0.02 ENSRNOT00000078800
Ankrd44
ankyrin repeat domain 44
chr1_+_220322940 0.02 ENSRNOT00000074972
LOC108348085
beta-1,4-glucuronyltransferase 1
chr12_-_22417980 0.02 ENSRNOT00000072208
Ephb4
EPH receptor B4
chr19_+_43251539 0.02 ENSRNOT00000024793
Ddx19a
DEAD-box helicase 19A
chr8_+_118013612 0.02 ENSRNOT00000056166
Map4
microtubule-associated protein 4
chr4_+_149908375 0.02 ENSRNOT00000019504
LOC100909657
uncharacterized LOC100909657
chr9_+_10995548 0.02 ENSRNOT00000070986
Ubxn6
UBX domain protein 6
chr17_+_53956203 0.02 ENSRNOT00000022483
Ggps1
geranylgeranyl diphosphate synthase 1
chr13_+_78979321 0.02 ENSRNOT00000003857
Ankrd45
ankyrin repeat domain 45
chr17_+_27496353 0.02 ENSRNOT00000077994
ENSRNOT00000019040
ENSRNOT00000089736
Ssr1
signal sequence receptor subunit 1
chr6_-_115352681 0.02 ENSRNOT00000005873
Gtf2a1
general transcription factor 2A subunit 1
chr6_-_145777767 0.01 ENSRNOT00000046799
Rpl32
ribosomal protein L32
chr10_-_85435016 0.01 ENSRNOT00000079921
4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr2_-_198120041 0.01 ENSRNOT00000079621
ENSRNOT00000028747
Plekho1
pleckstrin homology domain containing O1
chr5_-_136721379 0.01 ENSRNOT00000026704
Atp6v0b
ATPase H+ transporting V0 subunit B
chr20_+_4967194 0.01 ENSRNOT00000070846
Lsm2
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr1_+_69788609 0.01 ENSRNOT00000075340
NEWGENE_1305281
hippocampus abundant transcript 1
chr17_-_23923792 0.01 ENSRNOT00000018739
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr20_-_38985036 0.01 ENSRNOT00000001066
Serinc1
serine incorporator 1
chr14_+_21041621 0.01 ENSRNOT00000086571
Grsf1
G-rich RNA sequence binding factor 1
chr17_+_5342829 0.00 ENSRNOT00000079938
Spata31d3
SPATA31 subfamily D, member 3
chr2_-_9023104 0.00 ENSRNOT00000039652
Adgrv1
adhesion G protein-coupled receptor V1
chr19_+_14392423 0.00 ENSRNOT00000018880
Tom1
target of myb1 membrane trafficking protein
chr7_+_2504695 0.00 ENSRNOT00000003965
Atp5b
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr11_-_34791993 0.00 ENSRNOT00000002284
Dscr3
DSCR3 arrestin fold containing

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.1 GO:0097069 cellular response to thyroxine stimulus(GO:0097069)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.0 GO:0071049 nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.0 0.1 GO:0010992 ubiquitin homeostasis(GO:0010992)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.0 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease