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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Esrrg

Z-value: 0.69

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Transcription factors associated with Esrrg

Gene Symbol Gene ID Gene Info
Esrrg
ENSRNOG00000002593 estrogen-related receptor gamma

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Esrrgrn6_v1_chr13_+_106463368_1064633680.442.5e-16Click!

Activity profile of Esrrg motif

Sorted Z-values of Esrrg motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_126080698 22.83 ENSRNOT00000008739
Bsnd
barttin CLCNK type accessory beta subunit
chr13_-_85622314 21.04 ENSRNOT00000005719
Mgst3
microsomal glutathione S-transferase 3
chr3_+_151126591 20.46 ENSRNOT00000025859
Myh7b
myosin heavy chain 7B
chr5_-_126911520 19.58 ENSRNOT00000091521
Dio1
deiodinase, iodothyronine, type I
chr8_+_71167305 17.94 ENSRNOT00000021337
Rbpms2
RNA binding protein with multiple splicing 2
chr3_-_60813869 12.99 ENSRNOT00000058234
Atp5g3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr7_+_2504695 11.63 ENSRNOT00000003965
Atp5b
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr9_+_61692154 11.22 ENSRNOT00000082300
Hspe1
heat shock protein family E member 1
chr4_-_82209933 10.91 ENSRNOT00000091106
LOC100912608
homeobox protein Hox-A10-like
chr10_+_61432819 10.56 ENSRNOT00000003687
ENSRNOT00000092478
Cluh
clustered mitochondria homolog
chr4_-_82295470 10.38 ENSRNOT00000091073
Hoxa10
homeobox A10
chr7_-_120518653 10.10 ENSRNOT00000016362
Baiap2l2
BAI1-associated protein 2-like 2
chr19_-_10653800 9.59 ENSRNOT00000022128
Cx3cl1
C-X3-C motif chemokine ligand 1
chr7_-_81592206 8.80 ENSRNOT00000007979
Angpt1
angiopoietin 1
chr9_-_61690956 8.70 ENSRNOT00000066589
Hspd1
heat shock protein family D member 1
chr13_-_93677377 8.69 ENSRNOT00000004917
Fh
fumarate hydratase
chrX_-_40086870 8.60 ENSRNOT00000010027
Smpx
small muscle protein, X-linked
chr14_+_17210733 8.48 ENSRNOT00000003075
Cxcl10
C-X-C motif chemokine ligand 10
chr4_-_157679962 7.97 ENSRNOT00000050443
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr18_+_2416871 7.97 ENSRNOT00000081399
Gata6
GATA binding protein 6
chr15_+_61069581 7.90 ENSRNOT00000084333
Vwa8
von Willebrand factor A domain containing 8
chr12_-_48254822 7.88 ENSRNOT00000056865
Ung
uracil-DNA glycosylase
chr8_-_55037604 7.81 ENSRNOT00000059169
Sdhd
succinate dehydrogenase complex subunit D
chr8_+_39878955 7.70 ENSRNOT00000060300
LOC100911068
roundabout homolog 4-like
chr18_+_2416552 7.68 ENSRNOT00000030726
Gata6
GATA binding protein 6
chr18_+_74156553 7.61 ENSRNOT00000022892
Atp5a1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr10_+_10761477 6.98 ENSRNOT00000004176
Rogdi
rogdi homolog
chr6_+_128750795 6.76 ENSRNOT00000005781
Glrx5
glutaredoxin 5
chr1_+_190555177 6.74 ENSRNOT00000021514
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr4_+_51614676 6.74 ENSRNOT00000060494
Asb15
ankyrin repeat and SOCS box containing 15
chr1_+_261158261 6.67 ENSRNOT00000071965
Pgam1
phosphoglycerate mutase 1
chr7_+_117409576 6.43 ENSRNOT00000017067
Cyc1
cytochrome c-1
chr8_-_39093277 6.03 ENSRNOT00000043344
LOC100911068
roundabout homolog 4-like
chr7_-_80796670 6.02 ENSRNOT00000010539
Abra
actin-binding Rho activating protein
chr1_-_263269762 6.00 ENSRNOT00000022309
Got1
glutamic-oxaloacetic transaminase 1
chr18_-_27749235 5.77 ENSRNOT00000026696
Hspa9
heat shock protein family A member 9
chr5_+_159484370 5.66 ENSRNOT00000010593
Sdhb
succinate dehydrogenase complex iron sulfur subunit B
chr5_-_147412705 5.43 ENSRNOT00000010688
RGD1561149
similar to mKIAA1522 protein
chr10_-_71849293 5.30 ENSRNOT00000003799
Lhx1
LIM homeobox 1
chr8_+_106317124 5.01 ENSRNOT00000018411
Nmnat3
nicotinamide nucleotide adenylyltransferase 3
chr2_+_186980793 4.98 ENSRNOT00000091336
Arhgef11
Rho guanine nucleotide exchange factor 11
chr5_-_56576676 4.96 ENSRNOT00000029712
Ndufb6
NADH:ubiquinone oxidoreductase subunit B6
chr2_-_47096961 4.94 ENSRNOT00000077401
Itga2
integrin alpha 2
chr2_+_186980992 4.89 ENSRNOT00000020717
Arhgef11
Rho guanine nucleotide exchange factor 11
chr10_-_11085142 4.76 ENSRNOT00000081596
ENSRNOT00000005479
ENSRNOT00000085230
Dnaja3
DnaJ heat shock protein family (Hsp40) member A3
chr6_-_4520604 4.73 ENSRNOT00000042230
ENSRNOT00000043870
ENSRNOT00000070918
ENSRNOT00000046246
ENSRNOT00000052367
ENSRNOT00000042251
Slc8a1
solute carrier family 8 member A1
chr12_-_30566032 4.43 ENSRNOT00000093378
Gbas
glioblastoma amplified sequence
chr16_-_69242028 4.05 ENSRNOT00000019002
Zfp703
zinc finger protein 703
chr9_+_43259709 3.97 ENSRNOT00000022487
Cox5b
cytochrome c oxidase subunit 5B
chr4_+_115046693 3.84 ENSRNOT00000031583
Bola3
bolA family member 3
chr8_+_59164572 3.81 ENSRNOT00000015102
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr4_-_157331905 3.66 ENSRNOT00000020647
Tpi1
triosephosphate isomerase 1
chr9_+_20213776 3.59 ENSRNOT00000071439
LOC100911515
triosephosphate isomerase-like
chr16_+_1979191 3.58 ENSRNOT00000014382
Ppif
peptidylprolyl isomerase F
chr6_+_2216623 3.43 ENSRNOT00000008045
Rmdn2
regulator of microtubule dynamics 2
chr7_-_117259141 3.32 ENSRNOT00000040762
Plec
plectin
chr7_+_129860327 3.26 ENSRNOT00000043461
Pim3
Pim-3 proto-oncogene, serine/threonine kinase
chr2_+_252305874 3.26 ENSRNOT00000020972
Ctbs
chitobiase
chrX_+_158835811 3.13 ENSRNOT00000071888
ENSRNOT00000080110
Ints6l
integrator complex subunit 6 like
chr7_-_12424367 3.08 ENSRNOT00000060698
Midn
midnolin
chr6_+_64252970 2.88 ENSRNOT00000093700
Pnpla8
patatin-like phospholipase domain containing 8
chr5_+_173640780 2.87 ENSRNOT00000027476
Perm1
PPARGC1 and ESRR induced regulator, muscle 1
chr1_+_199555722 2.62 ENSRNOT00000054983
Itgax
integrin subunit alpha X
chr1_-_78968329 2.59 ENSRNOT00000023078
Ppp5c
protein phosphatase 5, catalytic subunit
chr1_-_263431290 2.56 ENSRNOT00000022633
Slc25a28
solute carrier family 25 member 28
chr14_-_114583122 2.55 ENSRNOT00000084595
Sptbn1
spectrin, beta, non-erythrocytic 1
chr10_-_20818128 2.50 ENSRNOT00000011061
Wwc1
WW and C2 domain containing 1
chr8_-_68312909 2.42 ENSRNOT00000066106
RGD1309779
similar to ENSANGP00000021391
chr5_-_100647727 2.36 ENSRNOT00000067435
Nfib
nuclear factor I/B
chr15_+_61662264 2.36 ENSRNOT00000072969
Mtrf1
mitochondrial translation release factor 1
chr10_+_109533487 2.32 ENSRNOT00000054975
Fscn2
fascin actin-bundling protein 2, retinal
chr5_+_118743632 2.04 ENSRNOT00000013785
Pgm1
phosphoglucomutase 1
chr12_-_24365324 2.03 ENSRNOT00000032250
Trim50
tripartite motif-containing 50
chr12_+_47024442 1.89 ENSRNOT00000001545
Cox6a1
cytochrome c oxidase subunit 6A1
chrX_+_159427745 1.88 ENSRNOT00000078226
Adgrg4
adhesion G protein-coupled receptor G4
chr3_+_2727254 1.78 ENSRNOT00000034089
Fbxw5
F-box and WD repeat domain containing 5
chr18_-_63185510 1.76 ENSRNOT00000024632
Afg3l2
AFG3 like matrix AAA peptidase subunit 2
chr4_-_99746560 1.75 ENSRNOT00000012021
Mrpl35
mitochondrial ribosomal protein L35
chr1_+_128637049 1.73 ENSRNOT00000018639
Ttc23
tetratricopeptide repeat domain 23
chr6_-_107678156 1.66 ENSRNOT00000014158
Elmsan1
ELM2 and Myb/SANT domain containing 1
chr5_-_59085676 1.60 ENSRNOT00000068105
Msmp
microseminoprotein, prostate associated
chr3_+_147609095 1.56 ENSRNOT00000041456
Srxn1
sulfiredoxin 1
chr7_+_13698647 1.53 ENSRNOT00000067342
Olr1086
olfactory receptor 1086
chr7_+_11521998 1.51 ENSRNOT00000026960
Sgta
small glutamine rich tetratricopeptide repeat containing alpha
chr9_-_15628881 1.38 ENSRNOT00000077318
ENSRNOT00000020950
Guca1b
guanylate cyclase activator 1B
chr1_-_221041401 1.24 ENSRNOT00000064136
Pcnx3
pecanex homolog 3 (Drosophila)
chr8_-_47404010 1.21 ENSRNOT00000038647
Tmem136
transmembrane protein 136
chr18_+_402295 1.19 ENSRNOT00000033618
Fundc2
FUN14 domain containing 2
chr3_+_11607225 1.14 ENSRNOT00000072685
St6galnac4
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr5_+_50381244 1.03 ENSRNOT00000012385
Cga
glycoprotein hormones, alpha polypeptide
chr1_+_255842783 1.01 ENSRNOT00000023562
March5
membrane associated ring-CH-type finger 5
chr17_-_84247038 0.99 ENSRNOT00000068553
Nebl
nebulette
chr10_-_88356538 0.93 ENSRNOT00000022430
Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr8_+_55037750 0.93 ENSRNOT00000013188
Timm8b
translocase of inner mitochondrial membrane 8 homolog B
chr5_-_75319765 0.92 ENSRNOT00000085698
Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr10_+_67559385 0.92 ENSRNOT00000082685
ENSRNOT00000006218
ENSRNOT00000079696
Rhot1
ras homolog family member T1
chr3_-_133232322 0.80 ENSRNOT00000034487
Esf1
ESF1 nucleolar pre-rRNA processing protein homolog
chr2_-_24923128 0.79 ENSRNOT00000044087
Pde8b
phosphodiesterase 8B
chr10_-_88357025 0.70 ENSRNOT00000080006
Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr3_+_8534440 0.69 ENSRNOT00000045827
ENSRNOT00000082672
Sptan1
spectrin, alpha, non-erythrocytic 1
chr15_-_3544685 0.67 ENSRNOT00000015179
ENSRNOT00000085126
Vcl
vinculin
chr2_+_38230757 0.63 ENSRNOT00000048598
RGD1564606
similar to 60S ribosomal protein L23a
chr1_+_145770135 0.62 ENSRNOT00000015320
Stard5
StAR-related lipid transfer domain containing 5
chr6_+_55085313 0.56 ENSRNOT00000005458
AABR07063901.1

chr5_-_136002900 0.31 ENSRNOT00000025197
Plk3
polo-like kinase 3
chr6_-_76552559 0.17 ENSRNOT00000065230
Ralgapa1
Ral GTPase activating protein catalytic alpha subunit 1
chr6_-_93562314 0.15 ENSRNOT00000010871
ENSRNOT00000088790
Timm9
translocase of inner mitochondrial membrane 9
chr8_+_12160067 0.12 ENSRNOT00000036338
Maml2
mastermind-like transcriptional coactivator 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Esrrg

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.6 GO:0032912 endodermal cell fate determination(GO:0007493) negative regulation of transforming growth factor beta2 production(GO:0032912)
4.9 14.7 GO:0006106 fumarate metabolic process(GO:0006106)
2.9 8.8 GO:0048014 Tie signaling pathway(GO:0048014)
2.9 11.6 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
2.9 8.7 GO:0045041 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) protein import into mitochondrial intermembrane space(GO:0045041)
2.8 8.5 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
2.7 8.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
2.6 7.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.6 10.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
2.3 6.8 GO:0009249 protein lipoylation(GO:0009249)
2.0 7.9 GO:0006285 base-excision repair, AP site formation(GO:0006285)
1.9 5.8 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
1.7 5.0 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
1.6 9.6 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
1.3 5.3 GO:0060066 metanephric part of ureteric bud development(GO:0035502) oviduct development(GO:0060066) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.3 17.9 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
1.2 3.6 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
1.0 6.7 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
1.0 6.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
1.0 4.8 GO:0060331 negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.9 20.6 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.8 4.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.8 2.4 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.7 3.7 GO:0019563 glycerol catabolic process(GO:0019563)
0.7 2.9 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.7 4.9 GO:0010694 positive regulation of alkaline phosphatase activity(GO:0010694)
0.7 10.1 GO:0051764 actin crosslink formation(GO:0051764)
0.7 11.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.7 3.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.6 3.8 GO:0006102 isocitrate metabolic process(GO:0006102)
0.6 1.8 GO:0034982 mitochondrial protein processing(GO:0034982)
0.6 10.6 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.5 1.5 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.4 2.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.4 5.7 GO:0006105 succinate metabolic process(GO:0006105)
0.3 4.0 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.3 1.0 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.3 10.4 GO:0060065 uterus development(GO:0060065)
0.3 2.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.3 20.4 GO:0042446 hormone biosynthetic process(GO:0042446)
0.3 3.6 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 2.0 GO:0019388 galactose catabolic process(GO:0019388)
0.2 3.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2 2.6 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.2 21.0 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.2 6.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 3.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 1.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.2 1.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 17.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.9 GO:0014850 response to muscle activity(GO:0014850)
0.1 2.4 GO:0006415 translational termination(GO:0006415)
0.1 5.0 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.1 0.3 GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 1.0 GO:0006590 thyroid hormone generation(GO:0006590) follicle-stimulating hormone secretion(GO:0046884)
0.1 2.6 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 3.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 0.6 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 8.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 7.0 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 0.9 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1 1.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.0 GO:0090344 negative regulation of cell aging(GO:0090344)
0.1 2.3 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 2.6 GO:0050798 activated T cell proliferation(GO:0050798)
0.0 8.6 GO:0006941 striated muscle contraction(GO:0006941)
0.0 0.7 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
2.4 19.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
2.3 20.5 GO:0097512 cardiac myofibril(GO:0097512)
1.7 8.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.7 8.6 GO:0005927 muscle tendon junction(GO:0005927)
1.6 4.9 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
1.3 3.8 GO:0045242 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
1.2 13.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
1.0 10.1 GO:0071439 clathrin complex(GO:0071439)
1.0 13.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.0 8.0 GO:0097452 GAIT complex(GO:0097452)
0.7 8.7 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.6 1.8 GO:0005745 m-AAA complex(GO:0005745)
0.5 4.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.4 3.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.4 5.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 3.2 GO:0032437 cuticular plate(GO:0032437)
0.3 2.6 GO:1990635 proximal dendrite(GO:1990635)
0.2 2.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 3.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 5.8 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 5.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.7 GO:1990357 terminal web(GO:1990357)
0.1 43.7 GO:0005635 nuclear envelope(GO:0005635)
0.1 2.6 GO:0008305 integrin complex(GO:0008305)
0.1 8.8 GO:0005902 microvillus(GO:0005902)
0.1 19.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 2.3 GO:0032420 stereocilium(GO:0032420)
0.1 4.7 GO:0014704 intercalated disc(GO:0014704)
0.1 1.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.0 GO:0016235 aggresome(GO:0016235)
0.0 2.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 6.4 GO:0030017 sarcomere(GO:0030017)
0.0 8.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 12.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 1.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 26.0 GO:0005739 mitochondrion(GO:0005739)
0.0 8.8 GO:0009986 cell surface(GO:0009986)
0.0 9.3 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 11.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.3 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
3.8 19.2 GO:0043532 angiostatin binding(GO:0043532)
2.4 19.6 GO:0008430 selenium binding(GO:0008430)
2.4 7.3 GO:0004807 triose-phosphate isomerase activity(GO:0004807)
2.0 6.0 GO:0080130 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
2.0 8.0 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.7 8.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.7 8.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.7 5.0 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
1.7 6.7 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.3 7.9 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
1.2 22.8 GO:0017081 chloride channel regulator activity(GO:0017081)
1.1 21.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.0 4.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
1.0 3.8 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.7 13.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.7 4.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.6 2.4 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.5 3.3 GO:0004568 chitinase activity(GO:0004568)
0.5 1.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.4 15.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.4 2.9 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.4 2.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 1.5 GO:1904288 BAT3 complex binding(GO:1904288)
0.3 19.1 GO:0009055 electron carrier activity(GO:0009055)
0.3 9.6 GO:0008009 chemokine activity(GO:0008009)
0.3 2.6 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.2 21.2 GO:0051082 unfolded protein binding(GO:0051082)
0.2 8.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 5.9 GO:0030506 ankyrin binding(GO:0030506)
0.1 28.5 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 15.5 GO:0003774 motor activity(GO:0003774)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 4.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 8.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 6.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 10.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 2.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 8.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.6 GO:0032052 bile acid binding(GO:0032052)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 5.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 4.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.6 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 10.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 7.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 15.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 9.9 ST GA13 PATHWAY G alpha 13 Pathway
0.2 8.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.2 8.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 2.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 8.0 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 9.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 2.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 2.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.7 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 26.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.3 20.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.2 19.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.7 21.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.6 24.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 21.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.4 8.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.4 18.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 4.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 17.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 9.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 4.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 3.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 15.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.9 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.1 2.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 5.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 6.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway