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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxd2

Z-value: 0.95

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Transcription factors associated with Foxd2

Gene Symbol Gene ID Gene Info
Foxd2
ENSRNOG00000007759 forkhead box D2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxd2rn6_v1_chr5_-_133709712_1337097120.302.6e-08Click!

Activity profile of Foxd2 motif

Sorted Z-values of Foxd2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_95501778 64.03 ENSRNOT00000086805
Spp2
secreted phosphoprotein 2
chr19_+_15081590 35.17 ENSRNOT00000024187
Ces1f
carboxylesterase 1F
chr19_+_15081158 34.37 ENSRNOT00000074070
Ces1f
carboxylesterase 1F
chr7_-_30105132 34.28 ENSRNOT00000091227
Nr1h4
nuclear receptor subfamily 1, group H, member 4
chr4_-_176294997 33.91 ENSRNOT00000015112
ENSRNOT00000051461
ENSRNOT00000000026
ENSRNOT00000039877
ENSRNOT00000049303
Slc21a4
kidney specific organic anion transporter
chr14_+_85113578 32.79 ENSRNOT00000011158
Nipsnap1
nipsnap homolog 1
chr1_-_253000760 30.47 ENSRNOT00000030024
Slc16a12
solute carrier family 16, member 12
chr6_+_80188943 24.64 ENSRNOT00000059335
Mia2
melanoma inhibitory activity 2
chr6_-_127620296 21.70 ENSRNOT00000012577
Serpina1
serpin family A member 1
chr10_+_3411380 20.70 ENSRNOT00000004346
RGD1305733
similar to RIKEN cDNA 2900011O08
chr2_+_235264219 20.69 ENSRNOT00000086245
Cfi
complement factor I
chr6_-_127508452 19.29 ENSRNOT00000073709
LOC100909524
protein Z-dependent protease inhibitor-like
chr2_-_187706300 18.54 ENSRNOT00000092349
ENSRNOT00000026414
Tmem79
transmembrane protein 79
chr16_+_50181316 18.19 ENSRNOT00000077662
F11
coagulation factor XI
chr1_-_76780230 18.18 ENSRNOT00000002046
LOC100912485
alcohol sulfotransferase-like
chr7_+_34326087 17.65 ENSRNOT00000006971
Hal
histidine ammonia lyase
chr7_-_143793970 16.02 ENSRNOT00000016205
Csad
cysteine sulfinic acid decarboxylase
chr8_-_21901829 15.92 ENSRNOT00000027963
Angptl6
angiopoietin-like 6
chr3_-_134696654 15.71 ENSRNOT00000006454
Flrt3
fibronectin leucine rich transmembrane protein 3
chr13_+_91080341 15.27 ENSRNOT00000000058
Crp
C-reactive protein
chr7_-_2677199 14.40 ENSRNOT00000043908
Apon
apolipoprotein N
chr15_-_44627765 14.15 ENSRNOT00000058887
Dock5
dedicator of cytokinesis 5
chr2_-_63166509 14.08 ENSRNOT00000018246
Cdh6
cadherin 6
chr1_-_189181901 13.74 ENSRNOT00000092022
Gp2
glycoprotein 2
chr15_-_77736892 13.42 ENSRNOT00000057924
Pcdh9
protocadherin 9
chr3_-_2453933 13.26 ENSRNOT00000014060
Slc34a3
solute carrier family 34 member 3
chr15_-_52320385 12.39 ENSRNOT00000067776
Dmtn
dematin actin binding protein
chr7_-_143523457 12.26 ENSRNOT00000012943
ENSRNOT00000082264
Krt4
keratin 4
chr20_+_20519031 12.09 ENSRNOT00000000780
AABR07044783.1

chr8_-_127900463 11.90 ENSRNOT00000078303
Slc22a13
solute carrier family 22 member 13
chrX_-_63807810 11.44 ENSRNOT00000084632
Maged1
MAGE family member D1
chr2_+_54466280 11.34 ENSRNOT00000033112
C6
complement C6
chr4_-_28437676 11.34 ENSRNOT00000012995
Hepacam2
HEPACAM family member 2
chr18_+_3900714 10.98 ENSRNOT00000092814
Lama3
laminin subunit alpha 3
chr3_-_12155098 10.85 ENSRNOT00000082696
Garnl3
GTPase activating Rap/RanGAP domain-like 3
chr3_-_66885085 10.48 ENSRNOT00000084299
ENSRNOT00000090547
Pde1a
phosphodiesterase 1A
chr10_-_70788309 10.47 ENSRNOT00000029184
Ccl9
chemokine (C-C motif) ligand 9
chr2_+_27905535 9.32 ENSRNOT00000022120
Fam169a
family with sequence similarity 169, member A
chr7_+_73273985 9.26 ENSRNOT00000077730
Pop1
POP1 homolog, ribonuclease P/MRP subunit
chr7_+_76092503 9.00 ENSRNOT00000079692
Grhl2
grainyhead-like transcription factor 2
chr8_-_54990604 8.90 ENSRNOT00000059192
Tex12
testis expressed 12
chr20_+_27592379 8.87 ENSRNOT00000047000
Trappc3l
trafficking protein particle complex 3-like
chr4_-_85915099 8.72 ENSRNOT00000016182
Neurod6
neuronal differentiation 6
chr3_-_48831417 8.46 ENSRNOT00000009920
ENSRNOT00000085246
Kcnh7
potassium voltage-gated channel subfamily H member 7
chr14_-_42560174 8.40 ENSRNOT00000003128
Tmem33
transmembrane protein 33
chr17_-_77527894 8.06 ENSRNOT00000032173
Bend7
BEN domain containing 7
chr19_+_38669230 7.88 ENSRNOT00000027273
Cdh3
cadherin 3
chr1_+_185356975 7.70 ENSRNOT00000086681
Plekha7
pleckstrin homology domain containing A7
chr17_-_51912496 7.57 ENSRNOT00000019272
Inhba
inhibin beta A subunit
chr18_-_77579969 7.46 ENSRNOT00000034896
Sall3
spalt-like transcription factor 3
chr5_+_116421894 7.26 ENSRNOT00000080577
ENSRNOT00000086628
ENSRNOT00000004017
Nfia
nuclear factor I/A
chr10_+_71546977 7.11 ENSRNOT00000041140
Acaca
acetyl-CoA carboxylase alpha
chr5_-_28131133 6.96 ENSRNOT00000067331
Slc26a7
solute carrier family 26 member 7
chr2_+_143475323 6.94 ENSRNOT00000044028
ENSRNOT00000015437
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr19_-_44101365 6.65 ENSRNOT00000082182
Tmem170a
transmembrane protein 170A
chr2_+_204427608 6.61 ENSRNOT00000083374
Nhlh2
nescient helix loop helix 2
chr20_+_18833481 6.32 ENSRNOT00000080846
Bicc1
BicC family RNA binding protein 1
chr17_-_21705773 6.25 ENSRNOT00000078010
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr5_-_33664435 6.23 ENSRNOT00000009047
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr10_+_83154423 6.08 ENSRNOT00000005939
Fam117a
family with sequence similarity 117, member A
chr4_+_108301129 5.98 ENSRNOT00000007993
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr4_+_35279063 5.89 ENSRNOT00000011833
Nxph1
neurexophilin 1
chr5_+_103251986 5.81 ENSRNOT00000008757
Cntln
centlein
chr1_-_67065797 5.72 ENSRNOT00000048152
Vom1r46
vomeronasal 1 receptor 46
chr2_-_191294374 5.70 ENSRNOT00000067469
RGD1562234
similar to S100 calcium-binding protein, ventral prostate
chr8_+_14060394 5.57 ENSRNOT00000014827
Smco4
single-pass membrane protein with coiled-coil domains 4
chr4_-_2201749 5.37 ENSRNOT00000089327
Lmbr1
limb development membrane protein 1
chr17_-_10622226 5.29 ENSRNOT00000044559
Simc1
SUMO-interacting motifs containing 1
chr15_-_60752106 5.13 ENSRNOT00000058148
Akap11
A-kinase anchoring protein 11
chr17_+_81455955 5.11 ENSRNOT00000044313
Slc39a12
solute carrier family 39 member 12
chr15_+_62406873 5.06 ENSRNOT00000047572
Olfm4
olfactomedin 4
chr9_+_73493027 5.00 ENSRNOT00000074427
ENSRNOT00000089478
Unc80
unc-80 homolog, NALCN activator
chr4_+_57034675 4.97 ENSRNOT00000080223
Smo
smoothened, frizzled class receptor
chr11_-_1983513 4.89 ENSRNOT00000000907
Htr1f
5-hydroxytryptamine receptor 1F
chr1_+_243276403 4.86 ENSRNOT00000021496
Kank1
KN motif and ankyrin repeat domains 1
chr17_-_66295014 4.84 ENSRNOT00000023974
Mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
chr9_-_28732919 4.66 ENSRNOT00000083915
Rims1
regulating synaptic membrane exocytosis 1
chr15_+_87886783 4.58 ENSRNOT00000065710
Slain1
SLAIN motif family, member 1
chr2_-_186232292 4.56 ENSRNOT00000087088
Dclk2
doublecortin-like kinase 2
chr8_+_82038967 4.40 ENSRNOT00000079535
Myo5a
myosin VA
chr4_+_31333970 4.26 ENSRNOT00000064866
LOC100911994
coiled-coil domain-containing protein 132-like
chr8_+_61671513 4.18 ENSRNOT00000091128
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr18_+_30581530 4.16 ENSRNOT00000048166
Pcdhb20
protocadherin beta 20
chr3_-_78066123 4.15 ENSRNOT00000073165
Olr690
olfactory receptor 690
chr7_-_55604403 4.12 ENSRNOT00000088732
Atxn7l3b
ataxin 7-like 3B
chr7_-_26983172 3.93 ENSRNOT00000089545
Txnrd1
thioredoxin reductase 1
chr5_-_128333805 3.84 ENSRNOT00000037523
Zfyve9
zinc finger FYVE-type containing 9
chr7_+_51794173 3.82 ENSRNOT00000043774
Otogl
otogelin-like
chr2_+_110306363 3.67 ENSRNOT00000040463
LOC499584
LRRGT00202
chr15_-_86142672 3.63 ENSRNOT00000057830
Commd6
COMM domain containing 6
chr1_+_53874860 3.60 ENSRNOT00000090486
Tcte2
t-complex-associated testis expressed 2
chr5_+_71742911 3.51 ENSRNOT00000047225
Zfp462
zinc finger protein 462
chr10_-_56465393 3.36 ENSRNOT00000056860
Tnk1
tyrosine kinase, non-receptor, 1
chr14_-_114649173 3.12 ENSRNOT00000083528
Sptbn1
spectrin, beta, non-erythrocytic 1
chr9_-_30844199 3.01 ENSRNOT00000017169
Col19a1
collagen type XIX alpha 1 chain
chr9_+_73418607 2.93 ENSRNOT00000092547
Map2
microtubule-associated protein 2
chr18_+_15856801 2.92 ENSRNOT00000071548
Zfp397
zinc finger protein 397
chr17_+_45199178 2.92 ENSRNOT00000080047
Zscan26
zinc finger and SCAN domain containing 26
chr6_+_43234526 2.91 ENSRNOT00000086808
Asap2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr14_-_5006594 2.91 ENSRNOT00000076571
Zfp326
zinc finger protein 326
chr5_+_16463597 2.90 ENSRNOT00000091550
AABR07047036.1

chr5_+_60850852 2.90 ENSRNOT00000016720
Trmt10b
tRNA methyltransferase 10B
chr2_-_250923744 2.88 ENSRNOT00000084996
Clca1
chloride channel accessory 1
chr3_+_119354904 2.74 ENSRNOT00000046977
LOC100363112
Aa2-296-like
chr14_+_34455934 2.68 ENSRNOT00000085991
ENSRNOT00000002981
Clock
clock circadian regulator
chrX_-_111179152 2.56 ENSRNOT00000089115
Morc4
MORC family CW-type zinc finger 4
chr4_+_67359531 2.46 ENSRNOT00000013277
ENSRNOT00000082241
Adck2
aarF domain containing kinase 2
chr4_-_29778039 2.12 ENSRNOT00000074177
Sgce
sarcoglycan, epsilon
chr1_+_167719947 2.08 ENSRNOT00000024971
Olr43
olfactory receptor 43
chr1_-_275882444 2.05 ENSRNOT00000083215
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chrX_+_40460047 2.05 ENSRNOT00000010970
Phex
phosphate regulating endopeptidase homolog, X-linked
chr18_+_30587872 1.98 ENSRNOT00000040016
Pcdhb21
protocadherin beta 21
chr19_-_41161765 1.95 ENSRNOT00000023117
Hydin
Hydin, axonemal central pair apparatus protein
chr7_+_117773948 1.91 ENSRNOT00000021673
Lrrc14
leucine rich repeat containing 14
chrX_-_153878806 1.79 ENSRNOT00000087990
Aff2
AF4/FMR2 family, member 2
chr17_-_53688966 1.75 ENSRNOT00000078643
LOC100912163
AT-rich interactive domain-containing protein 4B-like
chr5_+_5616483 1.74 ENSRNOT00000011026
Ncoa2
nuclear receptor coactivator 2
chr8_-_21453190 1.65 ENSRNOT00000078192
Zfp26
zinc finger protein 26
chr8_-_19527513 1.63 ENSRNOT00000008594
Olr1147
olfactory receptor 1147
chr13_+_68707776 1.61 ENSRNOT00000003558
ENSRNOT00000087997
Ivns1abp
influenza virus NS1A binding protein
chr1_+_203524426 1.60 ENSRNOT00000028020
Bub3
BUB3 mitotic checkpoint protein
chr1_+_150225373 1.55 ENSRNOT00000051266
Olr30
olfactory receptor 30
chrX_+_105419285 1.52 ENSRNOT00000015518
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr19_-_44211208 1.25 ENSRNOT00000026309
Adat1
adenosine deaminase, tRNA-specific 1
chr3_+_75987796 1.24 ENSRNOT00000091187
Olr594
olfactory receptor 594
chr17_-_34945317 1.23 ENSRNOT00000090457
Vma21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr1_+_225120061 1.23 ENSRNOT00000026875
B3gat3
beta-1,3-glucuronyltransferase 3
chr7_-_91756865 1.21 ENSRNOT00000041268
LOC100363319
high mobility group nucleosomal binding domain 2
chr14_+_45033309 1.21 ENSRNOT00000002933
Tlr6
toll-like receptor 6
chr6_-_125853461 1.17 ENSRNOT00000007505
Atxn3
ataxin 3
chr14_-_34172893 1.15 ENSRNOT00000090470
Exoc1
exocyst complex component 1
chr10_-_37311625 1.15 ENSRNOT00000043343
Jade2
jade family PHD finger 2
chr10_-_11005952 1.13 ENSRNOT00000005031
Hmox2
heme oxygenase 2
chr6_+_100337226 1.09 ENSRNOT00000011220
Fut8
fucosyltransferase 8
chr11_-_43561883 1.03 ENSRNOT00000060877
Olr1553
olfactory receptor 1553
chr10_-_89130339 0.96 ENSRNOT00000027640
Ezh1
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr8_-_68275720 0.91 ENSRNOT00000079122
Map2k5
mitogen activated protein kinase kinase 5
chr14_-_2610929 0.86 ENSRNOT00000036442
Ccdc18
coiled-coil domain containing 18
chr3_+_149668102 0.81 ENSRNOT00000055342
Bpifb1
BPI fold containing family B, member 1
chr3_+_154910626 0.81 ENSRNOT00000079515
Ralgapb
Ral GTPase activating protein non-catalytic beta subunit
chr1_-_170005597 0.78 ENSRNOT00000023325
Olr192
olfactory receptor 192
chr12_-_51965779 0.71 ENSRNOT00000056733
LOC100362927
replication protein A3-like
chrX_-_143274180 0.68 ENSRNOT00000051550
Mcf2
MCF.2 cell line derived transforming sequence
chr8_+_5734348 0.68 ENSRNOT00000013119
Mmp10
matrix metallopeptidase 10
chr4_-_80395502 0.67 ENSRNOT00000014437
Npvf
neuropeptide VF precursor
chr15_+_35761388 0.56 ENSRNOT00000086118
Olr1286
olfactory receptor 1286
chr18_-_52017734 0.50 ENSRNOT00000081020
March3
membrane associated ring-CH-type finger 3
chr3_+_77018186 0.49 ENSRNOT00000074443
Olr646
olfactory receptor 646
chr3_-_78271875 0.48 ENSRNOT00000008475
Olr701
olfactory receptor 701
chr16_-_3765917 0.44 ENSRNOT00000088284
Duxbl1
double homeobox B-like 1
chr12_+_16899025 0.41 ENSRNOT00000001716
Psmg3
proteasome assembly chaperone 3
chr1_+_172348583 0.36 ENSRNOT00000041144
Olr250
olfactory receptor 250
chr19_+_11450760 0.27 ENSRNOT00000026297
Nudt21
nudix hydrolase 21
chr3_+_146981984 0.26 ENSRNOT00000090211
Nsfl1c
NSFL1 cofactor
chr2_+_185846232 0.25 ENSRNOT00000023418
Lrba
LPS responsive beige-like anchor protein
chr17_+_45467015 0.24 ENSRNOT00000081408
Gpx5
glutathione peroxidase 5
chr7_+_18120715 0.21 ENSRNOT00000068151
Vom1r108
vomeronasal 1 receptor 108
chr15_-_32888095 0.16 ENSRNOT00000012233
Dad1
defender against cell death 1
chr10_+_86564928 0.12 ENSRNOT00000039892
Lrrc3c
leucine rich repeat containing 3C
chr1_+_203526850 0.07 ENSRNOT00000087065
Bub3
BUB3 mitotic checkpoint protein
chr3_+_102841615 0.01 ENSRNOT00000075178
Olr770
olfactory receptor 770

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 34.3 GO:0034971 histone H3-R17 methylation(GO:0034971)
8.5 33.9 GO:0051958 methotrexate transport(GO:0051958)
7.2 21.7 GO:0033986 response to methanol(GO:0033986)
6.2 18.5 GO:0042335 cuticle development(GO:0042335) cornification(GO:0070268)
5.9 17.7 GO:0015942 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) formamide metabolic process(GO:0043606)
5.3 16.0 GO:0042412 taurine biosynthetic process(GO:0042412)
5.2 20.7 GO:1903976 negative regulation of glial cell migration(GO:1903976)
4.7 14.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
4.1 24.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
3.8 11.3 GO:0001969 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
3.4 13.7 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
3.1 12.4 GO:0070560 protein secretion by platelet(GO:0070560)
2.9 20.4 GO:0051799 negative regulation of hair follicle development(GO:0051799)
2.6 18.2 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
2.5 15.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
2.3 9.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
2.3 9.0 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
2.1 8.4 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.9 13.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
1.8 7.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268) malonyl-CoA biosynthetic process(GO:2001295)
1.6 15.7 GO:0003344 pericardium morphogenesis(GO:0003344)
1.6 4.7 GO:0031632 positive regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031632)
1.5 7.7 GO:0045218 zonula adherens maintenance(GO:0045218)
1.3 8.9 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
1.2 4.9 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.1 4.4 GO:0051643 endoplasmic reticulum localization(GO:0051643)
1.1 11.9 GO:0015747 urate transport(GO:0015747)
1.1 30.5 GO:0072337 modified amino acid transport(GO:0072337)
1.0 6.2 GO:0036438 maintenance of lens transparency(GO:0036438)
1.0 11.4 GO:0007258 JUN phosphorylation(GO:0007258)
1.0 4.8 GO:1904640 response to methionine(GO:1904640)
0.8 10.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.7 6.0 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.7 14.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 20.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.7 2.0 GO:1904383 response to sodium phosphate(GO:1904383)
0.6 5.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.6 11.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.6 3.9 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.5 5.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.5 6.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.5 53.8 GO:0046849 bone remodeling(GO:0046849)
0.5 2.0 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.5 7.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.5 8.7 GO:0021542 dentate gyrus development(GO:0021542)
0.4 2.7 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.4 7.0 GO:0019532 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.4 7.3 GO:0072189 ureter development(GO:0072189)
0.4 10.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.4 1.2 GO:0070340 detection of diacyl bacterial lipopeptide(GO:0042496) detection of bacterial lipopeptide(GO:0070340)
0.4 3.1 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.4 1.1 GO:0006788 heme oxidation(GO:0006788)
0.4 1.8 GO:0035063 nuclear speck organization(GO:0035063)
0.3 6.9 GO:0006828 manganese ion transport(GO:0006828) gamma-aminobutyric acid secretion(GO:0014051)
0.3 3.8 GO:0019321 pentose metabolic process(GO:0019321)
0.3 0.9 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.3 3.8 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.3 1.7 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.3 1.1 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.2 1.2 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.2 4.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.2 2.0 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 6.6 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 0.8 GO:0060178 regulation of exocyst localization(GO:0060178)
0.2 27.6 GO:0019233 sensory perception of pain(GO:0019233)
0.1 1.2 GO:0051601 exocyst localization(GO:0051601)
0.1 2.9 GO:0030488 tRNA methylation(GO:0030488)
0.1 1.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 5.1 GO:0031113 regulation of microtubule polymerization(GO:0031113)
0.1 19.3 GO:0007596 blood coagulation(GO:0007596)
0.1 1.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520) positive regulation of ERAD pathway(GO:1904294)
0.1 1.0 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 1.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.8 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.1 4.0 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 5.4 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 6.3 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 3.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.4 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 2.9 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.1 3.6 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.1 2.9 GO:0032570 response to progesterone(GO:0032570)
0.0 8.5 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 6.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 8.9 GO:0048193 Golgi vesicle transport(GO:0048193)
0.0 1.5 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.7 GO:0030574 collagen catabolic process(GO:0030574)
0.0 2.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 5.1 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.6 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0 1.2 GO:0008033 tRNA processing(GO:0008033)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
3.1 9.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
2.5 7.6 GO:0043511 inhibin complex(GO:0043511)
1.8 11.0 GO:0005608 laminin-3 complex(GO:0005608)
1.6 11.3 GO:0005579 membrane attack complex(GO:0005579)
1.5 4.4 GO:0042642 actomyosin, myosin complex part(GO:0042642)
1.2 24.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.0 34.3 GO:0005719 nuclear euchromatin(GO:0005719)
1.0 2.9 GO:0044609 DBIRD complex(GO:0044609)
0.8 69.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.7 8.9 GO:0030008 TRAPP complex(GO:0030008)
0.7 7.7 GO:0005915 zonula adherens(GO:0005915)
0.7 8.9 GO:0000801 central element(GO:0000801)
0.7 2.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.7 18.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.6 4.7 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.4 20.7 GO:0044295 axonal growth cone(GO:0044295)
0.4 1.2 GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.4 2.0 GO:1990716 axonemal central apparatus(GO:1990716)
0.4 2.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 2.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 3.1 GO:0008091 spectrin(GO:0008091) cuticular plate(GO:0032437)
0.3 5.1 GO:0042581 specific granule(GO:0042581)
0.2 1.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 1.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 12.3 GO:0045095 keratin filament(GO:0045095)
0.2 30.1 GO:0030426 growth cone(GO:0030426)
0.1 13.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 8.4 GO:0005643 nuclear pore(GO:0005643)
0.1 6.9 GO:0034704 calcium channel complex(GO:0034704)
0.1 32.6 GO:0097060 synaptic membrane(GO:0097060)
0.1 1.7 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.3 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 7.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 11.0 GO:0001650 fibrillar center(GO:0001650)
0.1 4.3 GO:0031901 early endosome membrane(GO:0031901)
0.1 4.9 GO:0032587 ruffle membrane(GO:0032587)
0.1 68.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 11.7 GO:0030141 secretory granule(GO:0030141)
0.1 1.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 55.3 GO:0005615 extracellular space(GO:0005615)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.1 GO:0030054 cell junction(GO:0030054)
0.0 10.7 GO:0000785 chromatin(GO:0000785)
0.0 2.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.4 GO:0000502 proteasome complex(GO:0000502)
0.0 1.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.1 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.7 GO:0000776 kinetochore(GO:0000776)
0.0 10.0 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 30.9 GO:0070062 extracellular exosome(GO:0070062)
0.0 1.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 7.3 GO:0005794 Golgi apparatus(GO:0005794)
0.0 23.5 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 34.3 GO:0038181 bile acid receptor activity(GO:0038181)
8.5 33.9 GO:0015350 methotrexate transporter activity(GO:0015350)
4.1 24.6 GO:0042954 lipoprotein transporter activity(GO:0042954)
3.5 17.7 GO:0016841 ammonia-lyase activity(GO:0016841)
3.1 9.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
2.7 13.3 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
2.6 10.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
2.2 15.3 GO:0001849 complement component C1q binding(GO:0001849)
1.9 7.6 GO:0070699 type II activin receptor binding(GO:0070699)
1.8 7.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.6 6.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
1.5 30.5 GO:0051184 cofactor transporter activity(GO:0051184) modified amino acid transmembrane transporter activity(GO:0072349)
1.5 18.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
1.1 11.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.1 15.7 GO:0045499 chemorepellent activity(GO:0045499)
1.0 32.8 GO:0042165 neurotransmitter binding(GO:0042165)
0.9 10.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.8 11.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.7 5.3 GO:0032184 SUMO polymer binding(GO:0032184)
0.6 4.8 GO:0008172 S-methyltransferase activity(GO:0008172) cobalamin binding(GO:0031419)
0.6 7.7 GO:0070097 delta-catenin binding(GO:0070097)
0.6 2.9 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.6 3.9 GO:0045340 mercury ion binding(GO:0045340)
0.6 5.0 GO:0005113 patched binding(GO:0005113)
0.5 6.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.5 7.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.4 8.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 1.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.4 1.2 GO:0035663 Toll-like receptor 2 binding(GO:0035663) diacyl lipopeptide binding(GO:0042498)
0.4 1.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.4 8.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.4 16.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 4.9 GO:0051378 serotonin binding(GO:0051378)
0.3 2.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.3 54.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.3 10.5 GO:0048020 chemokine activity(GO:0008009) CCR chemokine receptor binding(GO:0048020)
0.3 4.4 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.3 12.4 GO:0030507 spectrin binding(GO:0030507)
0.3 12.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 1.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 5.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.2 1.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 21.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 3.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 6.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 13.7 GO:0003823 antigen binding(GO:0003823)
0.1 2.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 2.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 2.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 3.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.1 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 3.1 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 6.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 2.7 GO:0070888 E-box binding(GO:0070888)
0.1 5.9 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 1.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 4.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 11.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 12.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 28.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 3.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 4.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 6.2 GO:0016874 ligase activity(GO:0016874)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 5.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 34.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.6 11.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 29.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.3 5.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.3 15.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 7.6 PID ALK1 PATHWAY ALK1 signaling events
0.2 13.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 11.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 7.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 4.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 3.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 0.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 12.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.7 PID P73PATHWAY p73 transcription factor network
0.0 2.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 20.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.4 15.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.1 11.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.9 18.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.8 11.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.8 22.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.8 7.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.7 20.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.6 6.9 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 10.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.3 4.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 4.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.3 7.1 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.3 5.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 21.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 3.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 4.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 8.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 18.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 8.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 11.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 3.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 17.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.7 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 9.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.0 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 6.2 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.1 3.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.2 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.9 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane