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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Bhlhe40

Z-value: 0.37

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Transcription factors associated with Bhlhe40

Gene Symbol Gene ID Gene Info
Bhlhe40
ENSRNOG00000007152 basic helix-loop-helix family, member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bhlhe40rn6_v1_chr4_+_140703619_140703619-0.114.6e-02Click!

Activity profile of Bhlhe40 motif

Sorted Z-values of Bhlhe40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_106558366 9.36 ENSRNOT00000042126
Bex2
brain expressed X-linked 2
chrX_-_105622156 8.29 ENSRNOT00000029511
Armcx2
armadillo repeat containing, X-linked 2
chr5_+_152681101 7.86 ENSRNOT00000076052
ENSRNOT00000022574
Stmn1
stathmin 1
chr10_+_40543288 7.60 ENSRNOT00000016755
Slc36a1
solute carrier family 36 member 1
chrX_-_105417323 6.84 ENSRNOT00000015494
Gla
galactosidase, alpha
chr5_-_14356692 5.31 ENSRNOT00000085654
Atp6v1h
ATPase H+ transporting V1 subunit H
chr19_+_26151900 5.18 ENSRNOT00000005571
Tnpo2
transportin 2
chr15_-_27855999 5.11 ENSRNOT00000013225
Tmem55b
transmembrane protein 55B
chr9_+_94425252 4.82 ENSRNOT00000064965
ENSRNOT00000076099
Gigyf2
GRB10 interacting GYF protein 2
chr16_+_8497569 4.82 ENSRNOT00000027054
Ogdhl
oxoglutarate dehydrogenase-like
chrX_+_106823491 4.77 ENSRNOT00000045997
Bex3
brain expressed X-linked 3
chr5_-_164844586 4.61 ENSRNOT00000011287
Clcn6
chloride voltage-gated channel 6
chrX_+_74200972 4.34 ENSRNOT00000076956
Chic1
cysteine-rich hydrophobic domain 1
chrX_+_74205842 3.92 ENSRNOT00000077003
Chic1
cysteine-rich hydrophobic domain 1
chr19_-_43215077 3.79 ENSRNOT00000082151
Aars
alanyl-tRNA synthetase
chr2_+_93518806 3.38 ENSRNOT00000050987
Snx16
sorting nexin 16
chr12_+_38459832 3.15 ENSRNOT00000090343
Vps33a
VPS33A CORVET/HOPS core subunit
chr6_-_80334522 3.00 ENSRNOT00000059316
Fbxo33
F-box protein 33
chr4_+_99937558 2.91 ENSRNOT00000050249
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr10_+_94988362 2.82 ENSRNOT00000066525
Cep95
centrosomal protein 95
chr19_-_43215281 2.78 ENSRNOT00000025052
Aars
alanyl-tRNA synthetase
chr11_+_60613882 2.76 ENSRNOT00000002853
Slc35a5
solute carrier family 35, member A5
chr13_+_84588702 2.76 ENSRNOT00000058689
Tada1
transcriptional adaptor 1
chrX_-_84821775 2.72 ENSRNOT00000000174
Chm
CHM, Rab escort protein 1
chr10_+_10725819 2.67 ENSRNOT00000004159
Glyr1
glyoxylate reductase 1 homolog
chr13_+_70174936 2.66 ENSRNOT00000064068
ENSRNOT00000079861
ENSRNOT00000092562
Arpc5
actin related protein 2/3 complex, subunit 5
chr4_+_148139528 2.60 ENSRNOT00000092594
ENSRNOT00000015620
ENSRNOT00000092613
Washc2c
WASH complex subunit 2C
chr13_-_111765944 2.55 ENSRNOT00000073041
Syt14
synaptotagmin 14
chr1_-_219450451 2.54 ENSRNOT00000025317
Rad9a
RAD9 checkpoint clamp component A
chr3_+_163570532 2.25 ENSRNOT00000010054
Arfgef2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr14_-_44767120 2.11 ENSRNOT00000003991
Wdr19
WD repeat domain 19
chr1_-_101457126 1.75 ENSRNOT00000087061
ENSRNOT00000028328
Bax
BCL2 associated X, apoptosis regulator
chr18_+_3597240 1.66 ENSRNOT00000017045
RGD1311805
similar to RIKEN cDNA 2400010D15
chr10_-_94988461 1.64 ENSRNOT00000048490
Ddx5
DEAD-box helicase 5
chr1_-_164101578 1.56 ENSRNOT00000022176
Uvrag
UV radiation resistance associated
chr6_-_122239614 1.47 ENSRNOT00000005015
Galc
galactosylceramidase
chr7_+_41114697 1.43 ENSRNOT00000041354
Atp2b1
ATPase plasma membrane Ca2+ transporting 1
chr6_+_109617355 1.35 ENSRNOT00000011599
Flvcr2
feline leukemia virus subgroup C cellular receptor family, member 2
chr8_-_104995725 1.35 ENSRNOT00000037120
Slc25a36
solute carrier family 25 member 36
chr4_-_87257667 1.15 ENSRNOT00000083491
Nt5c3a
5'-nucleotidase, cytosolic IIIA
chr5_-_152227677 1.15 ENSRNOT00000020051
Dhdds
dehydrodolichyl diphosphate synthase subunit
chr2_+_198852500 1.05 ENSRNOT00000000110
Rnf115
ring finger protein 115
chr2_-_196270826 0.99 ENSRNOT00000028609
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
chr7_+_53878610 0.97 ENSRNOT00000091910
Osbpl8
oxysterol binding protein-like 8
chr1_-_72329856 0.85 ENSRNOT00000021391
U2af2
U2 small nuclear RNA auxiliary factor 2
chr1_+_200167169 0.84 ENSRNOT00000027665
Sec23ip
SEC23 interacting protein
chr2_-_198852161 0.80 ENSRNOT00000028815
Polr3c
RNA polymerase III subunit C
chr12_+_2054680 0.74 ENSRNOT00000001290
Mcoln1
mucolipin 1
chr7_+_143882000 0.72 ENSRNOT00000017110
ENSRNOT00000091053
Mfsd5
major facilitator superfamily domain containing 5
chr6_+_109617596 0.71 ENSRNOT00000085031
ENSRNOT00000089972
ENSRNOT00000082402
Flvcr2
feline leukemia virus subgroup C cellular receptor family, member 2
chr5_-_160352927 0.70 ENSRNOT00000017247
Dnajc16
DnaJ heat shock protein family (Hsp40) member C16
chr11_-_60613718 0.70 ENSRNOT00000002906
Atg3
autophagy related 3
chr10_-_56850085 0.65 ENSRNOT00000025767
Rnasek
ribonuclease K
chr1_-_92119951 0.64 ENSRNOT00000018153
ENSRNOT00000092121
Zfp507
zinc finger protein 507
chr2_-_210088949 0.60 ENSRNOT00000070994
Rbm15
RNA binding motif protein 15
chr13_-_53870428 0.60 ENSRNOT00000000812
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr10_-_62287189 0.58 ENSRNOT00000004365
Wdr81
WD repeat domain 81
chr1_-_282170017 0.57 ENSRNOT00000066947
Eif3a
eukaryotic translation initiation factor 3, subunit A
chr18_+_15298978 0.46 ENSRNOT00000021263
Trappc8
trafficking protein particle complex 8
chr10_-_10725655 0.35 ENSRNOT00000061236
Ubn1
ubinuclein 1
chr1_-_102849430 0.35 ENSRNOT00000086856
Saa4
serum amyloid A4
chr18_+_55797198 0.29 ENSRNOT00000026334
ENSRNOT00000026394
Dctn4
dynactin subunit 4
chr1_-_13175876 0.27 ENSRNOT00000084870
Abracl
ABRA C-terminal like
chr11_+_68198709 0.23 ENSRNOT00000003048
Dirc2
disrupted in renal carcinoma 2
chr1_+_144601410 0.13 ENSRNOT00000047408
Efl1
elongation factor like GTPase 1
chr10_-_62191512 0.13 ENSRNOT00000090262
Rpa1
replication protein A1
chr17_+_54280851 0.07 ENSRNOT00000024022
Arhgap12
Rho GTPase activating protein 12
chr19_+_25803262 0.05 ENSRNOT00000003941
Trmt1
tRNA methyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Bhlhe40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 7.9 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.6 6.6 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
1.0 8.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.9 7.6 GO:0015808 L-alanine transport(GO:0015808)
0.7 5.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.7 2.6 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
0.6 3.1 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.6 1.7 GO:0019740 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.5 2.1 GO:0061055 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.4 1.6 GO:0097680 maintenance of Golgi location(GO:0051684) double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.4 1.1 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.3 2.7 GO:0018344 protein geranylgeranylation(GO:0018344)
0.3 2.7 GO:0021769 orbitofrontal cortex development(GO:0021769)
0.2 1.0 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.2 1.4 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.2 4.8 GO:0061157 mRNA destabilization(GO:0061157)
0.2 2.1 GO:0015886 heme transport(GO:0015886)
0.2 1.6 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2 3.8 GO:0007035 vacuolar acidification(GO:0007035)
0.2 5.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.2 2.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 3.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 4.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.2 0.5 GO:0032258 CVT pathway(GO:0032258)
0.1 0.6 GO:0002188 translation reinitiation(GO:0002188)
0.1 2.9 GO:0097503 sialylation(GO:0097503)
0.1 0.6 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 1.4 GO:1901679 pyrimidine-containing compound transmembrane transport(GO:0072531) nucleotide transmembrane transport(GO:1901679)
0.1 1.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 2.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 4.6 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.7 GO:0044804 nucleophagy(GO:0044804)
0.0 4.8 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.8 GO:0001675 acrosome assembly(GO:0001675)
0.0 2.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.7 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.0 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.3 GO:0007097 nuclear migration(GO:0007097)
0.0 0.7 GO:0009303 rRNA transcription(GO:0009303)
0.0 2.8 GO:0015992 proton transport(GO:0015992)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 9.4 GO:0051726 regulation of cell cycle(GO:0051726)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
1.0 4.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.7 2.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.4 4.8 GO:1990635 proximal dendrite(GO:1990635)
0.4 2.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.4 3.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.4 2.2 GO:0005879 axonemal microtubule(GO:0005879) symmetric synapse(GO:0032280)
0.4 2.6 GO:0071203 WASH complex(GO:0071203)
0.3 3.1 GO:0033263 CORVET complex(GO:0033263)
0.3 2.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.2 1.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 2.8 GO:0030914 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.2 2.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 1.6 GO:0071141 SMAD protein complex(GO:0071141)
0.1 0.8 GO:0089701 U2AF(GO:0089701)
0.1 1.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.6 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 1.0 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 2.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 11.9 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.8 GO:0097038 endoplasmic reticulum exit site(GO:0070971) perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 4.8 GO:0034399 nuclear periphery(GO:0034399)
0.0 2.7 GO:0000786 nucleosome(GO:0000786)
0.0 1.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 7.9 GO:0005874 microtubule(GO:0005874)
0.0 2.8 GO:0000922 spindle pole(GO:0000922)
0.0 4.2 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
1.6 6.6 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
1.6 4.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
1.2 4.8 GO:0005163 nerve growth factor receptor binding(GO:0005163)
1.0 5.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.9 6.8 GO:0016936 galactoside binding(GO:0016936)
0.4 2.7 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.3 1.7 GO:0051434 BH3 domain binding(GO:0051434)
0.3 5.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 4.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 2.1 GO:0015232 heme transporter activity(GO:0015232)
0.2 2.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 2.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 0.7 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 2.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.2 1.6 GO:0070878 primary miRNA binding(GO:0070878)
0.2 5.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 4.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.7 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 2.2 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.9 GO:0008373 sialyltransferase activity(GO:0008373)
0.1 1.0 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.8 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 1.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 1.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 1.1 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 0.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 1.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 2.5 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 2.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 6.5 GO:0015631 tubulin binding(GO:0015631)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 1.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 1.6 GO:0000149 SNARE binding(GO:0000149)
0.0 0.7 GO:0004521 endoribonuclease activity(GO:0004521)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.7 PID ATR PATHWAY ATR signaling pathway
0.1 3.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.2 6.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 8.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.7 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.1 2.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.7 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.8 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development