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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Elf3

Z-value: 1.36

Motif logo

Transcription factors associated with Elf3

Gene Symbol Gene ID Gene Info
ENSRNOG00000006330 E74-like factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Elf3rn6_v1_chr13_-_52088780_520887800.529.7e-24Click!

Activity profile of Elf3 motif

Sorted Z-values of Elf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_47930633 57.00 ENSRNOT00000003515
GRB2-related adaptor protein
chr14_-_86796378 51.78 ENSRNOT00000092021
myosin IG
chr13_+_50164563 49.42 ENSRNOT00000029533
lymphocyte transmembrane adaptor 1
chrX_+_134979646 48.02 ENSRNOT00000006035
SAM and SH3 domain containing 3
chr13_-_111917587 40.87 ENSRNOT00000007649
TRAF3 interacting protein 3
chr9_+_43331155 38.82 ENSRNOT00000023036
zeta chain of T cell receptor associated protein kinase 70
chr6_-_138508753 36.43 ENSRNOT00000006888
immunoglobulin heavy constant mu
chr4_-_78342863 34.67 ENSRNOT00000049038
GTPase, IMAP family member 6
chr7_+_12782491 33.24 ENSRNOT00000065093
calponin 2
chr3_+_161018511 33.12 ENSRNOT00000019804
ENSRNOT00000039664
WAP four-disulfide core domain 2
chr10_-_19574094 31.69 ENSRNOT00000059810
dedicator of cytokinesis 2
chr9_-_54484533 31.34 ENSRNOT00000083514
signal transducer and activator of transcription 1
chr14_-_43992587 29.70 ENSRNOT00000003425
ras homolog family member H
chr4_+_78371121 29.64 ENSRNOT00000059157
GTPase, IMAP family member 1
chr2_+_183674522 29.44 ENSRNOT00000014433
transmembrane protein 154
chr7_-_60341264 29.40 ENSRNOT00000007747
lysozyme 2
chr1_+_64114721 28.66 ENSRNOT00000080466
transmembrane channel-like 4
chr20_+_9948908 28.65 ENSRNOT00000001541
ubiquitin associated and SH3 domain containing, A
chrX_+_15155230 28.47 ENSRNOT00000073289
ENSRNOT00000051439
Wiskott-Aldrich syndrome
chr6_-_137664133 27.23 ENSRNOT00000018613
G protein-coupled receptor 132
chr14_-_82347679 27.04 ENSRNOT00000032972
transforming, acidic coiled-coil containing protein 3
chr3_+_20303979 26.65 ENSRNOT00000058331

chr19_+_19395655 25.70 ENSRNOT00000019130
sorting nexin 20
chr2_-_196323881 22.94 ENSRNOT00000028642
TNF alpha induced protein 8 like 2
chr17_+_44794130 22.91 ENSRNOT00000077571
histone cluster 1, H2ac
chr15_+_52451161 22.25 ENSRNOT00000018725
docking protein 2
chr16_+_18716019 21.73 ENSRNOT00000047870
surfactant protein A1
chr4_+_109467272 21.51 ENSRNOT00000008212
regenerating family member 3 beta
chr1_+_223214132 21.32 ENSRNOT00000066559

chr7_+_11077411 20.96 ENSRNOT00000007117
sphingosine-1-phosphate receptor 4
chr13_+_91954138 20.92 ENSRNOT00000074608
ENSRNOT00000037655
absent in melanoma 2
chr2_+_186776644 20.78 ENSRNOT00000046778
Fc receptor-like 3
chr10_+_39109522 20.69 ENSRNOT00000010968
interferon regulatory factor 1
chr20_+_9743269 20.63 ENSRNOT00000001533
ENSRNOT00000083505
ATP binding cassette subfamily G member 1
chr10_-_70802782 20.59 ENSRNOT00000045867
chemokine (C-C motif) ligand 6
chr13_+_47602692 20.39 ENSRNOT00000038822
Fc fragment of IgM receptor
chr9_+_65620658 20.20 ENSRNOT00000084498
caspase 8
chr7_-_107616038 20.04 ENSRNOT00000088752
src-like adaptor
chr20_+_5184515 19.72 ENSRNOT00000089411
lymphotoxin-beta
chr5_+_154260062 19.61 ENSRNOT00000074998
cannabinoid receptor 2
chr20_-_4863198 19.47 ENSRNOT00000001108
lymphotoxin beta
chr7_-_117680004 19.44 ENSRNOT00000040422
solute carrier family 39 member 4
chr19_-_52499433 19.36 ENSRNOT00000021954
coactosin-like F-actin binding protein 1
chr7_+_70614617 19.36 ENSRNOT00000035382
Rho GTPase activating protein 9
chr20_+_30915213 19.28 ENSRNOT00000000681
perforin 1
chr15_+_32817343 19.23 ENSRNOT00000073853

chr8_+_133195288 18.94 ENSRNOT00000078529
C-C motif chemokine receptor 2
chr1_+_64046377 18.69 ENSRNOT00000085010
transmembrane channel-like 4
chr20_-_4863011 18.26 ENSRNOT00000079503
lymphotoxin beta
chr11_-_66759402 18.19 ENSRNOT00000003326
hematopoietic cell specific Lyn substrate 1
chr1_+_81643816 18.16 ENSRNOT00000027214
carcinoembryonic antigen-related cell adhesion molecule 1-like
chr10_+_17421075 18.14 ENSRNOT00000047011
serine/threonine kinase 10
chr17_-_44793927 18.06 ENSRNOT00000086309
histone cluster 1 H2B family member o
chr16_-_19349080 17.64 ENSRNOT00000038494
hematopoietic SH2 domain containing
chr1_+_63842277 17.22 ENSRNOT00000087957
ENSRNOT00000080820
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3A
chr1_+_219397850 17.05 ENSRNOT00000029829
coronin 1B
chr7_+_118895405 16.75 ENSRNOT00000092095
similar to apolipoprotein L2; apolipoprotein L-II
chr11_+_84745904 16.52 ENSRNOT00000002617
kelch-like family member 6
chr20_+_5040337 16.44 ENSRNOT00000068435
chloride intracellular channel 1
chr14_+_5928737 16.26 ENSRNOT00000071877
ENSRNOT00000040985
ENSRNOT00000074889
macrophage activation 2 like
chr13_+_88606894 16.16 ENSRNOT00000048692
SH2 domain containing 1B
chr1_+_91152635 15.97 ENSRNOT00000073438
dermokine-like
chr12_+_19890749 15.82 ENSRNOT00000074970
similar to cell surface receptor FDFACT
chr20_+_5351605 15.76 ENSRNOT00000089306
ENSRNOT00000041590
ENSRNOT00000081240
ENSRNOT00000082538
RT1 class Ia, locus A1
chr1_+_83003841 15.68 ENSRNOT00000057384
carcinoembryonic antigen-related cell adhesion molecule 4
chr9_-_45206427 15.19 ENSRNOT00000042227
AF4/FMR2 family, member 3
chr15_+_19338175 15.11 ENSRNOT00000075209
prostaglandin E receptor 2
chr10_-_57275708 14.61 ENSRNOT00000005370
profilin 1
chr8_+_49378644 14.53 ENSRNOT00000007588
junction adhesion molecule like
chr16_-_10706073 14.26 ENSRNOT00000089114
family with sequence similarity 25, member A
chr10_+_12046541 14.23 ENSRNOT00000081191
MEFV, pyrin innate immunity regulator
chr10_+_49000973 14.17 ENSRNOT00000057880
microfibril-associated glycoprotein 4-like
chr1_-_43638161 13.99 ENSRNOT00000024460
interaction protein for cytohesin exchange factors 1
chr12_-_2826378 13.98 ENSRNOT00000061749
C-type lectin domain family 4 member M
chr15_+_60084918 13.87 ENSRNOT00000012632
epithelial stromal interaction 1
chr10_+_47765432 13.22 ENSRNOT00000078231
microfibril-associated glycoprotein 4-like
chr4_+_163162211 12.77 ENSRNOT00000082537
C-type lectin domain family 1, member B
chr8_-_103608913 12.66 ENSRNOT00000013209
plastin 1
chr4_+_90990088 12.53 ENSRNOT00000030320
multimerin 1
chr1_-_191007503 12.45 ENSRNOT00000023262
immunoglobulin superfamily, member 6
chr4_-_170092848 12.40 ENSRNOT00000072147
histone cluster 2, H4
chr6_-_138852571 12.37 ENSRNOT00000081803

chr10_+_104952237 12.23 ENSRNOT00000085222
similar to immunoglobulin superfamily, member 7
chr2_-_112831476 12.19 ENSRNOT00000018055
epithelial cell transforming 2
chr3_+_55369214 12.04 ENSRNOT00000067161
nitric oxide synthase trafficking
chr9_+_65614142 11.78 ENSRNOT00000016613
caspase 8
chr12_-_20486276 11.70 ENSRNOT00000074057
similar to paired immunoglobin-like type 2 receptor beta
chr1_+_75440034 11.60 ENSRNOT00000033633
phospholipase A2, group IVC
chr1_-_206282575 11.48 ENSRNOT00000024974
ADAM metallopeptidase domain 12
chr15_+_31579478 11.30 ENSRNOT00000071642

chr7_+_95309928 10.91 ENSRNOT00000005887
MDM2 binding protein
chr15_-_45524582 10.59 ENSRNOT00000081912
guanylate cyclase 1 soluble subunit beta 2
chr15_+_87704340 10.58 ENSRNOT00000034987
sciellin
chr1_+_282638017 10.35 ENSRNOT00000079722
ENSRNOT00000082254
carboxylesterase 2C
chr5_+_48303366 10.31 ENSRNOT00000009973
gamma-aminobutyric acid type A receptor rho 2 subunit
chr8_+_48925604 10.27 ENSRNOT00000077445
DEAD-box helicase 6
chr15_-_30323833 10.03 ENSRNOT00000071631

chr11_+_82680253 10.00 ENSRNOT00000077119
ENSRNOT00000075512
lipase H
chr15_+_30270740 9.94 ENSRNOT00000070991

chr9_+_47134034 9.90 ENSRNOT00000020108
interleukin 1 receptor-like 1
chr6_+_139523495 9.82 ENSRNOT00000075467

chr1_-_260254600 9.81 ENSRNOT00000019014
B-cell linker
chr19_+_37652969 9.79 ENSRNOT00000041970
capping protein regulator and myosin 1 linker 2
chr6_+_126170911 9.57 ENSRNOT00000077477
Ras and Rab interactor 3
chr1_-_89509343 9.30 ENSRNOT00000028637
FXYD domain-containing ion transport regulator 3
chr6_+_126170720 9.29 ENSRNOT00000065246
Ras and Rab interactor 3
chr1_-_221015929 9.24 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr16_+_2379480 9.12 ENSRNOT00000079215
dynein, axonemal, heavy chain 12
chr6_+_102477036 9.08 ENSRNOT00000087132
RAD51 paralog B
chr10_+_103562725 9.04 ENSRNOT00000075199

chr15_-_33218456 9.02 ENSRNOT00000017753
ajuba LIM protein
chr15_-_42898150 8.98 ENSRNOT00000030036
protein tyrosine kinase 2 beta
chr15_+_32160364 8.94 ENSRNOT00000072888

chr6_-_125590049 8.90 ENSRNOT00000006371
tandem C2 domains, nuclear
chr4_+_71652354 8.84 ENSRNOT00000022672
ENSRNOT00000022543
caspase 2
chr8_-_68275720 8.74 ENSRNOT00000079122
mitogen activated protein kinase kinase 5
chr4_-_118595580 8.72 ENSRNOT00000024436
annexin A4
chr6_-_135877883 8.58 ENSRNOT00000079092

chr10_+_104437648 8.52 ENSRNOT00000035001

chr3_-_165360292 8.34 ENSRNOT00000065615
nuclear factor of activated T-cells 2
chr1_+_282694906 8.26 ENSRNOT00000074303
carboxylesterase 2C
chr10_-_59049482 8.20 ENSRNOT00000078272
spinster homolog 2
chr7_+_15242227 8.19 ENSRNOT00000084634
zinc finger protein 472
chr1_-_175586802 8.09 ENSRNOT00000071333

chr13_+_105684420 8.07 ENSRNOT00000040543
G patch domain containing 2
chrX_+_65566047 8.03 ENSRNOT00000092103
hephaestin
chr10_+_35133252 7.99 ENSRNOT00000051916
secretoglobin, family 3A, member 1
chr8_-_72714664 7.78 ENSRNOT00000024286
RAB8B, member RAS oncogene family
chr1_+_189550354 7.76 ENSRNOT00000083153
exonuclease NEF-sp
chr15_+_32188736 7.68 ENSRNOT00000081436

chr17_-_75886523 7.66 ENSRNOT00000046266
USP6 N-terminal like
chr1_+_189549960 7.66 ENSRNOT00000019654
exonuclease NEF-sp
chr10_-_56289882 7.47 ENSRNOT00000090762
ENSRNOT00000056903
tumor necrosis factor superfamily member 13
chr5_+_120498883 7.43 ENSRNOT00000007859
leptin receptor overlapping transcript
chr15_-_34469350 7.31 ENSRNOT00000067536
adenylate cyclase 4
chr15_-_33766438 7.16 ENSRNOT00000033977
adaptor-related protein complex 1, gamma 2 subunit
chr12_-_9864791 6.91 ENSRNOT00000073026
general transcription factor III A
chr18_-_36285444 6.87 ENSRNOT00000087852
PRELI domain containing 2
chr7_-_66909470 6.80 ENSRNOT00000066381
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr10_+_45322248 6.77 ENSRNOT00000047268
tripartite motif-containing 11
chr1_-_100993269 6.66 ENSRNOT00000027777
BCL2 like 12
chr15_-_29922522 6.45 ENSRNOT00000081778

chr5_-_169630340 6.41 ENSRNOT00000087043
potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr17_-_13586554 6.40 ENSRNOT00000041371
SECIS binding protein 2
chr11_+_36736586 6.35 ENSRNOT00000082098
immunoglobulin superfamily, member 5
chr4_+_167754525 6.32 ENSRNOT00000007889
ets variant 6
chr8_-_85840818 6.28 ENSRNOT00000013608
eukaryotic translation elongation factor 1 alpha 1
chr7_+_70987861 6.27 ENSRNOT00000072906
nuclear envelope integral membrane protein 1
chr10_+_59743544 6.19 ENSRNOT00000093497
ENSRNOT00000056460
Tax1 binding protein 3
chr12_+_41340815 6.15 ENSRNOT00000077542
2'-5' oligoadenylate synthetase 2
chr15_+_30735921 6.14 ENSRNOT00000078887

chr15_+_32051651 6.09 ENSRNOT00000071887
uncharacterized LOC103693854
chr13_+_52662996 6.08 ENSRNOT00000047682
troponin T2, cardiac type
chr5_+_172986291 6.06 ENSRNOT00000022900
NAD kinase
chr6_+_129519709 6.05 ENSRNOT00000006307
GSK3B interacting protein
chr5_-_154393697 6.03 ENSRNOT00000090019
ribosomal protein L11
chr3_+_124088157 6.00 ENSRNOT00000028876
spermine oxidase
chr3_-_2411544 5.98 ENSRNOT00000012406
torsin family 4, member A
chr12_-_41590244 5.97 ENSRNOT00000038736
solute carrier family 8 member B1
chr4_-_163214678 5.96 ENSRNOT00000091602
C-type lectin domain family 1, member A
chr1_-_13050644 5.72 ENSRNOT00000081259
hdc homolog, cell cycle regulator
chr9_+_69497121 5.64 ENSRNOT00000042562
neuropilin 2
chr15_-_33358138 5.61 ENSRNOT00000019155
CCAAT/enhancer binding protein epsilon
chr7_-_12601674 5.30 ENSRNOT00000093489
AT-rich interaction domain 3A
chr15_+_27875911 5.29 ENSRNOT00000013582
purine nucleoside phosphorylase
chr1_-_77844189 5.10 ENSRNOT00000017555
glioma tumor suppressor candidate region gene 2
chr11_+_57430166 5.06 ENSRNOT00000093201
pleckstrin homology-like domain, family B, member 2
chr3_+_113918629 5.04 ENSRNOT00000078978
ENSRNOT00000037168
CTD small phosphatase like 2
chr3_+_59819157 5.04 ENSRNOT00000040114
uncharacterized LOC103695172
chr5_+_60250546 5.01 ENSRNOT00000017707
zinc finger CCHC-type containing 7
chr4_+_45555077 5.00 ENSRNOT00000089007
LSM8 homolog, U6 small nuclear RNA associated
chr8_-_71533069 4.97 ENSRNOT00000021863
thyroid hormone receptor interactor 4
chr15_+_32012543 4.97 ENSRNOT00000078174

chr11_-_67647818 4.92 ENSRNOT00000003068
WD repeat domain 5B
chrX_-_38196060 4.88 ENSRNOT00000006741
ENSRNOT00000006438
SH3 domain-containing kinase-binding protein 1
chr12_+_11179329 4.87 ENSRNOT00000001302
zinc finger protein 394
chr5_+_5215196 4.86 ENSRNOT00000010481
translocation associated membrane protein 1
chrX_+_77119911 4.80 ENSRNOT00000080141
ATPase copper transporting alpha
chr6_+_12415805 4.74 ENSRNOT00000022380
general transcription factor 2A subunit 1 like
chr9_+_95274707 4.74 ENSRNOT00000045163
UDP glucuronosyltransferase family 1 member A5
chr7_-_122329443 4.68 ENSRNOT00000032232
megakaryoblastic leukemia (translocation) 1
chr17_-_27602934 4.48 ENSRNOT00000079298
ras responsive element binding protein 1
chr13_-_61306939 4.38 ENSRNOT00000086610
regulator of G-protein signaling 21
chr11_+_36737022 4.35 ENSRNOT00000032566
immunoglobulin superfamily, member 5
chr7_-_117068332 4.30 ENSRNOT00000082433
family with sequence similarity 83, member H
chr1_-_100231460 4.28 ENSRNOT00000032200
acid phosphatase, testicular
chr7_-_120026755 4.19 ENSRNOT00000077677
caspase recruitment domain family, member 10
chr13_+_88557860 4.14 ENSRNOT00000058547
SH2 domain containing 1B2
chr1_+_44019059 4.09 ENSRNOT00000065733
ENSRNOT00000083425
SR-related CTD-associated factor 8
chr18_-_399242 3.97 ENSRNOT00000045926
coagulation factor VIII
chr3_-_112174269 3.92 ENSRNOT00000067836
transmembrane protein 87A
chr9_+_121802673 3.89 ENSRNOT00000086534
YES proto-oncogene 1, Src family tyrosine kinase
chr1_+_252375933 3.88 ENSRNOT00000078405
lipase, family member N
chr2_+_45668969 3.74 ENSRNOT00000014761
ENSRNOT00000071353
ADP-ribosylation factor like GTPase 15
chr3_-_59688692 3.72 ENSRNOT00000078752
Sp3 transcription factor
chr4_-_51946715 3.71 ENSRNOT00000079130
protection of telomeres 1
chr3_-_147487170 3.62 ENSRNOT00000077580
family with sequence similarity 110, member A
chr19_-_41349681 3.54 ENSRNOT00000080694
ENSRNOT00000059147
Hydin, axonemal central pair apparatus protein
chr9_+_92435896 3.51 ENSRNOT00000022901
F-box protein 36
chr15_+_48327461 3.50 ENSRNOT00000018071
integrator complex subunit 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.9 38.8 GO:0043366 beta selection(GO:0043366)
10.6 31.7 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
8.6 51.8 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
8.4 33.5 GO:0035696 monocyte extravasation(GO:0035696)
7.8 31.3 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
6.5 19.4 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
5.8 40.4 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
5.7 17.0 GO:1902463 protein localization to cell leading edge(GO:1902463)
5.4 21.5 GO:1903576 response to L-arginine(GO:1903576)
5.3 15.8 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
5.2 20.6 GO:0034436 glycoprotein transport(GO:0034436)
4.7 28.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
4.5 18.2 GO:0042509 regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
4.5 9.0 GO:2000537 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
4.0 16.0 GO:1903575 cornified envelope assembly(GO:1903575)
3.7 48.0 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
3.6 10.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
3.6 14.2 GO:0071640 regulation of macrophage inflammatory protein 1 alpha production(GO:0071640)
3.5 17.6 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
3.3 9.9 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
3.2 12.7 GO:1902896 terminal web assembly(GO:1902896)
3.1 30.8 GO:0060546 negative regulation of necroptotic process(GO:0060546)
3.1 9.2 GO:0042631 cellular response to water deprivation(GO:0042631)
3.0 20.9 GO:0070269 pyroptosis(GO:0070269)
2.9 8.7 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
2.7 27.0 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
2.7 5.3 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
2.6 20.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
2.6 10.3 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
2.4 9.8 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
2.4 21.7 GO:0008228 opsonization(GO:0008228)
2.2 29.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
2.2 19.6 GO:0038171 cannabinoid signaling pathway(GO:0038171)
2.1 6.4 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
2.1 27.0 GO:0030953 astral microtubule organization(GO:0030953)
2.0 6.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
1.9 5.6 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
1.9 7.4 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
1.8 48.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
1.8 5.3 GO:0046495 nicotinamide riboside catabolic process(GO:0006738) urate biosynthetic process(GO:0034418) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
1.7 33.2 GO:0050765 negative regulation of phagocytosis(GO:0050765)
1.6 14.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
1.6 28.6 GO:0038065 collagen-activated signaling pathway(GO:0038065)
1.6 6.3 GO:0007296 vitellogenesis(GO:0007296)
1.6 14.0 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
1.4 9.5 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
1.2 8.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
1.2 75.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.2 3.7 GO:0060383 positive regulation of DNA strand elongation(GO:0060383)
1.2 6.1 GO:0006741 NADP biosynthetic process(GO:0006741)
1.2 19.3 GO:0001771 immunological synapse formation(GO:0001771)
1.2 4.8 GO:1904959 regulation of iron ion transmembrane transport(GO:0034759) negative regulation of iron ion transmembrane transport(GO:0034760) elastin biosynthetic process(GO:0051542) regulation of cytochrome-c oxidase activity(GO:1904959)
1.2 1.2 GO:0014735 regulation of muscle atrophy(GO:0014735)
1.1 6.8 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.1 4.5 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
1.1 7.8 GO:0051461 positive regulation of corticotropin secretion(GO:0051461)
1.1 7.7 GO:0048227 plasma membrane to endosome transport(GO:0048227)
1.0 3.1 GO:1904815 negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
1.0 5.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.0 6.0 GO:0046208 spermine catabolic process(GO:0046208)
1.0 4.0 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
1.0 8.8 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
1.0 13.4 GO:0002467 germinal center formation(GO:0002467)
0.9 3.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.9 3.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.8 16.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.8 2.4 GO:0035330 regulation of hippo signaling(GO:0035330)
0.8 16.4 GO:0050832 defense response to fungus(GO:0050832)
0.8 6.1 GO:0018377 protein myristoylation(GO:0018377)
0.7 12.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.7 2.1 GO:0000105 histidine biosynthetic process(GO:0000105)
0.7 2.1 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828) endodermal cell fate determination(GO:0007493) gall bladder development(GO:0061010)
0.7 6.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.6 6.4 GO:0070995 NADPH oxidation(GO:0070995)
0.6 38.4 GO:0072676 lymphocyte migration(GO:0072676)
0.6 29.4 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.6 5.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.6 9.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.6 27.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.6 1.8 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.6 4.7 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.6 1.7 GO:0051409 response to nitrosative stress(GO:0051409)
0.6 6.2 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.6 15.1 GO:0071380 cellular response to prostaglandin E stimulus(GO:0071380)
0.6 9.9 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.5 4.7 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.5 2.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.5 1.5 GO:0043323 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.5 2.0 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.5 9.3 GO:0006825 copper ion transport(GO:0006825)
0.5 3.4 GO:0070092 negative regulation of glycogen biosynthetic process(GO:0045719) glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.5 29.7 GO:0045576 mast cell activation(GO:0045576)
0.5 3.7 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.4 5.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.4 6.0 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.4 16.4 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.4 1.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.4 17.9 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.3 3.3 GO:0030223 neutrophil differentiation(GO:0030223)
0.3 2.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 2.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 5.6 GO:0030225 macrophage differentiation(GO:0030225)
0.3 28.5 GO:0030183 B cell differentiation(GO:0030183)
0.3 5.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.3 4.1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.3 20.2 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.3 9.2 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.3 6.3 GO:1903427 negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.3 22.7 GO:0006342 chromatin silencing(GO:0006342)
0.2 1.0 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.2 18.1 GO:0006334 nucleosome assembly(GO:0006334)
0.2 2.2 GO:0030259 lipid glycosylation(GO:0030259)
0.2 7.5 GO:1901998 toxin transport(GO:1901998)
0.2 15.7 GO:0030317 sperm motility(GO:0030317)
0.2 9.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 1.9 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.1 3.5 GO:0016180 snRNA processing(GO:0016180)
0.1 33.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 4.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 9.8 GO:0042113 B cell activation(GO:0042113)
0.1 0.7 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.1 1.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 4.3 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 2.3 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 0.9 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.8 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.3 GO:0048820 hair follicle maturation(GO:0048820)
0.1 2.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 1.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 1.5 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 2.1 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 0.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.1 4.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 8.2 GO:0002250 adaptive immune response(GO:0002250)
0.1 0.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 5.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 0.7 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 5.7 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 6.0 GO:0007596 blood coagulation(GO:0007596)
0.0 0.2 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.0 14.7 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.0 0.5 GO:0036344 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 0.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 2.3 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 1.0 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.0 6.1 GO:0008380 RNA splicing(GO:0008380)
0.0 3.4 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.6 GO:0019933 cAMP-mediated signaling(GO:0019933)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 32.0 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
4.9 29.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
4.2 20.9 GO:0097169 AIM2 inflammasome complex(GO:0097169)
3.9 19.3 GO:0031904 endosome lumen(GO:0031904)
3.0 12.2 GO:0097149 centralspindlin complex(GO:0097149)
2.2 38.8 GO:0042101 T cell receptor complex(GO:0042101)
1.8 51.8 GO:0001891 phagocytic cup(GO:0001891)
1.8 9.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
1.8 12.7 GO:1990357 terminal web(GO:1990357)
1.5 6.1 GO:1990584 cardiac Troponin complex(GO:1990584)
1.2 12.5 GO:0008290 F-actin capping protein complex(GO:0008290)
1.2 3.5 GO:0005760 gamma DNA polymerase complex(GO:0005760)
1.1 15.8 GO:0042612 MHC class I protein complex(GO:0042612)
1.0 10.3 GO:0097227 sperm annulus(GO:0097227)
0.8 27.0 GO:0001772 immunological synapse(GO:0001772)
0.8 2.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.8 4.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.8 7.8 GO:0051286 cell tip(GO:0051286)
0.8 109.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.7 21.5 GO:0042588 zymogen granule(GO:0042588)
0.7 17.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.7 3.5 GO:1990716 axonemal central apparatus(GO:1990716)
0.7 6.8 GO:0070187 telosome(GO:0070187)
0.6 5.0 GO:0005688 U6 snRNP(GO:0005688)
0.5 53.2 GO:0000786 nucleosome(GO:0000786)
0.5 26.8 GO:0034707 chloride channel complex(GO:0034707)
0.4 3.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.4 5.1 GO:0045180 basal cortex(GO:0045180)
0.4 15.7 GO:0005771 multivesicular body(GO:0005771)
0.4 6.0 GO:0030061 mitochondrial crista(GO:0030061)
0.4 25.7 GO:0031901 early endosome membrane(GO:0031901)
0.4 15.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 45.5 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 27.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 2.6 GO:0005796 Golgi lumen(GO:0005796)
0.3 28.5 GO:0005884 actin filament(GO:0005884)
0.3 0.9 GO:0044609 DBIRD complex(GO:0044609)
0.3 86.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 3.5 GO:0042581 specific granule(GO:0042581)
0.2 7.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 3.5 GO:0032039 integrator complex(GO:0032039)
0.2 5.4 GO:0031012 extracellular matrix(GO:0031012)
0.2 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 60.2 GO:0000790 nuclear chromatin(GO:0000790)
0.2 21.5 GO:0005923 bicellular tight junction(GO:0005923)
0.2 14.2 GO:0005776 autophagosome(GO:0005776)
0.1 2.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 6.9 GO:0030286 dynein complex(GO:0030286)
0.1 8.2 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 0.8 GO:0090543 Flemming body(GO:0090543)
0.1 1.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 10.9 GO:0000776 kinetochore(GO:0000776)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 9.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.3 GO:0032420 stereocilium(GO:0032420)
0.1 9.0 GO:0005769 early endosome(GO:0005769)
0.1 25.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.9 GO:0030133 transport vesicle(GO:0030133)
0.1 3.3 GO:0043596 nuclear replication fork(GO:0043596)
0.1 13.9 GO:0009986 cell surface(GO:0009986)
0.1 4.8 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0030139 endocytic vesicle(GO:0030139)
0.0 4.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 2.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 8.8 GO:0043235 receptor complex(GO:0043235)
0.0 13.5 GO:0005813 centrosome(GO:0005813)
0.0 3.0 GO:0005819 spindle(GO:0005819)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 117.3 GO:0005576 extracellular region(GO:0005576)
0.0 1.4 GO:0010008 endosome membrane(GO:0010008)
0.0 4.7 GO:0098793 presynapse(GO:0098793)
0.0 0.9 GO:0000123 histone acetyltransferase complex(GO:0000123)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 32.0 GO:0035877 death effector domain binding(GO:0035877)
7.5 37.7 GO:0043120 tumor necrosis factor binding(GO:0043120)
6.9 20.6 GO:0034041 sterol-transporting ATPase activity(GO:0034041) glycoprotein transporter activity(GO:0034437)
5.8 11.5 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
4.9 19.6 GO:0004949 cannabinoid receptor activity(GO:0004949)
4.7 18.6 GO:0047619 acylcarnitine hydrolase activity(GO:0047619)
4.0 32.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
3.9 15.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
3.3 9.9 GO:0002114 interleukin-33 receptor activity(GO:0002114)
3.2 18.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
2.9 31.7 GO:0042608 T cell receptor binding(GO:0042608)
2.6 31.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
2.2 123.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
2.2 15.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
2.2 51.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
2.1 21.0 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
2.1 27.2 GO:0003796 lysozyme activity(GO:0003796)
2.0 6.0 GO:0046592 polyamine oxidase activity(GO:0046592)
1.8 5.3 GO:0004731 purine nucleobase binding(GO:0002060) purine-nucleoside phosphorylase activity(GO:0004731)
1.5 6.1 GO:0030172 troponin C binding(GO:0030172)
1.5 14.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
1.4 8.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
1.2 27.5 GO:0042288 MHC class I protein binding(GO:0042288)
1.1 17.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.1 6.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
1.1 6.4 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
1.1 9.5 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
1.0 38.6 GO:0042169 SH2 domain binding(GO:0042169)
1.0 17.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.0 7.8 GO:0030911 TPR domain binding(GO:0030911)
1.0 4.8 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
0.9 3.7 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.9 16.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.9 3.5 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
0.9 4.3 GO:1990254 keratin filament binding(GO:1990254)
0.9 6.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.8 25.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.8 19.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.8 8.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.8 16.9 GO:0043274 phospholipase binding(GO:0043274)
0.7 10.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.7 14.0 GO:0001618 virus receptor activity(GO:0001618)
0.7 8.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.7 17.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.7 24.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.7 5.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.7 9.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.7 6.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7 19.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.5 20.4 GO:0022829 wide pore channel activity(GO:0022829)
0.5 2.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.5 9.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.5 33.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.4 3.1 GO:0098505 ankyrin repeat binding(GO:0071532) G-rich strand telomeric DNA binding(GO:0098505)
0.4 2.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.4 1.7 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.4 1.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.3 36.6 GO:0017124 SH3 domain binding(GO:0017124)
0.3 4.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 7.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.3 6.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 6.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.3 6.1 GO:0003951 NAD+ kinase activity(GO:0003951)
0.3 9.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 3.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.2 2.0 GO:0004630 phospholipase D activity(GO:0004630)
0.2 97.7 GO:0005525 GTP binding(GO:0005525)
0.2 4.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 1.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 1.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 9.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 8.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 54.8 GO:0030246 carbohydrate binding(GO:0030246)
0.2 4.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 18.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 10.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 9.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 11.5 GO:0004527 exonuclease activity(GO:0004527)
0.1 11.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 39.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 11.4 GO:0005178 integrin binding(GO:0005178)
0.1 8.3 GO:0008013 beta-catenin binding(GO:0008013)
0.1 10.0 GO:0004620 phospholipase activity(GO:0004620)
0.1 1.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 1.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 53.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 9.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 43.5 GO:0003779 actin binding(GO:0003779)
0.1 6.7 GO:0002039 p53 binding(GO:0002039)
0.1 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 2.0 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 46.9 GO:0003690 double-stranded DNA binding(GO:0003690)
0.1 2.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 1.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 0.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 7.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 9.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 16.4 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.0 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 32.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
2.2 31.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
1.3 18.8 PID S1P S1P4 PATHWAY S1P4 pathway
1.2 23.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.1 40.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
1.1 21.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.0 55.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
1.0 33.8 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.7 26.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.7 22.3 PID IL2 1PATHWAY IL2-mediated signaling events
0.7 27.0 PID AURORA A PATHWAY Aurora A signaling
0.6 9.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5 5.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.5 11.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 8.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.4 7.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.4 13.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.3 14.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.3 12.2 PID PLK1 PATHWAY PLK1 signaling events
0.2 3.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.2 2.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 11.4 PID P53 REGULATION PATHWAY p53 pathway
0.2 8.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 13.3 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 6.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 10.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 4.9 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 4.7 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 1.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 1.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 20.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 7.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 38.8 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
4.7 18.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
2.9 32.0 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
2.4 31.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
1.9 15.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
1.8 35.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
1.8 47.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
1.5 28.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.4 13.7 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
1.2 21.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
1.2 33.8 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
1.1 22.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
1.0 19.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
1.0 9.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.8 8.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.8 54.2 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.7 11.6 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.6 9.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.6 12.0 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.5 5.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.5 7.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.5 5.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 6.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 10.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.3 6.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 8.8 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.3 4.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3 0.3 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.3 3.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 4.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 36.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 18.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 4.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 4.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 18.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 8.7 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.2 2.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 6.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 21.0 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 4.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.3 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 9.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 11.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.2 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 2.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation