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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Cebpa_Cebpg

Z-value: 1.54

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Transcription factors associated with Cebpa_Cebpg

Gene Symbol Gene ID Gene Info
Cebpa
ENSRNOG00000010918 CCAAT/enhancer binding protein alpha
Cebpg
ENSRNOG00000021144 CCAAT/enhancer binding protein gamma

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cebparn6_v1_chr1_+_91363492_913634920.702.4e-48Click!
Cebpgrn6_v1_chr1_-_91296656_912966560.164.3e-03Click!

Activity profile of Cebpa_Cebpg motif

Sorted Z-values of Cebpa_Cebpg motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_81717521 159.65 ENSRNOT00000058422
Ahsg
alpha-2-HS-glycoprotein
chr11_-_81444375 158.80 ENSRNOT00000058479
ENSRNOT00000078131
ENSRNOT00000080949
ENSRNOT00000080562
ENSRNOT00000084867
Kng1
kininogen 1
chr9_+_9721105 132.03 ENSRNOT00000073042
ENSRNOT00000075494
C3
complement C3
chr2_+_104744461 106.48 ENSRNOT00000016083
ENSRNOT00000082627
Cp
ceruloplasmin
chrX_+_143097525 99.60 ENSRNOT00000004559
F9
coagulation factor IX
chr10_+_96639924 82.75 ENSRNOT00000004756
Apoh
apolipoprotein H
chr15_+_57290849 82.49 ENSRNOT00000014909
Cpb2
carboxypeptidase B2
chr4_+_65110746 82.38 ENSRNOT00000017675
Akr1d1
aldo-keto reductase family 1, member D1
chr9_+_74124016 77.11 ENSRNOT00000019023
Cps1
carbamoyl-phosphate synthase 1
chr8_-_111721303 70.61 ENSRNOT00000045628
ENSRNOT00000012725
Tf
transferrin
chr15_+_28018040 63.35 ENSRNOT00000041495
Rnase4
ribonuclease A family member 4
chr14_-_19072677 62.90 ENSRNOT00000060548
LOC360919
similar to alpha-fetoprotein
chr2_+_55775274 56.96 ENSRNOT00000018545
C9
complement C9
chr9_-_78969013 52.56 ENSRNOT00000019772
ENSRNOT00000057585
Fn1
fibronectin 1
chr19_+_15081158 50.47 ENSRNOT00000074070
Ces1f
carboxylesterase 1F
chr19_+_15081590 50.15 ENSRNOT00000024187
Ces1f
carboxylesterase 1F
chr6_+_80188943 49.13 ENSRNOT00000059335
Mia2
melanoma inhibitory activity 2
chr9_-_4978892 46.88 ENSRNOT00000015189
Sult1c3
sulfotransferase family 1C member 3
chr11_+_74057361 45.35 ENSRNOT00000048746
Cpn2
carboxypeptidase N subunit 2
chr14_+_7113544 45.17 ENSRNOT00000038188
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr8_+_116857684 44.12 ENSRNOT00000026711
Mst1
macrophage stimulating 1
chr1_-_76517134 43.70 ENSRNOT00000064593
ENSRNOT00000085775
LOC100912485
alcohol sulfotransferase-like
chr7_-_101140308 42.61 ENSRNOT00000006279
Fam84b
family with sequence similarity 84, member B
chr3_-_101474890 41.22 ENSRNOT00000091869
Bbox1
gamma-butyrobetaine hydroxylase 1
chr10_-_87407634 39.47 ENSRNOT00000016657
Krt23
keratin 23
chr10_+_56710464 32.94 ENSRNOT00000065370
ENSRNOT00000064064
Asgr2
asialoglycoprotein receptor 2
chrX_-_110232179 32.81 ENSRNOT00000014739
Serpina7
serpin family A member 7
chr1_-_168972725 29.22 ENSRNOT00000090422
Hbb
hemoglobin subunit beta
chr9_+_46962288 27.94 ENSRNOT00000082146
Il1r1
interleukin 1 receptor type 1
chr2_+_158097843 27.58 ENSRNOT00000016541
Ptx3
pentraxin 3
chr4_-_157155609 26.80 ENSRNOT00000016330
C1s
complement C1s
chr1_-_101596822 26.19 ENSRNOT00000028490
Fgf21
fibroblast growth factor 21
chr10_-_62254287 25.99 ENSRNOT00000004313
Serpinf1
serpin family F member 1
chr9_+_81656116 24.46 ENSRNOT00000083421
Slc11a1
solute carrier family 11 member 1
chr18_-_7081356 24.10 ENSRNOT00000021253
Chst9
carbohydrate sulfotransferase 9
chr1_-_22661377 22.91 ENSRNOT00000021896
Vnn3
vanin 3
chr2_-_210782746 22.76 ENSRNOT00000025939
ENSRNOT00000081501
Gstm7
glutathione S-transferase, mu 7
chr8_+_22856539 22.66 ENSRNOT00000015381
Angptl8
angiopoietin-like 8
chr4_-_145390447 21.14 ENSRNOT00000091965
ENSRNOT00000012136
Cidec
cell death-inducing DFFA-like effector c
chr3_-_121882726 20.71 ENSRNOT00000006308
Il1b
interleukin 1 beta
chr4_-_176381477 20.68 ENSRNOT00000048367
Slco1a6
solute carrier organic anion transporter family, member 1a6
chr1_+_168964202 19.99 ENSRNOT00000089102
LOC103694855
hemoglobin subunit beta-2-like
chr9_-_46309451 19.55 ENSRNOT00000018684
Rnf149
ring finger protein 149
chr13_+_83073544 19.51 ENSRNOT00000066119
ENSRNOT00000079796
ENSRNOT00000077070
Dpt
dermatopontin
chrX_+_113510621 17.20 ENSRNOT00000025912
Nxt2
nuclear transport factor 2-like export factor 2
chr7_-_27240528 17.02 ENSRNOT00000029435
ENSRNOT00000079731
Hsp90b1
heat shock protein 90 beta family member 1
chr10_-_82116621 16.44 ENSRNOT00000003977
ENSRNOT00000051497
ENSRNOT00000085451
Abcc3
ATP binding cassette subfamily C member 3
chr8_-_7426611 16.10 ENSRNOT00000031492
Arhgap42
Rho GTPase activating protein 42
chrX_+_25016401 14.37 ENSRNOT00000059270
Clcn4
chloride voltage-gated channel 4
chr4_+_33890349 13.96 ENSRNOT00000078680
C1galt1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr17_-_77527894 13.94 ENSRNOT00000032173
Bend7
BEN domain containing 7
chr2_-_235161263 13.88 ENSRNOT00000080235
LOC103691699
uncharacterized LOC103691699
chr1_-_78180216 13.07 ENSRNOT00000071576
C5ar2
complement component 5a receptor 2
chrX_+_120624518 11.86 ENSRNOT00000007967
Slc6a14
solute carrier family 6 member 14
chr4_+_100166863 11.77 ENSRNOT00000014505
Sftpb
surfactant protein B
chr3_-_146396299 11.54 ENSRNOT00000040188
ENSRNOT00000008931
Apmap
adipocyte plasma membrane associated protein
chr5_-_117440254 11.52 ENSRNOT00000066139
Kank4
KN motif and ankyrin repeat domains 4
chr8_-_55162421 11.30 ENSRNOT00000083102
Dixdc1
DIX domain containing 1
chr14_+_45062662 11.17 ENSRNOT00000059124
Tlr10
toll-like receptor 10
chr3_-_11452529 10.54 ENSRNOT00000020206
Slc25a25
solute carrier family 25 member 25
chrX_-_154918095 10.45 ENSRNOT00000085224
LOC100911991
elongation factor 1-alpha 1-like
chr20_-_2103864 9.82 ENSRNOT00000001014
Rnf39
ring finger protein 39
chr11_-_69201380 9.81 ENSRNOT00000085618
Mylk
myosin light chain kinase
chr5_+_151181559 9.68 ENSRNOT00000085674
Fgr
FGR proto-oncogene, Src family tyrosine kinase
chr14_-_14390699 9.50 ENSRNOT00000046639
Anxa3
annexin A3
chr6_+_128750795 9.48 ENSRNOT00000005781
Glrx5
glutaredoxin 5
chr14_-_66978499 9.46 ENSRNOT00000081601
Slit2
slit guidance ligand 2
chr2_+_60169517 9.03 ENSRNOT00000080974
Prlr
prolactin receptor
chr14_+_84306466 8.90 ENSRNOT00000006116
Sec14l4
SEC14-like lipid binding 4
chr18_+_16590197 8.87 ENSRNOT00000066583
Mocos
molybdenum cofactor sulfurase
chr14_-_8548310 8.86 ENSRNOT00000092436
Arhgap24
Rho GTPase activating protein 24
chr12_-_20486276 8.80 ENSRNOT00000074057
LOC680910
similar to paired immunoglobin-like type 2 receptor beta
chr2_-_234296145 8.54 ENSRNOT00000014155
Elovl6
ELOVL fatty acid elongase 6
chr12_+_8725517 8.52 ENSRNOT00000001243
Slc46a3
solute carrier family 46, member 3
chr12_+_2213705 8.23 ENSRNOT00000031653
Mcemp1
mast cell-expressed membrane protein 1
chr1_-_191007503 8.23 ENSRNOT00000023262
Igsf6
immunoglobulin superfamily, member 6
chrX_+_43881246 8.21 ENSRNOT00000005153
LOC317456
hypothetical LOC317456
chr18_-_29562153 8.21 ENSRNOT00000023977
Cd14
CD14 molecule
chrX_-_153491837 7.92 ENSRNOT00000089027
LOC100360413
eukaryotic translation elongation factor 1 alpha 1-like
chr2_-_154542919 7.88 ENSRNOT00000076880
Slc33a1
solute carrier family 33 member 1
chr10_-_70871066 7.87 ENSRNOT00000015139
Ccl3
C-C motif chemokine ligand 3
chr8_+_116754178 6.79 ENSRNOT00000068295
ENSRNOT00000084429
Uba7
ubiquitin-like modifier activating enzyme 7
chr2_+_212257225 6.77 ENSRNOT00000077883
Vav3
vav guanine nucleotide exchange factor 3
chr5_+_148320438 6.57 ENSRNOT00000018742
Pef1
penta-EF hand domain containing 1
chr2_-_154418629 6.02 ENSRNOT00000076274
ENSRNOT00000076165
Plch1
phospholipase C, eta 1
chr6_-_42616548 5.89 ENSRNOT00000081433
Atp6v1c2
ATPase H+ transporting V1 subunit C2
chr4_-_23135354 5.51 ENSRNOT00000011432
Steap4
STEAP4 metalloreductase
chr2_+_58534476 5.47 ENSRNOT00000077646
Lmbrd2
LMBR1 domain containing 2
chr12_-_21362205 5.39 ENSRNOT00000064787
LOC108348155
paired immunoglobulin-like type 2 receptor beta-2
chr13_+_85818427 5.15 ENSRNOT00000077227
ENSRNOT00000006117
Rxrg
retinoid X receptor gamma
chr12_+_20667601 5.12 ENSRNOT00000090081
RGD1560281
similar to cell surface receptor FDFACT
chr1_+_252589785 4.47 ENSRNOT00000025928
Fas
Fas cell surface death receptor
chr6_-_125723732 4.44 ENSRNOT00000084815
Fbln5
fibulin 5
chr2_+_234375315 4.28 ENSRNOT00000071270
LOC102549542
elongation of very long chain fatty acids protein 6-like
chr1_+_168117526 4.25 ENSRNOT00000051894
Olr67
olfactory receptor 67
chr9_+_10952374 4.22 ENSRNOT00000074993
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr16_+_54319377 4.15 ENSRNOT00000090266
Mtus1
microtubule associated tumor suppressor 1
chr2_+_186980793 3.94 ENSRNOT00000091336
Arhgef11
Rho guanine nucleotide exchange factor 11
chr5_+_72103704 3.86 ENSRNOT00000021629
Rad23b
RAD23 homolog B, nucleotide excision repair protein
chr16_+_61954590 3.67 ENSRNOT00000017883
Rbpms
RNA binding protein with multiple splicing
chr7_+_2504695 3.57 ENSRNOT00000003965
Atp5b
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr1_-_233145924 3.48 ENSRNOT00000018763
ENSRNOT00000082442
Psat1
phosphoserine aminotransferase 1
chr7_-_123572082 3.04 ENSRNOT00000068020
Naga
N-acetyl galactosaminidase, alpha
chr13_-_73390393 2.88 ENSRNOT00000067253
ENSRNOT00000093438
Lhx4
LIM homeobox 4
chr1_-_80809769 2.81 ENSRNOT00000045073
Ceacam19
carcinoembryonic antigen-related cell adhesion molecule 19
chr8_+_2604962 2.57 ENSRNOT00000009993
Casp1
caspase 1
chr4_+_1417537 2.52 ENSRNOT00000072547
Olr1230
olfactory receptor 1230
chr20_-_848229 2.52 ENSRNOT00000000974
Olr1694
olfactory receptor 1694
chr1_+_222861777 2.47 ENSRNOT00000090872
Pla2g16
phospholipase A2, group XVI
chr16_+_61954809 2.46 ENSRNOT00000068011
Rbpms
RNA binding protein with multiple splicing
chr7_+_16461899 2.26 ENSRNOT00000051359
Olr1055
olfactory receptor 1055
chr7_-_9174330 2.18 ENSRNOT00000051063
Olr1060
olfactory receptor 1060
chr4_+_1658278 2.15 ENSRNOT00000073845
Olr1250
olfactory receptor 1250
chr17_+_39032661 2.15 ENSRNOT00000022381
Prl7a3
prolactin family 7, subfamily a, member 3
chr1_-_228524439 2.12 ENSRNOT00000028601
Olr323
olfactory receptor 323
chr3_-_102672294 1.94 ENSRNOT00000030909
Olr760
olfactory receptor 760
chr1_+_162320730 1.88 ENSRNOT00000035743
Kctd21
potassium channel tetramerization domain containing 21
chr2_+_186980992 1.88 ENSRNOT00000020717
Arhgef11
Rho guanine nucleotide exchange factor 11
chr3_+_73064092 1.83 ENSRNOT00000072178
LOC684539
similar to olfactory receptor Olr490
chr14_+_17492081 1.78 ENSRNOT00000003346
G3bp2
G3BP stress granule assembly factor 2
chr4_-_170129407 1.76 ENSRNOT00000075717
LOC100912609
uncharacterized LOC100912609
chr18_+_35249137 1.75 ENSRNOT00000017489
LOC100910942
serine protease inhibitor Kazal-type 6-like
chr8_-_40192831 1.71 ENSRNOT00000048448
Olr1194
olfactory receptor 1194
chr11_+_55497234 1.70 ENSRNOT00000070882
LOC108348268
olfactory receptor 2T33-like
chr13_+_52887649 1.70 ENSRNOT00000048033
Ascl5
achaete-scute family bHLH transcription factor 5
chr7_-_7311272 1.66 ENSRNOT00000040812
Olr1020
olfactory receptor 1020
chr5_-_59913348 1.64 ENSRNOT00000018164
LOC100359916
heterogeneous nuclear ribonucleoprotein K-like
chrX_-_75224268 1.62 ENSRNOT00000089809
Abcb7
ATP binding cassette subfamily B member 7
chr2_+_58448917 1.62 ENSRNOT00000082562
Ranbp3l
RAN binding protein 3-like
chr14_+_900696 1.62 ENSRNOT00000049544
Vom2r71
vomeronasal 2 receptor, 71
chr4_+_84478839 1.56 ENSRNOT00000012668
Prr15
proline rich 15
chr3_+_16817051 1.53 ENSRNOT00000071666
AABR07051550.1

chr10_-_83898527 1.47 ENSRNOT00000009815
Atp5g1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr2_-_1561464 1.25 ENSRNOT00000062055
ENSRNOT00000062054
ENSRNOT00000062052
Cast
calpastatin
chr3_-_103140972 1.12 ENSRNOT00000052368
Olr780
olfactory receptor 780
chrX_-_63809861 1.05 ENSRNOT00000009870
Maged1
MAGE family member D1
chr12_-_20660304 1.02 ENSRNOT00000091323
RGD1561730
similar to cell surface receptor FDFACT
chr7_-_9136515 0.96 ENSRNOT00000081964
Olr1059
olfactory receptor 1059
chr2_+_94266213 0.96 ENSRNOT00000090023
Pag1
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
chr1_+_252323865 0.95 ENSRNOT00000026299
Lipk
lipase, family member K
chr3_-_160573978 0.85 ENSRNOT00000018386
Wfdc5
WAP four-disulfide core domain 5
chr12_+_44046454 0.80 ENSRNOT00000064756
Fbxw8
F-box and WD repeat domain containing 8
chr15_-_46166335 0.63 ENSRNOT00000059215
Defb42
defensin beta 42
chr7_-_9104719 0.54 ENSRNOT00000088247
LOC103692758
olfactory receptor 6C74-like
chr11_+_43431431 0.53 ENSRNOT00000081261
Olr1545
olfactory receptor 1545
chr10_+_107502695 0.49 ENSRNOT00000038088
Engase
endo-beta-N-acetylglucosaminidase
chr1_+_91152635 0.49 ENSRNOT00000073438
LOC100912070
dermokine-like
chr7_-_75569778 0.48 ENSRNOT00000040687
LOC362901
Ac1254
chr3_-_74701712 0.41 ENSRNOT00000041127
Olr541
olfactory receptor 541
chr20_-_10013559 0.40 ENSRNOT00000091623
Rsph1
radial spoke head 1 homolog
chr10_+_61033113 0.34 ENSRNOT00000043016
Olr1513
olfactory receptor 1513
chr2_-_58534211 0.33 ENSRNOT00000089178
Skp2
S-phase kinase associated protein 2
chr15_+_41643541 0.32 ENSRNOT00000019646
Arl11
ADP-ribosylation factor like GTPase 11
chr1_-_82279145 0.31 ENSRNOT00000057433
Cxcl17
C-X-C motif chemokine ligand 17
chr1_-_74638587 0.31 ENSRNOT00000046047
Vom2r30
vomeronasal 2 receptor, 30
chr1_+_112976770 0.26 ENSRNOT00000079348
Gabrb3
gamma-aminobutyric acid type A receptor beta 3 subunit
chr7_+_23854846 0.25 ENSRNOT00000037290
Bpifc
BPI fold containing family C
chr3_+_73366155 0.25 ENSRNOT00000044979
Olr473
olfactory receptor 473
chr3_-_14386118 0.23 ENSRNOT00000025649
Rab14
RAB14, member RAS oncogene family
chr1_+_67917477 0.13 ENSRNOT00000052217
Vom1r40
vomeronasal 1 receptor 40
chr18_-_60002529 0.05 ENSRNOT00000081014
ENSRNOT00000024264
ENSRNOT00000059162
Nars
asparaginyl-tRNA synthetase

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpa_Cebpg

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
44.0 132.0 GO:0001905 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
27.5 82.5 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
20.7 82.8 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
17.7 70.6 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
17.5 52.6 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
15.4 77.1 GO:0071400 cellular response to oleic acid(GO:0071400)
13.3 106.5 GO:0015679 plasma membrane copper ion transport(GO:0015679)
9.3 27.9 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
8.2 49.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
8.2 24.5 GO:0055073 cadmium ion homeostasis(GO:0055073)
7.5 22.5 GO:0071623 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
7.3 29.2 GO:0010999 regulation of eIF2 alpha phosphorylation by heme(GO:0010999)
6.9 159.6 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
6.9 20.7 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
6.9 27.6 GO:0052422 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
6.9 41.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
6.3 82.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
6.3 44.1 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
5.7 57.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
5.4 16.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
5.2 26.2 GO:1904640 response to methionine(GO:1904640)
5.1 30.5 GO:0071279 cellular response to cobalt ion(GO:0071279)
4.7 14.0 GO:0016267 O-glycan processing, core 1(GO:0016267)
4.0 158.8 GO:0042311 vasodilation(GO:0042311)
3.2 9.5 GO:0009249 protein lipoylation(GO:0009249)
3.0 32.8 GO:0070327 thyroid hormone transport(GO:0070327)
2.7 16.4 GO:0042908 canalicular bile acid transport(GO:0015722) xenobiotic transport(GO:0042908)
2.5 9.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.4 11.8 GO:0050828 regulation of liquid surface tension(GO:0050828)
1.9 26.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.8 12.8 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
1.6 11.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
1.5 22.7 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
1.5 21.1 GO:0034389 lipid particle organization(GO:0034389)
1.4 20.0 GO:0015671 oxygen transport(GO:0015671)
1.4 6.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.3 7.9 GO:0051182 coenzyme transport(GO:0051182)
1.3 7.9 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.3 3.9 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
1.2 10.5 GO:0015866 ADP transport(GO:0015866)
1.1 3.3 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
1.0 9.0 GO:0038161 prolactin signaling pathway(GO:0038161)
0.9 5.5 GO:0015677 copper ion import(GO:0015677)
0.9 8.2 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.9 17.0 GO:0071287 cellular response to manganese ion(GO:0071287)
0.9 3.6 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.9 8.9 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.8 8.9 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.8 20.7 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.7 2.9 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.7 99.0 GO:0031638 zymogen activation(GO:0031638)
0.7 3.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.7 22.9 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.6 2.6 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.6 4.4 GO:0048251 elastic fiber assembly(GO:0048251) regulation of removal of superoxide radicals(GO:2000121)
0.5 9.7 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.5 3.0 GO:0016139 glycoside catabolic process(GO:0016139)
0.5 19.5 GO:0030199 collagen fibril organization(GO:0030199)
0.4 6.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.4 25.2 GO:0046889 positive regulation of lipid biosynthetic process(GO:0046889)
0.4 63.3 GO:0009267 cellular response to starvation(GO:0009267)
0.4 30.3 GO:0055088 lipid homeostasis(GO:0055088)
0.3 14.4 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.3 2.5 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.3 18.4 GO:0006414 translational elongation(GO:0006414)
0.3 5.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 7.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 4.2 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 55.1 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.2 6.8 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.2 4.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 1.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.3 GO:0007343 egg activation(GO:0007343)
0.1 1.8 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.5 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 11.2 GO:0051028 mRNA transport(GO:0051028)
0.1 9.8 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.1 9.5 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.1 0.3 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 8.9 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 0.8 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 1.6 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.5 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:0045176 apical protein localization(GO:0045176)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 1.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.0 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.0 2.2 GO:0007565 female pregnancy(GO:0007565)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
14.2 57.0 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
11.8 70.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
8.2 24.5 GO:0070821 tertiary granule membrane(GO:0070821)
7.3 29.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
6.6 52.6 GO:0005577 fibrinogen complex(GO:0005577)
6.4 82.8 GO:0042627 chylomicron(GO:0042627)
5.7 629.1 GO:0072562 blood microparticle(GO:0072562)
3.2 26.0 GO:0043203 axon hillock(GO:0043203)
2.9 20.0 GO:0005833 hemoglobin complex(GO:0005833)
2.6 49.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.6 8.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.5 17.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.4 97.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
1.4 71.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
1.3 3.9 GO:0071942 XPC complex(GO:0071942)
1.2 5.9 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
1.1 4.4 GO:0071953 elastic fiber(GO:0071953)
1.0 12.0 GO:0097208 alveolar lamellar body(GO:0097208)
0.9 66.3 GO:0005811 lipid particle(GO:0005811)
0.9 4.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.6 9.5 GO:0042581 specific granule(GO:0042581)
0.5 6.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.5 2.6 GO:0072558 IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
0.3 488.5 GO:0005615 extracellular space(GO:0005615)
0.3 13.1 GO:0009925 basal plasma membrane(GO:0009925)
0.3 39.5 GO:0005882 intermediate filament(GO:0005882)
0.3 6.1 GO:0005685 U1 snRNP(GO:0005685)
0.2 9.7 GO:0016235 aggresome(GO:0016235)
0.2 9.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 14.4 GO:0031902 late endosome membrane(GO:0031902)
0.2 11.9 GO:0031526 brush border membrane(GO:0031526)
0.1 0.8 GO:1990393 Cul7-RING ubiquitin ligase complex(GO:0031467) 3M complex(GO:1990393)
0.1 1.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 8.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 19.5 GO:0000139 Golgi membrane(GO:0000139)
0.0 18.8 GO:0005925 focal adhesion(GO:0005925)
0.0 2.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 60.9 GO:0070062 extracellular exosome(GO:0070062)
0.0 4.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 6.7 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
44.0 132.0 GO:0031714 C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
39.9 159.6 GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
27.6 82.8 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
27.5 82.4 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
17.7 106.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
11.7 46.9 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
9.7 29.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
9.3 27.9 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
8.8 70.6 GO:1990459 transferrin receptor binding(GO:1990459)
8.2 49.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
7.5 52.6 GO:0045340 mercury ion binding(GO:0045340)
6.4 77.1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
5.0 44.6 GO:0046790 virion binding(GO:0046790)
4.7 14.0 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
4.4 13.1 GO:0001847 opsonin receptor activity(GO:0001847)
4.1 32.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
4.0 24.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
3.1 82.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
3.0 9.0 GO:0004925 prolactin receptor activity(GO:0004925)
2.6 7.9 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
2.5 9.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.4 24.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
2.4 9.5 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
2.2 8.9 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
2.1 148.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
2.0 6.0 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
2.0 20.0 GO:0005344 oxygen transporter activity(GO:0005344)
1.9 9.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.8 16.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
1.6 11.5 GO:0004064 arylesterase activity(GO:0004064)
1.6 8.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
1.6 9.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.6 7.9 GO:0051185 coenzyme transporter activity(GO:0051185)
1.5 6.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
1.5 10.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
1.3 12.8 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.1 20.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.9 5.5 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.9 22.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.9 4.5 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.9 5.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.8 18.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.8 41.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.8 26.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.8 14.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.7 165.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.7 5.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.6 6.8 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.6 22.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 92.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.5 53.7 GO:0004540 ribonuclease activity(GO:0004540)
0.4 11.9 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.4 9.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.3 11.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 6.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 3.0 GO:0015925 galactosidase activity(GO:0015925)
0.3 6.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 18.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 22.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 2.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 1.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 3.5 GO:0008483 transaminase activity(GO:0008483)
0.1 18.9 GO:0005179 hormone activity(GO:0005179)
0.1 1.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 4.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 18.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 11.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 7.9 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 9.2 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
9.4 290.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
3.5 52.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
2.9 154.1 PID BMP PATHWAY BMP receptor signaling
2.7 70.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.7 23.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
1.4 101.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.3 53.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
1.1 27.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.9 27.9 PID IL1 PATHWAY IL1-mediated signaling events
0.8 175.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 8.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 4.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4 6.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4 9.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.4 24.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.4 17.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.3 15.6 SIG CHEMOTAXIS Genes related to chemotaxis
0.3 9.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 5.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.2 7.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 11.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 18.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 24.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
12.3 258.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
9.4 132.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
6.9 82.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
4.5 130.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
4.0 83.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
3.1 52.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
2.6 76.5 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
1.5 17.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.5 16.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
1.4 8.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
1.0 48.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
1.0 24.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.6 9.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.5 11.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 107.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.5 8.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.5 9.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.4 9.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.4 9.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 4.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 5.0 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 14.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 7.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 6.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.2 5.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 2.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 3.9 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.2 2.5 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 7.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 5.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 8.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 6.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 1.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 6.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21