ISMARA results: Esr1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Esr1

Z-value: 1.89

Motif logo

Transcription factors associated with Esr1

Gene Symbol	Gene ID	Gene Info
Esr1 NCBI RGD Ensembl	ENSRNOG00000019358	estrogen receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Esr1	rn6_v1_chr1_+_41325462_41325531	-0.26	3.5e-06	Click!

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_138250089 Show fit	103.03	ENSRNOT00000048378	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr3_-_17081510 Show fit	70.59	ENSRNOT00000063862	AABR07051562.1 NCBI RGD Ensembl Show fit
chr3_+_19495628 Show fit	64.51	ENSRNOT00000077990	Igkv4-57 NCBI RGD Ensembl Show fit	immunoglobulin kappa variable 4-57
chr17_-_31780120 Show fit	56.83	ENSRNOT00000058388	AABR07027450.1 NCBI RGD Ensembl Show fit
chr3_+_16817051 Show fit	55.09	ENSRNOT00000071666	AABR07051550.1 NCBI RGD Ensembl Show fit
chr6_-_138249382 Show fit	52.84	ENSRNOT00000085678 ENSRNOT00000006912	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr3_+_18706988 Show fit	48.42	ENSRNOT00000074650	AABR07051652.1 NCBI RGD Ensembl Show fit
chr6_-_140102325 Show fit	48.10	ENSRNOT00000072238	AABR07065750.2 NCBI RGD Ensembl Show fit
chr7_-_118840634 Show fit	43.71	ENSRNOT00000031568	Apol11a NCBI RGD Ensembl Show fit	apolipoprotein L 11a
chr7_-_107391184 Show fit	40.06	ENSRNOT00000056793	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71
chr3_+_16753703 Show fit	40.05	ENSRNOT00000077741	AABR07051548.2 NCBI RGD Ensembl Show fit
chr5_-_152324469 Show fit	39.50	ENSRNOT00000020688	Cd52 NCBI RGD Ensembl Show fit	CD52 molecule
chr4_+_98457810 Show fit	39.06	ENSRNOT00000074175	AABR07060872.1 NCBI RGD Ensembl Show fit
chr6_-_137664133 Show fit	37.91	ENSRNOT00000018613	Gpr132 NCBI RGD Ensembl Show fit	G protein-coupled receptor 132
chr7_+_70614617 Show fit	37.88	ENSRNOT00000035382	Arhgap9 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 9
chr1_-_219438779 Show fit	37.14	ENSRNOT00000029237	Tbc1d10c NCBI RGD Ensembl Show fit	TBC1 domain family, member 10C
chr15_-_34647421 Show fit	36.56	ENSRNOT00000072426	Mcpt8 NCBI RGD Ensembl Show fit	mast cell protease 8
chr12_+_19680712 Show fit	36.22	ENSRNOT00000081310	AABR07035561.2 NCBI RGD Ensembl Show fit
chr3_+_19045214 Show fit	35.12	ENSRNOT00000070878	AABR07051670.1 NCBI RGD Ensembl Show fit
chr9_-_16795887 Show fit	34.21	ENSRNOT00000071609	Cd79al NCBI RGD Ensembl Show fit	Cd79a molecule-like
chr1_+_81763614 Show fit	33.91	ENSRNOT00000027254	Cd79a NCBI RGD Ensembl Show fit	CD79a molecule
chr3_-_16750564 Show fit	33.58	ENSRNOT00000084111	AABR07051548.1 NCBI RGD Ensembl Show fit
chr4_-_103369224 Show fit	33.32	ENSRNOT00000075709	AABR07061057.1 NCBI RGD Ensembl Show fit
chr15_-_34625121 Show fit	32.33	ENSRNOT00000073555	Mcpt8l2 NCBI RGD Ensembl Show fit	mast cell protease 8-like 2
chr1_-_85317968 Show fit	32.28	ENSRNOT00000026891	Gmfg NCBI RGD Ensembl Show fit	glia maturation factor, gamma
chrX_+_96991658 Show fit	32.07	ENSRNOT00000049969	AABR07040288.1 NCBI RGD Ensembl Show fit
chr20_+_3945601 Show fit	31.95	ENSRNOT00000075342	RT1-DMb NCBI RGD Ensembl Show fit	RT1 class II, locus DMb
chr3_+_19174027 Show fit	31.32	ENSRNOT00000074445	AABR07051678.1 NCBI RGD Ensembl Show fit
chr15_-_28081465 Show fit	30.85	ENSRNOT00000033739	Rnase6 NCBI RGD Ensembl Show fit	ribonuclease, RNase A family, 6
chr6_-_139997537 Show fit	30.73	ENSRNOT00000073207	AABR07065740.1 NCBI RGD Ensembl Show fit
chr16_-_75481115 Show fit	30.69	ENSRNOT00000035128	Defa7 NCBI RGD Ensembl Show fit	defensin alpha 7
chr4_+_106323089 Show fit	30.08	ENSRNOT00000091402	AABR07061134.1 NCBI RGD Ensembl Show fit
chr3_+_19441604 Show fit	29.93	ENSRNOT00000090581	AABR07051692.1 NCBI RGD Ensembl Show fit
chr20_+_4039413 Show fit	28.39	ENSRNOT00000082136	RT1-Bb NCBI RGD Ensembl Show fit	RT1 class II, locus Bb
chr3_-_123631109 Show fit	27.30	ENSRNOT00000091493	Siglec1 NCBI RGD Ensembl Show fit	sialic acid binding Ig like lectin 1
chr1_-_98521551 Show fit	27.13	ENSRNOT00000081922	Siglec10 NCBI RGD Ensembl Show fit	sialic acid binding Ig-like lectin 10
chr3_-_2853272 Show fit	26.97	ENSRNOT00000023022	Fcna NCBI RGD Ensembl Show fit	ficolin A
chr11_+_85618714 Show fit	26.50	ENSRNOT00000074614	AC109901.1 NCBI RGD Ensembl Show fit
chr4_+_101645731 Show fit	26.36	ENSRNOT00000087901	AABR07060953.1 NCBI RGD Ensembl Show fit
chr2_+_87418517 Show fit	26.11	ENSRNOT00000048046	LOC100909879 NCBI RGD Ensembl Show fit	tyrosine-protein phosphatase non-receptor type substrate 1-like
chr15_-_34479741 Show fit	26.07	ENSRNOT00000027759	Ripk3 NCBI RGD Ensembl Show fit	receptor-interacting serine-threonine kinase 3
chr11_+_85508300 Show fit	25.96	ENSRNOT00000038646	AABR07034730.3 NCBI RGD Ensembl Show fit
chr6_-_138852571 Show fit	25.81	ENSRNOT00000081803	AABR07065656.8 NCBI RGD Ensembl Show fit
chr3_-_16537433 Show fit	25.75	ENSRNOT00000048523	AABR07051533.2 NCBI RGD Ensembl Show fit
chr9_+_9761536 Show fit	25.65	ENSRNOT00000074247	Tnfsf14 NCBI RGD Ensembl Show fit	tumor necrosis factor superfamily member 14
chr3_-_16753987 Show fit	25.48	ENSRNOT00000091257	AABR07051548.1 NCBI RGD Ensembl Show fit
chr19_-_37907714 Show fit	25.04	ENSRNOT00000026361	Ctrl NCBI RGD Ensembl Show fit	chymotrypsin-like
chr1_+_64074231 Show fit	24.81	ENSRNOT00000077327	Lilrb3l NCBI RGD Ensembl Show fit	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like
chr5_+_151172206 Show fit	24.58	ENSRNOT00000013778	Fgr NCBI RGD Ensembl Show fit	FGR proto-oncogene, Src family tyrosine kinase
chr11_-_60547201 Show fit	24.03	ENSRNOT00000093151	Btla NCBI RGD Ensembl Show fit	B and T lymphocyte associated
chr4_+_14151343 Show fit	23.97	ENSRNOT00000061687 ENSRNOT00000076573 ENSRNOT00000077219 ENSRNOT00000008319	Cd36 NCBI RGD Ensembl Show fit	CD36 molecule
chr10_-_87067456 Show fit	23.94	ENSRNOT00000014163	Ccr7 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 7
chr10_+_45258887 Show fit	23.93	ENSRNOT00000048642	Btnl10 NCBI RGD Ensembl Show fit	butyrophilin like 10
chr10_-_66858598 Show fit	23.78	ENSRNOT00000018898	Evi2b NCBI RGD Ensembl Show fit	ecotropic viral integration site 2B
chr14_-_71814523 Show fit	23.77	ENSRNOT00000004094	Bst1 NCBI RGD Ensembl Show fit	bone marrow stromal cell antigen 1
chr6_-_139142218 Show fit	23.47	ENSRNOT00000006975	Ighg NCBI RGD Ensembl Show fit	Immunoglobulin heavy chain (gamma polypeptide)
chr1_-_99587205 Show fit	23.44	ENSRNOT00000048947	Siglec8 NCBI RGD Ensembl Show fit	sialic acid binding Ig-like lectin 8
chr4_+_14070553 Show fit	23.35	ENSRNOT00000077505	Cd36 NCBI RGD Ensembl Show fit	CD36 molecule
chr5_-_160383782 Show fit	23.33	ENSRNOT00000018349	Cela2a NCBI RGD Ensembl Show fit	chymotrypsin-like elastase family, member 2A
chr6_-_142676432 Show fit	22.73	ENSRNOT00000074947	AABR07065815.2 NCBI RGD Ensembl Show fit
chr1_-_169534896 Show fit	22.57	ENSRNOT00000082645	Trim30c NCBI RGD Ensembl Show fit	tripartite motif-containing 30C
chr16_+_20027348 Show fit	22.14	ENSRNOT00000034589	Fam129c NCBI RGD Ensembl Show fit	family with sequence similarity 129, member C
chr1_+_63842277 Show fit	21.95	ENSRNOT00000087957 ENSRNOT00000080820	Lilrb3a NCBI RGD Ensembl Show fit	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3A
chr20_-_9876008 Show fit	21.94	ENSRNOT00000001537	Tff2 NCBI RGD Ensembl Show fit	trefoil factor 2
chr9_-_9675110 Show fit	21.92	ENSRNOT00000073294	Vav1 NCBI RGD Ensembl Show fit	vav guanine nucleotide exchange factor 1
chr15_+_32811135 Show fit	21.91	ENSRNOT00000067689	AABR07017902.1 NCBI RGD Ensembl Show fit
chr4_-_103145058 Show fit	21.91	ENSRNOT00000073076	AABR07061048.1 NCBI RGD Ensembl Show fit
chr20_-_5179217 Show fit	21.78	ENSRNOT00000065940 ENSRNOT00000092443	Lst1 NCBI RGD Ensembl Show fit	leukocyte specific transcript 1
chr7_-_18793289 Show fit	21.77	ENSRNOT00000036375	AABR07056026.1 NCBI RGD Ensembl Show fit
chr4_+_102351036 Show fit	21.75	ENSRNOT00000079277	AABR07060994.1 NCBI RGD Ensembl Show fit
chr3_-_80012750 Show fit	21.72	ENSRNOT00000018154	Nr1h3 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 1, group H, member 3
chr3_+_17107861 Show fit	21.48	ENSRNOT00000043097	AABR07051563.1 NCBI RGD Ensembl Show fit
chr12_-_21923281 Show fit	21.38	ENSRNOT00000075641	RGD1561143 NCBI RGD Ensembl Show fit	similar to cell surface receptor FDFACT
chr11_-_60546997 Show fit	21.09	ENSRNOT00000083124 ENSRNOT00000050092	Btla NCBI RGD Ensembl Show fit	B and T lymphocyte associated
chr1_+_64506735 Show fit	20.94	ENSRNOT00000086331	Nlrp12 NCBI RGD Ensembl Show fit	NLR family, pyrin domain containing 12
chr6_-_138772736 Show fit	20.93	ENSRNOT00000071492	AABR07065651.1 NCBI RGD Ensembl Show fit
chr20_-_27682861 Show fit	20.80	ENSRNOT00000057317	Fam26f NCBI RGD Ensembl Show fit	family with sequence similarity 26, member F
chr2_+_186555632 Show fit	20.79	ENSRNOT00000052347	Fcrl1 NCBI RGD Ensembl Show fit	Fc receptor-like 1
chr10_-_29026002 Show fit	20.75	ENSRNOT00000005070	Pttg1 NCBI RGD Ensembl Show fit	pituitary tumor-transforming 1
chr8_+_96551245 Show fit	20.33	ENSRNOT00000039850	Bcl2a1 NCBI RGD Ensembl Show fit	BCL2-related protein A1
chr4_-_157252104 Show fit	20.27	ENSRNOT00000082739	Ptpn6 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 6
chr4_-_157252565 Show fit	20.16	ENSRNOT00000079947	Ptpn6 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 6
chr5_-_160405050 Show fit	20.06	ENSRNOT00000081899	Ctrc NCBI RGD Ensembl Show fit	chymotrypsin C
chr17_-_12669573 Show fit	19.94	ENSRNOT00000016942 ENSRNOT00000041726	Syk NCBI RGD Ensembl Show fit	spleen associated tyrosine kinase
chr3_+_19141133 Show fit	19.88	ENSRNOT00000058323	AABR07051675.1 NCBI RGD Ensembl Show fit
chr4_+_119225040 Show fit	19.82	ENSRNOT00000012365	Bmp10 NCBI RGD Ensembl Show fit	bone morphogenetic protein 10
chr6_-_143590448 Show fit	19.74	ENSRNOT00000056771	Ighv8-4 NCBI RGD Ensembl Show fit	immunoglobulin heavy variable V8-4
chr1_-_73682247 Show fit	19.53	ENSRNOT00000079498	Lilra5 NCBI RGD Ensembl Show fit	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr11_+_85992696 Show fit	19.46	ENSRNOT00000084433	AABR07034736.1 NCBI RGD Ensembl Show fit
chr6_-_138662365 Show fit	19.26	ENSRNOT00000066209 ENSRNOT00000084892	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr16_-_81309954 Show fit	19.24	ENSRNOT00000092361	LOC290876 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA 1700029H14
chr1_+_101249522 Show fit	19.15	ENSRNOT00000033882	Slc6a16 NCBI RGD Ensembl Show fit	solute carrier family 6, member 16
chr4_+_70614524 Show fit	19.00	ENSRNOT00000041100	Prss3 NCBI RGD Ensembl Show fit	protease, serine 3
chr6_-_142993147 Show fit	19.00	ENSRNOT00000044381	LOC100359978 NCBI RGD Ensembl Show fit	mCG1038839-like
chr20_-_4943564 Show fit	18.93	ENSRNOT00000049310	RT1-CE1 NCBI RGD Ensembl Show fit	RT1 class I, locus1
chr6_+_138432550 Show fit	18.85	ENSRNOT00000056829	Adam6 NCBI RGD Ensembl Show fit	a disintegrin and metallopeptidase domain 6
chr3_+_16413080 Show fit	18.69	ENSRNOT00000040386	LOC100912707 NCBI RGD Ensembl Show fit	Ig kappa chain V19-17-like
chr3_+_19366370 Show fit	18.64	ENSRNOT00000086557	AABR07051689.1 NCBI RGD Ensembl Show fit
chr13_-_27653839 Show fit	18.43	ENSRNOT00000071638	LOC100360575 NCBI RGD Ensembl Show fit	signal-regulatory protein alpha-like
chr8_-_66893083 Show fit	18.41	ENSRNOT00000037028 ENSRNOT00000091755	Kif23 NCBI RGD Ensembl Show fit	kinesin family member 23
chr7_-_54778848 Show fit	18.41	ENSRNOT00000005399	Glipr1 NCBI RGD Ensembl Show fit	GLI pathogenesis-related 1
chr6_+_139209936 Show fit	17.94	ENSRNOT00000087620	AABR07065680.1 NCBI RGD Ensembl Show fit
chr17_-_44793927 Show fit	17.86	ENSRNOT00000086309	Hist1h2bo NCBI RGD Ensembl Show fit	histone cluster 1 H2B family member o
chr15_-_34670217 Show fit	17.82	ENSRNOT00000049315	Mcpt8 NCBI RGD Ensembl Show fit	mast cell protease 8
chr6_-_140485913 Show fit	17.80	ENSRNOT00000048463	AABR07065768.1 NCBI RGD Ensembl Show fit
chr10_-_31493419 Show fit	17.79	ENSRNOT00000009211	Itk NCBI RGD Ensembl Show fit	IL2-inducible T-cell kinase
chr5_-_155252003 Show fit	17.68	ENSRNOT00000017060	C1qb NCBI RGD Ensembl Show fit	complement C1q B chain
chr10_-_34242985 Show fit	17.60	ENSRNOT00000046438	RGD1559575 NCBI RGD Ensembl Show fit	similar to novel protein
chr1_+_247562202 Show fit	17.51	ENSRNOT00000021614	Pdcd1lg2 NCBI RGD Ensembl Show fit	programmed cell death 1 ligand 2
chr6_+_139158334 Show fit	17.40	ENSRNOT00000089227	AABR07065673.1 NCBI RGD Ensembl Show fit
chr9_+_112293388 Show fit	17.37	ENSRNOT00000020767	Man2a1 NCBI RGD Ensembl Show fit	mannosidase, alpha, class 2A, member 1
chr6_-_138685656 Show fit	17.26	ENSRNOT00000041706	AABR07065651.7 NCBI RGD Ensembl Show fit
chr20_-_5166252 Show fit	17.26	ENSRNOT00000001138	Aif1 NCBI RGD Ensembl Show fit	allograft inflammatory factor 1
chr13_-_89306219 Show fit	17.23	ENSRNOT00000004183 ENSRNOT00000079247	Fcrla NCBI RGD Ensembl Show fit	Fc receptor-like A
chr9_-_54457753 Show fit	17.13	ENSRNOT00000020032	Stat1 NCBI RGD Ensembl Show fit	signal transducer and activator of transcription 1
chr17_-_8429338 Show fit	16.90	ENSRNOT00000016390	Tgfbi NCBI RGD Ensembl Show fit	transforming growth factor, beta induced
chr17_-_31916553 Show fit	16.86	ENSRNOT00000074220	LOC100911032 NCBI RGD Ensembl Show fit	uncharacterized LOC100911032
chr3_+_19690016 Show fit	16.85	ENSRNOT00000085460	AABR07051707.1 NCBI RGD Ensembl Show fit
chr6_-_25211494 Show fit	16.60	ENSRNOT00000009634	Xdh NCBI RGD Ensembl Show fit	xanthine dehydrogenase
chr14_+_17195014 Show fit	16.52	ENSRNOT00000031667	Cxcl11 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 11
chr20_-_3397039 Show fit	16.50	ENSRNOT00000001084 ENSRNOT00000085259	Ppp1r18 NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 18
chr9_-_52912293 Show fit	16.48	ENSRNOT00000005228	Slc40a1 NCBI RGD Ensembl Show fit	solute carrier family 40 member 1
chr6_-_128727374 Show fit	16.40	ENSRNOT00000082152	Syne3 NCBI RGD Ensembl Show fit	spectrin repeat containing, nuclear envelope family member 3
chr1_-_73399579 Show fit	16.28	ENSRNOT00000077186	Lilrb4 NCBI RGD Ensembl Show fit	leukocyte immunoglobulin like receptor B4
chr16_-_31301880 Show fit	16.26	ENSRNOT00000084847 ENSRNOT00000083943	AABR07025272.1 NCBI RGD Ensembl Show fit
chr10_-_70339578 Show fit	16.10	ENSRNOT00000076618	Slfn13 NCBI RGD Ensembl Show fit	schlafen family member 13
chr12_+_1903165 Show fit	15.99	ENSRNOT00000083947	AABR07034956.1 NCBI RGD Ensembl Show fit
chr10_-_89900131 Show fit	15.92	ENSRNOT00000028238	Sost NCBI RGD Ensembl Show fit	sclerostin
chr2_-_30458542 Show fit	15.90	ENSRNOT00000072926	Naip6 NCBI RGD Ensembl Show fit	NLR family, apoptosis inhibitory protein 6
chr4_-_164536556 Show fit	15.81	ENSRNOT00000087796	Ly49i2 NCBI RGD Ensembl Show fit	Ly49 inhibitory receptor 2
chr12_-_18274515 Show fit	15.74	ENSRNOT00000078075	LOC100361826 NCBI RGD Ensembl Show fit	sialophorin-like
chr19_+_50045020 Show fit	15.65	ENSRNOT00000090165	Plcg2 NCBI RGD Ensembl Show fit	phospholipase C, gamma 2
chr4_-_163954817 Show fit	15.58	ENSRNOT00000079951	Ly49si3 NCBI RGD Ensembl Show fit	immunoreceptor Ly49si3
chr14_+_46649971 Show fit	15.54	ENSRNOT00000085875	AABR07015078.1 NCBI RGD Ensembl Show fit
chr4_-_157408176 Show fit	15.50	ENSRNOT00000021915	Cd4 NCBI RGD Ensembl Show fit	Cd4 molecule
chr11_+_84506703 Show fit	15.44	ENSRNOT00000066953	Cyp2ab1 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily ab, polypeptide 1
chr7_+_125288081 Show fit	15.44	ENSRNOT00000085216	Parvg NCBI RGD Ensembl Show fit	parvin, gamma
chr6_+_139405966 Show fit	15.42	ENSRNOT00000088974	AABR07065693.3 NCBI RGD Ensembl Show fit
chr20_-_30888735 Show fit	15.40	ENSRNOT00000090004 ENSRNOT00000063875	Adamts14 NCBI RGD Ensembl Show fit	ADAM metallopeptidase with thrombospondin type 1 motif, 14
chr15_-_34694180 Show fit	15.40	ENSRNOT00000079505 ENSRNOT00000027950 ENSRNOT00000079782 ENSRNOT00000080221	Mcpt8 NCBI RGD Ensembl Show fit	mast cell protease 8
chr20_-_5166448 Show fit	15.36	ENSRNOT00000076331	Aif1 NCBI RGD Ensembl Show fit	allograft inflammatory factor 1
chr3_+_171037957 Show fit	15.34	ENSRNOT00000008764	Rbm38 NCBI RGD Ensembl Show fit	RNA binding motif protein 38
chr15_+_32809069 Show fit	15.33	ENSRNOT00000070848	AABR07017902.1 NCBI RGD Ensembl Show fit
chr19_-_10620671 Show fit	15.25	ENSRNOT00000021842	Ccl17 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 17
chr7_-_126701872 Show fit	15.24	ENSRNOT00000041057	Pkdrej NCBI RGD Ensembl Show fit	polycystin (PKD) family receptor for egg jelly
chr6_-_139637354 Show fit	15.23	ENSRNOT00000072900	LOC100359993 NCBI RGD Ensembl Show fit	Ighg protein-like
chr11_+_67465236 Show fit	15.22	ENSRNOT00000042374	Stfa2 NCBI RGD Ensembl Show fit	stefin A2
chr11_+_84745904 Show fit	15.16	ENSRNOT00000002617	Klhl6 NCBI RGD Ensembl Show fit	kelch-like family member 6
chr5_-_138239306 Show fit	15.14	ENSRNOT00000039305	Ermap NCBI RGD Ensembl Show fit	erythroblast membrane-associated protein
chr7_-_14435967 Show fit	15.13	ENSRNOT00000074801	Pglyrp2 NCBI RGD Ensembl Show fit	peptidoglycan recognition protein 2
chr10_-_15125408 Show fit	15.07	ENSRNOT00000026395	Msln NCBI RGD Ensembl Show fit	mesothelin
chr10_+_12046701 Show fit	15.06	ENSRNOT00000011073 ENSRNOT00000084004	Mefv NCBI RGD Ensembl Show fit	MEFV, pyrin innate immunity regulator
chr6_-_138068648 Show fit	15.01	ENSRNOT00000081908	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr11_+_85633243 Show fit	14.98	ENSRNOT00000045807	LOC682352 NCBI RGD Ensembl Show fit	Ig lambda chain V-VI region AR-like
chr3_+_19071980 Show fit	14.94	ENSRNOT00000079487	Igkv4-81 NCBI RGD Ensembl Show fit	immunoglobulin kappa variable 4-81
chr9_-_10897240 Show fit	14.92	ENSRNOT00000074502	Tnfaip8l1 NCBI RGD Ensembl Show fit	TNF alpha induced protein 8 like 1
chr4_-_28437676 Show fit	14.84	ENSRNOT00000012995	Hepacam2 NCBI RGD Ensembl Show fit	HEPACAM family member 2
chr10_+_91254058 Show fit	14.80	ENSRNOT00000087218 ENSRNOT00000065373	Fmnl1 NCBI RGD Ensembl Show fit	formin-like 1
chr1_-_173528943 Show fit	14.63	ENSRNOT00000020393	Nlrp10 NCBI RGD Ensembl Show fit	NLR family, pyrin domain containing 10
chr3_+_19128400 Show fit	14.58	ENSRNOT00000074272	AABR07051673.1 NCBI RGD Ensembl Show fit
chr5_-_166628028 Show fit	14.53	ENSRNOT00000066179	Pik3cd NCBI RGD Ensembl Show fit	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr10_-_75171774 Show fit	14.52	ENSRNOT00000011735	Epx NCBI RGD Ensembl Show fit	eosinophil peroxidase
chr10_+_14689094 Show fit	14.38	ENSRNOT00000036630	RGD1559662 NCBI RGD Ensembl Show fit	similar to implantation serine proteinase 2
chr6_-_138550417 Show fit	14.37	ENSRNOT00000071945	AABR07065645.1 NCBI RGD Ensembl Show fit
chr18_+_56431820 Show fit	14.33	ENSRNOT00000079360 ENSRNOT00000049357	Csf1r NCBI RGD Ensembl Show fit	colony stimulating factor 1 receptor
chr3_-_123630929 Show fit	14.30	ENSRNOT00000028855	Siglec1 NCBI RGD Ensembl Show fit	sialic acid binding Ig like lectin 1
chr20_-_4921348 Show fit	14.24	ENSRNOT00000082497 ENSRNOT00000041151	RT1-CE4 NCBI RGD Ensembl Show fit	RT1 class I, locus CE4
chr6_-_139710905 Show fit	14.15	ENSRNOT00000077430	AABR07065705.2 NCBI RGD Ensembl Show fit
chr6_-_143131118 Show fit	14.07	ENSRNOT00000074930	AABR07065834.1 NCBI RGD Ensembl Show fit
chr5_+_173460354 Show fit	13.97	ENSRNOT00000038747	Tnfrsf18 NCBI RGD Ensembl Show fit	TNF receptor superfamily member 18
chr1_-_208020454 Show fit	13.97	ENSRNOT00000038176	Mki67 NCBI RGD Ensembl Show fit	marker of proliferation Ki-67
chr3_-_105298108 Show fit	13.94	ENSRNOT00000010994	Arhgap11a NCBI RGD Ensembl Show fit	Rho GTPase activating protein 11A
chr12_-_22126350 Show fit	13.91	ENSRNOT00000076328	Sap25 NCBI RGD Ensembl Show fit	Sin3A-associated protein 25
chr2_-_250778269 Show fit	13.89	ENSRNOT00000085670 ENSRNOT00000083535 ENSRNOT00000017824	Clca5 NCBI RGD Ensembl Show fit	chloride channel accessory 5
chr3_-_20457554 Show fit	13.89	ENSRNOT00000074237	AABR07051733.1 NCBI RGD Ensembl Show fit
chr6_-_138764901 Show fit	13.85	ENSRNOT00000075175	AABR07065651.2 NCBI RGD Ensembl Show fit
chr15_-_44411004 Show fit	13.80	ENSRNOT00000031163	Cdca2 NCBI RGD Ensembl Show fit	cell division cycle associated 2
chr6_-_138954741 Show fit	13.74	ENSRNOT00000083278	AABR07065656.7 NCBI RGD Ensembl Show fit
chr13_-_83425641 Show fit	13.45	ENSRNOT00000063870	Tbx19 NCBI RGD Ensembl Show fit	T-box 19
chr12_+_19714324 Show fit	13.43	ENSRNOT00000072303	RGD1559588 NCBI RGD Ensembl Show fit	similar to cell surface receptor FDFACT
chr1_+_100830064 Show fit	13.36	ENSRNOT00000027320	Il4i1 NCBI RGD Ensembl Show fit	interleukin 4 induced 1
chr1_-_190914610 Show fit	13.33	ENSRNOT00000023189	Cdr2 NCBI RGD Ensembl Show fit	cerebellar degeneration-related protein 2
chr18_+_12056113 Show fit	13.25	ENSRNOT00000038450	Dsg4 NCBI RGD Ensembl Show fit	desmoglein 4
chr1_-_47502952 Show fit	13.15	ENSRNOT00000025580	Tagap NCBI RGD Ensembl Show fit	T-cell activation RhoGTPase activating protein
chr20_-_2191640 Show fit	13.12	ENSRNOT00000001016	Trim10 NCBI RGD Ensembl Show fit	tripartite motif-containing 10
chr1_+_63964155 Show fit	12.93	ENSRNOT00000078512	AABR07002001.1 NCBI RGD Ensembl Show fit
chr15_+_52234563 Show fit	12.85	ENSRNOT00000015169	Reep4 NCBI RGD Ensembl Show fit	receptor accessory protein 4
chr6_-_51498337 Show fit	12.83	ENSRNOT00000012487	Pik3cg NCBI RGD Ensembl Show fit	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr1_+_213040024 Show fit	12.77	ENSRNOT00000050237	Olr300 NCBI RGD Ensembl Show fit	olfactory receptor 300
chr13_-_36101411 Show fit	12.76	ENSRNOT00000074471	Tmem37 NCBI RGD Ensembl Show fit	transmembrane protein 37
chr10_+_90192627 Show fit	12.75	ENSRNOT00000080965 ENSRNOT00000065182	LOC303566 NCBI RGD Ensembl Show fit	E2F1-inducible gene
chr13_+_92136290 Show fit	12.73	ENSRNOT00000049819	Olr1587 NCBI RGD Ensembl Show fit	olfactory receptor 1587
chr17_-_43614844 Show fit	12.70	ENSRNOT00000023054	Hist1h1a NCBI RGD Ensembl Show fit	histone cluster 1 H1 family member a
chr8_+_116708027 Show fit	12.69	ENSRNOT00000047309	Actl11 NCBI RGD Ensembl Show fit	actin-like 11
chr8_-_33661049 Show fit	12.66	ENSRNOT00000068037	Fli1 NCBI RGD Ensembl Show fit	Fli-1 proto-oncogene, ETS transcription factor
chr6_+_139412328 Show fit	12.56	ENSRNOT00000070810	AABR07065693.1 NCBI RGD Ensembl Show fit
chr7_+_118692851 Show fit	12.55	ENSRNOT00000091911	LOC100911562 NCBI RGD Ensembl Show fit	apolipoprotein L3-like
chr20_-_3793985 Show fit	12.50	ENSRNOT00000049540 ENSRNOT00000086293	RT1-CE16 NCBI RGD Ensembl Show fit	RT1 class I, locus CE16
chr15_+_60084918 Show fit	12.43	ENSRNOT00000012632	Epsti1 NCBI RGD Ensembl Show fit	epithelial stromal interaction 1
chr1_+_226077120 Show fit	12.38	ENSRNOT00000027611	Rab3il1 NCBI RGD Ensembl Show fit	RAB3A interacting protein-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.5	46.6	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
10.9	32.6	GO:0014739	positive regulation of muscle hyperplasia(GO:0014739)
10.5	41.9	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
10.1	40.4	GO:0033277	abortive mitotic cell cycle(GO:0033277)
10.0	19.9	GO:0071226	cellular response to molecule of fungal origin(GO:0071226)
9.6	28.9	GO:2000449	regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449)
8.3	33.1	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
8.2	41.1	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
7.9	47.3	GO:0072564	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
7.8	23.5	GO:0001788	antibody-dependent cellular cytotoxicity(GO:0001788)
7.8	23.4	GO:0060101	negative regulation of phagocytosis, engulfment(GO:0060101)
7.1	28.4	GO:0002343	peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
6.7	27.0	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
6.1	18.4	GO:0000915	assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
5.7	17.0	GO:0060128	corticotropin hormone secreting cell differentiation(GO:0060128)
5.3	15.9	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
5.2	15.5	GO:0035723	interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
4.9	48.8	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
4.8	14.5	GO:0002215	defense response to nematode(GO:0002215)
4.8	43.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)
4.7	14.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
4.4	8.8	GO:1902412	regulation of mitotic cytokinesis(GO:1902412)
4.3	13.0	GO:0002149	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
4.3	21.5	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
4.3	17.1	GO:0034240	negative regulation of macrophage fusion(GO:0034240)
4.2	25.0	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
4.1	12.4	GO:0060370	susceptibility to T cell mediated cytotoxicity(GO:0060370)
4.1	16.5	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
4.1	12.3	GO:0043316	cytotoxic T cell degranulation(GO:0043316) constitutive secretory pathway(GO:0045054)
4.0	19.8	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
3.8	15.1	GO:0032824	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
3.7	14.6	GO:2000318	positive regulation of T-helper 17 type immune response(GO:2000318)
3.6	10.8	GO:0046601	positive regulation of centriole replication(GO:0046601)
3.5	31.6	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
3.4	10.3	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
3.3	10.0	GO:0046967	cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
3.3	16.6	GO:0009115	xanthine catabolic process(GO:0009115)
3.2	12.8	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
3.2	6.4	GO:0002238	response to molecule of fungal origin(GO:0002238)
3.0	15.1	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
2.9	8.8	GO:0019355	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
2.9	14.3	GO:0038145	macrophage colony-stimulating factor signaling pathway(GO:0038145)
2.8	8.5	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
2.8	11.3	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
2.7	27.3	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
2.7	8.2	GO:0008594	photoreceptor cell morphogenesis(GO:0008594)
2.7	5.4	GO:0002296	T-helper 1 cell lineage commitment(GO:0002296)
2.7	10.7	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
2.7	5.3	GO:0032258	CVT pathway(GO:0032258)
2.6	2.6	GO:1904975	response to bleomycin(GO:1904975)
2.6	34.1	GO:0010818	T cell chemotaxis(GO:0010818)
2.6	26.1	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
2.6	10.4	GO:0002184	cytoplasmic translational termination(GO:0002184)
2.6	41.6	GO:0070234	positive regulation of T cell apoptotic process(GO:0070234)
2.5	5.0	GO:0043133	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
2.4	12.2	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
2.4	11.9	GO:0072719	cellular response to cisplatin(GO:0072719)
2.4	9.5	GO:0097278	complement-dependent cytotoxicity(GO:0097278)
2.3	9.3	GO:1904009	cellular response to monosodium glutamate(GO:1904009)
2.3	15.9	GO:0070269	pyroptosis(GO:0070269)
2.2	8.6	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
2.2	6.5	GO:0001543	ovarian follicle rupture(GO:0001543)
2.1	8.2	GO:2001295	malonyl-CoA biosynthetic process(GO:2001295)
2.0	12.3	GO:0015860	purine nucleoside transmembrane transport(GO:0015860)
2.0	8.0	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
2.0	6.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
1.9	5.8	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
1.9	5.8	GO:1904404	traversing start control point of mitotic cell cycle(GO:0007089) response to formaldehyde(GO:1904404)
1.9	5.7	GO:0046671	regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of retinal cell programmed cell death(GO:0046671) cellular response to fluoride(GO:1902618)
1.9	7.5	GO:0060279	positive regulation of ovulation(GO:0060279)
1.9	7.5	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
1.8	12.8	GO:0032252	secretory granule localization(GO:0032252)
1.8	5.5	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
1.8	43.9	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
1.8	7.2	GO:1904373	response to kainic acid(GO:1904373)
1.8	5.4	GO:0071283	cellular response to iron(III) ion(GO:0071283)
1.8	19.7	GO:0085020	protein K6-linked ubiquitination(GO:0085020)
1.8	5.3	GO:1902304	positive regulation of potassium ion export(GO:1902304)
1.8	5.3	GO:0072702	regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) response to environmental enrichment(GO:0090648) positive regulation of peptidyl-serine dephosphorylation(GO:1902310) response to gold nanoparticle(GO:1990268)
1.8	14.1	GO:0042989	sequestering of actin monomers(GO:0042989)
1.7	13.8	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.7	10.2	GO:0010360	negative regulation of anion channel activity(GO:0010360)
1.7	53.0	GO:0035458	cellular response to interferon-beta(GO:0035458)
1.7	8.3	GO:0042276	error-prone translesion synthesis(GO:0042276)
1.7	66.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
1.6	17.8	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
1.6	17.8	GO:0001865	NK T cell differentiation(GO:0001865)
1.6	17.4	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
1.6	17.4	GO:0006013	mannose metabolic process(GO:0006013)
1.5	4.6	GO:0009227	nucleotide-sugar catabolic process(GO:0009227)
1.5	4.6	GO:0032077	positive regulation of deoxyribonuclease activity(GO:0032077)
1.5	5.9	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
1.5	20.5	GO:0043306	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
1.4	4.3	GO:0036378	calcitriol biosynthetic process from calciol(GO:0036378)
1.4	7.1	GO:0006548	histidine catabolic process(GO:0006548)
1.4	1.4	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
1.4	7.0	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
1.4	1.4	GO:0010609	mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
1.4	4.2	GO:0043605	cellular amide catabolic process(GO:0043605)
1.4	8.3	GO:0071918	urea transmembrane transport(GO:0071918)
1.4	5.5	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
1.4	18.0	GO:0043312	neutrophil degranulation(GO:0043312)
1.4	4.1	GO:0031204	posttranslational protein targeting to membrane, translocation(GO:0031204)
1.4	17.8	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
1.3	14.8	GO:0051014	actin filament severing(GO:0051014)
1.3	4.0	GO:0009182	purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
1.3	9.3	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
1.3	5.2	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
1.3	6.5	GO:0006751	glutathione catabolic process(GO:0006751)
1.3	8.9	GO:0006685	sphingomyelin catabolic process(GO:0006685)
1.3	3.8	GO:1905225	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) response to thyrotropin-releasing hormone(GO:1905225)
1.3	10.0	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.2	2.5	GO:0030824	negative regulation of cGMP metabolic process(GO:0030824)
1.2	2.5	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
1.2	3.7	GO:0033364	mast cell secretory granule organization(GO:0033364)
1.2	12.3	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
1.2	9.8	GO:0001955	blood vessel maturation(GO:0001955)
1.2	2.4	GO:0001546	preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
1.2	8.5	GO:0007144	female meiosis I(GO:0007144)
1.2	10.8	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
1.2	3.6	GO:0010133	proline catabolic process to glutamate(GO:0010133)
1.2	9.5	GO:0050916	sensory perception of sweet taste(GO:0050916)
1.2	10.6	GO:0007603	phototransduction, visible light(GO:0007603)
1.2	3.5	GO:0060112	generation of ovulation cycle rhythm(GO:0060112)
1.2	4.7	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
1.2	3.5	GO:0016267	O-glycan processing, core 1(GO:0016267)
1.2	4.6	GO:0072709	cellular response to sorbitol(GO:0072709)
1.1	3.4	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
1.1	8.0	GO:0006477	protein sulfation(GO:0006477)
1.1	3.4	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
1.1	3.3	GO:1904569	regulation of selenocysteine incorporation(GO:1904569)
1.1	7.7	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
1.1	4.3	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
1.1	11.8	GO:0014883	transition between fast and slow fiber(GO:0014883)
1.1	6.4	GO:2000819	regulation of nucleotide-excision repair(GO:2000819)
1.0	4.2	GO:0071718	sodium-independent icosanoid transport(GO:0071718)
1.0	3.1	GO:0002803	positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
1.0	3.1	GO:2000360	regulation of binding of sperm to zona pellucida(GO:2000359) negative regulation of binding of sperm to zona pellucida(GO:2000360)
1.0	9.4	GO:0060700	regulation of ribonuclease activity(GO:0060700)
1.0	7.3	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
1.0	9.3	GO:0070235	regulation of activation-induced cell death of T cells(GO:0070235)
1.0	10.4	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.0	12.4	GO:0002176	male germ cell proliferation(GO:0002176)
1.0	5.2	GO:0002553	histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) Golgi reassembly(GO:0090168)
1.0	5.1	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
1.0	6.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
1.0	7.0	GO:1990822	basic amino acid transmembrane transport(GO:1990822)
1.0	5.0	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
1.0	12.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
1.0	4.0	GO:2000813	negative regulation of barbed-end actin filament capping(GO:2000813)
1.0	8.9	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
1.0	9.8	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.0	5.8	GO:0061737	leukotriene signaling pathway(GO:0061737)
1.0	4.8	GO:0045852	pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
1.0	12.5	GO:0007076	mitotic chromosome condensation(GO:0007076)
1.0	2.9	GO:0032430	regulation of renal output by angiotensin(GO:0002019) positive regulation of phospholipase A2 activity(GO:0032430) phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.9	40.6	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.9	17.5	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.9	2.7	GO:0071724	response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.9	4.6	GO:1904717	regulation of AMPA glutamate receptor clustering(GO:1904717)
0.9	23.3	GO:0061436	establishment of skin barrier(GO:0061436)
0.9	3.6	GO:0018211	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.9	3.6	GO:0071802	negative regulation of podosome assembly(GO:0071802)
0.9	3.5	GO:0061055	myotome development(GO:0061055)
0.9	3.4	GO:0060155	platelet dense granule organization(GO:0060155)
0.9	64.9	GO:0030593	neutrophil chemotaxis(GO:0030593)
0.8	10.2	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.8	2.5	GO:0010813	neuropeptide catabolic process(GO:0010813)
0.8	6.6	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.8	3.3	GO:0035772	interleukin-13-mediated signaling pathway(GO:0035772)
0.8	4.1	GO:0036233	glycine import(GO:0036233)
0.8	30.0	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.8	3.2	GO:0030576	Cajal body organization(GO:0030576)
0.8	4.8	GO:0060312	regulation of blood vessel remodeling(GO:0060312)
0.8	12.7	GO:0035855	megakaryocyte development(GO:0035855)
0.8	2.3	GO:0070084	protein initiator methionine removal(GO:0070084)
0.8	1.5	GO:0021747	cochlear nucleus development(GO:0021747)
0.8	12.2	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.7	2.2	GO:0030242	pexophagy(GO:0030242)
0.7	2.2	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.7	4.5	GO:0014042	positive regulation of neuron maturation(GO:0014042)
0.7	2.2	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.7	2.9	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.7	2.9	GO:0044211	CTP salvage(GO:0044211)
0.7	2.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.7	2.8	GO:0060178	regulation of exocyst localization(GO:0060178)
0.7	6.3	GO:0071415	cellular response to purine-containing compound(GO:0071415)
0.7	3.5	GO:0060346	bone trabecula formation(GO:0060346)
0.7	6.3	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.7	1.4	GO:0060468	prevention of polyspermy(GO:0060468)
0.7	2.7	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.7	2.7	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.7	6.7	GO:0071284	cellular response to lead ion(GO:0071284)
0.7	6.0	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.7	4.0	GO:0033184	positive regulation of histone ubiquitination(GO:0033184)
0.7	19.0	GO:0006958	complement activation, classical pathway(GO:0006958)
0.6	1.9	GO:0002877	regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.6	17.5	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6	16.1	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.6	3.2	GO:0043652	engulfment of apoptotic cell(GO:0043652) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.6	3.8	GO:0042256	mature ribosome assembly(GO:0042256)
0.6	7.6	GO:0007379	segment specification(GO:0007379)
0.6	3.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.6	5.0	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.6	2.5	GO:0014064	positive regulation of serotonin secretion(GO:0014064) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.6	3.0	GO:0000055	ribosomal large subunit export from nucleus(GO:0000055) positive regulation of protein localization to nucleolus(GO:1904751)
0.6	7.8	GO:0036035	osteoclast development(GO:0036035)
0.6	13.2	GO:0050901	leukocyte tethering or rolling(GO:0050901)
0.6	3.0	GO:2001270	regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.6	7.7	GO:0098719	sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.6	10.5	GO:0097435	fibril organization(GO:0097435)
0.6	2.3	GO:1903847	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.6	1.7	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.6	1.2	GO:0045415	negative regulation of interleukin-8 biosynthetic process(GO:0045415)
0.6	4.0	GO:0070417	cellular response to cold(GO:0070417)
0.6	5.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.6	7.7	GO:1900048	positive regulation of blood coagulation(GO:0030194) positive regulation of hemostasis(GO:1900048)
0.6	3.3	GO:0006528	asparagine metabolic process(GO:0006528)
0.6	8.3	GO:0002227	innate immune response in mucosa(GO:0002227)
0.5	1.6	GO:1990167	protein K27-linked deubiquitination(GO:1990167)
0.5	1.6	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.5	4.3	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.5	4.3	GO:0050862	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857) positive regulation of T cell receptor signaling pathway(GO:0050862)
0.5	5.4	GO:0099638	endosome to plasma membrane protein transport(GO:0099638)
0.5	7.3	GO:0036065	fucosylation(GO:0036065)
0.5	1.5	GO:0042732	D-xylose metabolic process(GO:0042732)
0.5	8.2	GO:0046415	urate metabolic process(GO:0046415)
0.5	4.5	GO:0035879	plasma membrane lactate transport(GO:0035879)
0.5	7.2	GO:0006851	mitochondrial calcium ion transport(GO:0006851)
0.5	4.8	GO:0006265	DNA topological change(GO:0006265)
0.5	8.0	GO:0030261	chromosome condensation(GO:0030261)
0.5	2.3	GO:1903275	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.5	5.9	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.5	5.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.5	6.3	GO:0042832	defense response to protozoan(GO:0042832)
0.4	1.3	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4	4.3	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.4	3.9	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.4	1.7	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.4	2.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.4	0.8	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.4	4.6	GO:0030259	lipid glycosylation(GO:0030259)
0.4	1.6	GO:0060672	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.4	9.5	GO:0060046	regulation of acrosome reaction(GO:0060046)
0.4	1.2	GO:0021898	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.4	1.2	GO:1990164	histone H2A phosphorylation(GO:1990164)
0.4	2.8	GO:0051531	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.4	4.8	GO:0070233	negative regulation of T cell apoptotic process(GO:0070233)
0.4	2.0	GO:0033313	meiotic cell cycle checkpoint(GO:0033313)
0.4	2.8	GO:0000103	sulfate assimilation(GO:0000103)
0.4	7.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.4	50.5	GO:0090501	RNA phosphodiester bond hydrolysis(GO:0090501)
0.4	1.6	GO:0070662	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.4	2.3	GO:0006561	proline biosynthetic process(GO:0006561)
0.4	2.3	GO:0015866	ADP transport(GO:0015866)
0.4	6.9	GO:0006907	pinocytosis(GO:0006907)
0.4	1.9	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.4	5.3	GO:0033622	integrin activation(GO:0033622)
0.4	1.1	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.4	10.0	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.4	2.6	GO:0015722	canalicular bile acid transport(GO:0015722)
0.4	6.2	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.4	5.4	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
0.4	6.1	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.4	4.3	GO:0035634	response to stilbenoid(GO:0035634)
0.4	1.4	GO:1904252	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.4	5.3	GO:0019835	cytolysis(GO:0019835)
0.4	3.5	GO:0017121	phospholipid scrambling(GO:0017121)
0.4	6.7	GO:0008210	estrogen metabolic process(GO:0008210)
0.3	0.7	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3	12.5	GO:0030199	collagen fibril organization(GO:0030199)
0.3	1.0	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.3	4.5	GO:0097577	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3	1.7	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.3	17.5	GO:0019882	antigen processing and presentation(GO:0019882)
0.3	4.0	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.3	9.0	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.3	7.6	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.3	79.2	GO:0016485	protein processing(GO:0016485)
0.3	7.2	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.3	1.0	GO:0035544	negative regulation of SNARE complex assembly(GO:0035544)
0.3	3.9	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.3	2.6	GO:0006545	glycine biosynthetic process(GO:0006545)
0.3	1.9	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.3	1.3	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.3	2.5	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.3	3.8	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.3	5.3	GO:0048240	sperm capacitation(GO:0048240)
0.3	3.7	GO:0055015	ventricular cardiac muscle cell development(GO:0055015)
0.3	3.7	GO:0006921	cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.3	4.8	GO:2000678	negative regulation of transcription regulatory region DNA binding(GO:2000678)
0.3	4.2	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.3	2.7	GO:0032790	ribosome disassembly(GO:0032790)
0.3	1.2	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) negative regulation of mast cell degranulation(GO:0043305)
0.3	3.6	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.3	11.8	GO:0032945	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.3	0.3	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.3	13.4	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.3	1.4	GO:0061450	trophoblast cell migration(GO:0061450)
0.3	8.0	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.3	1.7	GO:0098535	de novo centriole assembly(GO:0098535)
0.3	7.1	GO:0006879	cellular iron ion homeostasis(GO:0006879)
0.3	2.7	GO:0046085	adenosine metabolic process(GO:0046085)
0.3	2.7	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3	0.8	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.3	2.8	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.3	2.5	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.2	3.0	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.2	3.1	GO:0006783	heme biosynthetic process(GO:0006783)
0.2	6.6	GO:0006458	'de novo' protein folding(GO:0006458)
0.2	2.1	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.2	6.0	GO:0035902	response to immobilization stress(GO:0035902)
0.2	2.3	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
0.2	2.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2	1.3	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
0.2	9.8	GO:0051225	spindle assembly(GO:0051225)
0.2	3.8	GO:0006895	Golgi to endosome transport(GO:0006895)
0.2	7.1	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.2	12.4	GO:0006342	chromatin silencing(GO:0006342)
0.2	0.2	GO:0034021	response to silicon dioxide(GO:0034021)
0.2	12.9	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.2	1.1	GO:0035766	cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) branch elongation involved in ureteric bud branching(GO:0060681) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544)
0.2	9.4	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2	2.5	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.2	3.3	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2	3.3	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.2	1.7	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.2	0.8	GO:1990830	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2	1.4	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.2	1.2	GO:0043686	co-translational protein modification(GO:0043686)
0.2	3.9	GO:0035196	dsRNA fragmentation(GO:0031050) production of miRNAs involved in gene silencing by miRNA(GO:0035196) production of small RNA involved in gene silencing by RNA(GO:0070918)
0.2	4.5	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.2	2.9	GO:0019236	response to pheromone(GO:0019236)
0.2	1.3	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.2	21.8	GO:0002250	adaptive immune response(GO:0002250)
0.2	0.5	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.2	5.8	GO:0051290	protein heterotetramerization(GO:0051290)
0.2	0.5	GO:0098507	polynucleotide 5' dephosphorylation(GO:0098507)
0.2	1.4	GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.2	1.0	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.2	2.0	GO:0070266	necroptotic process(GO:0070266)
0.2	4.4	GO:0033120	positive regulation of RNA splicing(GO:0033120)
0.2	0.7	GO:0009597	detection of virus(GO:0009597)
0.2	8.9	GO:0006334	nucleosome assembly(GO:0006334)
0.2	6.9	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.2	2.8	GO:0036159	inner dynein arm assembly(GO:0036159)
0.2	7.9	GO:0050728	negative regulation of inflammatory response(GO:0050728)
0.2	3.9	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2	3.7	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.2	0.8	GO:0021650	vestibulocochlear nerve formation(GO:0021650)
0.2	1.2	GO:0018298	protein-chromophore linkage(GO:0018298)
0.2	0.6	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1	3.6	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.1	9.2	GO:0001942	hair follicle development(GO:0001942) skin epidermis development(GO:0098773)
0.1	0.4	GO:0071692	sequestering of BMP in extracellular matrix(GO:0035582) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.1	0.4	GO:0033869	coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.1	2.8	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.1	1.5	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.1	0.4	GO:1901550	regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.1	9.0	GO:0031398	positive regulation of protein ubiquitination(GO:0031398)
0.1	2.1	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1	0.4	GO:0046061	dATP catabolic process(GO:0046061)
0.1	1.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	1.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.1	1.3	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1	4.0	GO:0006278	RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.1	25.0	GO:0007059	chromosome segregation(GO:0007059)
0.1	0.4	GO:0010041	response to iron(III) ion(GO:0010041)
0.1	1.1	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	1.1	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.1	5.3	GO:0046834	lipid phosphorylation(GO:0046834)
0.1	0.3	GO:0032472	Golgi calcium ion transport(GO:0032472)
0.1	0.7	GO:0033572	transferrin transport(GO:0033572)
0.1	4.0	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.1	6.0	GO:0035914	skeletal muscle cell differentiation(GO:0035914)
0.1	0.2	GO:0072003	kidney rudiment formation(GO:0072003) nephric duct formation(GO:0072179) mesonephric duct morphogenesis(GO:0072180) mesonephric duct formation(GO:0072181)
0.1	1.1	GO:0055012	ventricular cardiac muscle cell differentiation(GO:0055012)
0.1	6.0	GO:0031016	pancreas development(GO:0031016)
0.1	0.8	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.1	0.9	GO:0007602	phototransduction(GO:0007602)
0.1	0.2	GO:0032429	negative regulation of phospholipase activity(GO:0010519) regulation of phospholipase A2 activity(GO:0032429)
0.1	0.5	GO:0055091	phospholipid homeostasis(GO:0055091)
0.1	1.7	GO:0006471	protein ADP-ribosylation(GO:0006471)
0.1	3.0	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.1	0.3	GO:0000255	allantoin metabolic process(GO:0000255)
0.1	0.8	GO:1902065	response to L-glutamate(GO:1902065)
0.1	4.0	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.1	0.2	GO:0042350	GDP-L-fucose biosynthetic process(GO:0042350) GDP-L-fucose metabolic process(GO:0046368)
0.1	0.5	GO:0017062	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1	1.4	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043280)
0.1	1.0	GO:0043248	proteasome assembly(GO:0043248)
0.1	0.4	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1	0.7	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.1	0.2	GO:0060296	regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.1	1.9	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1	0.4	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1	0.2	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.1	2.4	GO:0006182	cGMP biosynthetic process(GO:0006182)
0.1	1.1	GO:2000036	regulation of stem cell population maintenance(GO:2000036)
0.1	2.9	GO:0032092	positive regulation of protein binding(GO:0032092)
0.1	0.3	GO:0046654	brainstem development(GO:0003360) 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654)
0.1	0.1	GO:0032823	regulation of natural killer cell differentiation(GO:0032823)
0.1	0.8	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0	1.6	GO:0060711	labyrinthine layer development(GO:0060711)
0.0	1.8	GO:0002088	lens development in camera-type eye(GO:0002088)
0.0	0.5	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	1.7	GO:0045454	cell redox homeostasis(GO:0045454)
0.0	2.6	GO:0007368	determination of left/right symmetry(GO:0007368)
0.0	1.3	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.6	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)
0.0	1.2	GO:0006405	RNA export from nucleus(GO:0006405)
0.0	0.1	GO:0003365	establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0	0.2	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.1	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0042226	interleukin-6 biosynthetic process(GO:0042226)
0.0	0.9	GO:0002062	chondrocyte differentiation(GO:0002062)
0.0	0.8	GO:0045727	positive regulation of translation(GO:0045727)
0.0	0.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.3	GO:0016925	protein sumoylation(GO:0016925)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
13.5	53.9	GO:0019815	B cell receptor complex(GO:0019815)
6.8	27.3	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
5.1	40.4	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
4.9	19.7	GO:0031436	BRCA1-BARD1 complex(GO:0031436)
4.8	28.9	GO:0097342	ripoptosome(GO:0097342)
4.8	14.3	GO:1990682	CSF1-CSF1R complex(GO:1990682)
4.6	18.4	GO:0097149	centralspindlin complex(GO:0097149)
4.4	70.3	GO:0042613	MHC class II protein complex(GO:0042613)
4.3	12.8	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
3.3	16.6	GO:0020003	symbiont-containing vacuole(GO:0020003)
3.1	18.8	GO:0033093	Weibel-Palade body(GO:0033093)
3.1	15.5	GO:0072557	IPAF inflammasome complex(GO:0072557)
2.9	8.8	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
2.6	10.5	GO:0000444	MIS12/MIND type complex(GO:0000444)
2.6	10.4	GO:0018444	translation release factor complex(GO:0018444)
2.3	34.8	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
2.2	27.0	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
2.2	10.8	GO:0098536	deuterosome(GO:0098536)
2.2	6.5	GO:0046691	intracellular canaliculus(GO:0046691)
2.0	13.8	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.8	5.3	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
1.7	8.3	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
1.6	25.5	GO:0042612	MHC class I protein complex(GO:0042612)
1.6	40.6	GO:0097225	sperm midpiece(GO:0097225)
1.5	4.6	GO:0070557	PCNA-p21 complex(GO:0070557)
1.5	28.3	GO:0031527	filopodium membrane(GO:0031527)
1.4	10.0	GO:0042825	TAP complex(GO:0042825)
1.4	19.5	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
1.3	2.5	GO:1990462	omegasome membrane(GO:1903349) omegasome(GO:1990462)
1.2	10.9	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
1.2	14.3	GO:0005861	troponin complex(GO:0005861)
1.2	9.3	GO:0005638	lamin filament(GO:0005638)
1.1	10.3	GO:0000813	ESCRT I complex(GO:0000813)
1.1	16.8	GO:1990023	mitotic spindle midzone(GO:1990023)
1.1	3.3	GO:1990590	ATF1-ATF4 transcription factor complex(GO:1990590)
1.1	3.2	GO:0032173	septin collar(GO:0032173)
1.0	3.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
1.0	17.3	GO:0042581	specific granule(GO:0042581)
1.0	23.3	GO:0030057	desmosome(GO:0030057)
1.0	8.9	GO:1990075	periciliary membrane compartment(GO:1990075)
1.0	3.9	GO:0070876	SOSS complex(GO:0070876)
1.0	6.8	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.9	6.3	GO:0090543	Flemming body(GO:0090543)
0.9	4.5	GO:1903768	sweet taste receptor complex(GO:1903767) taste receptor complex(GO:1903768)
0.9	17.6	GO:0010369	chromocenter(GO:0010369)
0.9	40.2	GO:0016235	aggresome(GO:0016235)
0.8	12.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.8	5.8	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.8	2.5	GO:0044611	nuclear pore inner ring(GO:0044611)
0.8	4.5	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
0.7	3.0	GO:0002947	tumor necrosis factor receptor superfamily complex(GO:0002947)
0.7	222.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.7	4.4	GO:0089701	U2AF(GO:0089701)
0.7	4.3	GO:0097512	cardiac myofibril(GO:0097512)
0.7	5.0	GO:0036449	microtubule minus-end(GO:0036449)
0.7	7.1	GO:0070652	HAUS complex(GO:0070652)
0.7	4.7	GO:0001652	granular component(GO:0001652)
0.7	9.3	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.7	7.3	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.7	63.9	GO:0000786	nucleosome(GO:0000786)
0.6	15.5	GO:0005839	proteasome core complex(GO:0005839)
0.6	2.6	GO:0070552	BRISC complex(GO:0070552)
0.6	4.1	GO:0031415	NatA complex(GO:0031415)
0.6	1.7	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.6	3.4	GO:0031904	endosome lumen(GO:0031904)
0.5	3.1	GO:0097209	epidermal lamellar body(GO:0097209)
0.5	12.6	GO:0001891	phagocytic cup(GO:0001891)
0.5	7.4	GO:0000800	lateral element(GO:0000800)
0.5	7.3	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.5	4.6	GO:0008290	F-actin capping protein complex(GO:0008290)
0.5	4.2	GO:0031983	vesicle lumen(GO:0031983)
0.4	27.8	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.4	4.5	GO:0005796	Golgi lumen(GO:0005796)
0.4	3.0	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.4	1.7	GO:0032044	DSIF complex(GO:0032044)
0.4	2.9	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.4	29.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.4	4.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.4	2.5	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.3	2.1	GO:0002081	outer acrosomal membrane(GO:0002081)
0.3	2.7	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.3	3.0	GO:0071821	FANCM-MHF complex(GO:0071821)
0.3	8.4	GO:0035145	exon-exon junction complex(GO:0035145)
0.3	2.2	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.3	5.9	GO:0030014	CCR4-NOT complex(GO:0030014)
0.3	2.4	GO:0044613	nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.3	28.3	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.3	5.3	GO:0043196	varicosity(GO:0043196)
0.3	1.5	GO:0005642	annulate lamellae(GO:0005642)
0.3	2.0	GO:0036128	CatSper complex(GO:0036128)
0.3	1.4	GO:0071203	WASH complex(GO:0071203)
0.3	1.4	GO:0042587	glycogen granule(GO:0042587)
0.3	5.1	GO:0033391	chromatoid body(GO:0033391)
0.3	2.9	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.3	1.0	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.3	2.5	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2	1.0	GO:0097422	tubular endosome(GO:0097422)
0.2	11.3	GO:0005801	cis-Golgi network(GO:0005801)
0.2	1.6	GO:0000796	condensin complex(GO:0000796)
0.2	5.6	GO:0000145	exocyst(GO:0000145)
0.2	1.1	GO:0048476	Holliday junction resolvase complex(GO:0048476) ERCC4-ERCC1 complex(GO:0070522)
0.2	1.5	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.2	1.3	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.2	5.2	GO:0042629	mast cell granule(GO:0042629)
0.2	3.4	GO:0031011	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.2	1.4	GO:0045293	mRNA editing complex(GO:0045293)
0.2	7.9	GO:0055038	recycling endosome membrane(GO:0055038)
0.2	14.2	GO:0005776	autophagosome(GO:0005776)
0.2	1.9	GO:0042555	MCM complex(GO:0042555)
0.2	4.5	GO:0046930	pore complex(GO:0046930)
0.2	0.5	GO:0097543	ciliary inversin compartment(GO:0097543)
0.2	3.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	1.4	GO:0032009	early phagosome(GO:0032009)
0.2	2.7	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1	3.4	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.1	0.4	GO:0032798	Swi5-Sfr1 complex(GO:0032798)
0.1	1.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	6.9	GO:0005876	spindle microtubule(GO:0005876)
0.1	0.8	GO:0000125	PCAF complex(GO:0000125)
0.1	12.4	GO:0000793	condensed chromosome(GO:0000793)
0.1	0.8	GO:0097539	ciliary transition fiber(GO:0097539)
0.1	2.8	GO:1990752	microtubule end(GO:1990752)
0.1	2.9	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	15.5	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.1	2.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	1.3	GO:0005859	muscle myosin complex(GO:0005859)
0.1	1.0	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1	1.2	GO:0071564	npBAF complex(GO:0071564)
0.1	1.4	GO:0044666	MLL3/4 complex(GO:0044666)
0.1	1.7	GO:0001520	outer dense fiber(GO:0001520)
0.1	10.2	GO:0030496	midbody(GO:0030496)
0.1	3.6	GO:0002102	podosome(GO:0002102)
0.1	1.0	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1	1.2	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1	4.0	GO:0015030	Cajal body(GO:0015030)
0.1	1.4	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1	7.0	GO:0072562	blood microparticle(GO:0072562)
0.1	1.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	1.2	GO:0035102	PRC1 complex(GO:0035102)
0.1	1.1	GO:0045120	pronucleus(GO:0045120)
0.1	1.0	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	0.4	GO:1990635	proximal dendrite(GO:1990635)
0.1	90.3	GO:0005615	extracellular space(GO:0005615)
0.1	1.3	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1	0.4	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.4	GO:0030061	mitochondrial crista(GO:0030061)
0.0	1.3	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.3	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.8	GO:0032420	stereocilium(GO:0032420)
0.0	1.8	GO:0005814	centriole(GO:0005814)
0.0	1.5	GO:0036064	ciliary basal body(GO:0036064)
0.0	1.2	GO:0045095	keratin filament(GO:0045095)
0.0	3.6	GO:0000790	nuclear chromatin(GO:0000790)
0.0	0.1	GO:0000243	commitment complex(GO:0000243)
0.0	0.2	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.9	GO:0015934	large ribosomal subunit(GO:0015934)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.5	47.3	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
8.7	26.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
7.9	23.8	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
7.2	21.7	GO:0032810	sterol response element binding(GO:0032810)
5.2	26.1	GO:0019770	IgG receptor activity(GO:0019770)
4.6	9.2	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
4.5	40.4	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
4.5	13.4	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
4.3	51.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)
3.8	15.1	GO:0016019	peptidoglycan receptor activity(GO:0016019)
3.6	14.3	GO:0031686	A1 adenosine receptor binding(GO:0031686)
3.3	10.0	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
3.3	16.6	GO:0016726	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
3.3	16.5	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
3.3	9.9	GO:0004852	uroporphyrinogen-III synthase activity(GO:0004852)
3.1	12.3	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
3.0	27.0	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
2.9	8.8	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
2.8	19.8	GO:0031433	telethonin binding(GO:0031433)
2.8	8.4	GO:0001847	opsonin receptor activity(GO:0001847)
2.7	10.8	GO:0004949	cannabinoid receptor activity(GO:0004949)
2.6	10.6	GO:0019862	IgA binding(GO:0019862)
2.6	7.9	GO:0070976	TIR domain binding(GO:0070976)
2.6	15.5	GO:0042289	MHC class II protein binding(GO:0042289)
2.5	12.7	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
2.4	21.9	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
2.4	12.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
2.4	23.9	GO:0019957	C-C chemokine binding(GO:0019957)
2.2	20.0	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
2.2	28.4	GO:1990405	protein antigen binding(GO:1990405)
2.2	6.5	GO:0015203	polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
2.2	32.3	GO:0071933	Arp2/3 complex binding(GO:0071933)
2.1	8.5	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
2.1	38.0	GO:0023026	MHC class II protein complex binding(GO:0023026)
2.1	8.2	GO:0003989	acetyl-CoA carboxylase activity(GO:0003989)
2.0	6.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
2.0	43.8	GO:0042288	MHC class I protein binding(GO:0042288)
2.0	5.9	GO:0031728	CCR3 chemokine receptor binding(GO:0031728)
2.0	9.8	GO:0005111	type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
1.9	13.6	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
1.8	16.5	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
1.8	23.0	GO:0033691	sialic acid binding(GO:0033691)
1.7	13.9	GO:0030274	LIM domain binding(GO:0030274)
1.7	12.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
1.7	8.5	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.5	12.4	GO:0016494	C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
1.5	7.7	GO:0001729	ceramide kinase activity(GO:0001729)
1.5	4.6	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
1.5	9.0	GO:0016493	C-C chemokine receptor activity(GO:0016493)
1.5	8.8	GO:0032051	clathrin light chain binding(GO:0032051)
1.4	5.8	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.4	2.9	GO:0031711	bradykinin receptor binding(GO:0031711)
1.4	5.7	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
1.4	17.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
1.4	4.1	GO:0048408	epidermal growth factor binding(GO:0048408)
1.3	12.1	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
1.3	4.0	GO:0044715	8-oxo-dGDP phosphatase activity(GO:0044715)
1.3	17.4	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
1.3	8.0	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.3	6.5	GO:0030348	syntaxin-3 binding(GO:0030348)
1.3	20.6	GO:0051400	BH domain binding(GO:0051400)
1.3	3.8	GO:0070053	thrombospondin receptor activity(GO:0070053)
1.3	5.0	GO:0015265	urea channel activity(GO:0015265)
1.2	7.4	GO:0000150	recombinase activity(GO:0000150)
1.2	3.6	GO:0004657	proline dehydrogenase activity(GO:0004657)
1.2	4.8	GO:0089720	caspase binding(GO:0089720)
1.2	5.8	GO:0004974	leukotriene receptor activity(GO:0004974)
1.2	12.8	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303)
1.2	3.5	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
1.1	3.4	GO:0035651	AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
1.1	3.4	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
1.1	4.5	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
1.1	4.5	GO:0005163	nerve growth factor receptor binding(GO:0005163)
1.1	3.3	GO:0015204	urea transmembrane transporter activity(GO:0015204)
1.1	5.4	GO:0045322	unmethylated CpG binding(GO:0045322)
1.1	4.3	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.0	9.4	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.0	225.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.0	21.6	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.0	19.5	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
1.0	27.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.0	2.9	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
1.0	5.8	GO:0019788	NEDD8 transferase activity(GO:0019788)
1.0	8.6	GO:0008494	translation activator activity(GO:0008494)
0.9	44.6	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.9	16.6	GO:0008009	chemokine activity(GO:0008009)
0.9	2.8	GO:0004020	adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.9	3.6	GO:0004963	follicle-stimulating hormone receptor activity(GO:0004963)
0.9	8.0	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.9	3.5	GO:0050682	AF-2 domain binding(GO:0050682)
0.9	10.4	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.9	2.6	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.9	4.3	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.8	14.8	GO:0032794	GTPase activating protein binding(GO:0032794)
0.8	16.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.8	4.8	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.8	2.3	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.8	7.7	GO:0015386	potassium:proton antiporter activity(GO:0015386)
0.7	3.0	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
0.7	2.9	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.7	8.6	GO:0008097	5S rRNA binding(GO:0008097)
0.7	3.6	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.7	29.8	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.7	2.8	GO:0051431	corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.7	18.5	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.7	2.7	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.7	3.4	GO:0031404	chloride ion binding(GO:0031404)
0.7	2.7	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.7	3.3	GO:0001007	transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007) RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.7	7.4	GO:0039706	co-receptor binding(GO:0039706)
0.7	3.3	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.7	3.9	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.7	4.6	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.6	3.2	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.6	15.5	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6	2.5	GO:0015056	corticotrophin-releasing factor receptor activity(GO:0015056) corticotropin-releasing hormone receptor activity(GO:0043404)
0.6	31.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.6	3.6	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.6	3.0	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.6	7.8	GO:0050321	tau-protein kinase activity(GO:0050321)
0.6	7.7	GO:0004954	prostanoid receptor activity(GO:0004954)
0.6	4.2	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.6	2.9	GO:0004849	uridine kinase activity(GO:0004849)
0.6	8.2	GO:0019865	immunoglobulin binding(GO:0019865)
0.6	7.0	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.6	11.1	GO:0001614	purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.6	4.5	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.6	6.7	GO:0042809	vitamin D receptor binding(GO:0042809)
0.6	3.3	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.5	12.8	GO:0001784	phosphotyrosine binding(GO:0001784)
0.5	17.6	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.5	23.4	GO:0004601	peroxidase activity(GO:0004601)
0.5	1.6	GO:0005135	interleukin-3 receptor binding(GO:0005135)
0.5	2.1	GO:0032190	acrosin binding(GO:0032190)
0.5	2.5	GO:0008502	melatonin receptor activity(GO:0008502)
0.5	2.5	GO:0043426	MRF binding(GO:0043426)
0.5	54.8	GO:0004540	ribonuclease activity(GO:0004540)
0.5	2.9	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5	6.7	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.5	5.8	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.5	6.1	GO:0043274	phospholipase binding(GO:0043274)
0.5	3.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.5	0.9	GO:0005131	growth hormone receptor binding(GO:0005131)
0.4	1.3	GO:0030984	kininogen binding(GO:0030984)
0.4	1.3	GO:0050145	uridylate kinase activity(GO:0009041) nucleoside phosphate kinase activity(GO:0050145)
0.4	4.4	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.4	1.3	GO:0000991	transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.4	2.2	GO:0070513	death domain binding(GO:0070513)
0.4	2.6	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.4	6.8	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.4	2.9	GO:0031014	troponin T binding(GO:0031014)
0.4	3.3	GO:0030957	Tat protein binding(GO:0030957)
0.4	1.6	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.4	2.8	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.4	8.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4	5.1	GO:0008408	3'-5' exonuclease activity(GO:0008408)
0.4	3.5	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.4	3.9	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.4	1.9	GO:0008420	CTD phosphatase activity(GO:0008420)
0.4	3.9	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.4	4.4	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.4	11.6	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.4	1.4	GO:0038132	neuregulin binding(GO:0038132)
0.3	10.1	GO:0003785	actin monomer binding(GO:0003785)
0.3	1.0	GO:0043398	HLH domain binding(GO:0043398)
0.3	7.8	GO:0015288	porin activity(GO:0015288)
0.3	7.4	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.3	10.2	GO:0042605	peptide antigen binding(GO:0042605)
0.3	1.3	GO:0019002	GMP binding(GO:0019002)
0.3	9.3	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.3	4.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.3	0.6	GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.3	2.7	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3	4.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3	8.6	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.3	1.4	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3	2.5	GO:0043515	kinetochore binding(GO:0043515)
0.3	3.3	GO:0004000	adenosine deaminase activity(GO:0004000)
0.3	8.8	GO:0050699	WW domain binding(GO:0050699)
0.3	6.1	GO:0019825	oxygen binding(GO:0019825)
0.3	2.4	GO:0043522	leucine zipper domain binding(GO:0043522)
0.3	11.6	GO:0015485	cholesterol binding(GO:0015485)
0.3	4.2	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.3	2.3	GO:0015217	ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.3	4.8	GO:0031005	filamin binding(GO:0031005)
0.3	9.8	GO:0005044	scavenger receptor activity(GO:0005044)
0.2	1.2	GO:0005499	vitamin D binding(GO:0005499)
0.2	4.9	GO:0004806	triglyceride lipase activity(GO:0004806)
0.2	2.9	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2	8.5	GO:0005504	fatty acid binding(GO:0005504)
0.2	2.2	GO:0009881	photoreceptor activity(GO:0009881)
0.2	16.1	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.2	23.3	GO:0001158	enhancer sequence-specific DNA binding(GO:0001158)
0.2	2.6	GO:0017127	cholesterol transporter activity(GO:0017127)
0.2	4.5	GO:0008199	ferric iron binding(GO:0008199)
0.2	0.7	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.2	2.1	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.2	2.3	GO:0016004	phospholipase activator activity(GO:0016004)
0.2	5.0	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.2	4.5	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.2	5.1	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.2	8.9	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2	0.8	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.2	1.5	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.2	4.4	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.2	4.3	GO:0070840	dynein complex binding(GO:0070840)
0.2	2.9	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2	2.9	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.2	2.5	GO:0042043	neurexin family protein binding(GO:0042043)
0.2	6.4	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.2	0.5	GO:0004651	polynucleotide 5'-phosphatase activity(GO:0004651)
0.2	1.7	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.2	1.2	GO:0004111	creatine kinase activity(GO:0004111)
0.2	0.8	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2	1.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.2	3.6	GO:0000030	mannosyltransferase activity(GO:0000030)
0.1	0.4	GO:0016015	morphogen activity(GO:0016015)
0.1	0.5	GO:0016492	G-protein coupled neurotensin receptor activity(GO:0016492)
0.1	1.8	GO:0019789	SUMO transferase activity(GO:0019789)
0.1	4.6	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.1	1.1	GO:0070300	phosphatidic acid binding(GO:0070300)
0.1	0.5	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1	0.4	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	7.5	GO:0019955	cytokine binding(GO:0019955)
0.1	7.1	GO:0031490	chromatin DNA binding(GO:0031490)
0.1	2.6	GO:0005355	glucose transmembrane transporter activity(GO:0005355) hexose transmembrane transporter activity(GO:0015149)
0.1	28.2	GO:0030246	carbohydrate binding(GO:0030246)
0.1	1.1	GO:0044548	S100 protein binding(GO:0044548)
0.1	1.3	GO:0051371	muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.1	8.5	GO:0003697	single-stranded DNA binding(GO:0003697)
0.1	1.2	GO:0004579	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1	0.3	GO:0004903	growth hormone receptor activity(GO:0004903)
0.1	0.3	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1	2.4	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.1	4.0	GO:0000049	tRNA binding(GO:0000049)
0.1	3.0	GO:0043022	ribosome binding(GO:0043022)
0.1	18.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	3.3	GO:0003727	single-stranded RNA binding(GO:0003727)
0.1	0.5	GO:0070182	DNA polymerase binding(GO:0070182)
0.1	0.8	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1	0.7	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	8.1	GO:0019902	phosphatase binding(GO:0019902)
0.1	1.7	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	7.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	1.0	GO:0001594	trace-amine receptor activity(GO:0001594)
0.1	0.2	GO:0030350	iron-responsive element binding(GO:0030350)
0.1	2.0	GO:0005109	frizzled binding(GO:0005109)
0.1	0.5	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	0.4	GO:0019208	phosphatase regulator activity(GO:0019208)
0.1	12.9	GO:0005096	GTPase activator activity(GO:0005096)
0.1	0.5	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	0.2	GO:0008254	3'-nucleotidase activity(GO:0008254)
0.1	0.8	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.8	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	2.7	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	0.2	GO:0070401	NADP+ binding(GO:0070401)
0.0	5.2	GO:0005125	cytokine activity(GO:0005125)
0.0	1.6	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.1	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
0.0	0.9	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.6	GO:0043531	ADP binding(GO:0043531)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0030619	U1 snRNA binding(GO:0030619)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	1.0	GO:0017022	myosin binding(GO:0017022)
0.0	2.0	GO:0042393	histone binding(GO:0042393)
0.0	0.6	GO:0070491	repressing transcription factor binding(GO:0070491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	122.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
1.7	66.4	PID EPO PATHWAY	EPO signaling pathway
1.4	21.9	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
1.4	10.9	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
1.3	54.2	PID BCR 5PATHWAY	BCR signaling pathway
1.0	28.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
1.0	27.6	PID CD40 PATHWAY	CD40/CD40L signaling
1.0	18.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.8	36.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.8	26.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.8	30.0	PID BARD1 PATHWAY	BARD1 signaling events
0.8	19.8	PID IL23 PATHWAY	IL23-mediated signaling events
0.7	9.5	PID TRAIL PATHWAY	TRAIL signaling pathway
0.7	31.1	PID AURORA B PATHWAY	Aurora B signaling
0.7	30.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.7	11.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.6	23.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.6	12.8	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.5	4.8	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.5	4.6	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.5	20.7	PID ATR PATHWAY	ATR signaling pathway
0.5	5.0	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.5	9.5	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.5	13.2	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.5	9.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.4	19.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	10.6	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.4	3.8	ST GA12 PATHWAY	G alpha 12 Pathway
0.4	6.5	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.4	15.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.4	3.3	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4	8.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3	12.3	PID FGF PATHWAY	FGF signaling pathway
0.3	11.9	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.3	7.6	ST GA13 PATHWAY	G alpha 13 Pathway
0.3	1.7	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3	5.3	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2	4.8	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	28.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	0.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	5.8	PID PLK1 PATHWAY	PLK1 signaling events
0.2	4.8	SIG CHEMOTAXIS	Genes related to chemotaxis
0.2	45.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	1.3	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.1	2.6	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.1	0.9	PID IFNG PATHWAY	IFN-gamma pathway
0.1	4.3	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	1.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	10.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.3	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.4	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	0.2	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.4	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.9	73.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
2.9	113.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
2.1	21.5	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
1.8	87.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.6	27.0	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.5	26.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
1.5	16.9	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
1.5	7.5	REACTOME HEMOSTASIS	Genes involved in Hemostasis
1.4	17.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
1.4	15.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
1.3	12.7	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
1.2	10.8	REACTOME P75NTR SIGNALS VIA NFKB	Genes involved in p75NTR signals via NF-kB
1.2	14.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
1.2	45.1	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
1.1	10.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
1.1	11.0	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
1.1	48.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.1	19.6	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
1.0	13.6	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
1.0	20.7	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.9	68.3	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.9	12.8	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.9	2.7	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.9	12.3	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.9	7.8	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.8	5.7	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.8	5.5	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.8	12.8	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.7	4.2	REACTOME DEFENSINS	Genes involved in Defensins
0.7	17.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.7	17.9	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.7	9.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.7	4.6	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.6	7.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.6	9.9	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.6	5.8	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.5	4.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5	21.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	12.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.5	5.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.5	11.1	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.5	22.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.5	8.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.5	10.3	REACTOME MEIOSIS	Genes involved in Meiosis
0.5	48.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.5	1.8	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5	12.2	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.4	4.9	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.4	47.9	REACTOME MITOTIC M M G1 PHASES	Genes involved in Mitotic M-M/G1 phases
0.4	9.1	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4	8.9	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.4	4.8	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.4	7.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.4	2.3	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.4	15.6	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.4	11.3	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.4	5.5	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.4	1.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3	9.6	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.3	3.5	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.3	8.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.3	5.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.3	2.0	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.3	2.2	REACTOME OPSINS	Genes involved in Opsins
0.3	3.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	5.9	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.3	4.8	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3	13.1	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2	6.7	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.2	4.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	2.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.2	4.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.2	10.1	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.2	3.5	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	4.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.2	24.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	7.0	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	5.1	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2	3.3	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.1	2.8	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1	2.7	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1	5.3	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.1	2.0	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.1	2.7	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1	0.7	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	3.4	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1	3.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	0.1	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	1.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	1.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	1.9	REACTOME RNA POL III TRANSCRIPTION	Genes involved in RNA Polymerase III Transcription
0.1	0.3	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	0.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.3	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	2.8	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway

Results for Esr1

Z-value: 1.89

Motif logo

Transcription factors associated with Esr1

Activity-expression correlation:

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: