Project

GSE49485: Hypoxia transcriptome sequencing of rat brain.

Navigation
Downloads

Results for Tbx2

Z-value: 0.52

Motif logo

logo of

Transcription factors associated with Tbx2

Gene Symbol Gene ID Gene Info
Tbx2
ENSRNOG00000003517 T-box 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx2rn6_v1_chr10_+_73279119_73279119-0.991.8e-03Click!

Activity profile of Tbx2 motif

Sorted Z-values of Tbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_141550633 0.35 ENSRNOT00000020047
Mesp2
mesoderm posterior bHLH transcription factor 2
chr1_-_20155960 0.32 ENSRNOT00000061389
Samd3
sterile alpha motif domain containing 3
chr5_+_50381244 0.28 ENSRNOT00000012385
Cga
glycoprotein hormones, alpha polypeptide
chr8_+_52829085 0.25 ENSRNOT00000007754
RGD1563941
similar to hypothetical protein FLJ20010
chr20_+_6356423 0.24 ENSRNOT00000000628
Cdkn1a
cyclin-dependent kinase inhibitor 1A
chr2_-_45077219 0.21 ENSRNOT00000014319
Gzmk
granzyme K
chr13_-_55878094 0.20 ENSRNOT00000014218
Lhx9
LIM homeobox 9
chr4_-_148845267 0.17 ENSRNOT00000037397
Tmem72
transmembrane protein 72
chrX_-_111102464 0.15 ENSRNOT00000084176
Ripply1
ripply transcriptional repressor 1
chr20_-_4677506 0.15 ENSRNOT00000061297
RT1-CE6
RT1 class I, locus CE6
chr11_-_61530567 0.14 ENSRNOT00000076277
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr14_-_21709084 0.14 ENSRNOT00000087477
Smr3b
submaxillary gland androgen regulated protein 3B
chr8_-_75995371 0.13 ENSRNOT00000014014
Foxb1
forkhead box B1
chr1_+_85485289 0.13 ENSRNOT00000026182
Dll3
delta like canonical Notch ligand 3
chr1_-_124803363 0.12 ENSRNOT00000066380
Klf13
Kruppel-like factor 13
chr16_-_49574314 0.11 ENSRNOT00000017568
ENSRNOT00000085535
ENSRNOT00000017054
Pdlim3
PDZ and LIM domain 3
chr9_+_98505259 0.10 ENSRNOT00000051810
Erfe
erythroferrone
chr10_+_49541051 0.10 ENSRNOT00000041606
Pmp22
peripheral myelin protein 22
chr3_-_164388492 0.09 ENSRNOT00000090493
Tmem189
transmembrane protein 189
chr2_-_210738378 0.09 ENSRNOT00000025746
Gstm6
glutathione S-transferase, mu 6
chr14_-_14390699 0.09 ENSRNOT00000046639
Anxa3
annexin A3
chr7_-_120839577 0.09 ENSRNOT00000018526
Dmc1
DNA meiotic recombinase 1
chr1_-_260341723 0.08 ENSRNOT00000030656
Opalin
oligodendrocytic myelin paranodal and inner loop protein
chr12_+_40466495 0.08 ENSRNOT00000001816
Aldh2
aldehyde dehydrogenase 2 family (mitochondrial)
chr1_+_89017479 0.08 ENSRNOT00000038154
U2af1l4
U2 small nuclear RNA auxiliary factor 1-like 4
chr1_+_185863043 0.08 ENSRNOT00000079072
Sox6
SRY box 6
chr18_+_16616937 0.08 ENSRNOT00000093641
Mocos
molybdenum cofactor sulfurase
chr5_+_24434872 0.08 ENSRNOT00000010696
Ccne2
cyclin E2
chr1_-_89017290 0.08 ENSRNOT00000028438
Psenen
presenilin enhancer gamma secretase subunit
chr1_+_21525421 0.08 ENSRNOT00000017911
Arg1
arginase 1
chr8_+_58431407 0.07 ENSRNOT00000011974
Sln
sarcolipin
chr2_+_198755262 0.07 ENSRNOT00000028807
Rbm8a
RNA binding motif protein 8A
chr1_-_141533908 0.07 ENSRNOT00000020117
Mesp1
mesoderm posterior bHLH transcription factor 1
chr1_+_220243473 0.07 ENSRNOT00000084650
ENSRNOT00000027091
mrpl11
mitochondrial ribosomal protein L11
chr2_-_251532312 0.07 ENSRNOT00000019501
Cyr61
cysteine-rich, angiogenic inducer, 61
chr4_-_145678066 0.07 ENSRNOT00000014103
Ghrl
ghrelin and obestatin prepropeptide
chr3_+_170994038 0.07 ENSRNOT00000081823
Spo11
SPO11, initiator of meiotic double stranded breaks
chr10_+_63884338 0.07 ENSRNOT00000007100
Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
chr3_+_122720769 0.06 ENSRNOT00000009323
Tmc2
transmembrane channel-like 2
chrX_+_128897181 0.06 ENSRNOT00000008444
Sh2d1a
SH2 domain containing 1A
chr19_-_25288335 0.06 ENSRNOT00000050214
Nanos3
nanos C2HC-type zinc finger 3
chrX_+_70563570 0.05 ENSRNOT00000003772
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chrX_+_135348436 0.05 ENSRNOT00000008868
Rab33a
RAB33A, member RAS oncogene family
chr20_-_4677034 0.05 ENSRNOT00000075244
Rn60_20_0047.3

chr1_+_22332090 0.05 ENSRNOT00000091252
AABR07000663.1
trace amine-associated receptor 8c (Taar8c), mRNA
chr4_+_113887115 0.05 ENSRNOT00000010602
Aup1
ancient ubiquitous protein 1
chr5_+_57845819 0.05 ENSRNOT00000017712
Nudt2
nudix hydrolase 2
chr1_-_89559960 0.05 ENSRNOT00000092133
Scn1b
sodium voltage-gated channel beta subunit 1
chr5_+_164808323 0.05 ENSRNOT00000011005
Nppa
natriuretic peptide A
chr7_-_12635943 0.05 ENSRNOT00000015029
Cfd
complement factor D
chr14_-_84662143 0.05 ENSRNOT00000057529
ENSRNOT00000080078
Hormad2
HORMA domain containing 2
chr20_-_3728844 0.05 ENSRNOT00000074958
Psors1c2
psoriasis susceptibility 1 candidate 2
chr2_+_51672722 0.05 ENSRNOT00000016485
Fgf10
fibroblast growth factor 10
chr18_+_53609214 0.05 ENSRNOT00000077443
Slc27a6
solute carrier family 27 member 6
chr19_+_12097632 0.05 ENSRNOT00000049452
Ces5a
carboxylesterase 5A
chr4_-_114853868 0.05 ENSRNOT00000090828
Wdr54
WD repeat domain 54
chr17_-_14828329 0.04 ENSRNOT00000022830
Barx1
BARX homeobox 1
chr13_-_95943761 0.04 ENSRNOT00000005961
Adss
adenylosuccinate synthase
chr15_+_28295368 0.04 ENSRNOT00000013786
Slc39a2
solute carrier family 39 member 2
chr13_-_85443976 0.04 ENSRNOT00000005213
Uck2
uridine-cytidine kinase 2
chr9_+_47225585 0.04 ENSRNOT00000077303
Il18rap
interleukin 18 receptor accessory protein
chr1_-_22404002 0.04 ENSRNOT00000044098
Taar8a
trace amine-associated receptor 8a
chr4_-_113988246 0.04 ENSRNOT00000013128
LOC103692166
WD repeat-containing protein 54
chr13_+_82429063 0.04 ENSRNOT00000076879
Selp
selectin P
chr11_+_87677966 0.04 ENSRNOT00000068711
Klhl22
kelch-like family member 22
chr6_+_109300433 0.04 ENSRNOT00000010712
Fos
FBJ osteosarcoma oncogene
chr6_-_103605256 0.03 ENSRNOT00000006005
Dcaf5
DDB1 and CUL4 associated factor 5
chr1_+_277689729 0.03 ENSRNOT00000051834
Vwa2
von Willebrand factor A domain containing 2
chr7_-_122926336 0.03 ENSRNOT00000000205
Chadl
chondroadherin-like
chr6_-_44363915 0.03 ENSRNOT00000085925
Id2
inhibitor of DNA binding 2, HLH protein
chr8_+_42511520 0.03 ENSRNOT00000042974
Olr1259
olfactory receptor 1259
chr13_+_49092306 0.03 ENSRNOT00000000039
Nuak2
NUAK family kinase 2
chr12_-_3924415 0.03 ENSRNOT00000067752
AABR07035074.1

chr5_-_150704117 0.03 ENSRNOT00000067455
Sesn2
sestrin 2
chrX_+_104734082 0.03 ENSRNOT00000005020
Srpx2
sushi-repeat-containing protein, X-linked 2
chr5_-_74029238 0.03 ENSRNOT00000031432
Frrs1l
ferric-chelate reductase 1-like
chr1_+_22364551 0.03 ENSRNOT00000043157
LOC108348200
trace amine-associated receptor 8a
chr9_+_70310932 0.02 ENSRNOT00000088268
LOC103690541
uncharacterized LOC103690541
chr19_+_24496569 0.02 ENSRNOT00000004982
Mgat4d
MGAT4 family, member D
chrX_-_72370044 0.02 ENSRNOT00000004224
Hdac8
histone deacetylase 8
chr1_+_213686046 0.02 ENSRNOT00000019808
LOC108348167
NACHT, LRR and PYD domains-containing protein 6-like
chr13_-_85443727 0.02 ENSRNOT00000090668
ENSRNOT00000076125
Uck2
uridine-cytidine kinase 2
chr8_-_13680870 0.02 ENSRNOT00000081616
Hephl1
hephaestin-like 1
chr1_+_213676954 0.02 ENSRNOT00000050551
Nlrp6
NLR family, pyrin domain containing 6
chr17_-_89163113 0.02 ENSRNOT00000050445
LOC100360843
ribosomal protein S19-like
chr4_+_114854458 0.02 ENSRNOT00000013312
LOC500227
hypothetical gene supported by BC079424
chr16_+_61130755 0.02 ENSRNOT00000042609
AABR07026048.1

chr19_-_31867850 0.02 ENSRNOT00000024689
Anapc10
anaphase promoting complex subunit 10
chr4_-_70973842 0.02 ENSRNOT00000051687
Trpv5
transient receptor potential cation channel, subfamily V, member 5
chr10_-_88645364 0.01 ENSRNOT00000030344
Rab5c
RAB5C, member RAS oncogene family
chr15_-_34322115 0.01 ENSRNOT00000026734
Tm9sf1
transmembrane 9 superfamily member 1
chr5_-_171415354 0.01 ENSRNOT00000055398
Tp73
tumor protein p73
chrX_+_33599671 0.01 ENSRNOT00000006843
Txlng
taxilin gamma
chr15_-_51386190 0.01 ENSRNOT00000022706
R3hcc1
R3H domain and coiled-coil containing 1
chrX_-_142248369 0.01 ENSRNOT00000091330
Fgf13
fibroblast growth factor 13
chr1_+_100224401 0.01 ENSRNOT00000025846
Fv1
Friend virus susceptibility 1
chr1_-_226353611 0.01 ENSRNOT00000037624
Dagla
diacylglycerol lipase, alpha
chr17_+_72240802 0.01 ENSRNOT00000025993
ENSRNOT00000090453
Atp5c1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr7_+_143679617 0.01 ENSRNOT00000014033
Eif4b
eukaryotic translation initiation factor 4B
chr9_+_61738471 0.00 ENSRNOT00000090305
AABR07067762.1

chr11_+_75905443 0.00 ENSRNOT00000002650
Fgf12
fibroblast growth factor 12
chrX_+_68713123 0.00 ENSRNOT00000076690
Stard8
StAR-related lipid transfer domain containing 8
chr1_+_238843338 0.00 ENSRNOT00000024583
Zfand5
zinc finger AN1-type containing 5
chrX_+_134979646 0.00 ENSRNOT00000006035
Sash3
SAM and SH3 domain containing 3
chr5_+_113592919 0.00 ENSRNOT00000011336
Ift74
intraflagellar transport 74
chr7_-_141624972 0.00 ENSRNOT00000078785
AABR07058884.1

chr1_+_85003280 0.00 ENSRNOT00000057122
Fcgbp
Fc fragment of IgG binding protein
chr1_+_80777014 0.00 ENSRNOT00000079758
Gm19345
predicted gene, 19345
chr19_+_33932532 0.00 ENSRNOT00000078395
ENSRNOT00000091985
ENSRNOT00000078701
ENSRNOT00000080317
Ednra
endothelin receptor type A
chr7_-_11406771 0.00 ENSRNOT00000047450
Eef2
eukaryotic translation elongation factor 2
chr4_-_52350624 0.00 ENSRNOT00000060476
Tmem229a
transmembrane protein 229A

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008078 mesodermal cell migration(GO:0008078)
0.1 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.2 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.1 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.3 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.0 0.1 GO:0051464 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) negative regulation of interleukin-6 biosynthetic process(GO:0045409) positive regulation of cortisol secretion(GO:0051464)
0.0 0.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.1 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:1902023 regulation of amino acid import(GO:0010958) L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.0 0.0 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0051177 meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.0 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.0 0.1 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.0 0.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
0.0 0.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation