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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxo3

Z-value: 0.66

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Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
Foxo3
ENSRNOG00000000299 forkhead box O3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo3rn6_v1_chr20_+_46429222_464292220.072.1e-01Click!

Activity profile of Foxo3 motif

Sorted Z-values of Foxo3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_64818813 27.88 ENSRNOT00000009111
ENSRNOT00000086505
Aldob
aldolase, fructose-bisphosphate B
chr7_-_119689938 20.71 ENSRNOT00000000200
Tmprss6
transmembrane protease, serine 6
chr13_+_91080341 19.42 ENSRNOT00000000058
Crp
C-reactive protein
chr4_+_154391647 18.53 ENSRNOT00000081488
ENSRNOT00000079192
Mug1
murinoglobulin 1
chr14_+_87448692 17.73 ENSRNOT00000077177
Igfbp1
insulin-like growth factor binding protein 1
chr20_-_54517709 17.49 ENSRNOT00000076234
Grik2
glutamate ionotropic receptor kainate type subunit 2
chr13_+_89597138 16.51 ENSRNOT00000004662
Apoa2
apolipoprotein A2
chr2_+_262914327 15.69 ENSRNOT00000029312
Negr1
neuronal growth regulator 1
chr1_+_234252757 15.15 ENSRNOT00000091814
Rorb
RAR-related orphan receptor B
chr1_+_88750462 15.13 ENSRNOT00000028247
LOC108348122
CAP-Gly domain-containing linker protein 3
chr3_-_937102 14.28 ENSRNOT00000007471
Hnmt
histamine N-methyltransferase
chr16_+_50049828 13.48 ENSRNOT00000034448
Fam149a
family with sequence similarity 149, member A
chr10_+_86399827 13.01 ENSRNOT00000009299
Grb7
growth factor receptor bound protein 7
chr1_-_90978907 12.54 ENSRNOT00000072819
Clip3
CAP-GLY domain containing linker protein 3
chr10_+_89285855 12.18 ENSRNOT00000028033
G6pc
glucose-6-phosphatase, catalytic subunit
chr10_+_89286047 10.98 ENSRNOT00000085831
G6pc
glucose-6-phosphatase, catalytic subunit
chr5_+_124690214 10.76 ENSRNOT00000011237
Plpp3
phospholipid phosphatase 3
chr2_-_258997138 9.22 ENSRNOT00000045020
ENSRNOT00000042256
Adgrl2
adhesion G protein-coupled receptor L2
chrX_+_65040775 8.79 ENSRNOT00000081354
Zc3h12b
zinc finger CCCH-type containing 12B
chr6_-_27487284 8.71 ENSRNOT00000084344
Selenoi
selenoprotein I
chrX_+_65040934 8.40 ENSRNOT00000044006
Zc3h12b
zinc finger CCCH-type containing 12B
chr3_+_131351587 8.16 ENSRNOT00000010835
Btbd3
BTB domain containing 3
chr10_-_25845634 7.04 ENSRNOT00000004269
Mat2b
methionine adenosyltransferase 2B
chr1_-_131454689 6.91 ENSRNOT00000014152
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr3_+_61658245 6.63 ENSRNOT00000033511
Hoxd3
homeo box D3
chr10_-_46720907 6.56 ENSRNOT00000083093
ENSRNOT00000067866
Tom1l2
target of myb1 like 2 membrane trafficking protein
chr6_-_44363915 6.50 ENSRNOT00000085925
Id2
inhibitor of DNA binding 2, HLH protein
chr10_-_71849293 6.49 ENSRNOT00000003799
Lhx1
LIM homeobox 1
chr14_-_44845218 5.52 ENSRNOT00000004003
Klhl5
kelch-like family member 5
chr2_-_188596222 5.41 ENSRNOT00000027920
Efna1
ephrin A1
chr18_+_44810388 5.38 ENSRNOT00000021646
ENSRNOT00000089750
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
chr15_-_28313841 5.24 ENSRNOT00000085897
Ndrg2
NDRG family member 2
chr10_-_81942188 5.01 ENSRNOT00000003784
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr11_-_15858281 4.58 ENSRNOT00000090586
AABR07033287.1

chr14_+_104191517 4.48 ENSRNOT00000006573
Spred2
sprouty-related, EVH1 domain containing 2
chr6_-_51018050 4.13 ENSRNOT00000082691
Gpr22
G protein-coupled receptor 22
chr18_+_13386133 4.07 ENSRNOT00000020661
Asxl3
additional sex combs like 3, transcriptional regulator
chr15_+_2374582 3.99 ENSRNOT00000019644
Zfp503
zinc finger protein 503
chr7_-_107775712 3.70 ENSRNOT00000010811
ENSRNOT00000093459
Ndrg1
N-myc downstream regulated 1
chr3_+_116899878 3.68 ENSRNOT00000090802
ENSRNOT00000066101
Sema6d
semaphorin 6D
chr3_-_37480984 3.58 ENSRNOT00000030373
Nmi
N-myc (and STAT) interactor
chr2_-_30634243 3.33 ENSRNOT00000077537
Marveld2
MARVEL domain containing 2
chr7_-_120770435 3.32 ENSRNOT00000077000
Ddx17
DEAD-box helicase 17
chr4_+_41364441 3.02 ENSRNOT00000087146
Foxp2
forkhead box P2
chr15_-_108120279 2.98 ENSRNOT00000090572
Dock9
dedicator of cytokinesis 9
chr14_-_8432195 2.80 ENSRNOT00000089800
Arhgap24
Rho GTPase activating protein 24
chr8_+_85417838 2.73 ENSRNOT00000012257
Ick
intestinal cell kinase
chr11_+_73693814 2.41 ENSRNOT00000081081
ENSRNOT00000002354
ENSRNOT00000090940
Lsg1
large 60S subunit nuclear export GTPase 1
chr3_-_21148897 2.22 ENSRNOT00000010501
Olr425
olfactory receptor 425
chr7_+_59326518 2.22 ENSRNOT00000085231
Ptprb
protein tyrosine phosphatase, receptor type, B
chr18_-_5314511 2.14 ENSRNOT00000022637
ENSRNOT00000079682
Zfp521
zinc finger protein 521
chr19_+_38601786 2.04 ENSRNOT00000087655
Zfp90
zinc finger protein 90
chr3_+_80614937 1.94 ENSRNOT00000065462
Harbi1
harbinger transposase derived 1
chr2_-_98610368 1.91 ENSRNOT00000011641
Zfhx4
zinc finger homeobox 4
chr13_-_30800451 1.87 ENSRNOT00000046791
Rpl21
ribosomal protein L21
chr2_+_184243976 1.76 ENSRNOT00000042146
Dear
dual endothelin 1, angiotensin II receptor
chr18_+_3887419 1.61 ENSRNOT00000093089
Lama3
laminin subunit alpha 3
chr4_-_115516296 1.59 ENSRNOT00000019399
Paip2b
poly(A) binding protein interacting protein 2B
chrX_+_10430847 1.50 ENSRNOT00000047936
Rpl21
ribosomal protein L21
chr3_+_91870208 1.49 ENSRNOT00000040249
Rpl21
ribosomal protein L21
chr20_+_46519431 1.43 ENSRNOT00000077765
AABR07045405.1

chr3_-_58009514 1.40 ENSRNOT00000048356
AABR07052498.1

chr2_-_34254968 1.32 ENSRNOT00000016439
Trappc13
trafficking protein particle complex 13
chr2_+_34255305 1.28 ENSRNOT00000016649
ENSRNOT00000016596
Trim23
tripartite motif-containing 23
chr17_-_74679696 1.16 ENSRNOT00000048420
AABR07028558.1

chr13_-_91638661 1.04 ENSRNOT00000045429
Olr1579
olfactory receptor 1579
chr10_+_11393103 1.01 ENSRNOT00000076022
Adcy9
adenylate cyclase 9
chr1_-_170801560 0.97 ENSRNOT00000047852
Olr211
olfactory receptor 211
chr9_+_42315682 0.95 ENSRNOT00000071995
AABR07067388.1

chr8_+_32604365 0.89 ENSRNOT00000071210
AABR07069587.1

chr17_-_84705052 0.78 ENSRNOT00000050803
AABR07028749.1

chr10_-_87335823 0.74 ENSRNOT00000079297
Krt12
keratin 12
chr16_-_69280109 0.69 ENSRNOT00000058595
AABR07026240.1

chr4_+_152630469 0.54 ENSRNOT00000013721
Ninj2
ninjurin 2
chr10_-_72556564 0.52 ENSRNOT00000048373
AABR07030162.1

chr9_-_66627007 0.51 ENSRNOT00000049571
AABR07067829.1

chr20_+_11649814 0.43 ENSRNOT00000073516
LOC103694398
keratin-associated protein 10-1-like
chr16_+_27399467 0.35 ENSRNOT00000065642
Tll1
tolloid-like 1
chr1_-_173393390 0.29 ENSRNOT00000050657
Olr285
olfactory receptor 285
chr1_+_190671696 0.28 ENSRNOT00000084934
AABR07005633.1

chr6_+_42947334 0.24 ENSRNOT00000041376
RGD1563157
similar to 60S ribosomal protein L35
chr3_+_63536166 0.20 ENSRNOT00000016132
Plekha3
pleckstrin homology domain containing A3
chr9_-_121972055 0.18 ENSRNOT00000089735
AABR07068851.1
clusterin-like protein 1
chrX_-_20359945 0.11 ENSRNOT00000049138
AABR07037412.1

chr16_-_32299542 0.10 ENSRNOT00000072321
AABR07025299.1

chr18_+_47740328 0.01 ENSRNOT00000025119
Sncaip
synuclein, alpha interacting protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.3 27.9 GO:0006116 NADH oxidation(GO:0006116)
5.5 16.5 GO:0046340 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) diacylglycerol catabolic process(GO:0046340)
4.0 4.0 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
3.6 10.8 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330)
3.6 14.3 GO:0001692 histamine metabolic process(GO:0001692)
3.5 27.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
3.2 19.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
2.3 23.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.3 6.9 GO:0060849 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
2.2 6.5 GO:0001966 thigmotaxis(GO:0001966)
1.9 20.7 GO:0097264 self proteolysis(GO:0097264)
1.8 5.4 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
1.7 6.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
1.6 6.5 GO:0060066 metanephric part of ureteric bud development(GO:0035502) oviduct development(GO:0060066)
1.4 7.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
1.4 5.4 GO:0014028 notochord formation(GO:0014028)
1.3 5.2 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.3 15.2 GO:0046548 amacrine cell differentiation(GO:0035881) retinal rod cell development(GO:0046548) retinal cone cell development(GO:0046549)
1.0 13.0 GO:0034063 stress granule assembly(GO:0034063)
0.9 3.6 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.9 17.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.7 2.7 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.6 17.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.6 8.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.4 3.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 1.8 GO:0086100 endothelin receptor signaling pathway(GO:0086100)
0.3 3.7 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.3 18.5 GO:0006953 acute-phase response(GO:0006953)
0.3 2.8 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 4.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 3.3 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1 6.6 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 3.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 7.1 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.1 15.7 GO:0007631 feeding behavior(GO:0007631)
0.1 0.7 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 8.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 3.3 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 8.2 GO:0021987 cerebral cortex development(GO:0021987)
0.1 1.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 1.0 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 2.1 GO:0048663 neuron fate commitment(GO:0048663)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 27.9 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
2.9 17.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
2.3 7.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
1.8 16.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
1.0 27.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.7 3.3 GO:0061689 tricellular tight junction(GO:0061689)
0.3 1.6 GO:0005608 laminin-3 complex(GO:0005608)
0.3 13.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 2.7 GO:0097542 ciliary tip(GO:0097542)
0.2 21.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 23.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 19.4 GO:0030175 filopodium(GO:0030175)
0.2 6.6 GO:0016235 aggresome(GO:0016235)
0.2 18.5 GO:0072562 blood microparticle(GO:0072562)
0.1 8.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 5.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 5.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.4 GO:0015030 Cajal body(GO:0015030)
0.0 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.5 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 5.2 GO:0030426 growth cone(GO:0030426)
0.0 36.3 GO:0005615 extracellular space(GO:0005615)
0.0 22.9 GO:0043005 neuron projection(GO:0043005)
0.0 6.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.2 GO:0043235 receptor complex(GO:0043235)
0.0 3.3 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
4.8 14.3 GO:0098603 selenol Se-methyltransferase activity(GO:0098603)
4.6 23.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
4.0 27.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
4.0 27.7 GO:0097001 ceramide binding(GO:0097001)
3.6 10.8 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
3.0 15.2 GO:0008502 melatonin receptor activity(GO:0008502)
2.9 8.7 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
2.8 19.4 GO:0001849 complement component C1q binding(GO:0001849)
2.5 17.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
2.0 17.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.8 5.4 GO:0016508 long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.6 4.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.4 6.9 GO:0001972 retinoic acid binding(GO:0001972)
0.4 1.8 GO:0004962 angiotensin type II receptor activity(GO:0004945) endothelin receptor activity(GO:0004962)
0.3 3.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 23.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 3.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 20.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.0 GO:0050681 androgen receptor binding(GO:0050681)
0.1 6.6 GO:0030276 clathrin binding(GO:0030276)
0.1 3.3 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 9.2 GO:0030165 PDZ domain binding(GO:0030165)
0.1 6.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 13.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 6.5 GO:0044325 ion channel binding(GO:0044325)
0.0 1.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 8.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.3 GO:0019003 GDP binding(GO:0019003)
0.0 4.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.4 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 68.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 5.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 13.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 19.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 14.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 6.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 3.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 19.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.1 17.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.0 16.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.8 17.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.7 27.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 5.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.5 11.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.5 23.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 7.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 15.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 4.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 3.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.0 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 2.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization