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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Creb3l2

Z-value: 0.79

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Transcription factors associated with Creb3l2

Gene Symbol Gene ID Gene Info
Creb3l2
ENSRNOG00000012826 cAMP responsive element binding protein 3-like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb3l2rn6_v1_chr4_-_64981384_649813840.377.1e-12Click!

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_73270308 30.59 ENSRNOT00000007430
Rida
reactive intermediate imine deaminase A homolog
chr3_-_10375826 27.81 ENSRNOT00000093365
Ass1
argininosuccinate synthase 1
chr9_+_80118029 27.09 ENSRNOT00000023068
Igfbp2
insulin-like growth factor binding protein 2
chrX_-_138435391 25.05 ENSRNOT00000043258
Mbnl3
muscleblind-like splicing regulator 3
chr3_+_114176309 23.23 ENSRNOT00000023350
Sord
sorbitol dehydrogenase
chr11_-_70499200 22.86 ENSRNOT00000002439
Slc12a8
solute carrier family 12, member 8
chr10_+_88459490 19.22 ENSRNOT00000080231
ENSRNOT00000067559
Ttc25
tetratricopeptide repeat domain 25
chr20_-_10386663 17.74 ENSRNOT00000045275
ENSRNOT00000042432
Cbs
cystathionine beta synthase
chr7_+_141249044 15.63 ENSRNOT00000084911
Aqp5
aquaporin 5
chr1_+_15620653 15.19 ENSRNOT00000017401
Map7
microtubule-associated protein 7
chr16_-_21348391 13.78 ENSRNOT00000083537
Lpar2
lysophosphatidic acid receptor 2
chr2_-_204032023 12.91 ENSRNOT00000040430
Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
chr7_+_69213147 12.26 ENSRNOT00000032786
Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
chr3_+_55094637 12.25 ENSRNOT00000058763
Cers6
ceramide synthase 6
chr16_-_21347968 12.12 ENSRNOT00000068554
Lpar2
lysophosphatidic acid receptor 2
chr3_+_125503638 12.09 ENSRNOT00000028900
Crls1
cardiolipin synthase 1
chr12_+_16912249 11.91 ENSRNOT00000085936
Tmem184a
transmembrane protein 184A
chr19_-_38120578 11.78 ENSRNOT00000026873
Esrp2
epithelial splicing regulatory protein 2
chr8_-_47529689 11.21 ENSRNOT00000012826
Oaf
out at first homolog
chr3_-_81282157 10.83 ENSRNOT00000051258
Large2
LARGE xylosyl- and glucuronyltransferase 2
chr17_-_9837293 10.53 ENSRNOT00000091320
ENSRNOT00000022134
Prelid1
PRELI domain containing 1
chr10_-_104564480 10.40 ENSRNOT00000008525
Galk1
galactokinase 1
chr1_-_198045154 10.08 ENSRNOT00000072875
Nupr1l1
nuclear protein, transcriptional regulator, 1-like 1
chrX_+_16050780 9.89 ENSRNOT00000079054
Clcn5
chloride voltage-gated channel 5
chr18_-_15637715 9.72 ENSRNOT00000022270
Dsg2
desmoglein 2
chr5_+_138470069 9.54 ENSRNOT00000076343
ENSRNOT00000064073
Zmynd12
zinc finger, MYND-type containing 12
chr16_+_2338333 9.38 ENSRNOT00000017692
Arf4
ADP-ribosylation factor 4
chr2_+_227455722 9.28 ENSRNOT00000064809
Sec24d
SEC24 homolog D, COPII coat complex component
chr5_+_151776004 9.00 ENSRNOT00000009683
Nr0b2
nuclear receptor subfamily 0, group B, member 2
chr1_-_194769524 8.82 ENSRNOT00000025988
Nupr1
nuclear protein 1, transcriptional regulator
chr7_+_3332788 8.75 ENSRNOT00000010180
Cd63
Cd63 molecule
chr10_+_37032043 8.58 ENSRNOT00000037303
ENSRNOT00000091242
Phykpl
5-phosphohydroxy-L-lysine phospho-lyase
chr10_-_37209881 8.35 ENSRNOT00000090475
Sec24a
SEC24 homolog A, COPII coat complex component
chr1_+_266333440 8.24 ENSRNOT00000071243
Sfxn2
sideroflexin 2
chr3_+_176230378 7.61 ENSRNOT00000013623
Slc17a9
solute carrier family 17 member 9
chr10_+_34938667 7.59 ENSRNOT00000086443
ENSRNOT00000059104
LOC103690164
5-phosphohydroxy-L-lysine phospho-lyase
chr11_+_39482408 7.37 ENSRNOT00000075126
Hmgn1
high mobility group nucleosome binding domain 1
chr11_-_36479868 6.93 ENSRNOT00000075762
LOC100911295
non-histone chromosomal protein HMG-14-like
chr20_-_41209728 6.78 ENSRNOT00000000657
Nt5dc1
5'-nucleotidase domain containing 1
chr1_-_82120902 6.72 ENSRNOT00000027684
Erf
Ets2 repressor factor
chr11_-_83867203 6.65 ENSRNOT00000002394
Chrd
chordin
chr6_+_26797126 6.57 ENSRNOT00000010586
Cgref1
cell growth regulator with EF hand domain 1
chr20_+_6288267 6.45 ENSRNOT00000000627
Srsf3
serine and arginine rich splicing factor 3
chr15_-_52029816 6.37 ENSRNOT00000013067
Slc39a14
solute carrier family 39 member 14
chr2_+_209097927 6.29 ENSRNOT00000023807
Dennd2d
DENN domain containing 2D
chr9_-_61690956 6.23 ENSRNOT00000066589
Hspd1
heat shock protein family D member 1
chr14_+_104475082 6.12 ENSRNOT00000084481
Rab1a
RAB1A, member RAS oncogene family
chr18_-_33414236 6.00 ENSRNOT00000020385
Yipf5
Yip1 domain family, member 5
chr1_-_84812486 5.97 ENSRNOT00000078369
AABR07002779.1

chr15_-_34322115 5.54 ENSRNOT00000026734
Tm9sf1
transmembrane 9 superfamily member 1
chr5_-_138470096 5.28 ENSRNOT00000011392
Ppcs
phosphopantothenoylcysteine synthetase
chr10_+_13996645 4.74 ENSRNOT00000016490
Nthl1
nth-like DNA glycosylase 1
chr7_+_73270455 4.40 ENSRNOT00000007190
Pop1
POP1 homolog, ribonuclease P/MRP subunit
chr6_+_42852683 4.20 ENSRNOT00000079185
Odc1
ornithine decarboxylase 1
chr7_+_72924799 4.16 ENSRNOT00000008969
Laptm4b
lysosomal protein transmembrane 4 beta
chr11_-_16889201 4.11 ENSRNOT00000002121
Btg3
BTG anti-proliferation factor 3
chr7_-_130451283 4.00 ENSRNOT00000017783
Arsa
arylsulfatase A
chr12_-_13210758 3.93 ENSRNOT00000001438
Kdelr2
KDEL endoplasmic reticulum protein retention receptor 2
chr1_+_140602542 3.86 ENSRNOT00000085570
Isg20
interferon stimulated exonuclease gene 20
chr2_-_61414038 3.84 ENSRNOT00000051910
ENSRNOT00000088202
Tars
threonyl-tRNA synthetase
chr17_+_85356042 3.78 ENSRNOT00000022201
Commd3
COMM domain containing 3
chr7_-_124198200 3.66 ENSRNOT00000078947
Arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr4_-_34779776 3.66 ENSRNOT00000077329
Ica1
islet cell autoantigen 1
chr4_-_66002444 3.59 ENSRNOT00000018645
Zc3hav1l
zinc finger CCCH-type containing, antiviral 1 like
chr14_-_85350786 3.38 ENSRNOT00000012634
LOC100912481
RNA-binding protein EWS-like
chr4_+_24612205 3.36 ENSRNOT00000057382
Ewsr1
EWS RNA-binding protein 1
chr10_+_70134729 3.33 ENSRNOT00000076739
Lig3
DNA ligase 3
chr4_+_98648545 3.24 ENSRNOT00000008451
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
chrX_+_68627313 3.11 ENSRNOT00000076699
ENSRNOT00000076795
ENSRNOT00000008705
Yipf6
Yip1 domain family, member 6
chr2_-_210874304 2.96 ENSRNOT00000088657
Ampd2
adenosine monophosphate deaminase 2
chr2_+_250600823 2.85 ENSRNOT00000083750
Sep15
selenoprotein 15
chr18_+_27956429 2.84 ENSRNOT00000080999
Ctnna1
catenin alpha 1
chr1_+_48176106 2.73 ENSRNOT00000021840
Igf2r
insulin-like growth factor 2 receptor
chr2_-_142686577 2.51 ENSRNOT00000014562
Nhlrc3
NHL repeat containing 3
chr14_+_35683442 2.41 ENSRNOT00000003085
Chic2
cysteine-rich hydrophobic domain 2
chr3_-_119405453 2.33 ENSRNOT00000090355
Sppl2a
signal peptide peptidase-like 2A
chr10_+_88326337 2.19 ENSRNOT00000022029
ENSRNOT00000076461
Fkbp10
FK506 binding protein 10
chr20_+_22728208 2.15 ENSRNOT00000000794
LOC100363472
nuclear receptor-binding factor 2-like
chr10_+_36099263 2.14 ENSRNOT00000083568
Adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr1_+_154377447 2.09 ENSRNOT00000084268
ENSRNOT00000092086
ENSRNOT00000091470
ENSRNOT00000025415
Picalm
phosphatidylinositol binding clathrin assembly protein
chr20_-_30888735 2.09 ENSRNOT00000090004
ENSRNOT00000063875
Adamts14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
chrX_-_10413984 2.05 ENSRNOT00000039551
ENSRNOT00000091448
Ddx3x
DEAD-box helicase 3, X-linked
chr5_-_173081839 1.84 ENSRNOT00000066880
Mmp23
matrix metallopeptidase 23
chr6_-_26680284 1.80 ENSRNOT00000039709
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr10_+_88326080 1.72 ENSRNOT00000076475
Fkbp10
FK506 binding protein 10
chr5_+_60250546 1.63 ENSRNOT00000017707
Zcchc7
zinc finger CCHC-type containing 7
chr9_+_94425252 1.63 ENSRNOT00000064965
ENSRNOT00000076099
Gigyf2
GRB10 interacting GYF protein 2
chr3_-_119405300 1.61 ENSRNOT00000015568
Sppl2a
signal peptide peptidase-like 2A
chr1_+_225015616 1.51 ENSRNOT00000026416
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr1_+_170471238 1.45 ENSRNOT00000076961
ENSRNOT00000075597
ENSRNOT00000076631
ENSRNOT00000076783
Timm10b
Dnhd1
translocase of inner mitochondrial membrane 10B
dynein heavy chain domain 1
chr7_+_120923274 1.45 ENSRNOT00000049247
Gtpbp1
GTP binding protein 1
chr19_-_57422093 1.44 ENSRNOT00000025512
RGD1559896
similar to RIKEN cDNA 2310022B05
chrX_-_154722220 1.43 ENSRNOT00000089743
ENSRNOT00000087893
Fmr1
fragile X mental retardation 1
chr2_+_198823366 1.36 ENSRNOT00000083769
ENSRNOT00000028814
Pias3
protein inhibitor of activated STAT, 3
chr9_+_10013854 1.32 ENSRNOT00000077653
ENSRNOT00000072033
Khsrp
KH-type splicing regulatory protein
chr10_-_102576878 1.04 ENSRNOT00000091129
Sdk2
sidekick cell adhesion molecule 2
chr3_+_14588870 1.02 ENSRNOT00000071712
LOC100912604
spermidine synthase-like
chr4_-_34780193 0.99 ENSRNOT00000011651
Ica1
islet cell autoantigen 1
chr4_+_119815139 0.98 ENSRNOT00000083402
ENSRNOT00000016137
Hmces
5-hydroxymethylcytosine (hmC) binding, ES cell-specific
chr5_+_154668179 0.87 ENSRNOT00000015971
Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chrX_+_138046494 0.74 ENSRNOT00000010596
Stk26
serine/threonine kinase 26
chr5_-_164844586 0.66 ENSRNOT00000011287
Clcn6
chloride voltage-gated channel 6
chr19_-_43215281 0.53 ENSRNOT00000025052
Aars
alanyl-tRNA synthetase
chr2_+_189106039 0.45 ENSRNOT00000028210
Ube2q1
ubiquitin conjugating enzyme E2 Q1
chr15_+_38096994 0.29 ENSRNOT00000064635
Mrpl57
mitochondrial ribosomal protein L57
chr2_+_44512895 0.03 ENSRNOT00000013218
Slc38a9
solute carrier family 38, member 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.2 33.6 GO:0006059 hexitol metabolic process(GO:0006059)
9.3 27.8 GO:0000053 argininosuccinate metabolic process(GO:0000053)
5.9 17.7 GO:0070814 cysteine biosynthetic process via cystathionine(GO:0019343) hydrogen sulfide biosynthetic process(GO:0070814)
4.1 12.3 GO:0032474 otolith morphogenesis(GO:0032474)
3.1 30.6 GO:0070314 G1 to G0 transition(GO:0070314)
3.0 11.9 GO:0018992 germ-line sex determination(GO:0018992)
2.5 7.4 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
2.4 4.7 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
2.2 15.6 GO:0015670 carbon dioxide transport(GO:0015670)
2.2 12.9 GO:1990573 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) potassium ion import across plasma membrane(GO:1990573)
2.1 6.2 GO:0002840 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) protein import into mitochondrial intermembrane space(GO:0045041)
1.7 12.1 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.4 9.7 GO:0003164 His-Purkinje system development(GO:0003164)
1.3 9.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
1.3 6.7 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
1.3 3.9 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.3 3.8 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
1.1 3.3 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
1.1 8.7 GO:2000680 regulation of rubidium ion transport(GO:2000680)
1.1 3.2 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
1.1 10.5 GO:1901857 positive regulation of cellular respiration(GO:1901857)
1.0 27.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.9 2.8 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.9 8.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.9 4.4 GO:0016078 tRNA catabolic process(GO:0016078)
0.9 25.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.8 6.1 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.8 15.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.7 6.7 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.7 10.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.7 23.3 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.7 4.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.7 2.1 GO:1902962 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.6 6.0 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.6 8.8 GO:2000194 regulation of female gonad development(GO:2000194)
0.6 6.4 GO:0015684 ferrous iron transport(GO:0015684) zinc II ion transmembrane import(GO:0071578) ferrous iron transmembrane transport(GO:1903874)
0.6 3.9 GO:0006621 protein retention in ER lumen(GO:0006621)
0.5 3.0 GO:0032264 IMP salvage(GO:0032264)
0.5 1.4 GO:1904009 negative regulation of long term synaptic depression(GO:1900453) regulation of intracellular transport of viral material(GO:1901252) cellular response to monosodium glutamate(GO:1904009) regulation of modification of synaptic structure(GO:1905244)
0.4 3.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.4 11.8 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.3 5.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.3 2.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.3 1.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.3 12.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.3 1.8 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.2 4.4 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.2 4.6 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.2 30.1 GO:0006821 chloride transport(GO:0006821)
0.2 4.0 GO:0051597 response to methylmercury(GO:0051597)
0.2 3.1 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.2 1.3 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.1 7.6 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 9.0 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 9.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 2.3 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.1 4.2 GO:0030199 collagen fibril organization(GO:0030199)
0.1 3.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 6.5 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.5 GO:0070459 prolactin secretion(GO:0070459)
0.0 1.0 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 6.6 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 2.3 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.7 GO:0030033 microvillus assembly(GO:0030033)
0.0 4.1 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 3.8 GO:0006814 sodium ion transport(GO:0006814)
0.0 7.8 GO:0043547 positive regulation of GTPase activity(GO:0043547)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.7 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.7 27.8 GO:0070852 cell body fiber(GO:0070852)
1.5 4.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.3 17.6 GO:0030127 COPII vesicle coat(GO:0030127)
1.2 6.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.1 3.3 GO:0070421 DNA ligase III-XRCC1 complex(GO:0070421)
1.1 12.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.6 3.9 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.5 1.4 GO:0097444 spine apparatus(GO:0097444)
0.4 9.7 GO:0030057 desmosome(GO:0030057)
0.3 6.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.3 4.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.3 1.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 2.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 14.5 GO:0009925 basal plasma membrane(GO:0009925)
0.2 5.5 GO:0000421 autophagosome membrane(GO:0000421)
0.2 2.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.2 16.6 GO:0030667 secretory granule membrane(GO:0030667)
0.2 1.6 GO:1990635 proximal dendrite(GO:1990635)
0.2 25.9 GO:0030139 endocytic vesicle(GO:0030139)
0.1 10.5 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 7.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 23.2 GO:0031514 motile cilium(GO:0031514)
0.1 7.2 GO:0015030 Cajal body(GO:0015030)
0.1 1.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 20.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 9.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 6.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 34.8 GO:0045177 apical part of cell(GO:0045177)
0.1 3.3 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 8.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.9 GO:0019013 viral nucleocapsid(GO:0019013)
0.0 13.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 7.8 GO:0016607 nuclear speck(GO:0016607)
0.0 9.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 6.5 GO:0000785 chromatin(GO:0000785)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
3.5 10.4 GO:0004335 galactokinase activity(GO:0004335)
3.3 29.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
3.1 30.6 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
2.5 17.7 GO:1904047 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) S-adenosyl-L-methionine binding(GO:1904047)
1.9 22.9 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.7 8.6 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
1.6 4.7 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
1.5 12.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.5 4.4 GO:0000171 ribonuclease MRP activity(GO:0000171)
1.5 27.8 GO:0015643 toxic substance binding(GO:0015643)
1.3 12.9 GO:1990239 steroid hormone binding(GO:1990239)
1.3 3.8 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
1.2 6.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.2 10.8 GO:0042285 xylosyltransferase activity(GO:0042285)
1.1 15.6 GO:0015250 water channel activity(GO:0015250)
0.8 4.2 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.8 6.7 GO:0045545 syndecan binding(GO:0045545)
0.8 3.9 GO:0046923 ER retention sequence binding(GO:0046923)
0.8 3.9 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.7 3.0 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.7 6.4 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.7 3.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.6 4.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.6 10.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 12.1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.5 3.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.5 3.5 GO:0033592 RNA strand annealing activity(GO:0033592)
0.4 9.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.4 14.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 3.3 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.4 2.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 3.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 2.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 1.8 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.3 5.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 5.4 GO:0008483 transaminase activity(GO:0008483)
0.2 3.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 2.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 9.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 25.9 GO:0030165 PDZ domain binding(GO:0030165)
0.1 6.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 10.5 GO:0051287 NAD binding(GO:0051287)
0.1 1.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 11.9 GO:0008201 heparin binding(GO:0008201)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 12.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 6.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 10.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 20.9 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.4 18.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 25.9 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.3 6.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 6.7 PID BMP PATHWAY BMP receptor signaling
0.1 1.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 27.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.1 PID PLK1 PATHWAY PLK1 signaling events
0.1 3.4 PID BARD1 PATHWAY BARD1 signaling events
0.1 8.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 1.8 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 15.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.3 27.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 12.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.7 9.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.6 17.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 9.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.5 8.1 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.4 5.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.4 4.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.3 12.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 12.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 3.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 6.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 4.6 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.1 7.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 6.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 25.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 9.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 17.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 8.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 4.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing