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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Cebpb

Z-value: 2.48

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Transcription factors associated with Cebpb

Gene Symbol Gene ID Gene Info
Cebpb
ENSRNOG00000057347 CCAAT/enhancer binding protein beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cebpbrn6_v1_chr3_+_164424515_1644245150.608.3e-33Click!

Activity profile of Cebpb motif

Sorted Z-values of Cebpb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_181987217 196.04 ENSRNOT00000034521
Fgg
fibrinogen gamma chain
chr11_-_81717521 157.82 ENSRNOT00000058422
Ahsg
alpha-2-HS-glycoprotein
chr9_+_74124016 157.18 ENSRNOT00000019023
Cps1
carbamoyl-phosphate synthase 1
chr15_+_28018040 155.80 ENSRNOT00000041495
Rnase4
ribonuclease A family member 4
chr2_+_55775274 149.13 ENSRNOT00000018545
C9
complement C9
chr1_-_76614279 148.08 ENSRNOT00000041367
ENSRNOT00000089371
LOC100912485
alcohol sulfotransferase-like
chrX_+_33443186 137.09 ENSRNOT00000005622
S100g
S100 calcium binding protein G
chr1_-_76780230 132.59 ENSRNOT00000002046
LOC100912485
alcohol sulfotransferase-like
chr1_-_76722965 127.69 ENSRNOT00000052129
LOC100912485
alcohol sulfotransferase-like
chr2_+_182006242 126.94 ENSRNOT00000064091
Fga
fibrinogen alpha chain
chr9_-_78969013 126.22 ENSRNOT00000019772
ENSRNOT00000057585
Fn1
fibronectin 1
chrX_+_143097525 123.62 ENSRNOT00000004559
F9
coagulation factor IX
chr2_+_104744461 121.43 ENSRNOT00000016083
ENSRNOT00000082627
Cp
ceruloplasmin
chr10_+_96639924 113.55 ENSRNOT00000004756
Apoh
apolipoprotein H
chr8_-_111721303 109.14 ENSRNOT00000045628
ENSRNOT00000012725
Tf
transferrin
chr1_-_256813711 103.63 ENSRNOT00000021055
Rbp4
retinol binding protein 4
chr7_+_99142450 99.16 ENSRNOT00000079036
ENSRNOT00000091923
LOC108348266
cytochrome P450 2B1
chr4_+_100166863 96.95 ENSRNOT00000014505
Sftpb
surfactant protein B
chr1_-_76517134 94.01 ENSRNOT00000064593
ENSRNOT00000085775
LOC100912485
alcohol sulfotransferase-like
chr8_+_116857684 93.97 ENSRNOT00000026711
Mst1
macrophage stimulating 1
chr16_+_18690246 90.66 ENSRNOT00000081484
Mat1a
methionine adenosyltransferase 1A
chr10_+_56710464 85.90 ENSRNOT00000065370
ENSRNOT00000064064
Asgr2
asialoglycoprotein receptor 2
chr3_-_101474890 85.03 ENSRNOT00000091869
Bbox1
gamma-butyrobetaine hydroxylase 1
chr10_-_62254287 83.26 ENSRNOT00000004313
Serpinf1
serpin family F member 1
chr1_+_276240703 71.80 ENSRNOT00000022126
Acsl5
acyl-CoA synthetase long-chain family member 5
chr13_-_111972603 71.72 ENSRNOT00000007870
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr8_+_22856539 67.75 ENSRNOT00000015381
Angptl8
angiopoietin-like 8
chrX_-_110232179 65.96 ENSRNOT00000014739
Serpina7
serpin family A member 7
chr3_-_147819571 65.28 ENSRNOT00000009840
Trib3
tribbles pseudokinase 3
chr9_+_46962288 63.70 ENSRNOT00000082146
Il1r1
interleukin 1 receptor type 1
chr2_-_189254628 62.13 ENSRNOT00000028234
Il6r
interleukin 6 receptor
chr10_-_87407634 60.33 ENSRNOT00000016657
Krt23
keratin 23
chr7_-_143538579 60.29 ENSRNOT00000081518
Krt79
keratin 79
chr19_+_15081158 60.10 ENSRNOT00000074070
Ces1f
carboxylesterase 1F
chr14_+_7113544 59.43 ENSRNOT00000038188
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr4_-_157155609 58.76 ENSRNOT00000016330
C1s
complement C1s
chr1_-_101596822 58.54 ENSRNOT00000028490
Fgf21
fibroblast growth factor 21
chr6_-_25211494 58.33 ENSRNOT00000009634
Xdh
xanthine dehydrogenase
chr19_+_15081590 58.07 ENSRNOT00000024187
Ces1f
carboxylesterase 1F
chr7_+_3216497 56.27 ENSRNOT00000008909
Mmp19
matrix metallopeptidase 19
chr9_+_95233957 53.70 ENSRNOT00000071003
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chr5_+_151181559 53.68 ENSRNOT00000085674
Fgr
FGR proto-oncogene, Src family tyrosine kinase
chr9_+_81656116 53.54 ENSRNOT00000083421
Slc11a1
solute carrier family 11 member 1
chr11_-_34142753 53.46 ENSRNOT00000002297
Cldn14
claudin 14
chr13_+_83073544 52.58 ENSRNOT00000066119
ENSRNOT00000079796
ENSRNOT00000077070
Dpt
dermatopontin
chr16_+_61954809 48.20 ENSRNOT00000068011
Rbpms
RNA binding protein with multiple splicing
chr20_+_3176107 46.88 ENSRNOT00000001036
RT1-S3
RT1 class Ib, locus S3
chr18_+_16590197 46.57 ENSRNOT00000066583
Mocos
molybdenum cofactor sulfurase
chr3_-_121882726 46.27 ENSRNOT00000006308
Il1b
interleukin 1 beta
chr10_-_70871066 45.32 ENSRNOT00000015139
Ccl3
C-C motif chemokine ligand 3
chr1_-_22661377 44.96 ENSRNOT00000021896
Vnn3
vanin 3
chr1_-_253185533 44.22 ENSRNOT00000067822
Pank1
pantothenate kinase 1
chr16_+_61954590 44.00 ENSRNOT00000017883
Rbpms
RNA binding protein with multiple splicing
chr6_+_56846789 43.56 ENSRNOT00000032108
Agmo
alkylglycerol monooxygenase
chr3_+_154786215 41.28 ENSRNOT00000019787
Lbp
lipopolysaccharide binding protein
chr14_+_84306466 40.84 ENSRNOT00000006116
Sec14l4
SEC14-like lipid binding 4
chr19_+_14508616 39.86 ENSRNOT00000019192
Hmox1
heme oxygenase 1
chr11_-_69201380 39.46 ENSRNOT00000085618
Mylk
myosin light chain kinase
chr20_-_45260119 38.99 ENSRNOT00000000718
Slc16a10
solute carrier family 16 member 10
chr20_+_22913694 38.92 ENSRNOT00000067920
Reep3
receptor accessory protein 3
chr10_-_82117109 38.10 ENSRNOT00000079711
Abcc3
ATP binding cassette subfamily C member 3
chr7_-_101140308 37.71 ENSRNOT00000006279
Fam84b
family with sequence similarity 84, member B
chr1_+_145770135 37.44 ENSRNOT00000015320
Stard5
StAR-related lipid transfer domain containing 5
chr13_-_80775230 36.66 ENSRNOT00000091389
ENSRNOT00000004762
Fmo2
flavin containing monooxygenase 2
chr11_+_82680253 36.60 ENSRNOT00000077119
ENSRNOT00000075512
Liph
lipase H
chr9_+_10952374 36.03 ENSRNOT00000074993
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr18_-_29562153 35.77 ENSRNOT00000023977
Cd14
CD14 molecule
chr10_-_82116621 35.70 ENSRNOT00000003977
ENSRNOT00000051497
ENSRNOT00000085451
Abcc3
ATP binding cassette subfamily C member 3
chr5_-_137372993 35.24 ENSRNOT00000092823
Tmem125
transmembrane protein 125
chr6_-_125723732 34.42 ENSRNOT00000084815
Fbln5
fibulin 5
chr18_-_15688117 33.87 ENSRNOT00000022584
Dsg3
desmoglein 3
chr4_-_82173207 33.86 ENSRNOT00000074167
Hoxa5
homeo box A5
chr20_-_45259928 33.82 ENSRNOT00000087226
Slc16a10
solute carrier family 16 member 10
chr14_+_45062662 33.63 ENSRNOT00000059124
Tlr10
toll-like receptor 10
chr1_-_167700332 33.03 ENSRNOT00000092890
Trim21
tripartite motif-containing 21
chr4_-_82258765 33.03 ENSRNOT00000008523
Hoxa5
homeo box A5
chr9_-_46309451 32.96 ENSRNOT00000018684
Rnf149
ring finger protein 149
chrX_+_120624518 32.28 ENSRNOT00000007967
Slc6a14
solute carrier family 6 member 14
chr14_+_22072024 31.78 ENSRNOT00000002680
ste2
estrogen sulfotransferase
chr1_+_256786124 30.56 ENSRNOT00000034563
Ffar4
free fatty acid receptor 4
chr6_-_125723944 30.49 ENSRNOT00000007004
Fbln5
fibulin 5
chr7_-_70829815 30.14 ENSRNOT00000011082
Shmt2
serine hydroxymethyltransferase 2
chr10_-_104628676 28.75 ENSRNOT00000010466
Unc13d
unc-13 homolog D
chr1_-_100537377 27.78 ENSRNOT00000026599
Spib
Spi-B transcription factor
chr20_-_2707108 27.01 ENSRNOT00000082052
ENSRNOT00000048535
LOC100364500
RT1 class I, locus CE11-like
chr2_-_190100276 26.13 ENSRNOT00000015351
S100a9
S100 calcium binding protein A9
chr18_+_16590408 25.20 ENSRNOT00000093715
Mocos
molybdenum cofactor sulfurase
chr17_-_46115004 24.64 ENSRNOT00000087838
Aoah
acyloxyacyl hydrolase
chr2_-_185168476 23.27 ENSRNOT00000093447
Fam160a1
family with sequence similarity 160, member A1
chr7_+_99954492 22.27 ENSRNOT00000005885
Trib1
tribbles pseudokinase 1
chr1_+_84256159 22.04 ENSRNOT00000031026
Blvrb
biliverdin reductase B
chr12_-_48238887 21.96 ENSRNOT00000078868
Acacb
acetyl-CoA carboxylase beta
chr20_+_4517307 21.29 ENSRNOT00000000483
Dxo
decapping exoribonuclease
chr14_+_60657686 21.28 ENSRNOT00000070892
Sepsecs
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr14_-_18591394 20.30 ENSRNOT00000003716
Ereg
epiregulin
chr14_-_7384876 20.22 ENSRNOT00000086694
Aff1
AF4/FMR2 family, member 1
chr16_-_85306366 19.85 ENSRNOT00000089650
Tnfsf13b
tumor necrosis factor superfamily member 13b
chr3_+_1285664 19.69 ENSRNOT00000007512
Il36g
interleukin 36, gamma
chr8_+_132607166 19.40 ENSRNOT00000007223
Sacm1l
SAC1 suppressor of actin mutations 1-like (yeast)
chr1_+_91152635 17.46 ENSRNOT00000073438
LOC100912070
dermokine-like
chr10_-_108196217 17.39 ENSRNOT00000075440
Cbx4
chromobox 4
chr7_-_14302552 16.70 ENSRNOT00000091368
Brd4
bromodomain containing 4
chr6_+_24163026 16.25 ENSRNOT00000061284
Lbh
limb bud and heart development
chr18_+_32594958 16.11 ENSRNOT00000018511
Spry4
sprouty RTK signaling antagonist 4
chr1_+_89215266 15.88 ENSRNOT00000093612
ENSRNOT00000084799
Dmkn
dermokine
chr2_-_178297172 15.35 ENSRNOT00000038543
Fnip2
folliculin interacting protein 2
chr2_-_147693082 15.23 ENSRNOT00000022507
Wwtr1
WW domain containing transcription regulator 1
chr8_-_48674748 14.56 ENSRNOT00000014127
Hmbs
hydroxymethylbilane synthase
chr1_-_6970040 14.14 ENSRNOT00000016273
Utrn
utrophin
chr3_+_151285249 14.13 ENSRNOT00000055254
Procr
protein C receptor
chr3_+_18706988 13.80 ENSRNOT00000074650
AABR07051652.1

chr2_-_1561464 13.77 ENSRNOT00000062055
ENSRNOT00000062054
ENSRNOT00000062052
Cast
calpastatin
chr1_-_254735548 13.49 ENSRNOT00000025258
Ankrd1
ankyrin repeat domain 1
chr8_+_5768811 13.33 ENSRNOT00000013936
Mmp8
matrix metallopeptidase 8
chr3_+_97349454 13.23 ENSRNOT00000089524
Dcdc5
doublecortin domain containing 5
chr14_-_8548310 13.19 ENSRNOT00000092436
Arhgap24
Rho GTPase activating protein 24
chr2_+_150756185 12.99 ENSRNOT00000088461
ENSRNOT00000036808
Mbnl1
muscleblind-like splicing regulator 1
chr11_+_85042348 12.97 ENSRNOT00000042220
AABR07034718.1

chr5_+_72103704 12.96 ENSRNOT00000021629
Rad23b
RAD23 homolog B, nucleotide excision repair protein
chr7_-_27240528 12.92 ENSRNOT00000029435
ENSRNOT00000079731
Hsp90b1
heat shock protein 90 beta family member 1
chr6_-_107678156 12.59 ENSRNOT00000014158
Elmsan1
ELM2 and Myb/SANT domain containing 1
chr4_+_147333056 12.56 ENSRNOT00000012137
Pparg
peroxisome proliferator-activated receptor gamma
chr14_-_38575785 12.37 ENSRNOT00000003146
Atp10d
ATPase phospholipid transporting 10D (putative)
chr9_-_54327958 12.29 ENSRNOT00000019465
Stat1
signal transducer and activator of transcription 1
chr5_+_142731767 11.26 ENSRNOT00000067762
Inpp5b
inositol polyphosphate-5-phosphatase B
chr19_-_11057254 11.25 ENSRNOT00000025559
Herpud1
homocysteine inducible ER protein with ubiquitin like domain 1
chr7_+_2504695 11.23 ENSRNOT00000003965
Atp5b
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr4_-_35730599 11.10 ENSRNOT00000051149
Rps4x
ribosomal protein S4, X-linked
chr11_-_28777603 11.00 ENSRNOT00000002132
Krtap14
keratin associated protein 14
chr1_-_83418777 10.89 ENSRNOT00000049175
Cyp2b21
cytochrome P450, family 2, subfamily b, polypeptide 21
chr3_+_18315320 10.73 ENSRNOT00000006954
AABR07051626.2

chr20_-_2103864 10.70 ENSRNOT00000001014
Rnf39
ring finger protein 39
chr1_+_252323865 10.58 ENSRNOT00000026299
Lipk
lipase, family member K
chr11_-_60547201 10.30 ENSRNOT00000093151
Btla
B and T lymphocyte associated
chr16_-_85305782 10.07 ENSRNOT00000067511
ENSRNOT00000076737
Tnfsf13b
tumor necrosis factor superfamily member 13b
chr13_+_48427038 9.89 ENSRNOT00000009241
Ctse
cathepsin E
chr7_-_137856485 9.74 ENSRNOT00000007003
LOC688906
similar to splicing factor, arginine/serine-rich 2, interacting protein
chr3_-_152259156 9.33 ENSRNOT00000065729
LOC100910882
RNA-binding protein 39-like
chr20_+_7908304 9.28 ENSRNOT00000000603
Rpl10a
ribosomal protein L10A
chr7_-_14303055 9.07 ENSRNOT00000008963
Brd4
bromodomain containing 4
chr4_-_28953067 8.77 ENSRNOT00000013989
Tfpi2
tissue factor pathway inhibitor 2
chr14_-_100184192 8.69 ENSRNOT00000007044
Plek
pleckstrin
chr12_+_38160464 8.69 ENSRNOT00000032249
Hcar2
hydroxycarboxylic acid receptor 2
chr3_-_151724654 8.63 ENSRNOT00000026964
Rbm39
RNA binding motif protein 39
chr11_-_60546997 7.65 ENSRNOT00000083124
ENSRNOT00000050092
Btla
B and T lymphocyte associated
chr3_+_11921715 7.43 ENSRNOT00000021689
Fam129b
family with sequence similarity 129, member B
chr8_-_133002201 7.32 ENSRNOT00000008772
Ccr1
C-C motif chemokine receptor 1
chr5_+_144031402 7.25 ENSRNOT00000011694
Csf3r
colony stimulating factor 3 receptor
chr8_-_117932518 7.14 ENSRNOT00000028130
Camp
cathelicidin antimicrobial peptide
chr8_-_96132634 6.64 ENSRNOT00000041655
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr2_+_149899538 6.63 ENSRNOT00000065365
RGD1560324
similar to hypothetical protein C130079G13
chr10_-_72188164 6.44 ENSRNOT00000085728
ENSRNOT00000042506
Ggnbp2
gametogenetin binding protein 2
chr10_-_84920886 5.62 ENSRNOT00000068083
Sp2
Sp2 transcription factor
chr1_-_73263466 5.24 ENSRNOT00000087826
Fcar
Fc fragment of IgA receptor
chr10_+_10725819 4.92 ENSRNOT00000004159
Glyr1
glyoxylate reductase 1 homolog
chr19_-_43215281 4.34 ENSRNOT00000025052
Aars
alanyl-tRNA synthetase
chr5_+_142986526 4.10 ENSRNOT00000012811
Rspo1
R-spondin 1
chr1_-_170092062 4.01 ENSRNOT00000023335
Olr197
olfactory receptor 197
chr3_+_159095876 3.73 ENSRNOT00000074363
LOC103694889
seminal vesicle secretory protein 4
chr5_+_74649765 3.64 ENSRNOT00000075952
Palm2
paralemmin 2
chr13_+_52887649 3.60 ENSRNOT00000048033
Ascl5
achaete-scute family bHLH transcription factor 5
chr20_+_7821755 3.58 ENSRNOT00000083109
Ppard
peroxisome proliferator-activated receptor delta
chr9_-_46206605 3.45 ENSRNOT00000018640
Tbc1d8
TBC1 domain family, member 8
chr10_-_90049112 3.30 ENSRNOT00000028323
Pyy
peptide YY (mapped)
chr10_+_43446526 3.07 ENSRNOT00000036959
Larp1
La ribonucleoprotein domain family, member 1
chr14_-_44375804 2.98 ENSRNOT00000042825
LOC100362751
ribosomal protein P2-like
chrX_+_25016401 2.69 ENSRNOT00000059270
Clcn4
chloride voltage-gated channel 4
chr8_-_96266342 2.61 ENSRNOT00000078891
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr19_-_10596851 2.26 ENSRNOT00000021716
Coq9
coenzyme Q9
chr20_-_32133431 2.21 ENSRNOT00000000443
Srgn
serglycin
chrX_+_111396995 2.06 ENSRNOT00000087634
Pih1d3
PIH1 domain containing 3
chr17_-_15402631 1.55 ENSRNOT00000019862
ENSRNOT00000093637
Iars
isoleucyl-tRNA synthetase
chr1_+_137799185 1.51 ENSRNOT00000083590
ENSRNOT00000092778
Agbl1
ATP/GTP binding protein-like 1
chr2_-_149754776 1.47 ENSRNOT00000035057
RGD1559622
similar to hypothetical protein C130079G13
chr9_-_24467892 1.15 ENSRNOT00000060803
Defb18
defensin beta 18
chr1_+_169912819 0.94 ENSRNOT00000023283
Olr185
olfactory receptor 185
chr19_-_43215077 0.87 ENSRNOT00000082151
Aars
alanyl-tRNA synthetase
chr18_-_15688284 0.56 ENSRNOT00000091816
Dsg3
desmoglein 3
chr5_+_139100898 0.45 ENSRNOT00000012569
Edn2
endothelin 2
chr7_+_122818975 0.06 ENSRNOT00000000206
Ep300
E1A binding protein p300

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
42.1 126.2 GO:2001201 calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
39.7 436.5 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
34.5 103.6 GO:0046865 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
31.4 157.2 GO:0071400 cellular response to oleic acid(GO:0071400)
27.3 109.1 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
23.9 71.8 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
23.9 71.7 GO:0006713 glucocorticoid catabolic process(GO:0006713)
22.3 66.9 GO:0060764 cell-cell signaling involved in mammary gland development(GO:0060764)
21.2 63.7 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
19.4 96.9 GO:0050828 regulation of liquid surface tension(GO:0050828)
18.1 90.7 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
17.8 53.5 GO:0055073 cadmium ion homeostasis(GO:0055073)
15.6 46.9 GO:0002488 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
15.4 46.3 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
15.2 121.4 GO:0015679 plasma membrane copper ion transport(GO:0015679)
14.6 72.8 GO:0015801 aromatic amino acid transport(GO:0015801)
14.2 85.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
13.9 83.3 GO:0071279 cellular response to cobalt ion(GO:0071279)
13.8 41.3 GO:0015920 lipopolysaccharide transport(GO:0015920)
13.6 149.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
13.3 39.9 GO:0006788 heme oxidation(GO:0006788)
12.4 62.1 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533) ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
12.3 73.8 GO:0042908 xenobiotic transport(GO:0042908)
12.2 36.7 GO:0072592 oxygen metabolic process(GO:0072592)
11.7 58.5 GO:1904640 response to methionine(GO:1904640)
11.7 58.3 GO:0009115 xanthine catabolic process(GO:0009115)
11.0 22.0 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
10.4 94.0 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
9.9 39.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
9.7 38.9 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
9.7 212.7 GO:0030502 negative regulation of bone mineralization(GO:0030502)
9.6 28.8 GO:0002432 granuloma formation(GO:0002432)
9.3 64.9 GO:0048251 elastic fiber assembly(GO:0048251)
8.7 26.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
8.3 33.3 GO:1903575 cornified envelope assembly(GO:1903575)
7.3 66.0 GO:0070327 thyroid hormone transport(GO:0070327)
6.6 19.7 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
6.5 71.8 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
6.0 29.9 GO:0002636 positive regulation of germinal center formation(GO:0002636)
6.0 53.7 GO:0052697 xenobiotic glucuronidation(GO:0052697)
5.6 22.3 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
5.5 55.0 GO:0001554 luteolysis(GO:0001554)
5.5 22.0 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
5.4 92.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
5.1 20.3 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
4.7 37.4 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
4.4 65.3 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
4.3 13.0 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
4.2 67.7 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
4.2 58.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
4.2 12.6 GO:1901558 response to metformin(GO:1901558) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
4.1 33.0 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
4.0 35.8 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
3.8 15.2 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
3.8 30.1 GO:0006545 glycine biosynthetic process(GO:0006545)
3.6 43.6 GO:0046485 ether lipid metabolic process(GO:0046485)
3.2 44.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
3.1 12.3 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
2.9 25.8 GO:2000002 histone H3-K14 acetylation(GO:0044154) negative regulation of DNA damage checkpoint(GO:2000002)
2.8 11.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
2.7 16.3 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
2.7 21.3 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
2.5 46.9 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
2.4 14.6 GO:0071418 protein-cofactor linkage(GO:0018065) cellular response to amine stimulus(GO:0071418)
2.3 11.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
2.2 8.7 GO:0070560 protein secretion by platelet(GO:0070560)
2.0 18.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
1.8 21.3 GO:0071027 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
1.7 13.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
1.6 36.0 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
1.5 9.2 GO:0090367 negative regulation of mRNA modification(GO:0090367)
1.5 13.8 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.4 7.1 GO:0071224 cellular response to peptidoglycan(GO:0071224)
1.4 44.6 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
1.3 13.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
1.3 52.6 GO:0030199 collagen fibril organization(GO:0030199)
1.3 5.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
1.1 30.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
1.1 153.3 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.9 27.8 GO:0030225 macrophage differentiation(GO:0030225)
0.9 109.2 GO:0031638 zymogen activation(GO:0031638)
0.8 13.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.8 9.9 GO:0016540 protein autoprocessing(GO:0016540)
0.7 30.6 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.7 13.3 GO:0030574 collagen catabolic process(GO:0030574)
0.7 27.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.6 3.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.6 4.1 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.5 13.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.5 12.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.4 3.6 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 0.4 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.4 12.4 GO:0045332 phospholipid translocation(GO:0045332)
0.4 48.0 GO:0055088 lipid homeostasis(GO:0055088)
0.4 17.4 GO:0016925 protein sumoylation(GO:0016925)
0.4 10.9 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.4 9.3 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.4 10.1 GO:0050819 negative regulation of coagulation(GO:0050819)
0.4 1.6 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.3 7.4 GO:0032274 gonadotropin secretion(GO:0032274)
0.3 33.0 GO:0035690 cellular response to drug(GO:0035690)
0.3 6.4 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.3 7.2 GO:0097186 amelogenesis(GO:0097186)
0.3 3.3 GO:0032096 negative regulation of response to food(GO:0032096)
0.3 14.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.3 1.5 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 16.1 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.2 34.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 24.6 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.2 15.4 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.1 2.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 11.1 GO:0045727 positive regulation of translation(GO:0045727)
0.1 2.7 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 19.8 GO:0016042 lipid catabolic process(GO:0016042)
0.1 3.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 2.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 3.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 1.8 GO:0070207 protein homotrimerization(GO:0070207)
0.0 13.4 GO:0006397 mRNA processing(GO:0006397)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
56.2 449.2 GO:0005577 fibrinogen complex(GO:0005577)
37.3 149.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
20.7 62.1 GO:0005896 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
18.2 109.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
17.8 53.5 GO:0070821 tertiary granule membrane(GO:0070821)
16.2 64.9 GO:0071953 elastic fiber(GO:0071953)
15.6 46.9 GO:0032398 MHC class Ib protein complex(GO:0032398)
10.4 83.3 GO:0043203 axon hillock(GO:0043203)
8.7 113.5 GO:0042627 chylomicron(GO:0042627)
7.2 35.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
6.9 96.9 GO:0097208 alveolar lamellar body(GO:0097208)
6.0 30.1 GO:0070552 BRISC complex(GO:0070552)
4.8 28.8 GO:0033093 Weibel-Palade body(GO:0033093)
4.3 13.0 GO:0071942 XPC complex(GO:0071942)
4.2 92.2 GO:0005685 U1 snRNP(GO:0005685)
3.8 11.3 GO:1990037 Lewy body core(GO:1990037)
3.3 168.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.9 338.0 GO:0072562 blood microparticle(GO:0072562)
2.9 25.8 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
2.3 27.0 GO:0042612 MHC class I protein complex(GO:0042612)
1.5 118.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
1.2 53.7 GO:0016235 aggresome(GO:0016235)
1.2 17.4 GO:0035102 PRC1 complex(GO:0035102)
1.2 9.2 GO:0071204 CRD-mediated mRNA stability complex(GO:0070937) histone pre-mRNA 3'end processing complex(GO:0071204) GAIT complex(GO:0097452)
0.9 58.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.9 39.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.8 14.1 GO:0070938 contractile ring(GO:0070938)
0.8 198.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.8 19.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 44.2 GO:0030118 clathrin coat(GO:0030118)
0.7 54.7 GO:0045095 keratin filament(GO:0045095)
0.7 51.5 GO:0005882 intermediate filament(GO:0005882)
0.7 957.0 GO:0005615 extracellular space(GO:0005615)
0.7 68.6 GO:0016363 nuclear matrix(GO:0016363)
0.6 40.2 GO:0005811 lipid particle(GO:0005811)
0.6 32.3 GO:0031526 brush border membrane(GO:0031526)
0.5 71.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.5 3.1 GO:0031931 TORC1 complex(GO:0031931)
0.4 20.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.3 13.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 83.7 GO:0031965 nuclear membrane(GO:0031965)
0.2 30.6 GO:0030139 endocytic vesicle(GO:0030139)
0.2 11.1 GO:0005844 polysome(GO:0005844)
0.2 12.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 14.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 12.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 46.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 21.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 29.0 GO:0005925 focal adhesion(GO:0005925)
0.1 51.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 3.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 39.3 GO:0005739 mitochondrion(GO:0005739)
0.0 7.0 GO:0005768 endosome(GO:0005768)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
39.5 157.8 GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
37.9 113.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
30.2 90.7 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
23.9 71.7 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
23.1 92.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
22.8 137.1 GO:0005499 vitamin D binding(GO:0005499)
21.2 63.7 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
20.2 121.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
18.0 126.2 GO:0045340 mercury ion binding(GO:0045340)
17.9 71.8 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
17.3 138.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
15.5 62.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
15.4 77.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
15.1 45.3 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
13.6 109.1 GO:1990459 transferrin receptor binding(GO:1990459)
13.3 39.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
13.1 157.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
11.7 58.3 GO:0004854 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
11.1 44.2 GO:0004594 pantothenate kinase activity(GO:0004594)
10.0 30.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
9.9 39.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
8.9 53.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
8.6 25.8 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
8.2 73.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
7.8 46.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
6.5 19.4 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
6.2 81.1 GO:0019841 retinol binding(GO:0019841)
6.2 43.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
6.0 71.8 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
5.5 22.0 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
5.4 53.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
4.9 14.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
4.7 37.4 GO:0032052 bile acid binding(GO:0032052)
4.6 87.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
4.4 26.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
4.3 13.0 GO:0001069 regulatory region RNA binding(GO:0001069)
3.5 66.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
3.1 36.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
2.6 15.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
2.4 7.3 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
2.4 318.0 GO:0030674 protein binding, bridging(GO:0030674)
2.4 7.2 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
2.2 11.2 GO:0043532 angiostatin binding(GO:0043532)
2.2 110.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
1.9 58.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.8 12.6 GO:0050692 DBD domain binding(GO:0050692)
1.8 21.3 GO:0008409 5'-3' exonuclease activity(GO:0008409)
1.7 53.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.6 11.3 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
1.5 94.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
1.4 12.9 GO:0046790 virion binding(GO:0046790)
1.4 155.8 GO:0004540 ribonuclease activity(GO:0004540)
1.3 5.2 GO:0019862 IgA binding(GO:0019862)
1.3 5.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
1.3 64.6 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
1.2 32.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
1.1 12.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.1 30.6 GO:0008527 taste receptor activity(GO:0008527)
1.0 13.5 GO:0031432 titin binding(GO:0031432)
1.0 17.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.9 152.5 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.8 22.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.8 4.9 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.8 178.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.8 89.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 29.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.7 9.2 GO:0008143 poly(A) binding(GO:0008143)
0.7 14.1 GO:0017166 vinculin binding(GO:0017166)
0.7 12.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.7 27.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.6 36.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.6 20.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.5 47.2 GO:0005178 integrin binding(GO:0005178)
0.4 64.2 GO:0005179 hormone activity(GO:0005179)
0.4 8.7 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.4 9.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.4 8.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 27.9 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3 3.1 GO:0008494 translation activator activity(GO:0008494)
0.3 34.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 14.6 GO:0000049 tRNA binding(GO:0000049)
0.3 13.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 13.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 59.1 GO:0030246 carbohydrate binding(GO:0030246)
0.2 3.6 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.2 32.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 120.3 GO:0005198 structural molecule activity(GO:0005198)
0.1 2.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 11.3 GO:0044325 ion channel binding(GO:0044325)
0.1 3.7 GO:0043621 protein self-association(GO:0043621)
0.1 13.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 12.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 5.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.1 GO:0042826 histone deacetylase binding(GO:0042826)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
10.4 323.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
8.4 126.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
6.0 108.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
4.2 109.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
3.5 147.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
2.9 157.8 PID BMP PATHWAY BMP receptor signaling
2.8 61.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
2.2 161.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.8 7.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
1.3 63.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
1.3 296.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1 20.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.9 12.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.9 50.6 SIG CHEMOTAXIS Genes related to chemotaxis
0.9 263.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.7 136.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 96.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6 25.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.6 42.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.5 29.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 1.6 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 3.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.7 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
25.0 449.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
12.4 123.6 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
8.2 65.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
6.1 73.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
6.1 270.4 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
6.1 207.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
6.1 60.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
5.8 58.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
5.7 74.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
4.0 71.8 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
4.0 35.8 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
3.4 44.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
2.8 53.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
2.6 36.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
2.6 53.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
2.5 83.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
2.5 73.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
2.5 34.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
1.7 73.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
1.6 53.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
1.5 39.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
1.5 71.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
1.4 32.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.3 12.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.1 22.0 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
1.1 52.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.0 182.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
1.0 19.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
1.0 74.9 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
1.0 20.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.8 15.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.7 11.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.6 13.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.3 18.0 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.3 6.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 24.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 20.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 33.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 10.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+