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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxg1

Z-value: 0.59

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Transcription factors associated with Foxg1

Gene Symbol Gene ID Gene Info
Foxg1
ENSRNOG00000047891 forkhead box G1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxg1rn6_v1_chr6_+_69971227_699712270.801.1e-73Click!

Activity profile of Foxg1 motif

Sorted Z-values of Foxg1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_136853957 28.35 ENSRNOT00000008985
Nell2
neural EGFL like 2
chr7_-_136853154 26.09 ENSRNOT00000087376
Nell2
neural EGFL like 2
chr2_-_231521052 23.46 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
Ank2
ankyrin 2
chr13_-_95348913 20.67 ENSRNOT00000057879
Akt3
AKT serine/threonine kinase 3
chr5_+_172364421 19.03 ENSRNOT00000018769
Hes5
hes family bHLH transcription factor 5
chr9_+_6970507 15.48 ENSRNOT00000079488
St6gal2
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
chr3_-_52664209 14.74 ENSRNOT00000065126
ENSRNOT00000079020
Scn9a
sodium voltage-gated channel alpha subunit 9
chr2_+_115739813 14.54 ENSRNOT00000085452
Slc7a14
solute carrier family 7, member 14
chrX_+_6273733 14.35 ENSRNOT00000074275
Ndp
NDP, norrin cystine knot growth factor
chr4_-_7228675 12.92 ENSRNOT00000064386
Agap3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr7_-_126465723 12.81 ENSRNOT00000021196
Wnt7b
wingless-type MMTV integration site family, member 7B
chr1_-_219532609 11.38 ENSRNOT00000025641
Ankrd13d
ankyrin repeat domain 13D
chr5_+_64326733 11.37 ENSRNOT00000065775
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr14_+_17534412 10.77 ENSRNOT00000079304
ENSRNOT00000046771
Cdkl2
cyclin dependent kinase like 2
chr5_-_20189721 10.25 ENSRNOT00000014661
Tox
thymocyte selection-associated high mobility group box
chr14_-_112946204 9.94 ENSRNOT00000056813
LOC103690141
coiled-coil domain-containing protein 85A-like
chr10_-_96015499 7.88 ENSRNOT00000004383
Cacng4
calcium voltage-gated channel auxiliary subunit gamma 4
chr13_-_95250235 7.72 ENSRNOT00000085648
Akt3
AKT serine/threonine kinase 3
chr1_+_81373340 7.41 ENSRNOT00000026814
Zfp428
zinc finger protein 428
chr15_-_108120279 7.21 ENSRNOT00000090572
Dock9
dedicator of cytokinesis 9
chr18_+_64084795 5.19 ENSRNOT00000022410
Rnmt
RNA (guanine-7-) methyltransferase
chr8_-_73194837 5.00 ENSRNOT00000024885
ENSRNOT00000081450
ENSRNOT00000064613
Tln2
talin 2
chr10_-_84847857 4.51 ENSRNOT00000071495
LOC102552549
migration and invasion enhancer 1-like
chr8_+_59164572 3.87 ENSRNOT00000015102
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr10_-_86393141 2.90 ENSRNOT00000009485
Mien1
migration and invasion enhancer 1
chr8_+_11931767 2.81 ENSRNOT00000087963
Maml2
mastermind-like transcriptional coactivator 2
chr9_-_80167033 2.57 ENSRNOT00000023530
Igfbp5
insulin-like growth factor binding protein 5
chr6_-_111477090 2.55 ENSRNOT00000016389
Alkbh1
alkB homolog 1, histone H2A dioxygenase
chr1_+_40389638 2.49 ENSRNOT00000021471
Plekhg1
pleckstrin homology and RhoGEF domain containing G1
chr18_+_44737154 2.41 ENSRNOT00000021972
Tnfaip8
TNF alpha induced protein 8
chr5_+_135574172 2.20 ENSRNOT00000023416
Tesk2
testis-specific kinase 2
chr3_-_22500765 2.00 ENSRNOT00000025443
Dennd1a
DENN domain containing 1A
chr1_-_164659992 1.88 ENSRNOT00000024281
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr10_-_18506337 1.76 ENSRNOT00000043036
Gabrp
gamma-aminobutyric acid type A receptor pi subunit
chr5_+_160356245 1.66 ENSRNOT00000085378
Casp9
caspase 9
chr8_+_114866768 1.61 ENSRNOT00000076731
Wdr82
WD repeat domain 82
chr17_+_77601877 1.60 ENSRNOT00000091554
ENSRNOT00000024872
Prpf18
pre-mRNA processing factor 18
chr3_-_148312791 1.43 ENSRNOT00000091419
Bcl2l1
Bcl2-like 1
chr1_-_99135977 1.34 ENSRNOT00000056515
Vom2r38
vomeronasal 2 receptor, 38
chr8_-_48727154 1.18 ENSRNOT00000088471
Trappc4
trafficking protein particle complex 4
chr6_-_29975730 1.14 ENSRNOT00000075574
Wdcp
WD repeat and coiled coil containing
chr1_-_92119951 0.99 ENSRNOT00000018153
ENSRNOT00000092121
Zfp507
zinc finger protein 507
chr1_-_101236065 0.81 ENSRNOT00000066834
Cd37
CD37 molecule
chr6_+_111476768 0.76 ENSRNOT00000016479
Slirp
SRA stem-loop interacting RNA binding protein
chr14_-_106864892 0.71 ENSRNOT00000090664
Otx1
orthodenticle homeobox 1
chr8_+_114867062 0.58 ENSRNOT00000074771
Wdr82
WD repeat domain 82
chr4_-_106983279 0.55 ENSRNOT00000007700
AABR07061152.1

chr15_+_26887767 0.49 ENSRNOT00000016674
Olr1627
olfactory receptor 1627
chr13_+_92264231 0.31 ENSRNOT00000066509
ENSRNOT00000004716
Spta1
spectrin, alpha, erythrocytic 1
chr4_+_68653369 0.08 ENSRNOT00000046917
Tas2r137
taste receptor, type 2, member 137
chr20_+_11588200 0.07 ENSRNOT00000041259
AABR07072821.1

chr1_+_171188133 0.07 ENSRNOT00000026511
Olr231
olfactory receptor 231

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxg1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 19.0 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974) negative regulation of forebrain neuron differentiation(GO:2000978)
5.9 23.5 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
4.5 54.4 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
4.3 12.8 GO:0072054 chemoattraction of axon(GO:0061642) renal outer medulla development(GO:0072054)
3.7 14.7 GO:0043179 rhythmic excitation(GO:0043179)
2.4 14.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.3 5.2 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
1.2 28.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.9 2.6 GO:0042245 RNA repair(GO:0042245)
0.7 15.5 GO:0097503 sialylation(GO:0097503)
0.6 3.9 GO:0006102 isocitrate metabolic process(GO:0006102)
0.6 2.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.5 1.6 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.5 1.4 GO:1905218 cellular response to astaxanthin(GO:1905218)
0.5 1.9 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.5 2.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.5 5.0 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.3 7.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 2.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 12.9 GO:0000060 protein import into nucleus, translocation(GO:0000060)
0.2 0.8 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.2 14.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.2 0.8 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 0.7 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 2.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 10.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.7 GO:0032025 response to cobalt ion(GO:0032025)
0.1 2.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 2.4 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 2.2 GO:0048041 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 10.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 1.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0045242 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
0.7 14.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.7 23.5 GO:0031430 M band(GO:0031430)
0.4 2.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.3 1.7 GO:0043293 apoptosome(GO:0043293)
0.3 5.2 GO:0005845 mRNA cap binding complex(GO:0005845)
0.3 5.0 GO:0005916 fascia adherens(GO:0005916)
0.3 7.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 54.4 GO:0043204 perikaryon(GO:0043204)
0.2 15.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 2.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 2.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.2 GO:0030008 TRAPP complex(GO:0030008)
0.1 2.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.3 GO:0032437 spectrin(GO:0008091) cuticular plate(GO:0032437)
0.1 1.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.6 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.0 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 25.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.8 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
3.9 15.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.3 82.8 GO:0005080 protein kinase C binding(GO:0005080)
1.0 3.9 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.7 5.2 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.6 2.6 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.6 14.7 GO:0031402 sodium ion binding(GO:0031402)
0.5 1.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.5 23.5 GO:0030507 spectrin binding(GO:0030507)
0.4 10.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.4 14.4 GO:0005109 frizzled binding(GO:0005109)
0.3 2.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 12.9 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 1.4 GO:0051434 BH3 domain binding(GO:0051434)
0.1 7.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 14.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 1.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 9.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 3.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 10.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 5.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.8 GO:0003713 transcription coactivator activity(GO:0003713)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 28.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 12.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 57.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 7.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 19.0 PID CDC42 PATHWAY CDC42 signaling events
0.2 3.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 5.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 28.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 21.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 7.9 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 3.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 1.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 1.7 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 5.0 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.1 12.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes