ISMARA results: E2f6

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f6

Z-value: 1.23

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Transcription factors associated with E2f6

Gene Symbol	Gene ID	Gene Info
E2f6 NCBI RGD Ensembl	ENSRNOG00000004449	E2F transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2f6	rn6_v1_chr6_+_42092467_42092467	-0.29	1.5e-07	Click!

Activity profile of E2f6 motif

Sorted Z-values of E2f6 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_71514281 Show fit	36.87	ENSRNOT00000022256	Ns5atp9 NCBI RGD Ensembl Show fit	NS5A (hepatitis C virus) transactivated protein 9
chr7_-_12741296 Show fit	30.42	ENSRNOT00000060648	Arhgap45 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 45
chr4_+_71740532 Show fit	28.93	ENSRNOT00000023537	Zyx NCBI RGD Ensembl Show fit	zyxin
chr18_+_51785111 Show fit	28.02	ENSRNOT00000019351	Lmnb1 NCBI RGD Ensembl Show fit	lamin B1
chr1_+_81230989 Show fit	27.75	ENSRNOT00000077952	Kcnn4 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily N member 4
chr1_+_81230612 Show fit	27.43	ENSRNOT00000026489	Kcnn4 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily N member 4
chr9_-_10757720 Show fit	27.26	ENSRNOT00000083848	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr9_-_10757954 Show fit	26.00	ENSRNOT00000075265	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr12_-_21720094 Show fit	24.95	ENSRNOT00000032838	LOC100910636 NCBI RGD Ensembl Show fit	zinc finger CW-type PWWP domain protein 1-like
chr9_-_26932201 Show fit	23.98	ENSRNOT00000017081	Mcm3 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 3
chr6_+_43884678 Show fit	23.10	ENSRNOT00000091551	Rrm2 NCBI RGD Ensembl Show fit	ribonucleotide reductase regulatory subunit M2
chr14_+_108826831 Show fit	21.80	ENSRNOT00000083146 ENSRNOT00000009421	Bcl11a NCBI RGD Ensembl Show fit	B-cell CLL/lymphoma 11A
chr3_+_59153280 Show fit	21.49	ENSRNOT00000002066	Cdca7 NCBI RGD Ensembl Show fit	cell division cycle associated 7
chr5_-_24631679 Show fit	21.20	ENSRNOT00000010846 ENSRNOT00000067129	Esrp1 NCBI RGD Ensembl Show fit	epithelial splicing regulatory protein 1
chr20_+_44436403 Show fit	20.62	ENSRNOT00000000733 ENSRNOT00000076859	Fyn NCBI RGD Ensembl Show fit	FYN proto-oncogene, Src family tyrosine kinase
chr6_+_91463308 Show fit	19.98	ENSRNOT00000005595	Lrr1 NCBI RGD Ensembl Show fit	leucine rich repeat protein 1
chr2_+_252018597 Show fit	19.75	ENSRNOT00000020452	Mcoln2 NCBI RGD Ensembl Show fit	mucolipin 2
chr17_+_44520537 Show fit	19.75	ENSRNOT00000077985	hist1h2ail2 NCBI RGD Ensembl Show fit	histone cluster 1, H2ai-like2
chr1_+_144831523 Show fit	19.21	ENSRNOT00000039748	Mex3b NCBI RGD Ensembl Show fit	mex-3 RNA binding family member B
chr7_-_75421874 Show fit	19.08	ENSRNOT00000012775	Pabpc1 NCBI RGD Ensembl Show fit	poly(A) binding protein, cytoplasmic 1
chr2_-_30780121 Show fit	19.01	ENSRNOT00000025129	Cenph NCBI RGD Ensembl Show fit	centromere protein H
chr5_+_127404450 Show fit	18.96	ENSRNOT00000017575	Lrp8 NCBI RGD Ensembl Show fit	LDL receptor related protein 8
chr9_+_81783349 Show fit	18.60	ENSRNOT00000021548	Cnot9 NCBI RGD Ensembl Show fit	CCR4-NOT transcription complex subunit 9
chr1_-_82610350 Show fit	18.29	ENSRNOT00000028177	Cyp2s1 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily s, polypeptide 1
chr17_-_44815995 Show fit	18.22	ENSRNOT00000091201	RGD1562378 NCBI RGD Ensembl Show fit	histone H4 variant H4-v.1
chr7_+_2643288 Show fit	17.59	ENSRNOT00000047241	Timeless NCBI RGD Ensembl Show fit	timeless circadian clock
chr20_+_3990820 Show fit	17.20	ENSRNOT00000000528	Psmb8 NCBI RGD Ensembl Show fit	proteasome subunit beta 8
chr9_-_76768770 Show fit	16.87	ENSRNOT00000087779 ENSRNOT00000057849	Ikzf2 NCBI RGD Ensembl Show fit	IKAROS family zinc finger 2
chr16_+_35934970 Show fit	16.85	ENSRNOT00000084707 ENSRNOT00000016474	Galnt7 NCBI RGD Ensembl Show fit	polypeptide N-acetylgalactosaminyltransferase 7
chr12_-_46718355 Show fit	16.66	ENSRNOT00000030031	Rab35 NCBI RGD Ensembl Show fit	RAB35, member RAS oncogene family
chr7_+_102586313 Show fit	16.46	ENSRNOT00000006188	Myc NCBI RGD Ensembl Show fit	myelocytomatosis oncogene
chr17_-_44520240 Show fit	16.02	ENSRNOT00000086538	Hist1h2bh NCBI RGD Ensembl Show fit	histone cluster 1 H2B family member h
chr3_-_177201525 Show fit	15.57	ENSRNOT00000022451	Rgs19 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 19
chr8_-_62424303 Show fit	15.42	ENSRNOT00000091223	Csk NCBI RGD Ensembl Show fit	c-src tyrosine kinase
chr7_-_63407241 Show fit	15.35	ENSRNOT00000024679	Tbc1d30 NCBI RGD Ensembl Show fit	TBC1 domain family, member 30
chr12_-_9331195 Show fit	15.35	ENSRNOT00000044134	Pan3 NCBI RGD Ensembl Show fit	PAN3 poly(A) specific ribonuclease subunit
chr7_+_120125633 Show fit	15.06	ENSRNOT00000012480	Sh3bp1 NCBI RGD Ensembl Show fit	SH3-domain binding protein 1
chr1_+_75356220 Show fit	14.80	ENSRNOT00000019799	Lig1 NCBI RGD Ensembl Show fit	DNA ligase 1
chr10_-_4910305 Show fit	14.68	ENSRNOT00000033122	Rmi2 NCBI RGD Ensembl Show fit	RecQ mediated genome instability 2
chr15_-_24056073 Show fit	14.63	ENSRNOT00000015100	Wdhd1 NCBI RGD Ensembl Show fit	WD repeat and HMG-box DNA binding protein 1
chr2_-_207300854 Show fit	14.61	ENSRNOT00000018061	Mov10 NCBI RGD Ensembl Show fit	Mov10 RISC complex RNA helicase
chr1_-_94494980 Show fit	14.56	ENSRNOT00000020014	Ccne1 NCBI RGD Ensembl Show fit	cyclin E1
chr13_-_110257367 Show fit	14.56	ENSRNOT00000005576	Dtl NCBI RGD Ensembl Show fit	denticleless E3 ubiquitin protein ligase homolog
chr16_+_47717951 Show fit	14.35	ENSRNOT00000018689	Ing2 NCBI RGD Ensembl Show fit	inhibitor of growth family, member 2
chr7_-_31784192 Show fit	14.07	ENSRNOT00000010869	Apaf1 NCBI RGD Ensembl Show fit	apoptotic peptidase activating factor 1
chr2_-_45077219 Show fit	14.02	ENSRNOT00000014319	Gzmk NCBI RGD Ensembl Show fit	granzyme K
chr3_+_124068865 Show fit	13.78	ENSRNOT00000079264	Smox NCBI RGD Ensembl Show fit	spermine oxidase
chr5_+_144581427 Show fit	13.67	ENSRNOT00000015227	Clspn NCBI RGD Ensembl Show fit	claspin
chr7_+_97984862 Show fit	13.61	ENSRNOT00000008508	Atad2 NCBI RGD Ensembl Show fit	ATPase family, AAA domain containing 2
chr20_-_3419831 Show fit	13.47	ENSRNOT00000046798	Mdc1 NCBI RGD Ensembl Show fit	mediator of DNA damage checkpoint 1
chr2_-_187820952 Show fit	13.41	ENSRNOT00000092762	Sema4a NCBI RGD Ensembl Show fit	semaphorin 4A
chr14_-_81725181 Show fit	13.38	ENSRNOT00000078252	Cfap99 NCBI RGD Ensembl Show fit	cilia and flagella associated protein 99
chr9_+_112293388 Show fit	13.30	ENSRNOT00000020767	Man2a1 NCBI RGD Ensembl Show fit	mannosidase, alpha, class 2A, member 1
chr8_+_114867062 Show fit	13.16	ENSRNOT00000074771	Wdr82 NCBI RGD Ensembl Show fit	WD repeat domain 82
chr7_+_144078496 Show fit	13.13	ENSRNOT00000055302	Pcbp2 NCBI RGD Ensembl Show fit	poly(rC) binding protein 2
chr2_-_206274079 Show fit	13.10	ENSRNOT00000056079	Hipk1 NCBI RGD Ensembl Show fit	homeodomain interacting protein kinase 1
chr10_-_85049331 Show fit	12.93	ENSRNOT00000012538	Tbx21 NCBI RGD Ensembl Show fit	T-box 21
chr4_-_81968832 Show fit	12.85	ENSRNOT00000016608	Skap2 NCBI RGD Ensembl Show fit	src kinase associated phosphoprotein 2
chr7_-_138039984 Show fit	12.76	ENSRNOT00000089806	Slc38a1 NCBI RGD Ensembl Show fit	solute carrier family 38, member 1
chr16_-_61091169 Show fit	12.65	ENSRNOT00000016328	Dusp4 NCBI RGD Ensembl Show fit	dual specificity phosphatase 4
chr12_-_38274036 Show fit	12.63	ENSRNOT00000063990	Kntc1 NCBI RGD Ensembl Show fit	kinetochore associated 1
chr6_-_146195819 Show fit	12.56	ENSRNOT00000007625	Sp4 NCBI RGD Ensembl Show fit	Sp4 transcription factor
chr2_+_113984646 Show fit	12.53	ENSRNOT00000016799	Tnik NCBI RGD Ensembl Show fit	TRAF2 and NCK interacting kinase
chr7_-_140617721 Show fit	12.51	ENSRNOT00000081355	Tuba1b NCBI RGD Ensembl Show fit	tubulin, alpha 1B
chr1_+_167538263 Show fit	12.46	ENSRNOT00000074058	Rrm1 NCBI RGD Ensembl Show fit	ribonucleotide reductase catalytic subunit M1
chr1_-_146029840 Show fit	12.36	ENSRNOT00000016455	Mesdc1 NCBI RGD Ensembl Show fit	mesoderm development candidate 1
chr19_+_37652969 Show fit	12.32	ENSRNOT00000041970	Carmil2 NCBI RGD Ensembl Show fit	capping protein regulator and myosin 1 linker 2
chr7_+_37812831 Show fit	12.27	ENSRNOT00000005910	Btg1 NCBI RGD Ensembl Show fit	BTG anti-proliferation factor 1
chr2_+_198418691 Show fit	12.25	ENSRNOT00000089409	Hist1h2bk NCBI RGD Ensembl Show fit	histone cluster 1, H2bk
chr3_-_148722710 Show fit	12.25	ENSRNOT00000090919 ENSRNOT00000068592	Plagl2 NCBI RGD Ensembl Show fit	PLAG1 like zinc finger 2
chr17_+_6909728 Show fit	12.22	ENSRNOT00000061231	LOC681410 NCBI RGD Ensembl Show fit	hypothetical protein LOC681410
chr8_-_78655856 Show fit	12.15	ENSRNOT00000081185	Tcf12 NCBI RGD Ensembl Show fit	transcription factor 12
chr7_-_143863186 Show fit	12.06	ENSRNOT00000017096	Rarg NCBI RGD Ensembl Show fit	retinoic acid receptor, gamma
chr4_+_70903253 Show fit	12.00	ENSRNOT00000019720	Ephb6 NCBI RGD Ensembl Show fit	Eph receptor B6
chr8_+_44136496 Show fit	11.95	ENSRNOT00000087022	Scn3b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 3
chr11_-_66695353 Show fit	11.64	ENSRNOT00000063995	Polq NCBI RGD Ensembl Show fit	DNA polymerase theta
chr9_+_10471742 Show fit	11.51	ENSRNOT00000072276	Safb2 NCBI RGD Ensembl Show fit	scaffold attachment factor B2
chrX_+_113948654 Show fit	11.18	ENSRNOT00000068431	Tmem164 NCBI RGD Ensembl Show fit	transmembrane protein 164
chrX_+_65226748 Show fit	11.07	ENSRNOT00000076181	Msn NCBI RGD Ensembl Show fit	moesin
chr10_+_29289203 Show fit	11.07	ENSRNOT00000067013	Pwwp2a NCBI RGD Ensembl Show fit	PWWP domain containing 2A
chr5_+_150032999 Show fit	11.00	ENSRNOT00000013301	Srsf4 NCBI RGD Ensembl Show fit	serine and arginine rich splicing factor 4
chr10_+_65606898 Show fit	10.88	ENSRNOT00000015091	Unc119 NCBI RGD Ensembl Show fit	unc-119 lipid binding chaperone
chr8_-_36314811 Show fit	10.87	ENSRNOT00000013243	St3gal4 NCBI RGD Ensembl Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr1_-_219450451 Show fit	10.67	ENSRNOT00000025317	Rad9a NCBI RGD Ensembl Show fit	RAD9 checkpoint clamp component A
chr15_+_51756978 Show fit	10.58	ENSRNOT00000024067	Egr3 NCBI RGD Ensembl Show fit	early growth response 3
chr5_+_128923934 Show fit	10.56	ENSRNOT00000064145	Eps15 NCBI RGD Ensembl Show fit	epidermal growth factor receptor pathway substrate 15
chr17_+_72429618 Show fit	10.29	ENSRNOT00000026187	Gata3 NCBI RGD Ensembl Show fit	GATA binding protein 3
chr10_+_83655460 Show fit	10.20	ENSRNOT00000008011	Gngt2 NCBI RGD Ensembl Show fit	G protein subunit gamma transducin 2
chr12_+_24978483 Show fit	10.19	ENSRNOT00000040069	Eln NCBI RGD Ensembl Show fit	elastin
chr10_-_40122915 Show fit	10.17	ENSRNOT00000063891	Cdc42se2 NCBI RGD Ensembl Show fit	CDC42 small effector 2
chr1_+_165382690 Show fit	10.03	ENSRNOT00000023802	C2cd3 NCBI RGD Ensembl Show fit	C2 calcium-dependent domain containing 3
chr8_+_11888591 Show fit	10.01	ENSRNOT00000083967	Ccdc82 NCBI RGD Ensembl Show fit	coiled-coil domain containing 82
chr2_+_189430041 Show fit	10.00	ENSRNOT00000023567 ENSRNOT00000023605	Tpm3 NCBI RGD Ensembl Show fit	tropomyosin 3
chr10_+_11206226 Show fit	9.93	ENSRNOT00000006979	Tfap4 NCBI RGD Ensembl Show fit	transcription factor AP-4
chr1_+_199412834 Show fit	9.92	ENSRNOT00000031891	Fus NCBI RGD Ensembl Show fit	fused in sarcoma RNA binding protein
chr1_+_167539036 Show fit	9.90	ENSRNOT00000093112	Rrm1 NCBI RGD Ensembl Show fit	ribonucleotide reductase catalytic subunit M1
chr2_-_238068694 Show fit	9.86	ENSRNOT00000079479 ENSRNOT00000078608 ENSRNOT00000090834	Npnt NCBI RGD Ensembl Show fit	nephronectin
chr7_+_123573930 Show fit	9.85	ENSRNOT00000066149	Fam109b NCBI RGD Ensembl Show fit	family with sequence similarity 109, member B
chr6_-_11274932 Show fit	9.83	ENSRNOT00000021538	Msh2 NCBI RGD Ensembl Show fit	mutS homolog 2
chr2_-_43999107 Show fit	9.82	ENSRNOT00000065473	LOC100912399 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase kinase kinase 1-like
chr5_-_76756140 Show fit	9.75	ENSRNOT00000022107 ENSRNOT00000089251	Ptbp3 NCBI RGD Ensembl Show fit	polypyrimidine tract binding protein 3
chr7_+_54247460 Show fit	9.69	ENSRNOT00000005361	Phlda1 NCBI RGD Ensembl Show fit	pleckstrin homology-like domain, family A, member 1
chr4_-_183426439 Show fit	9.64	ENSRNOT00000083310	Fam60a NCBI RGD Ensembl Show fit	family with sequence similarity 60, member A
chr3_+_7422820 Show fit	9.57	ENSRNOT00000064323	Ddx31 NCBI RGD Ensembl Show fit	DEAD-box helicase 31
chr20_+_4392626 Show fit	9.53	ENSRNOT00000000495	Prrt1 NCBI RGD Ensembl Show fit	proline-rich transmembrane protein 1
chr5_-_152122542 Show fit	9.52	ENSRNOT00000068634 ENSRNOT00000077248	Rps6ka1 NCBI RGD Ensembl Show fit	ribosomal protein S6 kinase A1
chr12_-_37047628 Show fit	9.52	ENSRNOT00000001337	Rflna NCBI RGD Ensembl Show fit	refilin A
chr5_-_152198813 Show fit	9.37	ENSRNOT00000082953	Hmgn2 NCBI RGD Ensembl Show fit	high mobility group nucleosomal binding domain 2
chr7_-_138039630 Show fit	9.36	ENSRNOT00000008138	Slc38a1 NCBI RGD Ensembl Show fit	solute carrier family 38, member 1
chr3_+_93920447 Show fit	9.35	ENSRNOT00000012625	Lmo2 NCBI RGD Ensembl Show fit	LIM domain only 2
chr1_+_198932870 Show fit	9.25	ENSRNOT00000055003	Fbrs NCBI RGD Ensembl Show fit	fibrosin
chr6_+_99402360 Show fit	9.22	ENSRNOT00000078498	Zbtb1 NCBI RGD Ensembl Show fit	zinc finger and BTB domain containing 1
chr2_+_212247451 Show fit	9.19	ENSRNOT00000027813	Vav3 NCBI RGD Ensembl Show fit	vav guanine nucleotide exchange factor 3
chr3_+_117514444 Show fit	9.19	ENSRNOT00000009549	Dut NCBI RGD Ensembl Show fit	deoxyuridine triphosphatase
chr7_-_14189688 Show fit	9.08	ENSRNOT00000037456	Notch3 NCBI RGD Ensembl Show fit	notch 3
chr12_-_24537313 Show fit	8.96	ENSRNOT00000001975	Baz1b NCBI RGD Ensembl Show fit	bromodomain adjacent to zinc finger domain, 1B
chrX_+_158835811 Show fit	8.93	ENSRNOT00000071888 ENSRNOT00000080110	Ints6l NCBI RGD Ensembl Show fit	integrator complex subunit 6 like
chr7_+_140315368 Show fit	8.89	ENSRNOT00000081206	Cacnb3 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit beta 3
chr7_+_137680530 Show fit	8.85	ENSRNOT00000006970	Arid2 NCBI RGD Ensembl Show fit	AT-rich interaction domain 2
chr19_+_37576075 Show fit	8.77	ENSRNOT00000089022	Fam65a NCBI RGD Ensembl Show fit	family with sequence similarity 65, member A
chr19_-_39300893 Show fit	8.71	ENSRNOT00000027695	Terf2 NCBI RGD Ensembl Show fit	telomeric repeat binding factor 2
chr3_-_146491837 Show fit	8.61	ENSRNOT00000061469	Vsx1 NCBI RGD Ensembl Show fit	visual system homeobox 1
chr6_-_36819821 Show fit	8.58	ENSRNOT00000006499	Kcns3 NCBI RGD Ensembl Show fit	potassium voltage-gated channel, modifier subfamily S, member 3
chr8_-_122532070 Show fit	8.52	ENSRNOT00000013705	Ccr4 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 4
chr4_+_160020472 Show fit	8.48	ENSRNOT00000078802	Parp11 NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 11
chr10_-_15228235 Show fit	8.47	ENSRNOT00000027121	Wdr90 NCBI RGD Ensembl Show fit	WD repeat domain 90
chr9_+_38544398 Show fit	8.46	ENSRNOT00000016828	Prim2 NCBI RGD Ensembl Show fit	primase (DNA) subunit 2
chr4_-_77347011 Show fit	8.45	ENSRNOT00000008149	Ezh2 NCBI RGD Ensembl Show fit	enhancer of zeste 2 polycomb repressive complex 2 subunit
chr1_+_167538744 Show fit	8.34	ENSRNOT00000093070	Rrm1 NCBI RGD Ensembl Show fit	ribonucleotide reductase catalytic subunit M1
chr4_-_83137527 Show fit	8.31	ENSRNOT00000039580	Jazf1 NCBI RGD Ensembl Show fit	JAZF zinc finger 1
chr5_+_2632712 Show fit	8.22	ENSRNOT00000009431	Rpl7 NCBI RGD Ensembl Show fit	ribosomal protein L7
chr6_-_2886465 Show fit	8.13	ENSRNOT00000038448	Srsf7 NCBI RGD Ensembl Show fit	serine and arginine rich splicing factor 7
chr20_-_46666830 Show fit	8.10	ENSRNOT00000000331	Cep57l1 NCBI RGD Ensembl Show fit	centrosomal protein 57-like 1
chr8_+_77107536 Show fit	8.08	ENSRNOT00000083255	Adam10 NCBI RGD Ensembl Show fit	ADAM metallopeptidase domain 10
chr10_-_15098791 Show fit	8.04	ENSRNOT00000026139	Chtf18 NCBI RGD Ensembl Show fit	chromosome transmission fidelity factor 18
chr3_-_93734282 Show fit	8.00	ENSRNOT00000012428	Caprin1 NCBI RGD Ensembl Show fit	cell cycle associated protein 1
chr1_-_143751789 Show fit	8.00	ENSRNOT00000026754	Hdgfrp3 NCBI RGD Ensembl Show fit	hepatoma-derived growth factor, related protein 3
chr13_-_74077783 Show fit	7.98	ENSRNOT00000005677	Soat1 NCBI RGD Ensembl Show fit	sterol O-acyltransferase 1
chr11_+_82373870 Show fit	7.91	ENSRNOT00000002429	Tra2b NCBI RGD Ensembl Show fit	transformer 2 beta homolog (Drosophila)
chr10_-_64202380 Show fit	7.85	ENSRNOT00000008982	Rflnb NCBI RGD Ensembl Show fit	refilin B
chr5_-_169658875 Show fit	7.84	ENSRNOT00000015840	Kcnab2 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr5_-_144221263 Show fit	7.82	ENSRNOT00000013570	Thrap3 NCBI RGD Ensembl Show fit	thyroid hormone receptor associated protein 3
chr10_+_82800704 Show fit	7.79	ENSRNOT00000089497	Ppp1r9b NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 9B
chr2_-_104133985 Show fit	7.78	ENSRNOT00000088167 ENSRNOT00000067725	Pde7a NCBI RGD Ensembl Show fit	phosphodiesterase 7A
chr2_+_188476820 Show fit	7.66	ENSRNOT00000027793	Clk2 NCBI RGD Ensembl Show fit	CDC-like kinase 2
chr4_+_79557854 Show fit	7.58	ENSRNOT00000013145	Npy NCBI RGD Ensembl Show fit	neuropeptide Y
chr8_-_115621394 Show fit	7.55	ENSRNOT00000018995	Rbm15b NCBI RGD Ensembl Show fit	RNA binding motif protein 15B
chr7_-_59514939 Show fit	7.54	ENSRNOT00000085579	Kcnmb4 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr12_-_25143480 Show fit	7.44	ENSRNOT00000001989	Rfc2 NCBI RGD Ensembl Show fit	replication factor C subunit 2
chrX_-_31140711 Show fit	7.43	ENSRNOT00000082358	Fancb NCBI RGD Ensembl Show fit	Fanconi anemia, complementation group B
chr3_-_119619865 Show fit	7.42	ENSRNOT00000016172	Itpripl1 NCBI RGD Ensembl Show fit	inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr2_+_226900619 Show fit	7.39	ENSRNOT00000019638	Pde5a NCBI RGD Ensembl Show fit	phosphodiesterase 5A
chr7_+_54213319 Show fit	7.36	ENSRNOT00000005286	Nap1l1 NCBI RGD Ensembl Show fit	nucleosome assembly protein 1-like 1
chr2_-_219458271 Show fit	7.35	ENSRNOT00000064735	Cdc14a NCBI RGD Ensembl Show fit	cell division cycle 14A
chr4_+_44597123 Show fit	7.33	ENSRNOT00000078250	Cav1 NCBI RGD Ensembl Show fit	caveolin 1
chr10_+_70689863 Show fit	7.32	ENSRNOT00000091122 ENSRNOT00000086987 ENSRNOT00000082030	Taf15 NCBI RGD Ensembl Show fit	TATA-box binding protein associated factor 15
chr19_+_25815207 Show fit	7.32	ENSRNOT00000003980	Lyl1 NCBI RGD Ensembl Show fit	LYL1, basic helix-loop-helix family member
chr9_+_82033543 Show fit	7.18	ENSRNOT00000023439	Wnt6 NCBI RGD Ensembl Show fit	wingless-type MMTV integration site family, member 6
chr10_+_61685241 Show fit	7.17	ENSRNOT00000092606	Mnt NCBI RGD Ensembl Show fit	MAX network transcriptional repressor
chr19_-_39087880 Show fit	7.17	ENSRNOT00000070822	Chtf8 NCBI RGD Ensembl Show fit	chromosome transmission fidelity factor 8
chr4_+_79573998 Show fit	7.17	ENSRNOT00000074351	LOC100912228 NCBI RGD Ensembl Show fit	pro-neuropeptide Y-like
chr8_+_78858570 Show fit	7.13	ENSRNOT00000089335	Zfp280d NCBI RGD Ensembl Show fit	zinc finger protein 280D
chr14_+_83510640 Show fit	7.05	ENSRNOT00000089928 ENSRNOT00000082242 ENSRNOT00000025378	Patz1 NCBI RGD Ensembl Show fit	POZ (BTB) and AT hook containing zinc finger 1
chr19_+_39087990 Show fit	7.05	ENSRNOT00000027553	Utp4 NCBI RGD Ensembl Show fit	UTP4 small subunit processome component
chr2_-_88414012 Show fit	6.98	ENSRNOT00000014762	Lrrcc1 NCBI RGD Ensembl Show fit	leucine rich repeat and coiled-coil centrosomal protein 1
chr7_-_2941122 Show fit	6.95	ENSRNOT00000082107	Esyt1 NCBI RGD Ensembl Show fit	extended synaptotagmin 1
chr4_-_98593664 Show fit	6.93	ENSRNOT00000007927	Rpia NCBI RGD Ensembl Show fit	ribose 5-phosphate isomerase A
chr1_-_220644636 Show fit	6.91	ENSRNOT00000027632	Pacs1 NCBI RGD Ensembl Show fit	phosphofurin acidic cluster sorting protein 1
chr10_+_86819472 Show fit	6.82	ENSRNOT00000081424	Cdc6 NCBI RGD Ensembl Show fit	cell division cycle 6
chr18_+_36596585 Show fit	6.81	ENSRNOT00000036613	Rbm27 NCBI RGD Ensembl Show fit	RNA binding motif protein 27
chr10_-_56154548 Show fit	6.80	ENSRNOT00000090809	Dnah2 NCBI RGD Ensembl Show fit	dynein, axonemal, heavy chain 2
chr5_-_147535240 Show fit	6.80	ENSRNOT00000029177	Rbbp4 NCBI RGD Ensembl Show fit	RB binding protein 4, chromatin remodeling factor
chr1_+_199225100 Show fit	6.80	ENSRNOT00000088606	Setd1a NCBI RGD Ensembl Show fit	SET domain containing 1A
chr10_+_11786121 Show fit	6.74	ENSRNOT00000033919	Slx4 NCBI RGD Ensembl Show fit	SLX4 structure-specific endonuclease subunit
chr3_-_161498951 Show fit	6.58	ENSRNOT00000024214	Ncoa5 NCBI RGD Ensembl Show fit	nuclear receptor coactivator 5
chr10_+_108340240 Show fit	6.50	ENSRNOT00000077535	Ccdc40 NCBI RGD Ensembl Show fit	coiled-coil domain containing 40
chr2_-_38208719 Show fit	6.48	ENSRNOT00000019189	Kif2a NCBI RGD Ensembl Show fit	kinesin family member 2A
chr6_-_43493816 Show fit	6.45	ENSRNOT00000077786	Ywhaq NCBI RGD Ensembl Show fit	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr1_+_154377447 Show fit	6.44	ENSRNOT00000084268 ENSRNOT00000092086 ENSRNOT00000091470 ENSRNOT00000025415	Picalm NCBI RGD Ensembl Show fit	phosphatidylinositol binding clathrin assembly protein
chr1_+_32058044 Show fit	6.40	ENSRNOT00000021898	Nkd2 NCBI RGD Ensembl Show fit	naked cuticle homolog 2
chr1_+_266255797 Show fit	6.40	ENSRNOT00000027047	Trim8 NCBI RGD Ensembl Show fit	tripartite motif-containing 8
chr10_+_67677071 Show fit	6.32	ENSRNOT00000007312	Rhbdl3 NCBI RGD Ensembl Show fit	rhomboid like 3
chr7_-_81592206 Show fit	6.32	ENSRNOT00000007979	Angpt1 NCBI RGD Ensembl Show fit	angiopoietin 1
chr1_+_126961389 Show fit	6.30	ENSRNOT00000016758	Snrpa1 NCBI RGD Ensembl Show fit	small nuclear ribonucleoprotein polypeptide A'
chr6_-_100011226 Show fit	6.27	ENSRNOT00000083286 ENSRNOT00000041442	Max NCBI RGD Ensembl Show fit	MYC associated factor X
chr9_-_17206994 Show fit	6.27	ENSRNOT00000026195	Gtpbp2 NCBI RGD Ensembl Show fit	GTP binding protein 2
chr10_+_86819929 Show fit	6.26	ENSRNOT00000038228	Cdc6 NCBI RGD Ensembl Show fit	cell division cycle 6
chr1_+_225129097 Show fit	6.25	ENSRNOT00000026938	Eml3 NCBI RGD Ensembl Show fit	echinoderm microtubule associated protein like 3
chr4_-_115157263 Show fit	6.25	ENSRNOT00000015296	Tet3 NCBI RGD Ensembl Show fit	tet methylcytosine dioxygenase 3
chr10_-_13892997 Show fit	6.24	ENSRNOT00000004192	Traf7 NCBI RGD Ensembl Show fit	TNF receptor associated factor 7
chr4_-_56114254 Show fit	6.22	ENSRNOT00000010673	Lrrc4 NCBI RGD Ensembl Show fit	leucine rich repeat containing 4
chr14_+_11198896 Show fit	6.22	ENSRNOT00000079767	Hnrnpdl NCBI RGD Ensembl Show fit	heterogeneous nuclear ribonucleoprotein D-like
chr6_-_128149220 Show fit	6.17	ENSRNOT00000014204	Gsc NCBI RGD Ensembl Show fit	goosecoid homeobox
chr8_-_67869019 Show fit	6.17	ENSRNOT00000066009	Pias1 NCBI RGD Ensembl Show fit	protein inhibitor of activated STAT, 1
chr4_+_157523110 Show fit	6.14	ENSRNOT00000081640	Zfp384 NCBI RGD Ensembl Show fit	zinc finger protein 384
chr14_+_19866408 Show fit	6.12	ENSRNOT00000060465	Adamts3 NCBI RGD Ensembl Show fit	ADAM metallopeptidase with thrombospondin type 1, motif 3
chr3_+_33641616 Show fit	6.01	ENSRNOT00000051953	Epc2 NCBI RGD Ensembl Show fit	enhancer of polycomb homolog 2
chr1_+_100811755 Show fit	5.97	ENSRNOT00000074847	Nup62 NCBI RGD Ensembl Show fit	nucleoporin 62
chr20_+_44803885 Show fit	5.92	ENSRNOT00000077936	Rev3l NCBI RGD Ensembl Show fit	REV3 like, DNA directed polymerase zeta catalytic subunit
chr7_+_70364813 Show fit	5.83	ENSRNOT00000084012 ENSRNOT00000031230	Agap2 NCBI RGD Ensembl Show fit	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.3	21.8	GO:1903860	negative regulation of dendrite extension(GO:1903860)
6.7	53.3	GO:0010216	maintenance of DNA methylation(GO:0010216)
6.5	19.5	GO:0002572	pro-T cell differentiation(GO:0002572)
6.1	24.6	GO:1904009	cellular response to monosodium glutamate(GO:1904009)
6.0	17.9	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
5.9	17.6	GO:1904976	cellular response to bleomycin(GO:1904976)
5.8	17.4	GO:0061181	regulation of chondrocyte development(GO:0061181)
5.7	17.0	GO:0003430	growth plate cartilage chondrocyte growth(GO:0003430)
5.5	16.5	GO:0090094	canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586)
5.4	27.0	GO:0072697	protein localization to cell cortex(GO:0072697)
5.0	55.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
4.3	4.3	GO:1990108	protein linear deubiquitination(GO:1990108)
4.0	12.0	GO:2000523	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
4.0	20.0	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
3.9	63.0	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
3.7	18.6	GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
3.7	22.1	GO:0006868	glutamine transport(GO:0006868)
3.6	10.9	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
3.4	20.6	GO:1902951	negative regulation of dendritic spine maintenance(GO:1902951)
3.4	10.2	GO:0071298	cellular response to L-ascorbic acid(GO:0071298)
3.3	10.0	GO:0021997	neural plate axis specification(GO:0021997)
3.3	10.0	GO:1905247	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
3.3	9.9	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
3.2	13.0	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
3.2	9.7	GO:0045210	FasL biosynthetic process(GO:0045210)
3.2	19.1	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
3.1	12.3	GO:2000813	negative regulation of barbed-end actin filament capping(GO:2000813)
2.9	11.6	GO:0097681	double-strand break repair via alternative nonhomologous end joining(GO:0097681)
2.9	8.7	GO:0048239	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
2.9	14.3	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.8	11.1	GO:1902965	regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
2.7	8.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
2.6	18.5	GO:0048227	plasma membrane to endosome transport(GO:0048227)
2.6	15.4	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
2.6	15.3	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
2.5	7.6	GO:0032902	nerve growth factor production(GO:0032902) positive regulation of eating behavior(GO:1904000)
2.5	22.6	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
2.5	14.8	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567)
2.4	14.6	GO:0070827	chromatin maintenance(GO:0070827)
2.3	13.8	GO:0046208	spermine catabolic process(GO:0046208)
2.3	9.1	GO:0072104	glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
2.3	18.2	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
2.1	6.4	GO:0048210	Golgi vesicle fusion to target membrane(GO:0048210)
2.1	6.4	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
2.1	6.3	GO:0048014	Tie signaling pathway(GO:0048014)
2.1	8.3	GO:1904688	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
2.0	6.1	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
2.0	6.0	GO:0046601	positive regulation of centriole replication(GO:0046601) regulation of mitotic cytokinesis(GO:1902412)
2.0	15.9	GO:0060235	lens induction in camera-type eye(GO:0060235)
1.9	7.6	GO:0070650	actin filament bundle distribution(GO:0070650)
1.9	13.1	GO:1904117	cellular response to vasopressin(GO:1904117)
1.9	7.4	GO:1905168	positive regulation of double-strand break repair via homologous recombination(GO:1905168)
1.8	5.5	GO:0007356	thorax and anterior abdomen determination(GO:0007356) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194)
1.8	5.4	GO:1903281	positive regulation of calcium:sodium antiporter activity(GO:1903281)
1.8	7.2	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
1.8	21.5	GO:0051382	kinetochore assembly(GO:0051382)
1.8	10.7	GO:0051660	establishment of centrosome localization(GO:0051660)
1.8	42.7	GO:0006270	DNA replication initiation(GO:0006270)
1.7	24.3	GO:0000076	DNA replication checkpoint(GO:0000076)
1.7	6.9	GO:0006014	D-ribose metabolic process(GO:0006014)
1.7	20.5	GO:0019985	translesion synthesis(GO:0019985)
1.7	5.1	GO:1990009	retinal cell apoptotic process(GO:1990009)
1.7	6.7	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429) positive regulation of t-circle formation(GO:1904431)
1.7	13.3	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
1.7	5.0	GO:0042668	auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974) negative regulation of forebrain neuron differentiation(GO:2000978)
1.7	5.0	GO:0033128	negative regulation of histone phosphorylation(GO:0033128) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
1.6	11.4	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
1.6	4.9	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
1.6	9.5	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
1.6	6.3	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
1.6	6.2	GO:0044725	chromatin reprogramming in the zygote(GO:0044725)
1.5	10.6	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
1.5	4.5	GO:0023016	signal transduction by trans-phosphorylation(GO:0023016)
1.5	8.9	GO:0098903	regulation of membrane repolarization during action potential(GO:0098903)
1.5	7.4	GO:0060282	negative regulation of cardiac muscle contraction(GO:0055118) positive regulation of oocyte development(GO:0060282)
1.5	5.9	GO:0090204	protein localization to nuclear pore(GO:0090204)
1.5	13.1	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
1.4	5.8	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
1.4	4.3	GO:1900368	regulation of RNA interference(GO:1900368)
1.4	12.9	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
1.4	5.7	GO:0000019	regulation of mitotic recombination(GO:0000019)
1.4	5.7	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
1.4	8.5	GO:0035983	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
1.4	2.8	GO:1903936	cellular response to sodium arsenite(GO:1903936)
1.4	5.5	GO:0032763	regulation of mast cell cytokine production(GO:0032763) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.4	4.1	GO:0016476	regulation of embryonic cell shape(GO:0016476)
1.3	8.0	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
1.3	34.8	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
1.3	5.1	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
1.3	3.8	GO:2000111	senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
1.2	9.9	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.2	13.6	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
1.2	3.7	GO:1903588	blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
1.2	13.3	GO:0006013	mannose metabolic process(GO:0006013)
1.2	15.4	GO:1902018	negative regulation of cilium assembly(GO:1902018)
1.2	3.5	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
1.1	9.0	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
1.1	12.3	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
1.1	12.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
1.1	3.3	GO:1902659	regulation of glucose mediated signaling pathway(GO:1902659)
1.1	8.8	GO:0060982	coronary artery morphogenesis(GO:0060982)
1.1	17.5	GO:0045063	T-helper 1 cell differentiation(GO:0045063)
1.1	18.2	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
1.0	4.0	GO:1904637	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
1.0	4.0	GO:0034696	response to prostaglandin F(GO:0034696)
1.0	2.9	GO:1904954	regulation of collateral sprouting in absence of injury(GO:0048696) Spemann organizer formation(GO:0060061) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
1.0	4.8	GO:2000317	negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.9	12.3	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.9	4.7	GO:0015074	DNA integration(GO:0015074)
0.9	2.8	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.9	3.7	GO:0002184	cytoplasmic translational termination(GO:0002184)
0.9	6.5	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.9	7.3	GO:0001955	blood vessel maturation(GO:0001955)
0.9	8.2	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.9	4.5	GO:0090116	C-5 methylation of cytosine(GO:0090116)
0.9	13.6	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.9	2.7	GO:0061443	endocardial cushion cell differentiation(GO:0061443)
0.9	23.0	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
0.8	6.8	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.8	8.2	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.8	4.9	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.8	2.4	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.8	7.8	GO:0070995	NADPH oxidation(GO:0070995)
0.8	9.3	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.8	3.1	GO:0036353	histone H2A-K119 monoubiquitination(GO:0036353)
0.8	13.2	GO:0080182	histone H3-K4 trimethylation(GO:0080182)
0.8	3.0	GO:0014043	negative regulation of neuron maturation(GO:0014043)
0.7	12.2	GO:0002227	innate immune response in mucosa(GO:0002227)
0.7	7.2	GO:0008343	adult feeding behavior(GO:0008343)
0.7	10.5	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.7	3.4	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.7	12.2	GO:0034377	plasma lipoprotein particle assembly(GO:0034377)
0.7	18.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.7	2.0	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.7	2.7	GO:0089700	protein kinase D signaling(GO:0089700)
0.7	2.0	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.7	3.9	GO:0070673	response to interleukin-18(GO:0070673)
0.6	7.1	GO:0014029	neural crest formation(GO:0014029)
0.6	1.9	GO:0000189	MAPK import into nucleus(GO:0000189)
0.6	5.6	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.6	4.8	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.6	3.5	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.6	2.3	GO:0070475	rRNA base methylation(GO:0070475)
0.6	8.3	GO:0042659	regulation of cell fate specification(GO:0042659)
0.5	2.2	GO:0048865	stem cell fate commitment(GO:0048865)
0.5	3.8	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.5	2.1	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.5	2.1	GO:0010994	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.5	1.5	GO:1905218	cellular response to astaxanthin(GO:1905218)
0.5	3.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.5	16.3	GO:0030033	microvillus assembly(GO:0030033)
0.5	10.9	GO:0097503	sialylation(GO:0097503)
0.5	7.8	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.5	6.8	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5	4.4	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5	3.3	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.5	4.7	GO:0018095	protein polyglutamylation(GO:0018095)
0.5	1.4	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.5	5.9	GO:0014010	Schwann cell proliferation(GO:0014010)
0.4	6.7	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.4	4.4	GO:0006465	signal peptide processing(GO:0006465)
0.4	11.5	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.4	3.0	GO:0048262	determination of dorsal/ventral asymmetry(GO:0048262)
0.4	7.5	GO:0005513	detection of calcium ion(GO:0005513)
0.4	6.2	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.4	2.9	GO:1904628	response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.4	4.8	GO:0006353	DNA-templated transcription, termination(GO:0006353)
0.4	3.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4	5.5	GO:0034389	lipid particle organization(GO:0034389)
0.4	5.4	GO:0040034	regulation of development, heterochronic(GO:0040034)
0.4	3.4	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.4	11.3	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.4	10.8	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.4	2.9	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.4	2.2	GO:1903659	regulation of complement-dependent cytotoxicity(GO:1903659)
0.4	1.1	GO:1990164	histone H2A phosphorylation(GO:1990164)
0.4	11.5	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.4	5.0	GO:0032682	negative regulation of chemokine production(GO:0032682)
0.4	6.4	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.4	4.2	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.3	1.7	GO:1903251	multi-ciliated epithelial cell differentiation(GO:1903251)
0.3	3.7	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.3	1.7	GO:0098734	macromolecule depalmitoylation(GO:0098734)
0.3	2.7	GO:0015871	choline transport(GO:0015871)
0.3	8.5	GO:0002507	tolerance induction(GO:0002507) regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927)
0.3	8.0	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.3	18.3	GO:0006342	chromatin silencing(GO:0006342)
0.3	18.0	GO:0033045	regulation of sister chromatid segregation(GO:0033045)
0.3	1.5	GO:0050925	negative regulation of negative chemotaxis(GO:0050925)
0.3	5.4	GO:2000651	positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.3	1.2	GO:0036337	Fas signaling pathway(GO:0036337)
0.3	4.5	GO:0006491	N-glycan processing(GO:0006491)
0.3	1.4	GO:0009405	pathogenesis(GO:0009405)
0.3	2.3	GO:0033602	negative regulation of dopamine secretion(GO:0033602)
0.3	2.8	GO:0016266	O-glycan processing(GO:0016266)
0.3	1.7	GO:0006863	purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851)
0.3	15.8	GO:0006334	nucleosome assembly(GO:0006334)
0.3	3.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.3	4.7	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.3	3.1	GO:0046325	negative regulation of glucose import(GO:0046325)
0.3	2.1	GO:0070459	prolactin secretion(GO:0070459)
0.3	3.6	GO:0043968	histone H2A acetylation(GO:0043968)
0.3	4.1	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.2	1.2	GO:0015860	purine nucleoside transmembrane transport(GO:0015860)
0.2	7.7	GO:0046627	negative regulation of insulin receptor signaling pathway(GO:0046627)
0.2	4.8	GO:0097186	amelogenesis(GO:0097186)
0.2	2.0	GO:0036089	cleavage furrow formation(GO:0036089)
0.2	0.9	GO:0021979	hypothalamus cell differentiation(GO:0021979)
0.2	3.9	GO:0006298	mismatch repair(GO:0006298)
0.2	8.0	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.2	4.5	GO:0032025	response to cobalt ion(GO:0032025)
0.2	8.5	GO:0006493	protein O-linked glycosylation(GO:0006493)
0.2	18.0	GO:0030038	contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.2	1.3	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.2	1.6	GO:0000212	meiotic spindle organization(GO:0000212)
0.2	1.6	GO:0046085	adenosine metabolic process(GO:0046085)
0.2	3.2	GO:0048485	sympathetic nervous system development(GO:0048485)
0.2	1.6	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.2	6.3	GO:2001240	negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2	7.0	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.2	1.5	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.2	1.6	GO:0035608	protein deglutamylation(GO:0035608)
0.2	1.6	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.2	1.8	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.2	4.9	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
0.2	2.7	GO:0034142	toll-like receptor 4 signaling pathway(GO:0034142)
0.2	1.9	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.2	12.3	GO:0007569	cell aging(GO:0007569)
0.2	3.4	GO:0035066	positive regulation of histone acetylation(GO:0035066)
0.1	6.5	GO:0090307	mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.1	6.9	GO:0000070	mitotic sister chromatid segregation(GO:0000070)
0.1	2.9	GO:0034453	microtubule anchoring(GO:0034453)
0.1	6.2	GO:0006998	nuclear envelope organization(GO:0006998)
0.1	2.4	GO:0010569	regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1	2.6	GO:0016578	histone deubiquitination(GO:0016578)
0.1	2.5	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	1.1	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.1	5.1	GO:0046513	ceramide biosynthetic process(GO:0046513)
0.1	1.0	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.1	3.3	GO:2000279	negative regulation of DNA biosynthetic process(GO:2000279)
0.1	0.4	GO:0097010	eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1	3.3	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.1	2.2	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.1	7.0	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.1	1.3	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.1	2.6	GO:0010165	response to X-ray(GO:0010165)
0.1	3.1	GO:0019835	cytolysis(GO:0019835)
0.1	7.2	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	7.1	GO:0048678	response to axon injury(GO:0048678)
0.1	0.5	GO:0060023	soft palate development(GO:0060023)
0.1	0.3	GO:0060743	prostate gland stromal morphogenesis(GO:0060741) epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1	2.1	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.1	11.3	GO:0019882	antigen processing and presentation(GO:0019882)
0.1	3.6	GO:0007131	reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1	4.5	GO:0045494	photoreceptor cell maintenance(GO:0045494)
0.1	6.2	GO:0007093	mitotic cell cycle checkpoint(GO:0007093)
0.1	3.3	GO:0015701	bicarbonate transport(GO:0015701)
0.1	0.2	GO:0014826	regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826)
0.1	1.7	GO:0031424	keratinization(GO:0031424)
0.1	1.7	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1	0.1	GO:0006116	NADH oxidation(GO:0006116)
0.1	18.1	GO:0098656	anion transmembrane transport(GO:0098656)
0.1	1.4	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.1	1.1	GO:1900273	positive regulation of long-term synaptic potentiation(GO:1900273)
0.1	1.5	GO:0016180	snRNA processing(GO:0016180)
0.1	8.2	GO:0042113	B cell activation(GO:0042113)
0.1	4.4	GO:0051092	positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0	1.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.9	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.7	GO:0031440	regulation of mRNA 3'-end processing(GO:0031440)
0.0	1.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.3	GO:0007320	insemination(GO:0007320)
0.0	0.2	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	6.9	GO:0006397	mRNA processing(GO:0006397)
0.0	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0070417	cellular response to cold(GO:0070417)
0.0	4.0	GO:0009615	response to virus(GO:0009615)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	4.1	GO:0006281	DNA repair(GO:0006281)
0.0	0.4	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	1.0	GO:0045727	positive regulation of translation(GO:0045727)
0.0	0.4	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
13.5	53.8	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
4.3	13.0	GO:0032301	MutSalpha complex(GO:0032301)
4.2	12.6	GO:1990423	RZZ complex(GO:1990423)
3.5	17.6	GO:0030015	CCR4-NOT core complex(GO:0030015)
3.5	28.0	GO:0005638	lamin filament(GO:0005638)
2.9	17.2	GO:1990111	spermatoproteasome complex(GO:1990111)
2.8	14.1	GO:0043293	apoptosome(GO:0043293)
2.7	13.4	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
2.5	22.6	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
2.4	9.6	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
2.3	6.8	GO:0033186	CAF-1 complex(GO:0033186)
2.2	6.7	GO:0033557	Slx1-Slx4 complex(GO:0033557)
2.2	23.9	GO:0042555	MCM complex(GO:0042555)
2.1	14.4	GO:0030870	Mre11 complex(GO:0030870)
2.0	14.3	GO:0016602	CCAAT-binding factor complex(GO:0016602)
2.0	10.2	GO:0071953	elastic fiber(GO:0071953)
2.0	2.0	GO:0061574	ASAP complex(GO:0061574)
2.0	92.4	GO:0000791	euchromatin(GO:0000791)
2.0	9.9	GO:0030485	smooth muscle contractile fiber(GO:0030485)
1.8	10.7	GO:0030896	checkpoint clamp complex(GO:0030896)
1.7	13.3	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
1.6	20.9	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
1.5	4.5	GO:1990590	ATF1-ATF4 transcription factor complex(GO:1990590)
1.4	10.0	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
1.4	7.0	GO:0034455	t-UTP complex(GO:0034455)
1.4	11.1	GO:0001940	male pronucleus(GO:0001940)
1.4	20.6	GO:0030122	AP-2 adaptor complex(GO:0030122)
1.3	5.2	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
1.3	15.4	GO:0044327	dendritic spine head(GO:0044327)
1.3	16.3	GO:0031143	pseudopodium(GO:0031143)
1.2	12.3	GO:0008290	F-actin capping protein complex(GO:0008290)
1.2	10.8	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.2	5.9	GO:0016035	zeta DNA polymerase complex(GO:0016035)
1.1	3.3	GO:0002944	cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
1.1	4.3	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
1.0	18.4	GO:0035098	ESC/E(Z) complex(GO:0035098)
1.0	5.1	GO:0032389	MutLalpha complex(GO:0032389)
1.0	8.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
1.0	6.0	GO:0005642	annulate lamellae(GO:0005642) Flemming body(GO:0090543)
1.0	4.8	GO:0016342	catenin complex(GO:0016342)
1.0	3.8	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.9	4.7	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.9	2.8	GO:0000811	GINS complex(GO:0000811)
0.9	3.7	GO:0018444	translation release factor complex(GO:0018444)
0.9	16.7	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.9	2.8	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.9	4.3	GO:0071797	LUBAC complex(GO:0071797)
0.8	22.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.8	17.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.8	6.1	GO:0005818	astral microtubule(GO:0000235) aster(GO:0005818)
0.8	5.3	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.8	2.3	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
0.7	9.6	GO:0016580	Sin3 complex(GO:0016580)
0.7	8.9	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.7	4.4	GO:0005787	signal peptidase complex(GO:0005787)
0.7	24.0	GO:0051233	spindle midzone(GO:0051233)
0.7	64.0	GO:0000786	nucleosome(GO:0000786)
0.7	6.2	GO:0061700	GATOR2 complex(GO:0061700)
0.6	5.7	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.6	11.9	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.6	0.6	GO:0031933	telomeric heterochromatin(GO:0031933)
0.6	2.9	GO:0097361	CIA complex(GO:0097361)
0.6	7.0	GO:0044232	organelle membrane contact site(GO:0044232)
0.6	11.1	GO:0005686	U2 snRNP(GO:0005686)
0.5	2.7	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.5	4.2	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.5	4.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.5	7.8	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.5	43.9	GO:0032432	actin filament bundle(GO:0032432)
0.5	45.7	GO:0016605	PML body(GO:0016605)
0.5	7.4	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.5	10.7	GO:0090544	BAF-type complex(GO:0090544)
0.5	8.7	GO:0019013	viral nucleocapsid(GO:0019013)
0.5	4.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.4	14.5	GO:0034451	centriolar satellite(GO:0034451)
0.4	2.6	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.4	1.3	GO:0030690	Noc1p-Noc2p complex(GO:0030690)
0.4	4.6	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.4	4.6	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.4	38.5	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.4	18.0	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4	9.0	GO:0005721	pericentric heterochromatin(GO:0005721)
0.4	9.8	GO:0001891	phagocytic cup(GO:0001891)
0.4	2.4	GO:0031595	nuclear proteasome complex(GO:0031595)
0.4	2.5	GO:0031415	NatA complex(GO:0031415)
0.3	3.7	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.3	2.1	GO:0044815	DNA packaging complex(GO:0044815)
0.3	22.2	GO:0017053	transcriptional repressor complex(GO:0017053)
0.3	8.8	GO:0031519	PcG protein complex(GO:0031519)
0.3	3.5	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.3	5.4	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.3	12.1	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.3	13.3	GO:0005801	cis-Golgi network(GO:0005801)
0.2	12.2	GO:0005844	polysome(GO:0005844)
0.2	5.3	GO:0030137	COPI-coated vesicle(GO:0030137)
0.2	19.0	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.2	1.6	GO:0005827	polar microtubule(GO:0005827)
0.2	4.4	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2	1.3	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2	9.0	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.2	18.2	GO:0005884	actin filament(GO:0005884)
0.2	6.5	GO:0005876	spindle microtubule(GO:0005876)
0.2	23.4	GO:0000775	chromosome, centromeric region(GO:0000775)
0.2	2.1	GO:0032433	filopodium tip(GO:0032433)
0.2	3.0	GO:0032039	integrator complex(GO:0032039)
0.2	6.8	GO:0030286	dynein complex(GO:0030286)
0.2	18.3	GO:0036064	ciliary basal body(GO:0036064)
0.2	4.1	GO:0044447	axoneme part(GO:0044447)
0.2	36.8	GO:0000790	nuclear chromatin(GO:0000790)
0.2	1.3	GO:0032437	cuticular plate(GO:0032437)
0.2	3.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	0.5	GO:0005592	collagen type XI trimer(GO:0005592)
0.1	10.8	GO:0030175	filopodium(GO:0030175)
0.1	4.1	GO:0046930	pore complex(GO:0046930)
0.1	6.5	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1	32.0	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	8.4	GO:0000785	chromatin(GO:0000785)
0.1	5.9	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	6.6	GO:0005902	microvillus(GO:0005902)
0.1	0.9	GO:0032591	dendritic spine membrane(GO:0032591)
0.1	48.0	GO:0016604	nuclear body(GO:0016604)
0.1	2.3	GO:0032040	small-subunit processome(GO:0032040)
0.1	3.5	GO:0005643	nuclear pore(GO:0005643)
0.1	3.0	GO:0000795	synaptonemal complex(GO:0000795)
0.1	1.5	GO:0030673	axolemma(GO:0030673)
0.1	0.2	GO:0061689	tricellular tight junction(GO:0061689)
0.1	4.8	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	0.2	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1	1.3	GO:0002102	podosome(GO:0002102)
0.1	3.1	GO:0035770	ribonucleoprotein granule(GO:0035770)
0.0	1.9	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	1.7	GO:0045095	keratin filament(GO:0045095)
0.0	4.3	GO:0015629	actin cytoskeleton(GO:0015629)
0.0	0.7	GO:0016363	nuclear matrix(GO:0016363)
0.0	1.9	GO:0005819	spindle(GO:0005819)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
14.7	58.7	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
9.0	53.8	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
7.9	55.2	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
5.5	22.1	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
5.2	20.6	GO:0042610	CD8 receptor binding(GO:0042610)
4.6	13.8	GO:0046592	polyamine oxidase activity(GO:0046592)
4.3	13.0	GO:0032142	single guanine insertion binding(GO:0032142)
4.2	12.6	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
3.4	10.2	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023)
2.8	14.1	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
2.7	13.7	GO:0010997	anaphase-promoting complex binding(GO:0010997)
2.7	10.9	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
2.4	9.5	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
2.3	34.3	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
2.1	19.0	GO:0043515	kinetochore binding(GO:0043515)
2.1	10.6	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
2.1	2.1	GO:0042809	vitamin D receptor binding(GO:0042809)
1.9	13.3	GO:0003896	DNA primase activity(GO:0003896)
1.7	5.1	GO:0000403	Y-form DNA binding(GO:0000403)
1.6	14.8	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
1.6	4.8	GO:0051916	granulocyte colony-stimulating factor binding(GO:0051916)
1.6	11.1	GO:0030620	U2 snRNA binding(GO:0030620)
1.6	25.3	GO:0008143	poly(A) binding(GO:0008143)
1.6	6.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
1.5	6.2	GO:0061665	SUMO ligase activity(GO:0061665)
1.5	20.0	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
1.5	6.1	GO:0047179	platelet-activating factor acetyltransferase activity(GO:0047179)
1.5	4.5	GO:0001641	group II metabotropic glutamate receptor activity(GO:0001641)
1.5	11.9	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.5	6.0	GO:0051425	PTB domain binding(GO:0051425)
1.5	17.4	GO:0003708	retinoic acid receptor activity(GO:0003708)
1.4	17.8	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
1.3	6.7	GO:0017108	5'-flap endonuclease activity(GO:0017108)
1.3	14.4	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
1.3	7.8	GO:0031749	D2 dopamine receptor binding(GO:0031749)
1.2	5.0	GO:0010385	double-stranded methylated DNA binding(GO:0010385)
1.2	5.9	GO:0005134	interleukin-2 receptor binding(GO:0005134)
1.2	15.3	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
1.1	10.0	GO:0032050	clathrin heavy chain binding(GO:0032050)
1.1	4.3	GO:0070883	pre-miRNA binding(GO:0070883)
1.0	6.2	GO:0070728	leucine binding(GO:0070728)
1.0	7.9	GO:0019103	pyrimidine nucleotide binding(GO:0019103)
1.0	4.8	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
1.0	3.8	GO:0055105	ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.9	3.8	GO:0001156	transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIC-class transcription factor binding(GO:0001156)
0.9	5.6	GO:0051434	BH3 domain binding(GO:0051434)
0.9	4.6	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.9	4.5	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.9	15.3	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.9	3.6	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.9	19.6	GO:0043274	phospholipase binding(GO:0043274)
0.8	8.5	GO:0070878	primary miRNA binding(GO:0070878)
0.8	5.5	GO:0016018	cyclosporin A binding(GO:0016018)
0.8	3.1	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.8	8.4	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.8	15.2	GO:0032794	GTPase activating protein binding(GO:0032794)
0.7	5.2	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.7	2.9	GO:1990715	mRNA CDS binding(GO:1990715)
0.7	18.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.7	13.8	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.7	23.5	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.7	6.9	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.7	3.5	GO:0001010	transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.7	4.7	GO:0008046	axon guidance receptor activity(GO:0008046)
0.7	26.8	GO:0003678	DNA helicase activity(GO:0003678)
0.7	15.8	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.6	16.6	GO:0008408	3'-5' exonuclease activity(GO:0008408)
0.6	17.2	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6	5.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.6	8.2	GO:0008097	5S rRNA binding(GO:0008097)
0.6	18.3	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.6	3.6	GO:0008266	poly(U) RNA binding(GO:0008266)
0.6	4.8	GO:0001055	RNA polymerase II activity(GO:0001055)
0.6	12.0	GO:0005003	ephrin receptor activity(GO:0005003)
0.6	2.4	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.6	3.6	GO:0050692	DBD domain binding(GO:0050692)
0.6	10.0	GO:0031005	filamin binding(GO:0031005)
0.6	28.2	GO:0070888	E-box binding(GO:0070888)
0.6	11.7	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.6	6.4	GO:0032036	myosin heavy chain binding(GO:0032036)
0.6	8.5	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.6	3.4	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.6	2.3	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.6	7.3	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.6	17.4	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6	12.3	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.6	5.6	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.6	4.4	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.6	3.3	GO:0001163	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.5	5.4	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.5	2.7	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.5	13.2	GO:0017091	AU-rich element binding(GO:0017091)
0.5	13.2	GO:0071889	14-3-3 protein binding(GO:0071889)
0.5	3.2	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.5	1.6	GO:0004359	glutaminase activity(GO:0004359)
0.5	4.2	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.5	2.6	GO:0070717	poly-purine tract binding(GO:0070717)
0.5	12.9	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.5	19.3	GO:0070063	RNA polymerase binding(GO:0070063)
0.5	4.1	GO:0015266	protein channel activity(GO:0015266)
0.4	2.2	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.4	1.7	GO:0004844	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.4	8.2	GO:0046965	retinoid X receptor binding(GO:0046965)
0.4	4.5	GO:0051011	microtubule minus-end binding(GO:0051011)
0.4	2.8	GO:0035252	UDP-xylosyltransferase activity(GO:0035252)
0.4	2.7	GO:0032184	SUMO polymer binding(GO:0032184)
0.4	3.9	GO:0030983	mismatched DNA binding(GO:0030983)
0.4	4.2	GO:0008432	JUN kinase binding(GO:0008432)
0.4	14.7	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.4	1.8	GO:0005111	type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4	11.0	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.4	7.8	GO:0004033	aldo-keto reductase (NADP) activity(GO:0004033)
0.3	25.7	GO:0003725	double-stranded RNA binding(GO:0003725)
0.3	2.8	GO:0046790	virion binding(GO:0046790)
0.3	3.4	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.3	3.7	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3	16.0	GO:0031593	polyubiquitin binding(GO:0031593)
0.3	53.5	GO:0042393	histone binding(GO:0042393)
0.3	3.3	GO:0000400	four-way junction DNA binding(GO:0000400)
0.3	4.5	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.3	7.7	GO:0042162	telomeric DNA binding(GO:0042162)
0.3	1.8	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.3	8.0	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.3	6.3	GO:0005112	Notch binding(GO:0005112)
0.3	9.9	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.3	5.1	GO:0038187	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.3	11.6	GO:0001784	phosphotyrosine binding(GO:0001784)
0.3	4.8	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.3	2.8	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2	2.9	GO:0015216	purine nucleotide transmembrane transporter activity(GO:0015216)
0.2	1.7	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2	16.7	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2	6.3	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2	1.6	GO:0004111	creatine kinase activity(GO:0004111)
0.2	1.7	GO:0043237	laminin-1 binding(GO:0043237)
0.2	6.2	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2	2.7	GO:0004697	protein kinase C activity(GO:0004697)
0.2	1.2	GO:0044388	small protein activating enzyme binding(GO:0044388)
0.2	2.5	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2	2.7	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.2	2.8	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.2	3.5	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2	1.4	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.2	5.8	GO:0030295	protein kinase activator activity(GO:0030295)
0.1	1.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.1	7.6	GO:0019894	kinesin binding(GO:0019894)
0.1	18.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	3.7	GO:0046875	ephrin receptor binding(GO:0046875)
0.1	1.1	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.1	2.9	GO:0048018	receptor agonist activity(GO:0048018)
0.1	1.2	GO:0019789	SUMO transferase activity(GO:0019789)
0.1	3.3	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.1	3.4	GO:0005326	neurotransmitter transporter activity(GO:0005326)
0.1	5.1	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.1	1.9	GO:0008376	acetylgalactosaminyltransferase activity(GO:0008376)
0.1	0.7	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.1	5.4	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	1.1	GO:0070300	phosphatidic acid binding(GO:0070300)
0.1	1.6	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.1	0.6	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1	2.9	GO:0030331	estrogen receptor binding(GO:0030331)
0.1	1.7	GO:0070491	repressing transcription factor binding(GO:0070491)
0.1	5.4	GO:0043621	protein self-association(GO:0043621)
0.1	10.3	GO:0008083	growth factor activity(GO:0008083)
0.1	10.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	0.4	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	3.9	GO:0003724	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1	3.2	GO:0030145	manganese ion binding(GO:0030145)
0.1	3.5	GO:0043130	ubiquitin binding(GO:0043130)
0.1	1.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1	0.9	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.1	2.1	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	0.2	GO:0031708	endothelin B receptor binding(GO:0031708)
0.1	1.6	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	1.1	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.1	1.5	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	1.0	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	2.3	GO:0019843	rRNA binding(GO:0019843)
0.0	6.9	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0	6.8	GO:0051015	actin filament binding(GO:0051015)
0.0	2.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.9	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	1.5	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	6.6	GO:0003713	transcription coactivator activity(GO:0003713)
0.0	1.3	GO:0030507	spectrin binding(GO:0030507)
0.0	10.0	GO:0005543	phospholipid binding(GO:0005543)
0.0	2.9	GO:0031072	heat shock protein binding(GO:0031072)
0.0	43.6	GO:0003723	RNA binding(GO:0003723)
0.0	2.5	GO:0008565	protein transporter activity(GO:0008565)
0.0	0.2	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	1.3	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	49.5	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
1.5	134.3	PID E2F PATHWAY	E2F transcription factor network
1.4	15.4	ST JAK STAT PATHWAY	Jak-STAT Pathway
1.2	49.4	PID ATR PATHWAY	ATR signaling pathway
1.0	3.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.9	14.7	PID SHP2 PATHWAY	SHP2 signaling
0.9	27.9	PID ATM PATHWAY	ATM pathway
0.9	23.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.8	14.4	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.7	26.7	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.7	20.9	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.7	11.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.6	14.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.6	16.7	PID REELIN PATHWAY	Reelin signaling pathway
0.6	33.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.6	15.4	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.5	12.0	PID MYC PATHWAY	C-MYC pathway
0.5	2.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5	5.6	PID S1P S1P3 PATHWAY	S1P3 pathway
0.5	12.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.4	9.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	21.7	PID NOTCH PATHWAY	Notch signaling pathway
0.4	10.2	PID CONE PATHWAY	Visual signal transduction: Cones
0.3	2.7	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3	7.4	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	5.0	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	9.8	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.2	10.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	9.0	PID P53 REGULATION PATHWAY	p53 pathway
0.2	9.2	PID PLK1 PATHWAY	PLK1 signaling events
0.2	4.6	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.2	11.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.2	19.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	4.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	2.8	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.2	4.9	PID TNF PATHWAY	TNF receptor signaling pathway
0.2	3.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	4.1	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	5.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	2.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.1	3.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	2.5	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	4.1	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	1.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	1.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.1	3.4	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.0	1.0	PID CDC42 PATHWAY	CDC42 signaling events
0.0	1.1	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.2	PID ENDOTHELIN PATHWAY	Endothelins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.4	26.8	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
2.3	50.7	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
2.0	23.5	REACTOME SIGNALING BY NOTCH3	Genes involved in Signaling by NOTCH3
1.9	28.1	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
1.6	12.6	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
1.5	15.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.5	7.4	REACTOME POL SWITCHING	Genes involved in Polymerase switching
1.5	20.6	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
1.5	37.8	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
1.4	5.5	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
1.2	22.9	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.2	10.6	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
1.1	19.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.1	8.7	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
1.1	25.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.1	12.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
1.1	19.0	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.9	16.8	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.9	4.5	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.9	6.9	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.8	20.9	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.8	13.4	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.8	18.4	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.8	22.9	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.7	4.3	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.7	30.0	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.7	12.0	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.7	12.5	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.7	10.6	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.6	16.8	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.6	49.9	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.6	13.3	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.6	11.0	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.6	18.3	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.6	22.1	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.6	7.9	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6	8.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5	2.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.5	19.7	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.5	52.5	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.5	7.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.5	7.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.5	11.1	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.5	7.4	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.5	7.8	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.5	6.3	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.5	4.5	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.4	5.4	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.4	7.4	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.4	12.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	17.2	REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.4	7.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.4	9.2	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.4	5.5	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.3	9.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.3	8.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	3.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	3.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	3.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3	3.4	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.3	16.9	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.2	4.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.2	4.5	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2	1.6	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	6.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.2	11.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	3.7	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.2	5.0	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2	8.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	8.4	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.2	19.2	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2	4.5	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	1.8	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.1	5.1	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	1.7	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.1	4.8	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.1	3.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	16.0	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	1.9	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	2.1	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	3.4	REACTOME MITOTIC G1 G1 S PHASES	Genes involved in Mitotic G1-G1/S phases
0.1	1.9	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1	2.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.1	4.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.1	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	1.6	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	0.4	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	2.8	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	1.1	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	6.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	1.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	3.3	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	3.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Results for E2f6

Z-value: 1.23

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Transcription factors associated with E2f6

Activity-expression correlation:

Activity profile of E2f6 motif

Sorted Z-values of E2f6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: