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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxc2

Z-value: 1.19

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Transcription factors associated with Foxc2

Gene Symbol Gene ID Gene Info
Foxc2
ENSRNOG00000047446 forkhead box C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxc2rn6_v1_chr19_+_53044379_53044379-0.091.1e-01Click!

Activity profile of Foxc2 motif

Sorted Z-values of Foxc2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_225283326 133.04 ENSRNOT00000027342
Scgb1a1
secretoglobin family 1A member 1
chr3_+_149624712 80.19 ENSRNOT00000018581
Bpifa1
BPI fold containing family A, member 1
chr20_-_31598118 71.24 ENSRNOT00000046537
Col13a1
collagen type XIII alpha 1 chain
chr2_+_208749996 46.39 ENSRNOT00000086321
Chia
chitinase, acidic
chr2_+_208750356 46.30 ENSRNOT00000041562
Chia
chitinase, acidic
chr7_-_143523457 40.66 ENSRNOT00000012943
ENSRNOT00000082264
Krt4
keratin 4
chr4_-_115239723 40.17 ENSRNOT00000042699
Actg2
actin, gamma 2, smooth muscle, enteric
chr20_-_31597830 40.00 ENSRNOT00000085877
Col13a1
collagen type XIII alpha 1 chain
chr18_+_68408890 31.39 ENSRNOT00000039702
Ccdc68
coiled-coil domain containing 68
chr18_+_3887419 27.74 ENSRNOT00000093089
Lama3
laminin subunit alpha 3
chr9_-_55256340 26.90 ENSRNOT00000028907
Sdpr
serum deprivation response
chr7_+_58814805 24.21 ENSRNOT00000005909
Tspan8
tetraspanin 8
chr8_+_58431407 22.83 ENSRNOT00000011974
Sln
sarcolipin
chr16_+_50181316 21.55 ENSRNOT00000077662
F11
coagulation factor XI
chr15_-_95514259 21.43 ENSRNOT00000038433
Slitrk6
SLIT and NTRK-like family, member 6
chr4_-_176528110 20.94 ENSRNOT00000049569
Slco1a2
solute carrier organic anion transporter family, member 1A2
chr13_-_44540516 19.99 ENSRNOT00000005244
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr3_+_162357356 15.27 ENSRNOT00000030119
Eya2
EYA transcriptional coactivator and phosphatase 2
chr2_-_3124543 12.51 ENSRNOT00000036547
Fam81b
family with sequence similarity 81, member B
chr16_-_23156962 12.40 ENSRNOT00000018543
Sh2d4a
SH2 domain containing 4A
chr2_-_233743866 11.83 ENSRNOT00000087062
Enpep
glutamyl aminopeptidase
chr4_+_21462779 11.71 ENSRNOT00000089747
Grm3
glutamate metabotropic receptor 3
chr4_-_15505362 11.55 ENSRNOT00000009763
Hgf
hepatocyte growth factor
chr7_+_142877086 11.40 ENSRNOT00000088730
Grasp
general receptor for phosphoinositides 1 associated scaffold protein
chr7_-_107392972 11.02 ENSRNOT00000093425
Tmem71
transmembrane protein 71
chr11_-_45124423 10.39 ENSRNOT00000046383
Filip1l
filamin A interacting protein 1-like
chr20_+_29655226 9.57 ENSRNOT00000089059
Spock2
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
chr6_-_78549669 9.50 ENSRNOT00000009940
Foxa1
forkhead box A1
chr1_-_267203986 9.44 ENSRNOT00000027574
Sh3pxd2a
SH3 and PX domains 2A
chr1_-_156327352 8.23 ENSRNOT00000074282
LOC100911776
coiled-coil domain-containing protein 89-like
chr18_-_70924708 8.20 ENSRNOT00000025257
Lipg
lipase G, endothelial type
chr1_+_154606490 8.03 ENSRNOT00000024095
Ccdc89
coiled-coil domain containing 89
chr9_+_51298426 7.85 ENSRNOT00000065212
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr2_-_172361779 7.66 ENSRNOT00000085876
Schip1
schwannomin interacting protein 1
chr9_+_118849302 7.38 ENSRNOT00000087592
Dlgap1
DLG associated protein 1
chr10_-_103687425 7.38 ENSRNOT00000039284
Cd300lf
Cd300 molecule-like family member F
chr4_+_139670092 7.31 ENSRNOT00000008879
Lrrn1
leucine rich repeat neuronal 1
chr3_-_63535991 6.52 ENSRNOT00000015722
Fkbp7
FK506 binding protein 7
chr4_+_62221011 6.20 ENSRNOT00000041264
Cald1
caldesmon 1
chr1_+_227592635 6.16 ENSRNOT00000072135
Ms4a4a
membrane-spanning 4-domains, subfamily A, member 4A
chr3_-_160038078 6.15 ENSRNOT00000013445
Serinc3
serine incorporator 3
chr1_-_89269930 6.02 ENSRNOT00000028532
Ffar2
free fatty acid receptor 2
chr5_+_124690214 5.84 ENSRNOT00000011237
Plpp3
phospholipid phosphatase 3
chr2_+_145174876 5.71 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chr4_+_14070553 5.70 ENSRNOT00000077505
Cd36
CD36 molecule
chr2_-_30634243 5.56 ENSRNOT00000077537
Marveld2
MARVEL domain containing 2
chr4_+_62220736 4.88 ENSRNOT00000086377
Cald1
caldesmon 1
chr2_-_5577369 4.55 ENSRNOT00000093420
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr8_-_61595032 4.52 ENSRNOT00000023428
Snx33
sorting nexin 33
chr9_-_82345262 3.61 ENSRNOT00000024975
Cnppd1
cyclin Pas1/PHO80 domain containing 1
chr2_+_143475323 2.84 ENSRNOT00000044028
ENSRNOT00000015437
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr20_+_46429222 2.63 ENSRNOT00000076818
Foxo3
forkhead box O3
chr8_-_55402711 2.59 ENSRNOT00000091732
Sik2
salt-inducible kinase 2
chr2_-_258997138 2.58 ENSRNOT00000045020
ENSRNOT00000042256
Adgrl2
adhesion G protein-coupled receptor L2
chr4_+_41364441 2.53 ENSRNOT00000087146
Foxp2
forkhead box P2
chr18_-_5314511 2.28 ENSRNOT00000022637
ENSRNOT00000079682
Zfp521
zinc finger protein 521
chr10_-_95434688 2.21 ENSRNOT00000074809
AABR07030603.1

chr5_+_103251986 1.89 ENSRNOT00000008757
Cntln
centlein
chr15_+_24942218 1.75 ENSRNOT00000016629
Peli2
pellino E3 ubiquitin protein ligase family member 2
chr11_-_11585078 1.25 ENSRNOT00000088878
Robo2
roundabout guidance receptor 2
chr13_+_78979321 0.99 ENSRNOT00000003857
Ankrd45
ankyrin repeat domain 45
chr18_-_69671199 0.97 ENSRNOT00000082484
Smad4
SMAD family member 4
chr16_+_27399467 0.79 ENSRNOT00000065642
Tll1
tolloid-like 1
chr10_+_105393072 0.75 ENSRNOT00000013359
Ubald2
UBA-like domain containing 2
chr6_-_51257625 0.68 ENSRNOT00000012004
Hbp1
HMG-box transcription factor 1
chr17_-_21739408 0.68 ENSRNOT00000060335
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr4_+_62380914 0.68 ENSRNOT00000029845
Tmem140
transmembrane protein 140
chr7_-_114848414 0.68 ENSRNOT00000032620
Slc45a4
solute carrier family 45, member 4
chr3_-_60023913 0.44 ENSRNOT00000064662
Cir1
corepressor interacting with RBPJ, 1
chr14_+_20266891 0.36 ENSRNOT00000004174
Gc
group specific component
chr5_+_50381244 0.23 ENSRNOT00000012385
Cga
glycoprotein hormones, alpha polypeptide
chr13_-_78521911 0.11 ENSRNOT00000087506
Rabgap1l
RAB GTPase activating protein 1-like
chr16_+_2634603 0.02 ENSRNOT00000019113
Hesx1
HESX homeobox 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxc2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
33.3 133.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
18.5 92.7 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
16.0 80.2 GO:0050828 regulation of liquid surface tension(GO:0050828)
8.0 40.2 GO:0090131 mesenchyme migration(GO:0090131)
4.3 21.4 GO:0060005 vestibular reflex(GO:0060005)
3.3 22.8 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
3.1 111.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
3.1 21.6 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
2.9 11.6 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
2.7 8.2 GO:0010986 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
2.5 7.4 GO:1902214 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
2.4 11.8 GO:0002003 angiotensin maturation(GO:0002003)
1.9 5.8 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330)
1.9 9.5 GO:0061144 prostate gland stromal morphogenesis(GO:0060741) alveolar secondary septum development(GO:0061144)
1.7 15.3 GO:0016576 histone dephosphorylation(GO:0016576)
1.6 9.4 GO:0072675 osteoclast fusion(GO:0072675)
1.5 6.2 GO:0009597 detection of virus(GO:0009597)
1.5 6.0 GO:0002752 leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
1.5 27.7 GO:0031581 hemidesmosome assembly(GO:0031581)
1.2 9.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.1 11.7 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.9 5.7 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.9 7.4 GO:0070842 aggresome assembly(GO:0070842)
0.8 9.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 24.2 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.5 4.5 GO:0036089 cleavage furrow formation(GO:0036089) macropinocytosis(GO:0044351)
0.5 1.0 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.4 2.6 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.4 7.7 GO:0008210 estrogen metabolic process(GO:0008210)
0.3 4.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 2.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 1.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 40.0 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.2 0.7 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 1.8 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 1.9 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 7.8 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 6.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.7 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 2.8 GO:0014051 manganese ion transport(GO:0006828) gamma-aminobutyric acid secretion(GO:0014051)
0.1 10.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 5.6 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 11.1 GO:0032092 positive regulation of protein binding(GO:0032092)
0.1 9.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 3.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.4 GO:0042359 vitamin D metabolic process(GO:0042359)
0.0 0.7 GO:0032369 negative regulation of lipid transport(GO:0032369) negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.0 1.4 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.0 0.2 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 27.7 GO:0005608 laminin-3 complex(GO:0005608)
2.7 40.2 GO:0032982 myosin filament(GO:0032982)
1.8 11.1 GO:0030478 actin cap(GO:0030478)
1.4 108.4 GO:0005581 collagen trimer(GO:0005581)
1.1 133.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
1.1 5.6 GO:0061689 tricellular tight junction(GO:0061689)
0.8 11.8 GO:0031983 vesicle lumen(GO:0031983)
0.8 89.7 GO:0005902 microvillus(GO:0005902)
0.7 11.7 GO:0097449 astrocyte projection(GO:0097449)
0.7 22.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 26.6 GO:0031526 brush border membrane(GO:0031526)
0.3 22.8 GO:0045095 keratin filament(GO:0045095)
0.3 29.7 GO:0005901 caveola(GO:0005901)
0.2 9.4 GO:0002102 podosome(GO:0002102)
0.2 1.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.1 9.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 96.7 GO:0005615 extracellular space(GO:0005615)
0.1 1.2 GO:0030673 axolemma(GO:0030673)
0.1 12.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 29.1 GO:0009986 cell surface(GO:0009986)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 4.5 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
26.6 133.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
15.4 92.7 GO:0004568 chitinase activity(GO:0004568)
3.9 11.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
2.6 20.9 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.9 5.8 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
1.8 7.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
1.8 21.6 GO:0070008 serine-type exopeptidase activity(GO:0070008)
1.4 8.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.1 5.7 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.0 11.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.9 9.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.6 11.6 GO:0042056 chemoattractant activity(GO:0042056)
0.6 110.1 GO:0008201 heparin binding(GO:0008201)
0.6 4.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.6 7.4 GO:0098919 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.5 11.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.5 6.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.5 6.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 26.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 9.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.7 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 24.2 GO:0005178 integrin binding(GO:0005178)
0.2 2.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 0.7 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 11.1 GO:0017022 myosin binding(GO:0017022)
0.1 86.4 GO:0008289 lipid binding(GO:0008289)
0.1 1.0 GO:0043199 sulfate binding(GO:0043199)
0.1 1.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 2.5 GO:0050681 androgen receptor binding(GO:0050681)
0.1 17.9 GO:0000287 magnesium ion binding(GO:0000287)
0.1 2.6 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 10.5 GO:0019902 phosphatase binding(GO:0019902)
0.0 30.7 GO:0005198 structural molecule activity(GO:0005198)
0.0 22.3 GO:0030234 enzyme regulator activity(GO:0030234)
0.0 2.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 19.1 GO:0005524 ATP binding(GO:0005524)
0.0 5.1 GO:0008134 transcription factor binding(GO:0008134)
0.0 3.6 GO:0019901 protein kinase binding(GO:0019901)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 141.9 PID HNF3A PATHWAY FOXA1 transcription factor network
2.5 122.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
1.7 27.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.8 40.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 9.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 7.6 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.0 PID ALK2 PATHWAY ALK2 signaling events
0.0 2.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 20.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
1.9 112.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
1.9 51.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
1.0 21.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.8 11.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.5 11.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 27.7 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.2 2.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 1.8 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 5.7 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 6.0 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones