ISMARA results: Ezh2_Atf2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ezh2_Atf2_Ikzf1

Z-value: 1.77

Motif logo

Transcription factors associated with Ezh2_Atf2_Ikzf1

Gene Symbol	Gene ID	Gene Info
Ezh2 NCBI RGD Ensembl	ENSRNOG00000006048	enhancer of zeste 2 polycomb repressive complex 2 subunit
Atf2 NCBI RGD Ensembl	ENSRNOG00000001597	activating transcription factor 2
Ikzf1 NCBI RGD Ensembl	ENSRNOG00000004444	IKAROS family zinc finger 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Atf2	rn6_v1_chr3_-_60765645_60765645	0.51	3.7e-22	Click!
Ikzf1	rn6_v1_chr14_+_91783514_91783514	-0.44	1.7e-16	Click!
Ezh2	rn6_v1_chr4_-_77347011_77347011	-0.21	1.3e-04	Click!

Activity profile of Ezh2_Atf2_Ikzf1 motif

Sorted Z-values of Ezh2_Atf2_Ikzf1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_-_110046687 Show fit	98.23	ENSRNOT00000057404 ENSRNOT00000006624 ENSRNOT00000089695	Nalcn NCBI RGD Ensembl Show fit	sodium leak channel, non-selective
chr7_+_123510804 Show fit	88.84	ENSRNOT00000010491	Sept3 NCBI RGD Ensembl Show fit	septin 3
chr15_+_33600102 Show fit	85.70	ENSRNOT00000022664	Cmtm5 NCBI RGD Ensembl Show fit	CKLF-like MARVEL transmembrane domain containing 5
chr17_-_10766253 Show fit	74.98	ENSRNOT00000000117	Cplx2 NCBI RGD Ensembl Show fit	complexin 2
chr4_+_175729726 Show fit	70.82	ENSRNOT00000013230	Slco1c1 NCBI RGD Ensembl Show fit	solute carrier organic anion transporter family, member 1c1
chr3_-_44086006 Show fit	69.53	ENSRNOT00000034449 ENSRNOT00000082604	Ermn NCBI RGD Ensembl Show fit	ermin
chr3_+_113318563 Show fit	69.08	ENSRNOT00000089230	Ckmt1 NCBI RGD Ensembl Show fit	creatine kinase, mitochondrial 1
chr7_-_136853154 Show fit	67.72	ENSRNOT00000087376	Nell2 NCBI RGD Ensembl Show fit	neural EGFL like 2
chr7_-_136853957 Show fit	66.84	ENSRNOT00000008985	Nell2 NCBI RGD Ensembl Show fit	neural EGFL like 2
chr11_-_35098883 Show fit	66.39	ENSRNOT00000079955	Kcnj6 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily J member 6
chr3_+_129599353 Show fit	66.03	ENSRNOT00000008734	Snap25 NCBI RGD Ensembl Show fit	synaptosomal-associated protein 25
chr11_+_58624198 Show fit	64.74	ENSRNOT00000002091	Gap43 NCBI RGD Ensembl Show fit	growth associated protein 43
chr1_+_234252757 Show fit	63.96	ENSRNOT00000091814	Rorb NCBI RGD Ensembl Show fit	RAR-related orphan receptor B
chr10_+_42614713 Show fit	62.85	ENSRNOT00000081136 ENSRNOT00000073148	Gria1 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor AMPA type subunit 1
chrX_+_107496072 Show fit	58.66	ENSRNOT00000003283	Plp1 NCBI RGD Ensembl Show fit	proteolipid protein 1
chr13_-_72367980 Show fit	55.26	ENSRNOT00000003928	Cacna1e NCBI RGD Ensembl Show fit	calcium voltage-gated channel subunit alpha1 E
chr1_+_25174456 Show fit	54.63	ENSRNOT00000092830	Clvs2 NCBI RGD Ensembl Show fit	clavesin 2
chr4_-_16669368 Show fit	54.10	ENSRNOT00000007608	Pclo NCBI RGD Ensembl Show fit	piccolo (presynaptic cytomatrix protein)
chr4_+_22859622 Show fit	53.76	ENSRNOT00000073501 ENSRNOT00000068410	Adam22 NCBI RGD Ensembl Show fit	ADAM metallopeptidase domain 22
chr10_+_42618487 Show fit	52.81	ENSRNOT00000071615	Gria1 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor AMPA type subunit 1
chr4_-_169999873 Show fit	52.53	ENSRNOT00000011697	Grin2b NCBI RGD Ensembl Show fit	glutamate ionotropic receptor NMDA type subunit 2B
chr15_-_77736892 Show fit	52.05	ENSRNOT00000057924	Pcdh9 NCBI RGD Ensembl Show fit	protocadherin 9
chr16_-_21089508 Show fit	50.15	ENSRNOT00000072565	Hapln4 NCBI RGD Ensembl Show fit	hyaluronan and proteoglycan link protein 4
chr4_-_51844331 Show fit	48.83	ENSRNOT00000003593	Gpr37 NCBI RGD Ensembl Show fit	G protein-coupled receptor 37
chr4_-_11497531 Show fit	48.69	ENSRNOT00000078799	Magi2 NCBI RGD Ensembl Show fit	membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_+_51687809 Show fit	48.03	ENSRNOT00000087242	Scn2a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 2
chr6_-_147172022 Show fit	46.66	ENSRNOT00000080675	Itgb8 NCBI RGD Ensembl Show fit	integrin subunit beta 8
chr2_-_179704629 Show fit	45.68	ENSRNOT00000083361 ENSRNOT00000077941	Gria2 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr9_+_60039297 Show fit	44.53	ENSRNOT00000016262	Slc39a10 NCBI RGD Ensembl Show fit	solute carrier family 39 member 10
chr4_-_16654811 Show fit	42.89	ENSRNOT00000008637	Pclo NCBI RGD Ensembl Show fit	piccolo (presynaptic cytomatrix protein)
chr17_-_58292624 Show fit	42.76	ENSRNOT00000047512	Adarb2 NCBI RGD Ensembl Show fit	adenosine deaminase, RNA-specific, B2
chr7_-_44121130 Show fit	42.31	ENSRNOT00000005706	Nts NCBI RGD Ensembl Show fit	neurotensin
chr2_-_187401786 Show fit	41.97	ENSRNOT00000025624	Hapln2 NCBI RGD Ensembl Show fit	hyaluronan and proteoglycan link protein 2
chr9_+_82571269 Show fit	40.95	ENSRNOT00000026941	Speg NCBI RGD Ensembl Show fit	SPEG complex locus
chr14_+_8080565 Show fit	40.42	ENSRNOT00000092395	Mapk10 NCBI RGD Ensembl Show fit	mitogen activated protein kinase 10
chr9_+_82596355 Show fit	39.43	ENSRNOT00000065076	Speg NCBI RGD Ensembl Show fit	SPEG complex locus
chr14_+_8080275 Show fit	39.35	ENSRNOT00000065965 ENSRNOT00000092542	Mapk10 NCBI RGD Ensembl Show fit	mitogen activated protein kinase 10
chr12_-_10307265 Show fit	39.20	ENSRNOT00000092627	Wasf3 NCBI RGD Ensembl Show fit	WAS protein family, member 3
chr7_-_125407806 Show fit	38.57	ENSRNOT00000084666	RGD1566029 NCBI RGD Ensembl Show fit	similar to mKIAA1644 protein
chr10_+_65586993 Show fit	37.06	ENSRNOT00000086036	Aldoc NCBI RGD Ensembl Show fit	aldolase, fructose-bisphosphate C
chr2_+_69415057 Show fit	36.93	ENSRNOT00000013152	Cdh10 NCBI RGD Ensembl Show fit	cadherin 10
chr18_-_18079560 Show fit	36.73	ENSRNOT00000072093	AABR07031533.1 NCBI RGD Ensembl Show fit
chr3_+_113257688 Show fit	35.45	ENSRNOT00000019320	Map1a NCBI RGD Ensembl Show fit	microtubule-associated protein 1A
chr18_-_67224566 Show fit	35.09	ENSRNOT00000064947	Dcc NCBI RGD Ensembl Show fit	DCC netrin 1 receptor
chr7_-_50278842 Show fit	34.24	ENSRNOT00000088950	Syt1 NCBI RGD Ensembl Show fit	synaptotagmin 1
chr3_+_35175313 Show fit	34.15	ENSRNOT00000081744	Kif5c NCBI RGD Ensembl Show fit	kinesin family member 5C
chr3_-_64554953 Show fit	33.95	ENSRNOT00000067452	LOC102553814 NCBI RGD Ensembl Show fit	serine/arginine repetitive matrix protein 1-like
chr2_-_35104963 Show fit	33.93	ENSRNOT00000018058	Rgs7bp NCBI RGD Ensembl Show fit	regulator of G-protein signaling 7-binding protein
chr6_-_114488880 Show fit	33.88	ENSRNOT00000087560	AC118957.1 NCBI RGD Ensembl Show fit
chr18_+_30562178 Show fit	33.79	ENSRNOT00000040998	LOC108348771 NCBI RGD Ensembl Show fit	protocadherin beta-16-like
chrX_-_116792864 Show fit	33.63	ENSRNOT00000090918	Amot NCBI RGD Ensembl Show fit	angiomotin
chrX_-_29648359 Show fit	33.39	ENSRNOT00000086721 ENSRNOT00000006777	Gpm6b NCBI RGD Ensembl Show fit	glycoprotein m6b
chrX_-_116792707 Show fit	32.67	ENSRNOT00000049482	Amot NCBI RGD Ensembl Show fit	angiomotin
chr11_+_36851038 Show fit	32.44	ENSRNOT00000002221 ENSRNOT00000061047	Pcp4 NCBI RGD Ensembl Show fit	Purkinje cell protein 4
chrX_+_107323215 Show fit	32.40	ENSRNOT00000071874	Tceal3 NCBI RGD Ensembl Show fit	transcription elongation factor A like 3
chrX_-_152642531 Show fit	32.35	ENSRNOT00000085037	Gabra3 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha3 subunit
chr11_+_45888221 Show fit	31.86	ENSRNOT00000071932 ENSRNOT00000066008 ENSRNOT00000060802	Lnp1 NCBI RGD Ensembl Show fit	leukemia NUP98 fusion partner 1
chr3_-_52664209 Show fit	31.84	ENSRNOT00000065126 ENSRNOT00000079020	Scn9a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 9
chr1_-_5165859 Show fit	31.75	ENSRNOT00000044325 ENSRNOT00000019319	Grm1 NCBI RGD Ensembl Show fit	glutamate metabotropic receptor 1
chr6_+_64789940 Show fit	31.49	ENSRNOT00000085979 ENSRNOT00000059739 ENSRNOT00000051908 ENSRNOT00000082793 ENSRNOT00000078583 ENSRNOT00000091677 ENSRNOT00000093241	Nrcam NCBI RGD Ensembl Show fit	neuronal cell adhesion molecule
chr10_-_15928169 Show fit	31.08	ENSRNOT00000028069	Nsg2 NCBI RGD Ensembl Show fit	neuron specific gene family member 2
chrX_-_142248369 Show fit	31.04	ENSRNOT00000091330	Fgf13 NCBI RGD Ensembl Show fit	fibroblast growth factor 13
chr9_-_71852113 Show fit	30.85	ENSRNOT00000083263 ENSRNOT00000072983	AABR07067896.1 NCBI RGD Ensembl Show fit
chr14_+_109533792 Show fit	29.90	ENSRNOT00000067690	LOC108348154 NCBI RGD Ensembl Show fit	ankyrin repeat domain-containing protein 29-like
chr1_-_225035687 Show fit	29.75	ENSRNOT00000026539	Gng3 NCBI RGD Ensembl Show fit	G protein subunit gamma 3
chr10_-_56211891 Show fit	29.66	ENSRNOT00000015076	Atp1b2 NCBI RGD Ensembl Show fit	ATPase Na+/K+ transporting subunit beta 2
chr13_-_88061108 Show fit	29.07	ENSRNOT00000003774	Rgs4 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 4
chr9_+_73433252 Show fit	29.07	ENSRNOT00000092540	Map2 NCBI RGD Ensembl Show fit	microtubule-associated protein 2
chr5_-_79570073 Show fit	28.40	ENSRNOT00000011845	Tnfsf15 NCBI RGD Ensembl Show fit	tumor necrosis factor superfamily member 15
chr7_-_50638798 Show fit	28.39	ENSRNOT00000048880	Syt1 NCBI RGD Ensembl Show fit	synaptotagmin 1
chr9_+_73418607 Show fit	28.34	ENSRNOT00000092547	Map2 NCBI RGD Ensembl Show fit	microtubule-associated protein 2
chr12_+_21767606 Show fit	28.29	ENSRNOT00000059602	LOC103691013 NCBI RGD Ensembl Show fit	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like
chr10_-_27179254 Show fit	28.21	ENSRNOT00000004619	Gabrg2 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor gamma 2 subunit
chr3_-_168018410 Show fit	28.09	ENSRNOT00000087579	Bcas1 NCBI RGD Ensembl Show fit	breast carcinoma amplified sequence 1
chr1_+_101517714 Show fit	27.87	ENSRNOT00000028423	Plekha4 NCBI RGD Ensembl Show fit	pleckstrin homology domain containing A4
chr3_-_113312127 Show fit	26.26	ENSRNOT00000065285	Mfap1a NCBI RGD Ensembl Show fit	microfibrillar-associated protein 1A
chr14_-_39112600 Show fit	25.97	ENSRNOT00000003170	Gabrb1 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor beta 1 subunit
chr15_-_44860604 Show fit	25.85	ENSRNOT00000018637	Nefm NCBI RGD Ensembl Show fit	neurofilament medium
chr13_+_57131395 Show fit	25.77	ENSRNOT00000017884	Kcnt2 NCBI RGD Ensembl Show fit	potassium sodium-activated channel subfamily T member 2
chr3_-_176666282 Show fit	25.60	ENSRNOT00000016947	Eef1a2 NCBI RGD Ensembl Show fit	eukaryotic translation elongation factor 1 alpha 2
chr7_+_6644643 Show fit	25.07	ENSRNOT00000051670	Olr962 NCBI RGD Ensembl Show fit	olfactory receptor 962
chr17_-_72046381 Show fit	24.94	ENSRNOT00000073919	AABR07028488.1 NCBI RGD Ensembl Show fit
chr3_-_168033457 Show fit	24.36	ENSRNOT00000055111	Bcas1 NCBI RGD Ensembl Show fit	breast carcinoma amplified sequence 1
chr5_-_147303346 Show fit	24.33	ENSRNOT00000009153	Hpca NCBI RGD Ensembl Show fit	hippocalcin
chr9_-_32019205 Show fit	24.32	ENSRNOT00000016194	Adgrb3 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor B3
chr9_+_118849302 Show fit	24.20	ENSRNOT00000087592	Dlgap1 NCBI RGD Ensembl Show fit	DLG associated protein 1
chr17_+_60059949 Show fit	24.03	ENSRNOT00000025458	Mpp7 NCBI RGD Ensembl Show fit	membrane palmitoylated protein 7
chrX_+_20351486 Show fit	23.58	ENSRNOT00000093675 ENSRNOT00000047444	Wnk3 NCBI RGD Ensembl Show fit	WNK lysine deficient protein kinase 3
chr20_+_40769586 Show fit	23.18	ENSRNOT00000001079	Fabp7 NCBI RGD Ensembl Show fit	fatty acid binding protein 7
chr2_-_95472115 Show fit	23.06	ENSRNOT00000015720	Stmn2 NCBI RGD Ensembl Show fit	stathmin 2
chr17_+_81922329 Show fit	22.69	ENSRNOT00000031542	Cacnb2 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit beta 2
chr10_-_82492918 Show fit	22.62	ENSRNOT00000066895	LOC100364194 NCBI RGD Ensembl Show fit	transmembrane protein 92-like
chr1_+_16478127 Show fit	22.26	ENSRNOT00000019076	Ahi1 NCBI RGD Ensembl Show fit	Abelson helper integration site 1
chr3_+_51883559 Show fit	22.22	ENSRNOT00000007197	Csrnp3 NCBI RGD Ensembl Show fit	cysteine and serine rich nuclear protein 3
chr18_-_5314511 Show fit	22.08	ENSRNOT00000022637 ENSRNOT00000079682	Zfp521 NCBI RGD Ensembl Show fit	zinc finger protein 521
chr13_-_72063347 Show fit	21.86	ENSRNOT00000090544 ENSRNOT00000003869	Cacna1e NCBI RGD Ensembl Show fit	calcium voltage-gated channel subunit alpha1 E
chr2_+_201289357 Show fit	21.55	ENSRNOT00000067358	Tbx15 NCBI RGD Ensembl Show fit	T-box 15
chr16_-_10296341 Show fit	21.33	ENSRNOT00000083990	Zfp488 NCBI RGD Ensembl Show fit	zinc finger protein 488
chr1_-_43638161 Show fit	21.31	ENSRNOT00000024460	Ipcef1 NCBI RGD Ensembl Show fit	interaction protein for cytohesin exchange factors 1
chr4_+_108301129 Show fit	21.26	ENSRNOT00000007993	LRRTM1 NCBI RGD Ensembl Show fit	leucine rich repeat transmembrane neuronal 1
chr15_-_76789298 Show fit	21.21	ENSRNOT00000077853	AABR07018857.1 NCBI RGD Ensembl Show fit
chr13_+_46169963 Show fit	20.85	ENSRNOT00000005212	Thsd7b NCBI RGD Ensembl Show fit	thrombospondin type 1 domain containing 7B
chr19_+_6046665 Show fit	20.84	ENSRNOT00000084126	Cdh8 NCBI RGD Ensembl Show fit	cadherin 8
chr11_+_69484293 Show fit	20.44	ENSRNOT00000049292	Kalrn NCBI RGD Ensembl Show fit	kalirin, RhoGEF kinase
chr6_+_101603319 Show fit	20.31	ENSRNOT00000030470	Gphn NCBI RGD Ensembl Show fit	gephyrin
chr9_-_63641400 Show fit	20.25	ENSRNOT00000087684	Satb2 NCBI RGD Ensembl Show fit	SATB homeobox 2
chr11_-_59110562 Show fit	20.18	ENSRNOT00000047907 ENSRNOT00000042024	Lsamp NCBI RGD Ensembl Show fit	limbic system-associated membrane protein
chrX_+_136460215 Show fit	20.09	ENSRNOT00000093538	Arhgap36 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 36
chr4_-_150829741 Show fit	20.01	ENSRNOT00000051846 ENSRNOT00000052017	Cacna1c NCBI RGD Ensembl Show fit	calcium voltage-gated channel subunit alpha1 C
chr18_+_30527705 Show fit	20.00	ENSRNOT00000027168	Pcdhb14 NCBI RGD Ensembl Show fit	protocadherin beta 14
chr20_-_31956649 Show fit	19.94	ENSRNOT00000072429	Hk1 NCBI RGD Ensembl Show fit	hexokinase 1
chr10_-_97582188 Show fit	19.64	ENSRNOT00000005076	Rgs9 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 9
chr8_-_98738446 Show fit	19.61	ENSRNOT00000019860	Zic1 NCBI RGD Ensembl Show fit	Zic family member 1
chr5_-_130085838 Show fit	19.60	ENSRNOT00000035252	Elavl4 NCBI RGD Ensembl Show fit	ELAV like RNA binding protein 4
chr3_-_176816114 Show fit	19.60	ENSRNOT00000079262 ENSRNOT00000018697	Stmn3 NCBI RGD Ensembl Show fit	stathmin 3
chr4_+_138441332 Show fit	19.37	ENSRNOT00000090847	Cntn4 NCBI RGD Ensembl Show fit	contactin 4
chr18_+_30474947 Show fit	19.11	ENSRNOT00000027188	Pcdhb9 NCBI RGD Ensembl Show fit	protocadherin beta 9
chrX_+_62363953 Show fit	19.07	ENSRNOT00000083362	Arx NCBI RGD Ensembl Show fit	aristaless related homeobox
chr2_+_247248407 Show fit	18.89	ENSRNOT00000082287	Unc5c NCBI RGD Ensembl Show fit	unc-5 netrin receptor C
chr1_+_187149453 Show fit	18.85	ENSRNOT00000082738	Xylt1 NCBI RGD Ensembl Show fit	xylosyltransferase 1
chr18_-_38088457 Show fit	18.75	ENSRNOT00000077814	Jakmip2 NCBI RGD Ensembl Show fit	janus kinase and microtubule interacting protein 2
chr2_-_57935334 Show fit	18.46	ENSRNOT00000022319 ENSRNOT00000085599 ENSRNOT00000077790 ENSRNOT00000035821	Slc1a3 NCBI RGD Ensembl Show fit	solute carrier family 1 member 3
chr7_-_129970550 Show fit	18.40	ENSRNOT00000055879	Mlc1 NCBI RGD Ensembl Show fit	megalencephalic leukoencephalopathy with subcortical cysts 1
chr16_-_20097287 Show fit	18.39	ENSRNOT00000025162	Unc13a NCBI RGD Ensembl Show fit	unc-13 homolog A
chr15_-_43542939 Show fit	18.19	ENSRNOT00000012996	Dpysl2 NCBI RGD Ensembl Show fit	dihydropyrimidinase-like 2
chr14_-_3288017 Show fit	18.15	ENSRNOT00000080452	LOC689986 NCBI RGD Ensembl Show fit	hypothetical protein LOC689986
chr2_+_18392142 Show fit	18.14	ENSRNOT00000043196	Hapln1 NCBI RGD Ensembl Show fit	hyaluronan and proteoglycan link protein 1
chr1_+_128924966 Show fit	18.03	ENSRNOT00000019267	Igf1r NCBI RGD Ensembl Show fit	insulin-like growth factor 1 receptor
chrX_+_6791136 Show fit	17.86	ENSRNOT00000003984	LOC100909913 NCBI RGD Ensembl Show fit	norrin-like
chr8_-_96985558 Show fit	17.83	ENSRNOT00000018553	LOC501033 NCBI RGD Ensembl Show fit	similar to UPF0258 protein KIAA1024
chr5_-_168734296 Show fit	17.76	ENSRNOT00000066120	Camta1 NCBI RGD Ensembl Show fit	calmodulin binding transcription activator 1
chr1_+_42169501 Show fit	17.35	ENSRNOT00000025477 ENSRNOT00000092791	Vip NCBI RGD Ensembl Show fit	vasoactive intestinal peptide
chr2_+_36246628 Show fit	17.30	ENSRNOT00000013618	Htr1a NCBI RGD Ensembl Show fit	5-hydroxytryptamine receptor 1A
chr15_-_88036354 Show fit	17.23	ENSRNOT00000014747	Ednrb NCBI RGD Ensembl Show fit	endothelin receptor type B
chr1_-_13915594 Show fit	17.20	ENSRNOT00000015927	Arfgef3 NCBI RGD Ensembl Show fit	ARFGEF family member 3
chr15_-_26175645 Show fit	17.03	ENSRNOT00000020175	Slc35f4 NCBI RGD Ensembl Show fit	solute carrier family 35, member F4
chr16_-_6245644 Show fit	16.92	ENSRNOT00000040759	Cacna1d NCBI RGD Ensembl Show fit	calcium voltage-gated channel subunit alpha1 D
chr7_+_130431213 Show fit	16.91	ENSRNOT00000055792	Mapk8ip2 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase 8 interacting protein 2
chr3_-_122206671 Show fit	16.84	ENSRNOT00000037576	Pdyn NCBI RGD Ensembl Show fit	prodynorphin
chr8_+_45797315 Show fit	16.80	ENSRNOT00000059997	AABR07070046.1 NCBI RGD Ensembl Show fit
chr1_-_89559960 Show fit	16.70	ENSRNOT00000092133	Scn1b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 1
chr16_-_36161089 Show fit	16.40	ENSRNOT00000017888	Scrg1 NCBI RGD Ensembl Show fit	stimulator of chondrogenesis 1
chr3_-_159775643 Show fit	16.11	ENSRNOT00000010939	Jph2 NCBI RGD Ensembl Show fit	junctophilin 2
chr5_-_158439078 Show fit	16.03	ENSRNOT00000025517	Klhdc7a NCBI RGD Ensembl Show fit	kelch domain containing 7A
chr4_-_155275161 Show fit	15.88	ENSRNOT00000032690	Rimklb NCBI RGD Ensembl Show fit	ribosomal modification protein rimK-like family member B
chr6_+_58467254 Show fit	15.80	ENSRNOT00000065396	Etv1 NCBI RGD Ensembl Show fit	ets variant 1
chr4_-_11610518 Show fit	15.72	ENSRNOT00000066643	Magi2 NCBI RGD Ensembl Show fit	membrane associated guanylate kinase, WW and PDZ domain containing 2
chrX_+_159165169 Show fit	15.65	ENSRNOT00000087274	Fhl1 NCBI RGD Ensembl Show fit	four and a half LIM domains 1
chr18_+_52215682 Show fit	15.64	ENSRNOT00000037901	Megf10 NCBI RGD Ensembl Show fit	multiple EGF-like domains 10
chr20_+_20105047 Show fit	15.58	ENSRNOT00000082181	Ank3 NCBI RGD Ensembl Show fit	ankyrin 3
chr2_+_102685513 Show fit	15.53	ENSRNOT00000033940	Bhlhe22 NCBI RGD Ensembl Show fit	basic helix-loop-helix family, member e22
chr20_+_5050327 Show fit	15.41	ENSRNOT00000083353	Ddah2 NCBI RGD Ensembl Show fit	dimethylarginine dimethylaminohydrolase 2
chr3_+_139695028 Show fit	15.24	ENSRNOT00000089098	Slc24a3 NCBI RGD Ensembl Show fit	solute carrier family 24 member 3
chr14_+_36047144 Show fit	15.23	ENSRNOT00000003088	Lnx1 NCBI RGD Ensembl Show fit	ligand of numb-protein X 1
chr9_+_16862248 Show fit	15.20	ENSRNOT00000080104 ENSRNOT00000024824	Ttbk1 NCBI RGD Ensembl Show fit	tau tubulin kinase 1
chr18_+_29966245 Show fit	15.13	ENSRNOT00000074028	Pcdha4 NCBI RGD Ensembl Show fit	protocadherin alpha 4
chr7_+_139698148 Show fit	14.88	ENSRNOT00000078579	Pfkm NCBI RGD Ensembl Show fit	phosphofructokinase, muscle
chrX_-_152641679 Show fit	14.87	ENSRNOT00000080277	Gabra3 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha3 subunit
chr2_+_229196616 Show fit	14.84	ENSRNOT00000012773	Ndst4 NCBI RGD Ensembl Show fit	N-deacetylase and N-sulfotransferase 4
chr9_-_30844199 Show fit	14.80	ENSRNOT00000017169	Col19a1 NCBI RGD Ensembl Show fit	collagen type XIX alpha 1 chain
chr10_+_54156649 Show fit	14.77	ENSRNOT00000074718	Gas7 NCBI RGD Ensembl Show fit	growth arrest specific 7
chr15_+_33121273 Show fit	14.65	ENSRNOT00000016020	Rem2 NCBI RGD Ensembl Show fit	RRAD and GEM like GTPase 2
chr14_-_13058172 Show fit	14.50	ENSRNOT00000002746 ENSRNOT00000071706	Prdm8 NCBI RGD Ensembl Show fit	PR/SET domain 8
chr3_-_64543100 Show fit	14.49	ENSRNOT00000025803	Zfp385b NCBI RGD Ensembl Show fit	zinc finger protein 385B
chr4_-_155563249 Show fit	14.40	ENSRNOT00000011298	Slc2a3 NCBI RGD Ensembl Show fit	solute carrier family 2 member 3
chr8_-_62987182 Show fit	14.36	ENSRNOT00000070885	Islr2 NCBI RGD Ensembl Show fit	immunoglobulin superfamily containing leucine-rich repeat 2
chr5_+_154077944 Show fit	14.36	ENSRNOT00000031512	Il22ra1 NCBI RGD Ensembl Show fit	interleukin 22 receptor subunit alpha 1
chrX_-_104932508 Show fit	14.32	ENSRNOT00000075325	Nox1 NCBI RGD Ensembl Show fit	NADPH oxidase 1
chr1_+_211423022 Show fit	14.28	ENSRNOT00000029587	Dpysl4 NCBI RGD Ensembl Show fit	dihydropyrimidinase-like 4
chr15_-_62200837 Show fit	14.27	ENSRNOT00000017599	Pcdh8 NCBI RGD Ensembl Show fit	protocadherin 8
chr15_+_33600337 Show fit	14.26	ENSRNOT00000075965	Cmtm5 NCBI RGD Ensembl Show fit	CKLF-like MARVEL transmembrane domain containing 5
chr10_+_77537340 Show fit	14.26	ENSRNOT00000003297	Tmem100 NCBI RGD Ensembl Show fit	transmembrane protein 100
chr18_+_30592794 Show fit	14.23	ENSRNOT00000027133	Pcdhb22 NCBI RGD Ensembl Show fit	protocadherin beta 22
chr6_-_88917070 Show fit	14.17	ENSRNOT00000000767	Mdga2 NCBI RGD Ensembl Show fit	MAM domain containing glycosylphosphatidylinositol anchor 2
chr2_+_262914327 Show fit	14.14	ENSRNOT00000029312	Negr1 NCBI RGD Ensembl Show fit	neuronal growth regulator 1
chrX_-_82743753 Show fit	14.09	ENSRNOT00000003512	Rps6ka6 NCBI RGD Ensembl Show fit	ribosomal protein S6 kinase A6
chr8_-_53899669 Show fit	14.06	ENSRNOT00000082257	Ncam1 NCBI RGD Ensembl Show fit	neural cell adhesion molecule 1
chr15_+_58016238 Show fit	14.03	ENSRNOT00000075786	Kctd4 NCBI RGD Ensembl Show fit	potassium channel tetramerization domain containing 4
chr3_+_113319456 Show fit	13.87	ENSRNOT00000051354	Ckmt1 NCBI RGD Ensembl Show fit	creatine kinase, mitochondrial 1
chrX_+_62363757 Show fit	13.87	ENSRNOT00000091240	Arx NCBI RGD Ensembl Show fit	aristaless related homeobox
chr14_+_114152472 Show fit	13.78	ENSRNOT00000042965	Rtn4 NCBI RGD Ensembl Show fit	reticulon 4
chr17_-_52477575 Show fit	13.78	ENSRNOT00000081290	Gli3 NCBI RGD Ensembl Show fit	GLI family zinc finger 3
chr8_+_7128656 Show fit	13.66	ENSRNOT00000038313	Pgr NCBI RGD Ensembl Show fit	progesterone receptor
chr14_+_39661968 Show fit	13.49	ENSRNOT00000064779	Gabra2 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha2 subunit
chr1_+_101682172 Show fit	13.44	ENSRNOT00000028540	Car11 NCBI RGD Ensembl Show fit	carbonic anhydrase 11
chrX_-_15553720 Show fit	13.44	ENSRNOT00000012646	Gripap1 NCBI RGD Ensembl Show fit	GRIP1 associated protein 1
chr5_-_6083083 Show fit	13.39	ENSRNOT00000072411	Sulf1 NCBI RGD Ensembl Show fit	sulfatase 1
chr3_-_104502471 Show fit	13.22	ENSRNOT00000040306	Ryr3 NCBI RGD Ensembl Show fit	ryanodine receptor 3
chr8_+_39848448 Show fit	13.20	ENSRNOT00000012248	Hepacam NCBI RGD Ensembl Show fit	hepatocyte cell adhesion molecule
chr15_-_34550850 Show fit	13.12	ENSRNOT00000027794 ENSRNOT00000090228	Cbln3 NCBI RGD Ensembl Show fit	cerebellin 3 precursor
chr3_+_131351587 Show fit	13.03	ENSRNOT00000010835	Btbd3 NCBI RGD Ensembl Show fit	BTB domain containing 3
chr2_-_173087648 Show fit	13.03	ENSRNOT00000091079	Iqcj NCBI RGD Ensembl Show fit	IQ motif containing J
chr20_+_25990656 Show fit	12.98	ENSRNOT00000081254	Lrrtm3 NCBI RGD Ensembl Show fit	leucine rich repeat transmembrane neuronal 3
chr1_+_168489077 Show fit	12.93	ENSRNOT00000021191	Olr96 NCBI RGD Ensembl Show fit	olfactory receptor 96
chr5_-_137584608 Show fit	12.90	ENSRNOT00000051470	LOC100911100 NCBI RGD Ensembl Show fit	olfactory receptor 2A2-like
chr7_+_82338663 Show fit	12.83	ENSRNOT00000006890	Emc2 NCBI RGD Ensembl Show fit	ER membrane protein complex subunit 2
chr1_+_42170583 Show fit	12.78	ENSRNOT00000093104	Vip NCBI RGD Ensembl Show fit	vasoactive intestinal peptide
chr2_-_89498395 Show fit	12.72	ENSRNOT00000068507	AABR07009224.1 NCBI RGD Ensembl Show fit
chr7_-_70480724 Show fit	12.59	ENSRNOT00000090057	Dtx3 NCBI RGD Ensembl Show fit	deltex E3 ubiquitin ligase 3
chr17_-_63994169 Show fit	12.52	ENSRNOT00000075651	Chrm3 NCBI RGD Ensembl Show fit	cholinergic receptor, muscarinic 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Ezh2_Atf2_Ikzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
24.0	168.2	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
22.1	66.3	GO:0003365	establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
22.0	66.0	GO:1990926	short-term synaptic potentiation(GO:1990926)
18.1	108.3	GO:0099526	presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
14.2	56.8	GO:1904009	cellular response to monosodium glutamate(GO:1904009)
12.7	89.2	GO:0060075	regulation of resting membrane potential(GO:0060075)
11.2	134.6	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
9.6	9.6	GO:0051643	endoplasmic reticulum localization(GO:0051643)
9.0	54.0	GO:0033564	anterior/posterior axon guidance(GO:0033564)
8.6	25.9	GO:0033693	neurofilament bundle assembly(GO:0033693)
8.5	34.2	GO:0098961	dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
8.5	42.3	GO:0097332	response to antipsychotic drug(GO:0097332)
8.4	92.3	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
8.3	41.4	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
8.1	64.4	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
8.0	31.8	GO:0043179	rhythmic excitation(GO:0043179)
7.9	23.6	GO:2000688	positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
7.7	84.2	GO:0007258	JUN phosphorylation(GO:0007258)
7.6	22.7	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
7.5	60.3	GO:0090273	regulation of somatostatin secretion(GO:0090273)
7.4	29.7	GO:1903288	positive regulation of potassium ion import(GO:1903288)
7.4	51.8	GO:0099645	protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
7.2	86.2	GO:0046548	retinal rod cell development(GO:0046548)
6.9	48.0	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
6.7	13.4	GO:1905244	regulation of modification of synaptic structure(GO:1905244)
6.7	67.0	GO:0016198	axon choice point recognition(GO:0016198)
6.0	18.0	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
5.8	23.3	GO:0071896	protein localization to adherens junction(GO:0071896)
5.8	40.4	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
5.7	17.2	GO:0014826	vein smooth muscle contraction(GO:0014826)
5.5	32.9	GO:0021759	globus pallidus development(GO:0021759)
5.5	43.9	GO:0008065	establishment of blood-nerve barrier(GO:0008065)
5.5	16.4	GO:0097168	mesenchymal stem cell proliferation(GO:0097168)
5.4	32.7	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
5.3	10.7	GO:0060300	regulation of cytokine activity(GO:0060300)
5.0	20.0	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
5.0	29.8	GO:0071313	cellular response to caffeine(GO:0071313)
4.9	44.5	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
4.9	24.4	GO:0061743	motor learning(GO:0061743)
4.8	14.3	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
4.7	14.1	GO:0001928	regulation of exocyst assembly(GO:0001928)
4.6	18.5	GO:0043490	malate-aspartate shuttle(GO:0043490)
4.6	13.7	GO:1904700	granulosa cell apoptotic process(GO:1904700) regulation of granulosa cell apoptotic process(GO:1904708)
4.5	62.6	GO:0005513	detection of calcium ion(GO:0005513)
4.5	22.3	GO:0060594	mammary gland specification(GO:0060594)
4.5	13.4	GO:0014846	esophagus smooth muscle contraction(GO:0014846)
4.4	48.8	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
4.4	31.0	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
4.1	12.4	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
4.1	12.4	GO:0060447	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) bud outgrowth involved in lung branching(GO:0060447) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
4.1	32.9	GO:0061193	taste bud development(GO:0061193)
4.0	24.2	GO:0047484	regulation of response to osmotic stress(GO:0047484)
4.0	16.1	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
3.9	15.8	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
3.9	43.2	GO:0070327	thyroid hormone transport(GO:0070327)
3.9	54.8	GO:0071420	cellular response to histamine(GO:0071420)
3.9	58.7	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
3.9	15.6	GO:1900827	positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
3.8	11.4	GO:0032972	regulation of muscle filament sliding speed(GO:0032972)
3.7	14.9	GO:0061622	glycolytic process through glucose-1-phosphate(GO:0061622)
3.7	11.0	GO:0042489	negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
3.5	21.3	GO:0002091	negative regulation of receptor internalization(GO:0002091)
3.5	31.5	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
3.5	7.0	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
3.4	37.2	GO:0071315	cellular response to morphine(GO:0071315)
3.3	30.1	GO:0060406	positive regulation of penile erection(GO:0060406)
3.3	19.9	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
3.1	9.4	GO:0097298	regulation of nucleus size(GO:0097298)
3.1	25.0	GO:0070842	aggresome assembly(GO:0070842)
3.1	9.3	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
3.1	98.5	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
3.1	9.2	GO:0060066	oviduct development(GO:0060066)
3.0	9.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
3.0	30.0	GO:0021540	corpus callosum morphogenesis(GO:0021540)
3.0	17.8	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
2.9	87.9	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
2.9	8.8	GO:0032053	ciliary basal body organization(GO:0032053)
2.9	14.3	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
2.7	8.2	GO:0032423	regulation of mismatch repair(GO:0032423)
2.7	16.3	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
2.7	8.0	GO:2000567	memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.7	74.9	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
2.7	8.0	GO:0021678	third ventricle development(GO:0021678)
2.5	10.1	GO:0001692	histamine metabolic process(GO:0001692)
2.5	15.0	GO:0097039	protein linear polyubiquitination(GO:0097039)
2.5	55.0	GO:0060992	response to fungicide(GO:0060992)
2.5	12.5	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
2.5	27.2	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.5	24.7	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
2.4	7.3	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
2.4	16.9	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
2.4	7.2	GO:1902269	positive regulation of polyamine transmembrane transport(GO:1902269)
2.4	48.1	GO:0032292	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
2.4	42.8	GO:0001573	ganglioside metabolic process(GO:0001573)
2.4	4.7	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
2.3	13.8	GO:0099525	presynaptic dense core granule exocytosis(GO:0099525)
2.3	13.8	GO:0021553	olfactory nerve development(GO:0021553)
2.3	9.1	GO:0072092	ureteric bud invasion(GO:0072092)
2.2	6.6	GO:0031959	mineralocorticoid receptor signaling pathway(GO:0031959)
2.2	4.3	GO:2000468	regulation of peroxidase activity(GO:2000468)
2.1	16.9	GO:0046958	nonassociative learning(GO:0046958)
2.1	38.0	GO:0031643	positive regulation of myelination(GO:0031643)
2.1	10.3	GO:0030205	dermatan sulfate metabolic process(GO:0030205)
1.9	7.6	GO:0097069	cellular response to thyroxine stimulus(GO:0097069)
1.8	9.1	GO:0042264	peptidyl-aspartic acid hydroxylation(GO:0042264)
1.8	10.8	GO:2000551	regulation of T-helper 2 cell cytokine production(GO:2000551)
1.8	3.6	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
1.8	28.4	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
1.7	17.4	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.7	6.9	GO:0010157	response to chlorate(GO:0010157)
1.7	18.8	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
1.7	6.8	GO:1902951	negative regulation of dendritic spine maintenance(GO:1902951)
1.7	23.2	GO:0060134	prepulse inhibition(GO:0060134)
1.6	3.3	GO:2000017	regulation of determination of dorsal identity(GO:2000015) positive regulation of determination of dorsal identity(GO:2000017)
1.6	6.5	GO:0001880	Mullerian duct regression(GO:0001880)
1.6	3.2	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
1.5	1.5	GO:0050915	sensory perception of sour taste(GO:0050915)
1.5	6.1	GO:0050955	negative regulation of translational elongation(GO:0045900) thermoception(GO:0050955)
1.5	18.2	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
1.5	11.9	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.5	11.7	GO:0060484	lung-associated mesenchyme development(GO:0060484)
1.5	26.3	GO:0006020	inositol metabolic process(GO:0006020)
1.4	14.4	GO:0070837	dehydroascorbic acid transport(GO:0070837)
1.4	11.5	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
1.4	4.2	GO:0042494	detection of bacterial lipoprotein(GO:0042494)
1.4	5.6	GO:0003166	bundle of His development(GO:0003166)
1.4	15.4	GO:0006527	arginine catabolic process(GO:0006527)
1.4	4.2	GO:0015755	fructose transport(GO:0015755)
1.4	6.9	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
1.4	1.4	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
1.3	5.3	GO:2000698	glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.3	13.3	GO:0048739	cardiac muscle fiber development(GO:0048739)
1.3	9.3	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
1.3	6.4	GO:0035063	nuclear speck organization(GO:0035063)
1.3	3.8	GO:0098939	dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
1.3	5.0	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.2	3.7	GO:0090247	cell motility involved in somitogenic axis elongation(GO:0090247) regulation of cell motility involved in somitogenic axis elongation(GO:0090249)
1.2	29.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
1.2	7.3	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
1.2	168.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.2	2.4	GO:0045105	intermediate filament polymerization or depolymerization(GO:0045105)
1.2	4.7	GO:1903527	positive regulation of membrane tubulation(GO:1903527)
1.2	82.0	GO:0055013	cardiac muscle cell development(GO:0055013)
1.2	3.5	GO:0042335	cuticle development(GO:0042335)
1.1	12.5	GO:0060012	synaptic transmission, glycinergic(GO:0060012)
1.1	21.3	GO:0048714	positive regulation of oligodendrocyte differentiation(GO:0048714)
1.1	15.5	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
1.1	3.3	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.1	9.8	GO:0070257	positive regulation of mucus secretion(GO:0070257)
1.1	4.3	GO:1902856	negative regulation of nonmotile primary cilium assembly(GO:1902856)
1.1	12.8	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
1.1	9.6	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
1.0	3.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.0	19.7	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
1.0	1.0	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
1.0	6.8	GO:0009838	abscission(GO:0009838)
1.0	20.2	GO:0035641	locomotory exploration behavior(GO:0035641)
1.0	10.6	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
1.0	2.9	GO:0016094	polyprenol biosynthetic process(GO:0016094)
0.9	2.8	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.9	7.5	GO:0051013	microtubule severing(GO:0051013)
0.9	4.6	GO:0008078	mesodermal cell migration(GO:0008078) establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.9	5.5	GO:0042989	sequestering of actin monomers(GO:0042989)
0.9	9.1	GO:0090331	negative regulation of platelet aggregation(GO:0090331)
0.9	4.5	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.9	8.0	GO:0051255	spindle midzone assembly(GO:0051255)
0.9	4.4	GO:0050957	equilibrioception(GO:0050957)
0.9	7.0	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.9	47.4	GO:0007040	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.8	3.4	GO:0046338	phosphatidylethanolamine catabolic process(GO:0046338)
0.8	73.5	GO:0032091	negative regulation of protein binding(GO:0032091)
0.8	2.5	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.8	7.5	GO:0051775	response to redox state(GO:0051775)
0.8	4.2	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.8	4.9	GO:1990928	response to amino acid starvation(GO:1990928)
0.8	5.7	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.8	4.8	GO:0036438	maintenance of lens transparency(GO:0036438)
0.8	5.5	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.8	14.2	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.8	29.1	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.8	17.3	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.8	6.2	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.8	3.1	GO:0009597	detection of virus(GO:0009597)
0.8	5.3	GO:0060017	parathyroid gland development(GO:0060017)
0.8	25.6	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.7	3.7	GO:0000454	snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.7	4.5	GO:0071000	response to magnetism(GO:0071000)
0.7	11.9	GO:0016048	detection of temperature stimulus(GO:0016048)
0.7	1.5	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.7	11.9	GO:0045793	positive regulation of cell size(GO:0045793)
0.7	8.0	GO:0046929	negative regulation of neurotransmitter secretion(GO:0046929)
0.7	4.4	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.7	9.4	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.7	3.6	GO:1904179	osteoblast fate commitment(GO:0002051) positive regulation of adipose tissue development(GO:1904179)
0.7	5.7	GO:1904424	regulation of GTP binding(GO:1904424)
0.7	3.5	GO:0044860	protein localization to plasma membrane raft(GO:0044860) protein transport into plasma membrane raft(GO:0044861)
0.7	10.5	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.7	1.4	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of smooth muscle cell chemotaxis(GO:0071672)
0.7	10.3	GO:0071801	regulation of podosome assembly(GO:0071801)
0.7	2.7	GO:0051660	establishment of centrosome localization(GO:0051660)
0.7	5.3	GO:0090261	positive regulation of inclusion body assembly(GO:0090261)
0.7	6.6	GO:0051764	actin crosslink formation(GO:0051764)
0.7	2.6	GO:1905049	negative regulation of metallopeptidase activity(GO:1905049)
0.7	3.9	GO:0042045	epithelial fluid transport(GO:0042045)
0.6	5.2	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.6	19.6	GO:0007628	adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.6	19.6	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.6	14.1	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.6	6.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.6	4.1	GO:0048664	neuron fate determination(GO:0048664)
0.6	4.0	GO:0042148	strand invasion(GO:0042148)
0.6	5.0	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.6	6.7	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.5	3.8	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.5	3.2	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.5	1.1	GO:0007172	signal complex assembly(GO:0007172)
0.5	2.6	GO:0060005	vestibular reflex(GO:0060005)
0.5	10.4	GO:0010107	potassium ion import(GO:0010107)
0.5	18.8	GO:0048747	muscle fiber development(GO:0048747)
0.5	13.4	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.5	45.4	GO:0035308	negative regulation of protein dephosphorylation(GO:0035308)
0.5	19.6	GO:0042220	response to cocaine(GO:0042220)
0.5	3.0	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.5	4.9	GO:0042761	very long-chain fatty acid biosynthetic process(GO:0042761)
0.5	1.4	GO:0035262	gonad morphogenesis(GO:0035262)
0.5	10.9	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.5	1.9	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.5	16.8	GO:0048663	neuron fate commitment(GO:0048663)
0.5	1.4	GO:0031989	bombesin receptor signaling pathway(GO:0031989)
0.5	22.7	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.5	5.4	GO:0051382	kinetochore assembly(GO:0051382)
0.4	0.9	GO:0002481	antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.4	6.8	GO:0010669	epithelial structure maintenance(GO:0010669)
0.4	2.5	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.4	10.4	GO:0017004	cytochrome complex assembly(GO:0017004)
0.4	8.7	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.4	2.5	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442)
0.4	15.2	GO:0050885	neuromuscular process controlling balance(GO:0050885)
0.4	1.2	GO:0097084	vascular smooth muscle cell development(GO:0097084)
0.4	0.4	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.4	4.9	GO:0006086	acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.4	7.4	GO:0008542	visual learning(GO:0008542)
0.4	3.7	GO:0044804	nucleophagy(GO:0044804)
0.4	2.8	GO:2000811	negative regulation of anoikis(GO:2000811)
0.3	2.7	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.3	1.0	GO:0071031	nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.3	1.6	GO:0022007	neural plate morphogenesis(GO:0001839) neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.3	5.6	GO:0090161	Golgi ribbon formation(GO:0090161)
0.3	5.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.3	2.5	GO:0016926	protein desumoylation(GO:0016926)
0.3	0.9	GO:0000958	mitochondrial mRNA catabolic process(GO:0000958) positive regulation of mitochondrial RNA catabolic process(GO:0000962)
0.3	4.5	GO:0071625	vocalization behavior(GO:0071625)
0.3	13.8	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.3	1.5	GO:0021903	rostrocaudal neural tube patterning(GO:0021903)
0.3	0.9	GO:0019086	late viral transcription(GO:0019086)
0.3	3.2	GO:0006390	transcription from mitochondrial promoter(GO:0006390)
0.3	1.3	GO:0021936	regulation of cerebellar granule cell precursor proliferation(GO:0021936)
0.3	9.3	GO:0021762	substantia nigra development(GO:0021762)
0.3	30.9	GO:0097485	neuron projection guidance(GO:0097485)
0.3	9.0	GO:0016239	positive regulation of macroautophagy(GO:0016239)
0.2	1.2	GO:0090168	Golgi reassembly(GO:0090168)
0.2	1.4	GO:0051418	interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.2	0.5	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.2	1.6	GO:0006824	cobalt ion transport(GO:0006824)
0.2	1.7	GO:0009642	response to light intensity(GO:0009642)
0.2	0.4	GO:0021626	hindbrain maturation(GO:0021578) cerebellum maturation(GO:0021590) central nervous system maturation(GO:0021626) cerebellar cortex maturation(GO:0021699)
0.2	1.1	GO:0048254	snoRNA localization(GO:0048254)
0.2	3.2	GO:0042574	retinal metabolic process(GO:0042574)
0.2	1.4	GO:0010815	bradykinin catabolic process(GO:0010815)
0.2	0.4	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2	1.1	GO:0051036	regulation of endosome size(GO:0051036)
0.2	5.8	GO:0030199	collagen fibril organization(GO:0030199)
0.2	1.7	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.2	2.3	GO:0001502	cartilage condensation(GO:0001502)
0.2	2.7	GO:0019236	response to pheromone(GO:0019236)
0.2	6.1	GO:0090263	positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.2	1.8	GO:0006228	UTP biosynthetic process(GO:0006228)
0.2	8.1	GO:0051290	protein heterotetramerization(GO:0051290)
0.2	5.1	GO:0006270	DNA replication initiation(GO:0006270)
0.2	2.5	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2	3.9	GO:0000729	DNA double-strand break processing(GO:0000729)
0.1	0.3	GO:1903054	negative regulation of extracellular matrix organization(GO:1903054)
0.1	3.0	GO:0030239	myofibril assembly(GO:0030239)
0.1	1.3	GO:0007000	nucleolus organization(GO:0007000)
0.1	1.9	GO:0051601	exocyst localization(GO:0051601)
0.1	0.9	GO:0019388	galactose catabolic process(GO:0019388)
0.1	4.4	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
0.1	0.3	GO:0002118	aggressive behavior(GO:0002118)
0.1	2.9	GO:0030032	lamellipodium assembly(GO:0030032)
0.1	11.4	GO:0007631	feeding behavior(GO:0007631)
0.1	4.4	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1	3.7	GO:0031032	actomyosin structure organization(GO:0031032)
0.1	0.9	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1	12.1	GO:0050808	synapse organization(GO:0050808)
0.1	3.4	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.1	1.6	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.1	3.0	GO:0002446	neutrophil mediated immunity(GO:0002446)
0.1	20.8	GO:0007015	actin filament organization(GO:0007015)
0.1	1.7	GO:0050974	detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1	0.6	GO:0032288	myelin assembly(GO:0032288)
0.1	0.9	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.1	0.4	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1	2.8	GO:0046579	positive regulation of Ras protein signal transduction(GO:0046579)
0.1	0.3	GO:0015838	amino-acid betaine transport(GO:0015838)
0.1	0.9	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.1	1.2	GO:0043982	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1	1.3	GO:0006221	pyrimidine nucleotide biosynthetic process(GO:0006221)
0.1	2.7	GO:1990090	cellular response to nerve growth factor stimulus(GO:1990090)
0.1	2.6	GO:0000186	activation of MAPKK activity(GO:0000186)
0.1	6.8	GO:0016358	dendrite development(GO:0016358)
0.1	0.5	GO:0046085	adenosine metabolic process(GO:0046085)
0.1	0.9	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	7.3	GO:0006813	potassium ion transport(GO:0006813)
0.0	0.9	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.5	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.4	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0	0.4	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.4	GO:0045879	negative regulation of smoothened signaling pathway(GO:0045879)
0.0	1.8	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)
0.0	1.0	GO:0070286	axonemal dynein complex assembly(GO:0070286)
0.0	0.7	GO:0045494	photoreceptor cell maintenance(GO:0045494)
0.0	0.5	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.4	GO:0031424	keratinization(GO:0031424)
0.0	0.3	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.9	GO:0022900	electron transport chain(GO:0022900)
0.0	0.3	GO:0030488	tRNA methylation(GO:0030488)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
39.4	197.2	GO:0099569	presynaptic cytoskeleton(GO:0099569)
23.5	141.0	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
19.3	115.7	GO:0044308	axonal spine(GO:0044308)
16.6	49.8	GO:0034686	integrin alphav-beta8 complex(GO:0034686)
12.5	99.8	GO:0032584	growth cone membrane(GO:0032584)
11.6	69.5	GO:0033269	internode region of axon(GO:0033269)
10.9	109.3	GO:0098839	postsynaptic density membrane(GO:0098839)
10.4	62.6	GO:0042584	chromaffin granule membrane(GO:0042584)
8.5	25.6	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
7.9	31.8	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
6.4	64.4	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
6.4	57.4	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
6.0	24.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
5.0	115.7	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
5.0	59.6	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
5.0	14.9	GO:0005945	6-phosphofructokinase complex(GO:0005945)
4.8	96.6	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
4.6	18.4	GO:0098831	presynaptic active zone cytoplasmic component(GO:0098831)
4.5	54.5	GO:0043083	synaptic cleft(GO:0043083)
4.5	18.0	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
4.5	13.4	GO:0098837	postsynaptic recycling endosome(GO:0098837)
4.4	39.8	GO:0030314	junctional membrane complex(GO:0030314)
4.2	12.5	GO:0098982	glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
3.9	15.7	GO:1990584	cardiac Troponin complex(GO:1990584)
3.9	27.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
3.6	58.3	GO:0005883	neurofilament(GO:0005883)
3.3	9.8	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
3.0	15.0	GO:0071797	LUBAC complex(GO:0071797)
3.0	32.5	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
2.8	30.9	GO:0044327	dendritic spine head(GO:0044327)
2.5	82.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
2.4	47.1	GO:0043194	axon initial segment(GO:0043194)
2.3	34.2	GO:0035253	ciliary rootlet(GO:0035253)
2.2	17.3	GO:0043203	axon hillock(GO:0043203)
2.0	14.3	GO:0071438	invadopodium membrane(GO:0071438)
2.0	73.3	GO:0032809	neuronal cell body membrane(GO:0032809)
2.0	8.1	GO:0097513	myosin II filament(GO:0097513)
2.0	371.3	GO:0043204	perikaryon(GO:0043204)
2.0	13.8	GO:0044305	calyx of Held(GO:0044305)
2.0	21.6	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
1.9	15.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
1.8	16.5	GO:0031209	SCAR complex(GO:0031209)
1.8	68.6	GO:0008180	COP9 signalosome(GO:0008180)
1.7	17.1	GO:0042788	polysomal ribosome(GO:0042788)
1.6	8.0	GO:0032133	chromosome passenger complex(GO:0032133)
1.5	4.6	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
1.3	5.3	GO:0071914	prominosome(GO:0071914)
1.3	14.4	GO:0072546	ER membrane protein complex(GO:0072546)
1.3	6.5	GO:0005927	muscle tendon junction(GO:0005927)
1.3	7.6	GO:0044294	dendritic growth cone(GO:0044294)
1.2	20.4	GO:0036038	MKS complex(GO:0036038)
1.1	27.4	GO:0060077	inhibitory synapse(GO:0060077)
1.1	5.4	GO:0033588	Elongator holoenzyme complex(GO:0033588)
1.1	43.9	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
1.0	12.5	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
1.0	6.1	GO:1990246	uniplex complex(GO:1990246)
1.0	4.0	GO:0070876	SOSS complex(GO:0070876)
1.0	6.8	GO:0090543	Flemming body(GO:0090543)
1.0	14.3	GO:0042734	presynaptic membrane(GO:0042734)
0.9	69.4	GO:0044291	cell-cell contact zone(GO:0044291)
0.9	10.6	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.9	9.6	GO:0032982	myosin filament(GO:0032982)
0.9	5.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.8	22.9	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.8	10.8	GO:0032839	dendrite cytoplasm(GO:0032839)
0.8	23.0	GO:0097228	sperm principal piece(GO:0097228)
0.8	7.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.7	3.7	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.7	10.4	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.7	20.7	GO:0043034	costamere(GO:0043034)
0.7	73.0	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.7	194.4	GO:0060076	excitatory synapse(GO:0060076)
0.7	7.0	GO:0034704	calcium channel complex(GO:0034704)
0.7	2.7	GO:1990745	GARP complex(GO:0000938) EARP complex(GO:1990745)
0.7	79.5	GO:0044306	neuron projection terminus(GO:0044306)
0.7	5.3	GO:0031595	nuclear proteasome complex(GO:0031595)
0.7	3.3	GO:0048179	activin receptor complex(GO:0048179)
0.6	1.9	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006)
0.6	10.6	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.6	6.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.6	178.3	GO:0030424	axon(GO:0030424)
0.6	24.5	GO:0043197	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.6	5.8	GO:0046581	intercellular canaliculus(GO:0046581)
0.5	1.6	GO:1990923	PET complex(GO:1990923)
0.5	4.2	GO:0016589	NURF complex(GO:0016589)
0.5	31.6	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.5	8.3	GO:0031430	M band(GO:0031430)
0.5	4.9	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.5	1.9	GO:0098592	cytoplasmic side of apical plasma membrane(GO:0098592)
0.5	12.3	GO:0002080	acrosomal membrane(GO:0002080)
0.5	1.4	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.5	44.1	GO:0031225	anchored component of membrane(GO:0031225)
0.5	0.9	GO:0045025	mitochondrial degradosome(GO:0045025)
0.4	6.6	GO:0035102	PRC1 complex(GO:0035102)
0.4	11.1	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.4	30.8	GO:0000118	histone deacetylase complex(GO:0000118)
0.4	2.5	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.4	47.9	GO:0005795	Golgi stack(GO:0005795)
0.4	3.2	GO:0005610	laminin-5 complex(GO:0005610)
0.4	13.2	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.4	3.6	GO:0030131	clathrin adaptor complex(GO:0030131) filopodium tip(GO:0032433)
0.4	0.4	GO:0030478	actin cap(GO:0030478)
0.4	2.3	GO:0005726	perichromatin fibrils(GO:0005726)
0.4	22.2	GO:0030018	Z disc(GO:0030018)
0.4	4.5	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4	11.2	GO:0002102	podosome(GO:0002102)
0.4	26.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4	10.4	GO:0030315	T-tubule(GO:0030315)
0.4	2.5	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.3	16.7	GO:0045171	intercellular bridge(GO:0045171)
0.3	15.6	GO:0016592	mediator complex(GO:0016592)
0.3	0.9	GO:0032398	MHC class Ib protein complex(GO:0032398)
0.3	33.4	GO:0030027	lamellipodium(GO:0030027)
0.3	5.5	GO:0001917	photoreceptor inner segment(GO:0001917)
0.3	37.0	GO:0043209	myelin sheath(GO:0043209)
0.3	14.4	GO:0005884	actin filament(GO:0005884)
0.3	4.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.3	2.8	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.2	4.0	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.2	11.2	GO:0045211	postsynaptic membrane(GO:0045211)
0.2	3.7	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.2	44.8	GO:0043025	neuronal cell body(GO:0043025)
0.2	1.5	GO:0070449	elongin complex(GO:0070449)
0.2	9.5	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.2	2.0	GO:0070652	HAUS complex(GO:0070652)
0.2	3.7	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.2	1.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.2	33.4	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.2	0.6	GO:0032593	insulin-responsive compartment(GO:0032593)
0.2	13.0	GO:0005814	centriole(GO:0005814)
0.1	16.8	GO:0001650	fibrillar center(GO:0001650)
0.1	7.0	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	1.0	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.1	0.9	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1	0.8	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)
0.1	2.8	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1	1.3	GO:0034709	methylosome(GO:0034709)
0.1	2.4	GO:0005839	proteasome core complex(GO:0005839)
0.1	1.3	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.1	7.6	GO:0005923	bicellular tight junction(GO:0005923)
0.1	2.7	GO:0031519	PcG protein complex(GO:0031519)
0.1	1.0	GO:0045277	respiratory chain complex IV(GO:0045277)
0.1	2.6	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	1.2	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.4	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0	0.8	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	2.5	GO:0000794	condensed nuclear chromosome(GO:0000794)
0.0	0.3	GO:0016459	myosin complex(GO:0016459)
0.0	1.0	GO:0031252	cell leading edge(GO:0031252)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
42.0	168.2	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
18.3	55.0	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
16.2	64.7	GO:0035727	lysophosphatidic acid binding(GO:0035727)
16.1	64.4	GO:0070699	type II activin receptor binding(GO:0070699)
15.4	77.1	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
13.3	66.4	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
13.3	66.3	GO:0043532	angiostatin binding(GO:0043532)
12.8	64.0	GO:0008502	melatonin receptor activity(GO:0008502)
12.5	62.6	GO:0030348	syntaxin-3 binding(GO:0030348)
12.3	98.2	GO:0022842	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
10.8	54.0	GO:0005042	netrin receptor activity(GO:0005042)
10.7	42.7	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
10.3	71.8	GO:0004111	creatine kinase activity(GO:0004111)
8.8	26.3	GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827)
8.4	84.2	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
6.3	18.8	GO:0030158	protein xylosyltransferase activity(GO:0030158)
6.2	49.8	GO:1990430	extracellular matrix protein binding(GO:1990430)
6.0	181.1	GO:0017075	syntaxin-1 binding(GO:0017075)
5.4	43.2	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
5.3	15.9	GO:0072590	N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
5.1	15.4	GO:0016403	dimethylargininase activity(GO:0016403)
5.1	20.3	GO:0008940	nitrate reductase activity(GO:0008940)
5.0	89.7	GO:0005522	profilin binding(GO:0005522)
4.9	39.5	GO:0022851	GABA-gated chloride ion channel activity(GO:0022851)
4.9	58.7	GO:0019911	structural constituent of myelin sheath(GO:0019911)
4.8	14.4	GO:0033222	xylose binding(GO:0033222)
4.8	14.4	GO:0042015	interleukin-20 binding(GO:0042015)
4.2	76.3	GO:0004890	GABA-A receptor activity(GO:0004890)
4.2	16.9	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
4.2	12.5	GO:0022852	glycine-gated chloride ion channel activity(GO:0022852)
4.1	32.9	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
3.9	110.3	GO:0005540	hyaluronic acid binding(GO:0005540)
3.9	15.7	GO:0030172	troponin C binding(GO:0030172)
3.7	14.9	GO:0003872	6-phosphofructokinase activity(GO:0003872)
3.7	18.5	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
3.6	86.7	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
3.6	96.6	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
3.5	31.5	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
3.4	17.2	GO:0004962	endothelin receptor activity(GO:0004962)
3.4	10.3	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
3.4	34.2	GO:0034190	apolipoprotein receptor binding(GO:0034190)
3.4	10.1	GO:0098603	selenol Se-methyltransferase activity(GO:0098603)
3.3	13.4	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
3.3	19.9	GO:0019158	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
3.3	13.2	GO:0048763	ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
3.3	16.4	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
3.2	31.8	GO:0098988	G-protein coupled glutamate receptor activity(GO:0098988)
2.9	26.3	GO:0043559	insulin binding(GO:0043559)
2.9	14.3	GO:0015252	hydrogen ion channel activity(GO:0015252)
2.8	16.8	GO:0001515	opioid peptide activity(GO:0001515)
2.7	32.8	GO:0004000	adenosine deaminase activity(GO:0004000)
2.7	172.6	GO:0005080	protein kinase C binding(GO:0005080)
2.7	8.0	GO:0044736	acid-sensing ion channel activity(GO:0044736)
2.6	15.6	GO:0001849	complement component C1q binding(GO:0001849)
2.6	59.4	GO:0002162	dystroglycan binding(GO:0002162)
2.5	10.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
2.5	12.5	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
2.5	14.8	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
2.4	7.2	GO:0015489	polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489) ornithine decarboxylase activator activity(GO:0042978)
2.4	32.9	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
2.3	7.0	GO:0031852	mu-type opioid receptor binding(GO:0031852)
2.3	6.8	GO:0023030	MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
2.2	6.7	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
2.2	15.2	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
2.1	29.7	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
2.0	13.7	GO:0043237	laminin-1 binding(GO:0043237)
2.0	27.5	GO:0051371	muscle alpha-actinin binding(GO:0051371)
1.9	24.2	GO:0098919	structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
1.8	5.4	GO:0008607	phosphorylase kinase regulator activity(GO:0008607) H3 histone acetyltransferase activity(GO:0010484)
1.8	38.8	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.7	12.0	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
1.7	6.8	GO:0042610	CD8 receptor binding(GO:0042610)
1.7	6.7	GO:0019870	potassium channel inhibitor activity(GO:0019870)
1.6	11.4	GO:0045503	dynein light chain binding(GO:0045503)
1.6	14.5	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.6	41.8	GO:0005184	neuropeptide hormone activity(GO:0005184)
1.6	1.6	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
1.6	8.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
1.6	1.6	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
1.6	7.9	GO:0004969	histamine receptor activity(GO:0004969)
1.6	18.9	GO:0019869	chloride channel inhibitor activity(GO:0019869)
1.5	10.8	GO:0016413	O-acetyltransferase activity(GO:0016413)
1.5	44.5	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
1.5	26.0	GO:0071617	lysophospholipid acyltransferase activity(GO:0071617)
1.5	4.4	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
1.4	12.6	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.4	28.4	GO:0005123	death receptor binding(GO:0005123)
1.3	10.7	GO:0036122	BMP binding(GO:0036122)
1.3	46.4	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
1.2	4.9	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
1.2	7.3	GO:0004144	2-acylglycerol O-acyltransferase activity(GO:0003846) diacylglycerol O-acyltransferase activity(GO:0004144)
1.2	4.8	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
1.2	9.4	GO:0030274	LIM domain binding(GO:0030274)
1.2	29.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.2	25.6	GO:0003746	translation elongation factor activity(GO:0003746)
1.2	5.8	GO:0090555	phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
1.1	4.5	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
1.1	6.6	GO:0035374	chondroitin sulfate binding(GO:0035374)
1.1	19.7	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.1	3.2	GO:0030337	DNA polymerase processivity factor activity(GO:0030337)
1.1	9.5	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
1.0	3.0	GO:0051373	FATZ binding(GO:0051373)
1.0	3.9	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.9	25.8	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.9	9.8	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.9	5.3	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.8	39.5	GO:0030544	Hsp70 protein binding(GO:0030544)
0.8	7.1	GO:0015266	protein channel activity(GO:0015266)
0.8	27.7	GO:0017080	sodium channel regulator activity(GO:0017080)
0.8	3.9	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.8	2.3	GO:0000703	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.8	6.9	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.8	12.1	GO:0035174	histone serine kinase activity(GO:0035174)
0.7	10.7	GO:0031005	filamin binding(GO:0031005)
0.7	2.8	GO:1904288	BAT3 complex binding(GO:1904288)
0.7	7.0	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.7	4.2	GO:1990239	steroid hormone binding(GO:1990239)
0.7	4.0	GO:0000150	recombinase activity(GO:0000150)
0.7	7.9	GO:0042809	vitamin D receptor binding(GO:0042809)
0.6	11.0	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.6	5.1	GO:0045545	syndecan binding(GO:0045545)
0.6	7.6	GO:0033691	sialic acid binding(GO:0033691)
0.6	5.0	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.6	5.0	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.6	10.4	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.6	90.3	GO:0051015	actin filament binding(GO:0051015)
0.6	10.6	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6	17.1	GO:0030371	translation repressor activity(GO:0030371)
0.6	6.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.5	3.3	GO:0016361	activin receptor activity, type I(GO:0016361)
0.5	4.9	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.5	13.9	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.5	5.9	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.5	5.8	GO:0050811	GABA receptor binding(GO:0050811)
0.5	14.3	GO:0030507	spectrin binding(GO:0030507)
0.5	15.6	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.5	7.5	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.5	7.9	GO:0001594	trace-amine receptor activity(GO:0001594)
0.5	1.4	GO:0004946	bombesin receptor activity(GO:0004946)
0.5	11.4	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.5	2.3	GO:0042731	PH domain binding(GO:0042731)
0.4	24.0	GO:0032947	protein complex scaffold(GO:0032947)
0.4	32.5	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.4	131.0	GO:0015631	tubulin binding(GO:0015631)
0.4	3.4	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.4	2.5	GO:0003923	GPI-anchor transamidase activity(GO:0003923) GPI anchor binding(GO:0034235)
0.4	4.2	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4	3.7	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.4	11.6	GO:0019894	kinesin binding(GO:0019894)
0.4	4.7	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.4	46.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.4	5.4	GO:0033038	bitter taste receptor activity(GO:0033038)
0.4	1.5	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.4	16.5	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.3	1.5	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3	1.4	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.3	5.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.3	2.6	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.3	3.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3	24.7	GO:0008565	protein transporter activity(GO:0008565)
0.3	0.8	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2	2.5	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.2	25.4	GO:0005516	calmodulin binding(GO:0005516)
0.2	1.2	GO:0071253	connexin binding(GO:0071253)
0.2	0.9	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.2	1.7	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2	5.3	GO:0042805	actinin binding(GO:0042805)
0.2	5.5	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.2	4.6	GO:0048365	Rac GTPase binding(GO:0048365)
0.2	2.4	GO:0019215	intermediate filament binding(GO:0019215)
0.2	2.9	GO:0004659	prenyltransferase activity(GO:0004659)
0.2	0.9	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.2	0.9	GO:0097322	7SK snRNA binding(GO:0097322)
0.2	39.7	GO:0005096	GTPase activator activity(GO:0005096)
0.2	2.2	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2	14.6	GO:0030165	PDZ domain binding(GO:0030165)
0.2	1.1	GO:0008432	JUN kinase binding(GO:0008432)
0.1	2.6	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1	1.1	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.1	2.8	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.1	10.6	GO:0044325	ion channel binding(GO:0044325)
0.1	1.5	GO:0008527	taste receptor activity(GO:0008527)
0.1	0.5	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	1.2	GO:0043995	histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1	6.8	GO:0003743	translation initiation factor activity(GO:0003743)
0.1	0.8	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1	3.1	GO:0005484	SNAP receptor activity(GO:0005484)
0.1	2.5	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.1	6.3	GO:0008013	beta-catenin binding(GO:0008013)
0.1	2.6	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	0.3	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1	11.3	GO:0005179	hormone activity(GO:0005179)
0.1	3.7	GO:0004601	peroxidase activity(GO:0004601)
0.1	2.4	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	0.6	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1	4.1	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1	7.6	GO:0016503	pheromone receptor activity(GO:0016503)
0.1	0.8	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.1	2.4	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	1.3	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	1.2	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.1	0.5	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1	1.8	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1	2.1	GO:0070888	E-box binding(GO:0070888)
0.0	0.4	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	1.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	7.3	GO:0008168	methyltransferase activity(GO:0008168)
0.0	0.8	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	1.5	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.4	GO:0016594	glycine binding(GO:0016594)
0.0	1.0	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	2.3	GO:0005262	calcium channel activity(GO:0005262)
0.0	0.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.5	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	1.4	GO:0016836	hydro-lyase activity(GO:0016836)
0.0	1.2	GO:0030145	manganese ion binding(GO:0030145)
0.0	1.0	GO:0003678	DNA helicase activity(GO:0003678)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.6	163.8	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
2.6	112.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
2.6	33.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
2.4	60.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
2.3	79.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
2.2	116.5	PID EPHB FWD PATHWAY	EPHB forward signaling
1.5	44.8	PID REELIN PATHWAY	Reelin signaling pathway
1.0	9.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
1.0	49.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.9	15.1	PID NECTIN PATHWAY	Nectin adhesion pathway
0.9	13.8	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.8	9.8	PID ALK2 PATHWAY	ALK2 signaling events
0.8	10.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.8	15.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.8	15.9	ST GA13 PATHWAY	G alpha 13 Pathway
0.8	47.4	PID LKB1 PATHWAY	LKB1 signaling events
0.7	28.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.7	7.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.6	13.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.6	4.4	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.5	10.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.5	13.3	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.5	17.4	PID FGF PATHWAY	FGF signaling pathway
0.4	9.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.4	7.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.4	8.3	PID ARF 3PATHWAY	Arf1 pathway
0.4	5.4	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.4	8.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.4	8.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.4	9.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.4	23.1	PID AP1 PATHWAY	AP-1 transcription factor network
0.3	3.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.3	2.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	9.1	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.2	3.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	8.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	13.6	PID NOTCH PATHWAY	Notch signaling pathway
0.2	40.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	3.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	1.9	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	0.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	5.0	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	5.7	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	1.4	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	1.4	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.1	PID PLK1 PATHWAY	PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
12.4	223.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
9.2	128.7	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
6.8	114.9	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
5.4	53.9	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
5.3	84.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
3.6	106.6	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
3.4	119.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
3.4	71.6	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
3.1	70.8	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
2.9	35.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
2.8	8.4	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
2.6	39.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
2.4	16.8	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
2.3	44.5	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
2.1	29.5	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
1.7	31.8	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.5	22.7	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
1.5	11.9	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
1.3	30.1	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
1.3	12.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
1.2	13.4	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
1.2	33.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
1.2	18.8	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
1.2	14.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
1.2	19.9	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.9	11.8	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.9	11.7	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.8	62.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.8	14.1	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.8	10.8	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.7	20.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.7	9.9	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.7	15.5	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.6	10.5	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.6	6.8	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6	23.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.6	5.8	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.6	21.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	21.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.5	20.0	REACTOME ION CHANNEL TRANSPORT	Genes involved in Ion channel transport
0.5	9.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.5	12.0	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.5	23.3	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.5	8.6	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.4	22.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.4	3.4	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.4	20.3	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.4	14.6	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.4	3.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.3	10.3	REACTOME KINESINS	Genes involved in Kinesins
0.3	7.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.3	4.9	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	4.5	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.3	7.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.3	12.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.3	5.7	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.3	8.0	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.3	2.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.3	7.1	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.2	9.9	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	3.1	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2	10.7	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	13.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	2.3	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2	3.6	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.2	3.2	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	4.9	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.2	2.3	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.1	3.0	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	7.7	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.1	11.5	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
0.1	3.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	1.4	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1	3.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	3.6	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	1.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	1.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	1.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	2.3	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.0	2.6	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.8	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	5.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.4	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Results for Ezh2_Atf2_Ikzf1

Z-value: 1.77

Motif logo

Transcription factors associated with Ezh2_Atf2_Ikzf1

Activity-expression correlation:

Activity profile of Ezh2_Atf2_Ikzf1 motif

Sorted Z-values of Ezh2_Atf2_Ikzf1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ezh2_Atf2_Ikzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: