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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ep300

Z-value: 0.58

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Transcription factors associated with Ep300

Gene Symbol Gene ID Gene Info
Ep300
ENSRNOG00000000190 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ep300rn6_v1_chr7_+_122818975_1228189750.494.1e-21Click!

Activity profile of Ep300 motif

Sorted Z-values of Ep300 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_1339488 15.47 ENSRNOT00000041074
RT1-M2
RT1 class Ib, locus M2
chr1_-_199823386 13.50 ENSRNOT00000027375
Rgs10
regulator of G-protein signaling 10
chr14_+_91783514 12.35 ENSRNOT00000080753
Ikzf1
IKAROS family zinc finger 1
chr16_-_9430743 11.09 ENSRNOT00000043811
Wdfy4
WDFY family member 4
chr4_-_119327822 9.88 ENSRNOT00000012645
Arhgap25
Rho GTPase activating protein 25
chr12_+_36694960 9.54 ENSRNOT00000064276
ENSRNOT00000001299
Scarb1
scavenger receptor class B, member 1
chr6_-_103470427 9.49 ENSRNOT00000091560
ENSRNOT00000088795
ENSRNOT00000079824
Actn1
actinin, alpha 1
chr7_-_12634641 8.59 ENSRNOT00000093132
Cfd
complement factor D
chr9_-_16795887 8.43 ENSRNOT00000071609
Cd79al
Cd79a molecule-like
chrX_+_15273933 7.36 ENSRNOT00000075082
LOC108348091
erythroid transcription factor
chr1_-_167347490 6.92 ENSRNOT00000076499
Rhog
ras homolog family member G
chr20_+_3230052 6.62 ENSRNOT00000078454
RT1-T24-3
RT1 class I, locus T24, gene 3
chr20_-_22004209 6.59 ENSRNOT00000086250
ENSRNOT00000068778
Rtkn2
rhotekin 2
chr20_-_1980101 6.58 ENSRNOT00000084582
ENSRNOT00000085050
ENSRNOT00000082545
ENSRNOT00000088396
Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
chr10_+_64360390 6.15 ENSRNOT00000010168
Fam57a
family with sequence similarity 57, member A
chr13_+_89774764 6.15 ENSRNOT00000005619
Arhgap30
Rho GTPase activating protein 30
chr1_-_167347662 6.01 ENSRNOT00000027641
ENSRNOT00000076592
Rhog
ras homolog family member G
chr7_+_12471824 5.99 ENSRNOT00000068197
Sbno2
strawberry notch homolog 2
chr8_-_21995806 5.84 ENSRNOT00000028034
S1pr2
sphingosine-1-phosphate receptor 2
chr7_-_59514939 5.79 ENSRNOT00000085579
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr14_+_22107416 5.69 ENSRNOT00000060179
ENSRNOT00000080114
Sult1d1
sulfotransferase family 1D, member 1
chr4_-_170117325 5.42 ENSRNOT00000074198
LOC100912564
histone H4-like
chrX_+_156463953 5.24 ENSRNOT00000079889
Flna
filamin A
chr11_+_27364916 5.23 ENSRNOT00000002151
Bach1
BTB domain and CNC homolog 1
chr14_-_34115273 5.18 ENSRNOT00000032156
Cep135
centrosomal protein 135
chr3_+_159995064 5.18 ENSRNOT00000012606
Ttpal
alpha tocopherol transfer protein like
chr4_-_170145262 5.15 ENSRNOT00000074526
Hist1h4b
histone cluster 1, H4b
chr7_-_28040510 5.09 ENSRNOT00000005674
Ascl1
achaete-scute family bHLH transcription factor 1
chr10_+_39109522 5.07 ENSRNOT00000010968
Irf1
interferon regulatory factor 1
chr18_-_1389929 4.84 ENSRNOT00000051362
Rock1
Rho-associated coiled-coil containing protein kinase 1
chr1_-_234670113 4.83 ENSRNOT00000017133
LOC499331
similar to hypothetical protein D030056L22
chr1_+_173252058 4.78 ENSRNOT00000073421
LOC499229
similar to very large inducible GTPase 1 isoform A
chr10_-_102269272 4.61 ENSRNOT00000048264
Cdc42ep4
CDC42 effector protein 4
chr15_-_51839341 4.50 ENSRNOT00000011277
RGD1308117
similar to 9930012K11Rik protein
chr6_-_107678156 4.45 ENSRNOT00000014158
Elmsan1
ELM2 and Myb/SANT domain containing 1
chr8_+_44047592 4.36 ENSRNOT00000085084
Zfp202
zinc finger protein 202
chr3_+_149221377 4.29 ENSRNOT00000016220
ENSRNOT00000087752
Mapre1
microtubule-associated protein, RP/EB family, member 1
chr20_+_30915213 4.29 ENSRNOT00000000681
Prf1
perforin 1
chr11_+_50781127 4.18 ENSRNOT00000002738
Alcam
activated leukocyte cell adhesion molecule
chr4_-_115354795 3.98 ENSRNOT00000017691
Cd207
CD207 molecule
chr2_+_230901126 3.95 ENSRNOT00000016026
ENSRNOT00000015564
ENSRNOT00000068198
Camk2d
calcium/calmodulin-dependent protein kinase II delta
chr18_-_14016713 3.84 ENSRNOT00000041125
Nol4
nucleolar protein 4
chr2_+_136993208 3.66 ENSRNOT00000040187
ENSRNOT00000066542
Pcdh10
protocadherin 10
chr10_-_81666523 3.57 ENSRNOT00000003658
Nme1
NME/NM23 nucleoside diphosphate kinase 1
chr5_+_48011864 3.51 ENSRNOT00000067610
Mdn1
midasin AAA ATPase 1
chr1_+_198932870 3.33 ENSRNOT00000055003
Fbrs
fibrosin
chr9_+_82647071 3.22 ENSRNOT00000027135
Asic4
acid sensing ion channel subunit family member 4
chr3_-_151258580 3.21 ENSRNOT00000026120
Edem2
ER degradation enhancing alpha-mannosidase like protein 2
chr8_-_63034226 3.18 ENSRNOT00000043434
Pml
promyelocytic leukemia
chr2_+_112868707 3.16 ENSRNOT00000017805
Nceh1
neutral cholesterol ester hydrolase 1
chr5_-_137238354 3.15 ENSRNOT00000039235
Szt2
seizure threshold 2 homolog (mouse)
chr8_-_21968415 3.15 ENSRNOT00000067325
ENSRNOT00000064932
Dnmt1
DNA methyltransferase 1
chr18_-_1390190 3.13 ENSRNOT00000061777
Rock1
Rho-associated coiled-coil containing protein kinase 1
chr19_+_54553419 3.09 ENSRNOT00000025392
Jph3
junctophilin 3
chr5_+_48012231 2.95 ENSRNOT00000077040
Mdn1
midasin AAA ATPase 1
chr6_+_91697109 2.77 ENSRNOT00000006355
Arf6
ADP-ribosylation factor 6
chr10_-_65507581 2.75 ENSRNOT00000016759
Supt6h
SPT6 homolog, histone chaperone
chr11_-_70961358 2.74 ENSRNOT00000002427
Lmln
leishmanolysin like peptidase
chr1_-_13175876 2.68 ENSRNOT00000084870
Abracl
ABRA C-terminal like
chr1_-_261229046 2.58 ENSRNOT00000075531
Mms19
MMS19 homolog, cytosolic iron-sulfur assembly component
chr7_+_116997020 2.52 ENSRNOT00000078368
Zfp707l1
zinc finger protein 707-like 1
chr10_-_62648844 2.31 ENSRNOT00000034282
Abhd15
abhydrolase domain containing 15
chr18_-_56115593 2.21 ENSRNOT00000045041
Tcof1
treacle ribosome biogenesis factor 1
chr20_+_26755911 2.21 ENSRNOT00000083017
Herc4
HECT and RLD domain containing E3 ubiquitin protein ligase 4
chr2_+_189922996 2.21 ENSRNOT00000016499
S100a16
S100 calcium binding protein A16
chr5_+_133865331 2.18 ENSRNOT00000035409
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chr4_+_6559545 2.08 ENSRNOT00000067183
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
chr10_-_57275708 1.94 ENSRNOT00000005370
Pfn1
profilin 1
chr5_+_61474000 1.90 ENSRNOT00000013930
Ccdc180
coiled-coil domain containing 180
chr10_+_65507364 1.83 ENSRNOT00000016297
Sdf2
stromal cell derived factor 2
chr7_+_117026097 1.82 ENSRNOT00000085758
Zfp707
zinc finger protein 707
chrX_+_140878216 1.82 ENSRNOT00000075840
ENSRNOT00000077026
Zic3
Zic family member 3
chr5_-_150520884 1.80 ENSRNOT00000085482
Rcc1
regulator of chromosome condensation 1
chr2_-_189818224 1.78 ENSRNOT00000020575
Ints3
integrator complex subunit 3
chr3_+_150188455 1.76 ENSRNOT00000072917
AABR07054370.1

chr2_+_187740531 1.75 ENSRNOT00000092653
Paqr6
progestin and adipoQ receptor family member 6
chr1_+_184301493 1.74 ENSRNOT00000078096
Insc
inscuteable homolog (Drosophila)
chr20_+_28815039 1.72 ENSRNOT00000075800
Sowahc
sosondowah ankyrin repeat domain family member C
chr1_-_77844189 1.60 ENSRNOT00000017555
Gltscr2
glioma tumor suppressor candidate region gene 2
chr6_+_110093819 1.59 ENSRNOT00000013602
Gpatch2l
G patch domain containing 2-like
chr1_+_101055622 1.55 ENSRNOT00000079189
Nosip
nitric oxide synthase interacting protein
chr2_-_88414012 1.49 ENSRNOT00000014762
Lrrcc1
leucine rich repeat and coiled-coil centrosomal protein 1
chr5_-_76756140 1.48 ENSRNOT00000022107
ENSRNOT00000089251
Ptbp3
polypyrimidine tract binding protein 3
chr8_-_96203677 1.46 ENSRNOT00000074515
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr10_+_56605140 1.38 ENSRNOT00000024079
Phf23
PHD finger protein 23
chr18_+_14756684 1.32 ENSRNOT00000076085
ENSRNOT00000076129
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr8_+_117836701 1.31 ENSRNOT00000043345
Plxnb1
plexin B1
chr18_-_69723869 1.19 ENSRNOT00000000125
Elac1
elaC ribonuclease Z 1
chr7_-_14302552 1.16 ENSRNOT00000091368
Brd4
bromodomain containing 4
chr15_-_108898703 1.13 ENSRNOT00000067577
Zic5
Zic family member 5
chr5_+_133864798 1.10 ENSRNOT00000091977
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chr2_-_33025271 1.09 ENSRNOT00000074941
NEWGENE_1310139
microtubule associated serine/threonine kinase family member 4
chrX_+_43497763 1.06 ENSRNOT00000005014
Prdx4
peroxiredoxin 4
chr8_+_109455786 0.98 ENSRNOT00000039593
Msl2
male-specific lethal 2 homolog (Drosophila)
chr15_-_33333417 0.94 ENSRNOT00000018982
Acin1
apoptotic chromatin condensation inducer 1
chr4_-_7281223 0.88 ENSRNOT00000019666
Slc4a2
solute carrier family 4 member 2
chr3_+_8450275 0.84 ENSRNOT00000020073
Odf2
outer dense fiber of sperm tails 2
chr9_+_82700468 0.82 ENSRNOT00000027227
Inha
inhibin alpha subunit
chr2_+_198823366 0.78 ENSRNOT00000083769
ENSRNOT00000028814
Pias3
protein inhibitor of activated STAT, 3
chr17_+_90802393 0.78 ENSRNOT00000003535
Edaradd
EDAR-associated death domain
chr1_-_174378926 0.77 ENSRNOT00000018309
Tmem9b
TMEM9 domain family, member B
chr2_+_57206613 0.74 ENSRNOT00000082694
ENSRNOT00000046069
Nup155
nucleoporin 155
chr3_-_2431148 0.74 ENSRNOT00000012978
Nelfb
negative elongation factor complex member B
chr6_+_104291340 0.72 ENSRNOT00000089313
Slc39a9
solute carrier family 39, member 9
chr20_+_2043719 0.67 ENSRNOT00000030174
RT1-M4
RT1 class Ib, locus M4
chr3_+_8450612 0.66 ENSRNOT00000040457
Odf2
outer dense fiber of sperm tails 2
chr11_+_71151132 0.64 ENSRNOT00000082594
ENSRNOT00000082435
Rubcn
RUN and cysteine rich domain containing beclin 1 interacting protein
chr5_+_104941066 0.63 ENSRNOT00000009225
Rraga
Ras-related GTP binding A
chr8_-_96266342 0.57 ENSRNOT00000078891
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr3_+_112916217 0.56 ENSRNOT00000030065
Tmem62
transmembrane protein 62
chr1_+_218945508 0.56 ENSRNOT00000034240
RGD1311946
similar to RIKEN cDNA 1810055G02
chr7_+_117055395 0.47 ENSRNOT00000091960
Mapk15
mitogen-activated protein kinase 15
chr9_+_6966908 0.46 ENSRNOT00000072796
St6gal2
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
chr15_+_33333420 0.44 ENSRNOT00000049927
RGD1308430
similar to 1700123O20Rik protein
chr5_-_79899054 0.40 ENSRNOT00000074379
AC229945.1

chr10_-_15211325 0.40 ENSRNOT00000027083
Rhot2
ras homolog family member T2
chr10_+_43446526 0.36 ENSRNOT00000036959
Larp1
La ribonucleoprotein domain family, member 1
chr20_-_5441706 0.31 ENSRNOT00000000549
Vps52
VPS52 GARP complex subunit
chr7_+_123222161 0.26 ENSRNOT00000007357
RGD1306782
similar to RIKEN cDNA 1700029P11
chr14_+_78939903 0.19 ENSRNOT00000078562
ENSRNOT00000088221
Man2b2
Mrfap1
mannosidase, alpha, class 2B, member 2
Morf4 family associated protein 1
chr6_+_24064738 0.11 ENSRNOT00000035362
Ypel5
yippee-like 5
chr3_-_5976244 0.11 ENSRNOT00000009893
Vav2
vav guanine nucleotide exchange factor 2
chr14_-_86706626 0.10 ENSRNOT00000082893
H2afv
H2A histone family, member V
chr10_-_105182834 0.09 ENSRNOT00000068050
Exoc7
exocyst complex component 7
chr14_+_83560541 0.07 ENSRNOT00000057738
ENSRNOT00000085228
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_-_154542919 0.06 ENSRNOT00000076880
Slc33a1
solute carrier family 33 member 1
chr5_+_140870140 0.05 ENSRNOT00000074347
Hpcal4
hippocalcin-like 4
chr11_+_86890585 0.01 ENSRNOT00000002579
Ranbp1
RAN binding protein 1
chr3_+_9366053 0.00 ENSRNOT00000073999
Fibcd1l1
fibrinogen C domain containing 1-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Ep300

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0015920 lipopolysaccharide transport(GO:0015920)
3.1 12.3 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
2.7 10.6 GO:0030221 basophil differentiation(GO:0030221)
2.0 6.0 GO:0071348 cellular response to interleukin-11(GO:0071348)
1.7 5.1 GO:0021530 neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) medulla oblongata development(GO:0021550) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
1.3 8.0 GO:0003383 apical constriction(GO:0003383)
1.3 3.9 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
1.1 6.6 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
1.1 3.2 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) endoplasmic reticulum mannose trimming(GO:1904380)
1.0 5.2 GO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905031)
1.0 5.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
1.0 5.8 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
1.0 13.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.8 5.7 GO:0000103 sulfate assimilation(GO:0000103)
0.8 3.2 GO:0030578 PML body organization(GO:0030578) negative regulation of interleukin-1 beta secretion(GO:0050713)
0.8 3.1 GO:0090309 DNA methylation on cytosine within a CG sequence(GO:0010424) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.8 8.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.7 4.3 GO:1904528 positive regulation of microtubule binding(GO:1904528)
0.7 9.5 GO:0051764 actin crosslink formation(GO:0051764)
0.7 2.0 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.6 10.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.5 3.1 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.5 22.1 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.5 14.9 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.5 2.8 GO:0070827 chromatin maintenance(GO:0070827)
0.4 1.3 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.4 5.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.4 6.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.4 4.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.3 2.0 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.3 3.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.3 5.8 GO:0005513 detection of calcium ion(GO:0005513)
0.3 1.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.3 0.8 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.3 1.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 1.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 4.3 GO:0002418 immune response to tumor cell(GO:0002418)
0.2 2.2 GO:0014029 neural crest formation(GO:0014029)
0.2 2.8 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.2 0.9 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.2 0.6 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 1.8 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 4.2 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 1.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 3.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.1 1.5 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 0.8 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.1 0.7 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 0.6 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 1.8 GO:0016180 snRNA processing(GO:0016180)
0.1 2.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 0.7 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.4 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 1.7 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 3.2 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 3.1 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.0 1.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 3.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.5 GO:0097503 sialylation(GO:0097503)
0.0 4.0 GO:0051607 defense response to virus(GO:0051607)
0.0 0.4 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 1.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 8.9 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 2.2 GO:0051592 response to calcium ion(GO:0051592)
0.0 0.1 GO:2000535 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 1.1 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.9 9.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.9 8.0 GO:0032059 bleb(GO:0032059)
0.8 12.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.7 4.3 GO:0031904 endosome lumen(GO:0031904)
0.6 4.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.5 3.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.4 1.8 GO:0070876 SOSS complex(GO:0070876)
0.4 3.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.4 10.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 9.5 GO:0031528 microvillus membrane(GO:0031528)
0.3 3.1 GO:0030314 junctional membrane complex(GO:0030314)
0.3 0.9 GO:0061574 ASAP complex(GO:0061574)
0.3 0.8 GO:0043511 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin complex(GO:0043511)
0.3 2.0 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937) GAIT complex(GO:0097452)
0.2 4.2 GO:0042101 T cell receptor complex(GO:0042101)
0.2 0.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.0 GO:0072487 MSL complex(GO:0072487)
0.2 3.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 0.7 GO:0032021 NELF complex(GO:0032021)
0.2 2.8 GO:0031527 filopodium membrane(GO:0031527)
0.2 5.2 GO:0097440 apical dendrite(GO:0097440)
0.1 3.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.6 GO:1990130 Iml1 complex(GO:1990130)
0.1 2.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 2.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 7.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.3 GO:0000938 GARP complex(GO:0000938) EARP complex(GO:1990745)
0.1 5.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 13.5 GO:0043197 dendritic spine(GO:0043197)
0.1 5.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 9.1 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 5.2 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 3.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 4.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 4.4 GO:0001650 fibrillar center(GO:0001650)
0.0 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
1.6 6.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.9 2.8 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.9 5.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.8 5.7 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.7 2.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.6 3.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 12.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.6 5.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.5 22.1 GO:0042605 peptide antigen binding(GO:0042605)
0.5 12.3 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.5 9.5 GO:0017166 vinculin binding(GO:0017166)
0.4 1.8 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.4 2.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.4 3.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.4 1.2 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.4 5.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4 1.8 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3 13.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 3.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 3.6 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.3 3.2 GO:0050897 cobalt ion binding(GO:0050897)
0.2 3.2 GO:0042301 phosphate ion binding(GO:0042301)
0.2 2.0 GO:0008143 poly(A) binding(GO:0008143)
0.2 5.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 4.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 8.4 GO:0070888 E-box binding(GO:0070888)
0.1 3.1 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.1 5.0 GO:0022829 wide pore channel activity(GO:0022829)
0.1 2.8 GO:0031996 thioesterase binding(GO:0031996)
0.1 1.1 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 0.8 GO:0034711 inhibin binding(GO:0034711)
0.1 0.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 3.2 GO:0005272 sodium channel activity(GO:0005272)
0.1 7.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 14.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.2 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 2.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.4 GO:0008494 translation activator activity(GO:0008494)
0.0 8.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 9.6 GO:0003924 GTPase activity(GO:0003924)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 6.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 4.6 GO:0042393 histone binding(GO:0042393)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 4.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.5 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.4 6.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.4 22.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.3 5.8 PID S1P S1P2 PATHWAY S1P2 pathway
0.3 9.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 12.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 7.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 9.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 3.2 PID MYC PATHWAY C-MYC pathway
0.1 0.8 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 22.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.6 9.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 9.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.4 8.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.3 3.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 6.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 5.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 2.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 5.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 3.9 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 5.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 3.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 9.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.5 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 10.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.5 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.0 5.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins