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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Fosb

Z-value: 0.47

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Transcription factors associated with Fosb

Gene Symbol Gene ID Gene Info
Fosb
ENSRNOG00000046667 FosB proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Fosbrn6_v1_chr1_-_80221710_80221710-0.172.3e-03Click!

Activity profile of Fosb motif

Sorted Z-values of Fosb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_81821127 9.78 ENSRNOT00000058199
Fbxo15
F-box protein 15
chr15_-_77736892 7.98 ENSRNOT00000057924
Pcdh9
protocadherin 9
chr1_-_199395363 7.42 ENSRNOT00000090368
ENSRNOT00000026587
Prss36
protease, serine, 36
chr20_+_3558827 7.31 ENSRNOT00000088130
Ddr1
discoidin domain receptor tyrosine kinase 1
chr2_-_149417212 7.21 ENSRNOT00000018573
Gpr87
G protein-coupled receptor 87
chr1_+_20332371 7.06 ENSRNOT00000037259
Tmem200a
transmembrane protein 200A
chr12_-_2568382 6.91 ENSRNOT00000035142
Lrrc8e
leucine rich repeat containing 8 family, member E
chr2_-_178297172 6.14 ENSRNOT00000038543
Fnip2
folliculin interacting protein 2
chr2_+_144861455 6.13 ENSRNOT00000093284
ENSRNOT00000019748
ENSRNOT00000072110
Dclk1
doublecortin-like kinase 1
chr14_+_104250617 5.90 ENSRNOT00000079874
Spred2
sprouty-related, EVH1 domain containing 2
chrX_-_142248369 5.83 ENSRNOT00000091330
Fgf13
fibroblast growth factor 13
chr2_-_186480278 5.78 ENSRNOT00000031743
Kirrel
kin of IRRE like (Drosophila)
chr1_+_221236773 5.57 ENSRNOT00000051979
Slc25a45
solute carrier family 25, member 45
chr1_-_31122093 5.19 ENSRNOT00000016712
NEWGENE_1307525
SOGA family member 3
chr2_-_28799266 4.91 ENSRNOT00000089293
Tmem171
transmembrane protein 171
chr4_-_157294047 4.88 ENSRNOT00000005601
Eno2
enolase 2
chr19_+_52077501 4.85 ENSRNOT00000079240
Osgin1
oxidative stress induced growth inhibitor 1
chr9_+_20251521 4.66 ENSRNOT00000005535
LOC100911625
gamma-enolase-like
chr8_+_5676665 4.61 ENSRNOT00000012310
Mmp3
matrix metallopeptidase 3
chr19_+_52077109 4.50 ENSRNOT00000020225
Osgin1
oxidative stress induced growth inhibitor 1
chr14_+_2892753 4.32 ENSRNOT00000061630
Evi5
ecotropic viral integration site 5
chr14_-_21127868 4.15 ENSRNOT00000020608
ENSRNOT00000092172
Rufy3
RUN and FYVE domain containing 3
chr15_-_34444244 3.86 ENSRNOT00000027612
Cideb
cell death-inducing DFFA-like effector b
chr3_+_110442637 3.43 ENSRNOT00000010471
Pak6
p21 (RAC1) activated kinase 6
chr1_-_256813711 2.61 ENSRNOT00000021055
Rbp4
retinol binding protein 4
chr1_-_142197182 2.61 ENSRNOT00000015521
Furin
furin (paired basic amino acid cleaving enzyme)
chr19_+_41631715 2.39 ENSRNOT00000022749
Chst4
carbohydrate sulfotransferase 4
chr13_+_51384389 2.29 ENSRNOT00000087025
Kdm5b
lysine demethylase 5B
chr20_+_5040337 2.24 ENSRNOT00000068435
Clic1
chloride intracellular channel 1
chr6_-_71199110 1.93 ENSRNOT00000081883
Prkd1
protein kinase D1
chr7_+_23854846 1.87 ENSRNOT00000037290
Bpifc
BPI fold containing family C
chr10_-_88152064 1.87 ENSRNOT00000019477
Krt16
keratin 16
chr20_-_3419831 1.80 ENSRNOT00000046798
Mdc1
mediator of DNA damage checkpoint 1
chr10_-_90312386 1.69 ENSRNOT00000028445
Slc4a1
solute carrier family 4 member 1
chr6_-_107678156 1.32 ENSRNOT00000014158
Elmsan1
ELM2 and Myb/SANT domain containing 1
chr8_+_5522739 1.24 ENSRNOT00000011507
Mmp13
matrix metallopeptidase 13
chr20_+_25990304 1.23 ENSRNOT00000033980
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr4_-_119148358 1.23 ENSRNOT00000012218
Gkn1
gastrokine 1
chr1_+_220826560 1.23 ENSRNOT00000027891
Fosl1
FOS like 1, AP-1 transcription factor subunit
chr4_+_176994129 1.22 ENSRNOT00000018734
Cmas
cytidine monophosphate N-acetylneuraminic acid synthetase
chr20_+_25990656 1.03 ENSRNOT00000081254
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_+_22964230 0.90 ENSRNOT00000041813
LOC100362149
ribosomal protein S20-like
chr1_+_218466289 0.67 ENSRNOT00000017948
Mrgprf
MAS related GPR family member F
chr8_+_5703206 0.65 ENSRNOT00000012595
Mmp1
matrix metallopeptidase 1
chr13_+_90533365 0.51 ENSRNOT00000082469
Dcaf8
DDB1 and CUL4 associated factor 8
chr10_-_71382058 0.44 ENSRNOT00000043148
Dusp14
dual specificity phosphatase 14
chr2_+_204886202 0.41 ENSRNOT00000022200
Ngf
nerve growth factor
chr5_+_135687538 0.36 ENSRNOT00000091664
AC126292.2

chr15_+_61692116 0.35 ENSRNOT00000071455
Kbtbd6
kelch repeat and BTB domain containing 6
chr5_-_16706909 0.32 ENSRNOT00000011314
Rps20
ribosomal protein S20
chr18_+_35249137 0.14 ENSRNOT00000017489
LOC100910942
serine protease inhibitor Kazal-type 6-like
chr10_-_87232723 0.11 ENSRNOT00000015150
Krt25
keratin 25
chr9_-_17206994 0.04 ENSRNOT00000026195
Gtpbp2
GTP binding protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Fosb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.6 GO:0000066 mitochondrial ornithine transport(GO:0000066)
1.1 9.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.9 2.6 GO:0046864 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.9 2.6 GO:2000645 negative regulation of neurotrophin production(GO:0032900) nerve growth factor production(GO:0032902) negative regulation of receptor catabolic process(GO:2000645)
0.8 5.8 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.7 7.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.7 4.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.6 7.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.6 2.4 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.6 2.3 GO:2000861 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.3 1.7 GO:0010037 response to carbon dioxide(GO:0010037)
0.3 1.9 GO:0089700 protein kinase D signaling(GO:0089700)
0.3 5.9 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.3 1.2 GO:0007296 vitellogenesis(GO:0007296)
0.2 1.2 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.2 0.6 GO:0071283 cellular response to iron(III) ion(GO:0071283)
0.2 2.3 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.2 4.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 6.1 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 3.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.9 GO:0051546 keratinocyte migration(GO:0051546)
0.1 5.8 GO:0007588 excretion(GO:0007588)
0.1 0.4 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.1 4.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 6.1 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 9.1 GO:0044070 regulation of anion transport(GO:0044070)
0.0 7.8 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 9.8 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 3.4 GO:0007613 memory(GO:0007613)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 8.0 GO:0030900 forebrain development(GO:0030900)
0.0 0.0 GO:0072344 rescue of stalled ribosome(GO:0072344)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 4.2 GO:0071437 invadopodium(GO:0071437)
0.1 9.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 13.5 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 2.6 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 1.9 GO:0000421 autophagosome membrane(GO:0000421)
0.1 5.8 GO:0043198 dendritic shaft(GO:0043198)
0.1 3.9 GO:0005811 lipid particle(GO:0005811)
0.0 5.9 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.4 GO:0001650 fibrillar center(GO:0001650)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.2 GO:0072562 blood microparticle(GO:0072562)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.0 GO:0014069 postsynaptic density(GO:0014069)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.1 GO:0034702 ion channel complex(GO:0034702)
0.0 2.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.0 7.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.9 6.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.8 5.9 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.7 5.6 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.6 7.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5 6.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.4 2.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.4 2.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.2 2.6 GO:0019841 retinol binding(GO:0019841)
0.2 2.6 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 2.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 5.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 1.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.4 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.1 1.9 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.7 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.1 5.8 GO:0017022 myosin binding(GO:0017022)
0.1 10.6 GO:0008083 growth factor activity(GO:0008083)
0.1 6.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 7.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 3.4 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 4.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 9.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 5.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.9 PID IGF1 PATHWAY IGF1 pathway
0.1 5.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.3 PID AURORA B PATHWAY Aurora B signaling
0.1 3.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 3.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.8 PID ATM PATHWAY ATM pathway
0.0 1.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 5.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 4.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.8 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides